{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T07:30:28Z","timestamp":1782113428855,"version":"3.54.5"},"reference-count":94,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T00:00:00Z","timestamp":1512345600000},"content-version":"vor","delay-in-days":3443,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["bjanaesthesia.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["British Journal of Anaesthesia"],"published-print":{"date-parts":[[2008,7]]},"DOI":"10.1093\/bja\/aen100","type":"journal-article","created":{"date-parts":[[2008,5,21]],"date-time":"2008-05-21T12:34:47Z","timestamp":1211373287000},"page":"87-94","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":86,"title":["Translational medicine: cancer pain mechanisms and management"],"prefix":"10.1016","volume":"101","author":[{"given":"A.","family":"Delaney","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.M.","family":"Fleetwood-Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.A.","family":"Colvin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Fallon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/bja\/aen100_bib1","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s11916-000-0069-4","article-title":"Nociceptors for the 21st century","volume":"4","author":"Alvarez","year":"2000","journal-title":"Curr Rev Pain"},{"key":"10.1093\/bja\/aen100_bib2","first-page":"6876","article-title":"A murine model of experimental metastasis to bone and bone marrow","volume":"48","author":"Arguello","year":"1988","journal-title":"Cancer Res"},{"key":"10.1093\/bja\/aen100_bib4","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature01658","article-title":"Osteoclast differentiation and activation","volume":"423","author":"Boyle","year":"2008","journal-title":"Nature"},{"key":"10.1093\/bja\/aen100_bib5","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1001\/jama.290.18.2476","article-title":"Cancer pain","volume":"290","author":"Bruera","year":"2003","journal-title":"JAMA"},{"key":"10.1093\/bja\/aen100_bib6","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1053\/ctrv.2000.0210","article-title":"Metastatic bone disease: clinical features, pathophysiology and treatment strategies","volume":"27","author":"Coleman","year":"2001","journal-title":"Cancer Treat Rev"},{"key":"10.1093\/bja\/aen100_bib7","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/bjc.1987.13","article-title":"The clinical course of bone metastases from breast cancer","volume":"55","author":"Coleman","year":"1987","journal-title":"Br J Cancer"},{"key":"10.1093\/bja\/aen100_bib8","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0305-7372(85)90008-8","article-title":"Bone metastases and breast cancer","volume":"12","author":"Coleman","year":"1985","journal-title":"Cancer Treat Rev"},{"key":"10.1093\/bja\/aen100_bib9","doi-asserted-by":"crossref","first-page":"4497","DOI":"10.1200\/JCO.2006.09.1462","article-title":"When opioids cause pain","volume":"25","author":"Davis","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1093\/bja\/aen100_bib10","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0304-3959(00)00455-3","article-title":"The Amsterdam Pain Management Index compared to eight frequently used outcome measures to evaluate the adequacy of pain treatment in cancer patients with chronic pain","volume":"91","author":"de Wit","year":"2001","journal-title":"Pain"},{"key":"10.1093\/bja\/aen100_bib11","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/0306-4522(92)90237-V","article-title":"Increased content and transport of substance P and calcitonin gene-related peptide in sensory nerves innervating inflamed tissue: evidence for a regulatory function of nerve growth factor in vivo","volume":"49","author":"Donnerer","year":"1992","journal-title":"Neuroscience"},{"key":"10.1093\/bja\/aen100_bib12","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/00000542-200501000-00022","article-title":"Gabapentin normalizes spinal neuronal responses that correlate with behavior in a rat model of cancer-induced bone pain","volume":"102","author":"Donovan-Rodriguez","year":"2005","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aen100_bib13","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.neulet.2005.09.073","article-title":"Evidence of a role for descending serotonergic facilitation in a rat model of cancer-induced bone pain","volume":"393","author":"Donovan-Rodriguez","year":"2006","journal-title":"Neurosci Lett"},{"key":"10.1093\/bja\/aen100_bib14","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1177\/030006059001800406","article-title":"Ketorolac, a new non-opioid analgesic: a double-blind trial versus pentazocine in cancer pain","volume":"18","author":"Estape","year":"1990","journal-title":"J Int Med Res"},{"key":"10.1093\/bja\/aen100_bib15","first-page":"41","article-title":"Biochemistry of cyclooxygenase (COX)-2 inhibitors and molecular pathology of COX-2 in neoplasia","volume":"37","author":"Fosslien","year":"2000","journal-title":"Crit Rev Neurobiol"},{"key":"10.1093\/bja\/aen100_bib16","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/cpt1975173277","article-title":"Doubleblind study of the analgesic effect of indoprofen (K 4277)","volume":"17","author":"Fuccella","year":"1975","journal-title":"Clin Pharmacol Ther"},{"key":"10.1093\/bja\/aen100_bib17","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/0306-4522(94)00545-G","article-title":"Plasticity in the synthesis and storage of substance P and calcitonin gene-related peptide in primary afferent neurons during peripheral inflammation","volume":"66","author":"Galeazza","year":"1995","journal-title":"Neuroscience"},{"key":"10.1093\/bja\/aen100_bib18","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1667\/RR3108","article-title":"Radiation treatment decreases bone cancer pain, osteolysis and tumor size","volume":"161","author":"Goblirsch","year":"2004","journal-title":"Radiat Res"},{"key":"10.1093\/bja\/aen100_bib19","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/jcb.21296","article-title":"Effects of Vitaxin, a novel therapeutic in trial for metastatic bone tumors, on osteoclast functions in vitro","volume":"102","author":"Gramoun","year":"2007","journal-title":"J Cell Biochem"},{"key":"10.1093\/bja\/aen100_bib20","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0304-3959(00)00346-8","article-title":"An excitatory role for 5-HT in spinal inflammatory nociceptive transmission; state-dependent actions via dorsal horn 5-HT(3) receptors in the anaesthetized rat","volume":"89","author":"Green","year":"2000","journal-title":"Pain"},{"key":"10.1093\/bja\/aen100_bib21","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1002\/1097-0142(20000615)88:12+<2892::AID-CNCR2>3.0.CO;2-Y","article-title":"Molecular mechanisms of osteolytic bone metastases","volume":"88","author":"Guise","year":"2000","journal-title":"Cancer"},{"key":"10.1093\/bja\/aen100_bib22","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1046\/j.1460-9568.1999.00503.x","article-title":"Immunocytochemical localization of the vanilloid receptor 1 (VR1): relationship to neuropeptides, the P2X(3) purinoceptor and IB4 binding sites","volume":"11","author":"Guo","year":"1999","journal-title":"Eur J Neurosci"},{"key":"10.1093\/bja\/aen100_bib23","doi-asserted-by":"crossref","first-page":"9426","DOI":"10.1158\/0008-5472.CAN-05-0826","article-title":"A blocking antibody to nerve growth factor attenuates skeletal pain induced by prostate tumor cells growing in bone","volume":"65","author":"Halvorson","year":"2005","journal-title":"Cancer Res"},{"key":"10.1093\/bja\/aen100_bib24","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1054\/bjoc.2001.1680","article-title":"Expert Working Group of the Research Network of the European Association for Palliative Care. Morphine and alternative opioids in cancer pain: the EAPC recommendations","volume":"84","author":"Hanks","year":"2001","journal-title":"Br J Cancer"},{"key":"10.1093\/bja\/aen100_bib25","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/BF00319037","article-title":"Distribution of CGRP-, VIP-, D beta H-, SP-, and NPY-immunoreactive nerves in the periosteum of the rat","volume":"264","author":"Hill","year":"1991","journal-title":"Cell Tissue Res"},{"key":"10.1093\/bja\/aen100_bib26","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/74999","article-title":"Osteoprotegerin blocks bone cancer-induced skeletal destruction, skeletal pain and pain-related neurochemical reorganization of the spinal cord","volume":"6","author":"Honore","year":"2000","journal-title":"Nat Med"},{"key":"10.1093\/bja\/aen100_bib27","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1046\/j.1526-4637.2000.00047.x","article-title":"Bone cancer pain: from mechanism to model to therapy","volume":"1","author":"Honore","year":"2000","journal-title":"Pain Med"},{"key":"10.1093\/bja\/aen100_bib28","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0306-4522(00)00110-X","article-title":"Murine models of inflammatory, neuropathic and cancer pain each generates a unique set of neurochemical changes in the spinal cord and sensory neurons","volume":"98","author":"Honore","year":"2000","journal-title":"Neuroscience"},{"key":"10.1093\/bja\/aen100_bib29","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0079-6123(00)29030-4","article-title":"Cellular and neurochemical remodeling of the spinal cord in bone cancer pain","volume":"129","author":"Honore","year":"2000","journal-title":"Prog Brain Res"},{"key":"10.1093\/bja\/aen100_bib30","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0896-6273(02)00908-X","article-title":"p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia","volume":"36","author":"Ji","year":"2002","journal-title":"Neuron"},{"key":"10.1093\/bja\/aen100_bib31","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.pain.2007.06.026","article-title":"Morphine treatment accelerates sarcoma induced bone pain, bone loss, and spontaneous fracture in a murine model of bone cancer","volume":"132","author":"King","year":"2007","journal-title":"Pain"},{"key":"10.1093\/bja\/aen100_bib32","first-page":"5452","article-title":"Increased growth rate and tumor burden of spontaneously metastatic Walker 256 cancer cells in the skeleton of bisphosphonate-treated rats","volume":"53","author":"Kostenuik","year":"1993","journal-title":"Cancer Res"},{"key":"10.1093\/bja\/aen100_bib33","first-page":"4038","article-title":"Osteoprotegerin diminishes advanced bone cancer pain","volume":"61","author":"Luger","year":"2001","journal-title":"Cancer Res"},{"key":"10.1093\/bja\/aen100_bib34","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1016\/j.jpainsymman.2005.01.008","article-title":"Bone cancer pain: from model to mechanism to therapy","volume":"29","author":"Luger","year":"2005","journal-title":"J Pain Symptom Manage"},{"key":"10.1093\/bja\/aen100_bib35","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0304-3959(02)00102-1","article-title":"Efficacy of systemic morphine suggests a fundamental difference in the mechanisms that generate bone cancer vs. inflammatory pain","volume":"99","author":"Luger","year":"2002","journal-title":"Pain"},{"key":"10.1093\/bja\/aen100_bib36","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0306-4522(02)00165-3","article-title":"Origins of skeletal pain: sensory and sympathetic innervation of the mouse femur","volume":"113","author":"Mach","year":"2002","journal-title":"Neuroscience"},{"key":"10.1093\/bja\/aen100_bib37","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nrc747","article-title":"Molecular mechanisms of cancer pain","volume":"2","author":"Mantyh","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"10.1093\/bja\/aen100_bib38","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0304-3959(94)90202-X","article-title":"Altered tachykinin expression by dorsal-root ganglion neurons in a rat model of neuropathic pain","volume":"58","author":"Marchand","year":"1994","journal-title":"Pain"},{"key":"10.1093\/bja\/aen100_bib39","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.neulet.2007.08.055","article-title":"Organization of a unique net-like meshwork of CGRP+ sensory fibers in the mouse periosteum: implications for the generation and maintenance of bone fracture pain","volume":"427","author":"Martin","year":"2007","journal-title":"Neurosci Lett"},{"key":"10.1093\/bja\/aen100_bib40","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/neu.20093","article-title":"Plasticity of pain signaling: role of neurotrophic factors exemplified by acid-induced pain","volume":"61","author":"McMahon","year":"2004","journal-title":"J Neurobiol"},{"key":"10.1093\/bja\/aen100_bib41","article-title":"Radiotherapy for the palliation of painful bone metastases","author":"McQuay","year":"2000","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1093\/bja\/aen100_bib42","first-page":"156P","article-title":"Antinociceptive effects of the bisphosphonate, zoledronic acid, in a novel rat model of bone cancer pain","volume":"134","author":"Medhurst","year":"2001","journal-title":"Br J Pharmacol"},{"key":"10.1093\/bja\/aen100_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0304-3959(96)03267-8","article-title":"Malignant bone pain: pathophysiology and treatment","volume":"69","author":"Mercadante","year":"1997","journal-title":"Pain"},{"key":"10.1093\/bja\/aen100_bib44","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0304-3959(92)90155-5","article-title":"Predictive factors in advanced cancer pain treated only by analgesics","volume":"50","author":"Mercadante","year":"1992","journal-title":"Pain"},{"key":"10.1093\/bja\/aen100_bib45","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0304-3959(01)00324-4","article-title":"Symptoms during cancer pain treatment following WHO-guidelines: a longitudinal follow-up study of symptom prevalence, severity and etiology","volume":"91","author":"Meuser","year":"2001","journal-title":"Pain"},{"key":"10.1093\/bja\/aen100_bib46","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0304-3959(97)00157-7","article-title":"Double-blind evaluation of short-term analgesic efficacy of orally administered diclofenac, diclofenac plus codeine, and diclofenac plus imipramine in chronic cancer pain","volume":"74","author":"Minotti","year":"1998","journal-title":"Pain"},{"key":"10.1093\/bja\/aen100_bib47","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0304-3959(89)90021-3","article-title":"Double-blind evaluation of analgesic efficacy of orally administered diclofenac, nefopam, and acetylsalicylic acid (ASA) plus codeine in chronic cancer pain","volume":"36","author":"Minotti","year":"1989","journal-title":"Pain"},{"key":"10.1093\/bja\/aen100_bib48","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0304-3959(94)90189-9","article-title":"Primary sensory neurons exhibit altered gene expression in a rat model of neuropathic pain","volume":"58","author":"Nahin","year":"1994","journal-title":"Pain"},{"key":"10.1093\/bja\/aen100_bib49","doi-asserted-by":"crossref","first-page":"S65","DOI":"10.1097\/01.ju.0000096372.07687.86","article-title":"Endothelin inhibition: novel therapy for prostate cancer","volume":"170","author":"Nelson","year":"2003","journal-title":"J Urol"},{"key":"10.1093\/bja\/aen100_bib50","first-page":"175","article-title":"Osteoid osteoma: the uniquely innervated bone tumor","volume":"11","author":"O\u2019Connell","year":"1998","journal-title":"Mod Pathol"},{"key":"10.1093\/bja\/aen100_bib51","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1097\/00001756-199804200-00028","article-title":"An acid sensing ion channel (ASIC) localizes to small primary afferent neurons in rats","volume":"9","author":"Olson","year":"1998","journal-title":"Neuroreport"},{"key":"10.1093\/bja\/aen100_bib52","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1016\/j.ijrobp.2004.12.070","article-title":"Alteration of cancer pain-related signals by radiation: proteomic analysis in an animal model with cancer bone invasion","volume":"61","author":"Park","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1093\/bja\/aen100_bib53","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.expneurol.2004.11.028","article-title":"Tumor-induced injury of primary afferent sensory nerve fibers in bone cancer pain","volume":"193","author":"Peters","year":"2005","journal-title":"Exp Neurol"},{"key":"10.1093\/bja\/aen100_bib54","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.neuroscience.2004.04.027","article-title":"Endothelin and the tumorigenic component of bone cancer pain","volume":"126","author":"Peters","year":"2004","journal-title":"Neuroscience"},{"key":"10.1093\/bja\/aen100_bib55","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1200\/JCO.2001.19.4.1207","article-title":"Clinical implications of circulating angiogenic factors in cancer patients","volume":"19","author":"Poon","year":"2001","journal-title":"J Clin Oncol"},{"key":"10.1093\/bja\/aen100_bib56","first-page":"263","article-title":"Breakthrough pain: characteristics and impacts in patients with cancer pain","volume":"82","author":"Portenoy","year":"1999","journal-title":"Pain"},{"key":"10.1093\/bja\/aen100_bib57","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.pain.2006.02.033","article-title":"Depletion of endogenous spinal 5-HT attenuates the behavioural hypersensitivity to mechanical and cooling stimuli induced by spinal nerve ligation","volume":"123","author":"Rahman","year":"2006","journal-title":"Pain"},{"key":"10.1093\/bja\/aen100_bib58","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1046\/j.1471-4159.2001.00288.x","article-title":"Nerve growth factor induces P2X(3) expression in sensory neurons","volume":"77","author":"Ramer","year":"2001","journal-title":"J Neurochem"},{"key":"10.1093\/bja\/aen100_bib59","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1126\/science.289.5484.1508","article-title":"Therapeutic approaches to bone diseases","volume":"289","author":"Rodan","year":"2000","journal-title":"Science"},{"key":"10.1093\/bja\/aen100_bib60","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1002\/1097-0029(20010215)52:4<450::AID-JEMT1030>3.0.CO;2-O","article-title":"TGF-beta and colorectal carcinogenesis","volume":"52","author":"Roman","year":"2001","journal-title":"Microsc Res Tech"},{"key":"10.1093\/bja\/aen100_bib61","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1136\/bmj.327.7413.469","article-title":"Systematic review of role of bisphosphonates on skeletal morbidity in metastatic cancer","volume":"327","author":"Ross","year":"2003","journal-title":"Br Med J"},{"key":"10.1093\/bja\/aen100_bib62","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1002\/ijc.10999","article-title":"Different tumors in bone each give rise to a distinct pattern of skeletal destruction, bone cancer-related pain behaviors and neurochemical changes in the central nervous system","volume":"104","author":"Sabino","year":"2003","journal-title":"Int J Cancer"},{"key":"10.1093\/bja\/aen100_bib63","first-page":"7343","article-title":"Simultaneous reduction in cancer pain, bone destruction, and tumor growth by selective inhibition of cyclooxygenase-2","volume":"62","author":"Sabino","year":"2002","journal-title":"Cancer Res"},{"key":"10.1093\/bja\/aen100_bib64","first-page":"3551","article-title":"Bisphosphonate risedronate reduces metastatic human breast cancer burden in bone in nude mice","volume":"55","author":"Sasaki","year":"1995","journal-title":"Cancer Res"},{"key":"10.1093\/bja\/aen100_bib65","doi-asserted-by":"crossref","first-page":"10886","DOI":"10.1523\/JNEUROSCI.19-24-10886.1999","article-title":"Neurochemical and cellular reorganization of the spinal cord in a murine model of bone cancer pain","volume":"19","author":"Schwei","year":"1999","journal-title":"J Neurosci"},{"key":"10.1093\/bja\/aen100_bib66","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/s004280000306","article-title":"Tumours may be innervated","volume":"438","author":"Seifert","year":"2001","journal-title":"Virchows Arch"},{"key":"10.1093\/bja\/aen100_bib67","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.pain.2005.02.022","article-title":"Anti-NGF therapy profoundly reduces bone cancer pain and the accompanying increase in markers of peripheral and central sensitization","volume":"115","author":"Sevcik","year":"2005","journal-title":"Pain"},{"key":"10.1093\/bja\/aen100_bib68","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.pain.2004.06.015","article-title":"Bone cancer pain: the effects of the bisphosphonate alendronate on pain, skeletal remodeling, tumor growth and tumor necrosis","volume":"111","author":"Sevcik","year":"2004","journal-title":"Pain"},{"key":"10.1093\/bja\/aen100_bib69","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1172\/JCI119400","article-title":"Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2","volume":"99","author":"Sheng","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1093\/bja\/aen100_bib70","article-title":"Opioid toxicity in cancer patients","author":"Sherry","year":"2000","journal-title":"Research Congress in Palliative Care"},{"key":"10.1093\/bja\/aen100_bib71","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0092-8674(00)80209-3","article-title":"Osteoprotegerin: a novel secreted protein involved in the regulation of bone density","volume":"89","author":"Simonet","year":"1997","journal-title":"Cell"},{"key":"10.1093\/bja\/aen100_bib72","doi-asserted-by":"crossref","first-page":"S34","DOI":"10.1002\/j.1552-4604.1988.tb05975.x","article-title":"A double-blind parallel evaluation of the efficacy and safety of a single dose of ketoprofen in cancer pain","volume":"28","author":"Stambaugh","year":"1988","journal-title":"J Clin Pharm"},{"key":"10.1093\/bja\/aen100_bib73","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1002\/j.1552-4604.1989.tb03274.x","article-title":"A double-blind study with placebo control of intramuscular ketorolac tromethamine in the treatment of cancer pain","volume":"29","author":"Staquet","year":"1989","journal-title":"J Clin Pharmacol"},{"key":"10.1093\/bja\/aen100_bib74","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1034\/j.1600-0714.2001.300107.x","article-title":"Specific inhibition of cyclooxygenase-2 results in inhibition of proliferation of oral cancer cell lines via suppression of prostaglandin E2 production","volume":"30","author":"Sumitani","year":"2001","journal-title":"J Oral Pathol Med"},{"key":"10.1093\/bja\/aen100_bib75","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1002\/j.1552-4604.1988.tb05977.x","article-title":"Analgesic efficacy of ketoprofen in postpartum, general surgery, and chronic cancer pain","volume":"28","author":"Sunshine","year":"1988","journal-title":"J Clin Pharm"},{"key":"10.1093\/bja\/aen100_bib76","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1038\/nn966","article-title":"Superficial NK1-expressing neurons control spinal excitability through activation of descending pathways","volume":"5","author":"Suzuki","year":"2002","journal-title":"Nat Neurosci"},{"key":"10.1093\/bja\/aen100_bib77","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.brainres.2004.05.108","article-title":"Descending facilitatory control of mechanically evoked responses is enhanced in deep dorsal horn neurones following peripheral nerve injury","volume":"1019","author":"Suzuki","year":"2004","journal-title":"Brain Res"},{"key":"10.1093\/bja\/aen100_bib78","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.pain.2005.06.015","article-title":"Spinal-supraspinal serotonergic circuits regulating neuropathic pain and its treatment with gabapentin","volume":"117","author":"Suzuki","year":"2005","journal-title":"Pain"},{"key":"10.1093\/bja\/aen100_bib79","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0006-8993(99)01666-2","article-title":"Ibudilast suppresses TNFalpha production by glial cells functioning mainly as type III phosphodiesterase inhibitor in the CNS","volume":"837","author":"Suzumura","year":"1999","journal-title":"Brain Res"},{"key":"10.1093\/bja\/aen100_bib80","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1046\/j.1440-1827.2001.01172.x","article-title":"S-100-positive nerve fibers in hepatocellular carcinoma and intrahepatic cholangiocarcinoma: an immunohistochemical study","volume":"51","author":"Terada","year":"2001","journal-title":"Pathol Int"},{"key":"10.1093\/bja\/aen100_bib81","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.pain.2003.08.002","article-title":"Alterations in dorsal horn neurones in a rat model of cancer-induced bone pain","volume":"106","author":"Urch","year":"2003","journal-title":"Pain"},{"key":"10.1093\/bja\/aen100_bib82","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0079-6123(08)61801-4","article-title":"Prostaglandin-induced neuropeptide release from spinal cord","volume":"104","author":"Vasko","year":"1995","journal-title":"Prog Brain Res"},{"key":"10.1093\/bja\/aen100_bib83","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1002\/cpt1975173284","article-title":"Indoprofen, a new analgesic and antiinflammatory drug in cancer pain","volume":"17","author":"Ventafridda","year":"1975","journal-title":"Clin Pharmacol Ther"},{"key":"10.1093\/bja\/aen100_bib84","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1523\/JNEUROSCI.15-03-02081.1995","article-title":"Differential influence of nerve growth factor on neuropeptide expression in vivo: a novel role in peptide suppression in adult sensory neurons","volume":"15","author":"Verge","year":"1995","journal-title":"J Neurosci"},{"key":"10.1093\/bja\/aen100_bib85","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.pain.2005.10.033","article-title":"The analgesic effect of low dose focal irradiation in a mouse model of bone cancer is associated with spinal changes in neuro-mediators of nociception","volume":"120","author":"Vit","year":"2006","journal-title":"Pain"},{"key":"10.1093\/bja\/aen100_bib86","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0304-3959(02)00312-3","article-title":"Tumor implantation in mouse humerus evokes movement-related hyperalgesia exceeding that evoked by intramuscular carrageenan","volume":"101","author":"Wacnik","year":"2003","journal-title":"Pain"},{"key":"10.1093\/bja\/aen100_bib87","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/386173a0","article-title":"A proton-gated cation channel involved in acid-sensing","volume":"386","author":"Waldmann","year":"1997","journal-title":"Nature"},{"key":"10.1093\/bja\/aen100_bib88","first-page":"A45","article-title":"Characterisation of cancer-induced bone pain","author":"Walley","year":"2006","journal-title":"Proc The British Pain Society"},{"key":"10.1093\/bja\/aen100_bib89","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD002068","article-title":"Bisphosphonates for the relief of pain secondary to bone metastases","author":"Wong","year":"2002","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1093\/bja\/aen100_bib90","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/j.1471-4159.2006.04363.x","article-title":"Transcription of rat TRPV1 utilizes a dual promoter system that is positively regulated by nerve growth factor","volume":"101","author":"Xue","year":"2007","journal-title":"J Neurochem"},{"key":"10.1093\/bja\/aen100_bib91","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.neuroscience.2007.11.025","article-title":"Down-regulation of mu opioid receptor expression within distinct subpopulations of dorsal root ganglion neurons in a murine model of bone cancer pain","volume":"151","author":"Yamamoto","year":"2008","journal-title":"Neuroscience"},{"key":"10.1093\/bja\/aen100_bib92","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1210\/endo.139.3.5837","article-title":"Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG\/OCIF inhibits osteoclastogenesis in vitro","volume":"139","author":"Yasuda","year":"1998","journal-title":"Endocrinology"},{"key":"10.1093\/bja\/aen100_bib93","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s00223-002-0025-x","article-title":"Bisphosphonate actions on cancer","volume":"73","author":"Yoneda","year":"2003","journal-title":"Calcif Tissue Int"},{"key":"10.1093\/bja\/aen100_bib94","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD004311.pub2","article-title":"Opioids for the management of breakthrough (episodic) pain in cancer patients","author":"Zeppetella","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1093\/bja\/aen100_bib3","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1002\/cncr.11138","article-title":"A phase I study of AMGN-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastases","volume":"97","author":"Body","year":"2003","journal-title":"Cancer"}],"container-title":["British Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091217342721?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091217342721?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/bja\/article-pdf\/101\/1\/87\/1022434\/aen100.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T18:47:14Z","timestamp":1757789234000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0007091217342721"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7]]},"references-count":94,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["S0007091217342721"],"URL":"https:\/\/doi.org\/10.1093\/bja\/aen100","relation":{},"ISSN":["0007-0912"],"issn-type":[{"value":"0007-0912","type":"print"}],"subject":[],"published":{"date-parts":[[2008,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Translational medicine: cancer pain mechanisms and management","name":"articletitle","label":"Article Title"},{"value":"British Journal of Anaesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/bja\/aen100","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}