{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:23:46Z","timestamp":1761708226539,"version":"3.44.0"},"reference-count":21,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T00:00:00Z","timestamp":1512345600000},"content-version":"vor","delay-in-days":3381,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["bjanaesthesia.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["British Journal of Anaesthesia"],"published-print":{"date-parts":[[2008,9]]},"DOI":"10.1093\/bja\/aen164","type":"journal-article","created":{"date-parts":[[2008,6,10]],"date-time":"2008-06-10T20:12:47Z","timestamp":1213128767000},"page":"320-323","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Transient hyperaemic response to assess vascular reactivity of skin: effect of topical anaesthesia"],"prefix":"10.1016","volume":"101","author":[{"given":"M.D.","family":"Wiles","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Dickson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.K.","family":"Moppett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1093\/bja\/aen164_bib1","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1152\/japplphysiol.01167.2000","article-title":"Vascular and neural mechanisms of ACh-mediated vasodilation in the forearm cutaneous microcirculation","volume":"92","author":"Berghoff","year":"2002","journal-title":"J Appl Physiol"},{"key":"10.1093\/bja\/aen164_bib2","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1093\/bja\/63.6.655","article-title":"Vascular response of human skin after analgesia with EMLA cream","volume":"63","author":"Bjerring","year":"1989","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aen164_bib3","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1161\/01.RES.73.1.147","article-title":"Evidence for sensory nerve involvement in cutaneous reactive hyperemia in humans","volume":"73","author":"Larkin","year":"1993","journal-title":"Circ Res"},{"key":"10.1093\/bja\/aen164_bib4","first-page":"91","article-title":"Rhythmical variations in human skin blood flow","volume":"2","author":"Salerud","year":"1983","journal-title":"Int J Microcirc Clin Exp"},{"key":"10.1093\/bja\/aen164_bib5","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1097\/00005344-199703000-00015","article-title":"Cutaneous vasodilation to acetylcholine in patients with essential hypertension","volume":"29","author":"Rossi","year":"1997","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1093\/bja\/aen164_bib6","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.2337\/diabetes.48.9.1856","article-title":"Microvascular and macrovascular reactivity is reduced in subjects at risk for type 2 diabetes","volume":"48","author":"Caballero","year":"1999","journal-title":"Diabetes"},{"key":"10.1093\/bja\/aen164_bib7","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/BF01711546","article-title":"Dynamics of skin blood flow in human sepsis","volume":"21","author":"Young","year":"1995","journal-title":"Intensive Care Med"},{"key":"10.1093\/bja\/aen164_bib8","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1093\/bja\/aeg099","article-title":"Transient hyperaemic response to assess vascular reactivity of skin: effect of locally iontophoresed acetylcholine, bradykinin, epinephrine and phenylephrine","volume":"90","author":"Brown","year":"2003","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aen164_bib9","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/bja\/aef188","article-title":"Transient hyperaemic response to assess vascular reactivity of skin; effect of locally iontophoresed sodium nitroprusside","volume":"89","author":"Webster","year":"2002","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aen164_bib10","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.vascn.2004.11.003","article-title":"Reproducibility of different laser Doppler fluximetry parameters of postocclusive reactive hyperemia in human forearm skin","volume":"52","author":"Yvonne-Tee","year":"2005","journal-title":"J Pharmacol Toxicol Methods"},{"key":"10.1093\/bja\/aen164_bib11","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/bja\/aeg194","article-title":"Non-selective and cyclo-oxygenase-2-specific non-steroidal anti-inflammatory drugs impair the hyperaemic response of skin to brief axillary artery occlusion","volume":"91","author":"Moppett","year":"2003","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aen164_bib12","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s00228-003-0577-3","article-title":"Validation of laser Doppler flowmetry coupled with intra-dermal injection for investigating effects of vasoactive agents on the skin microcirculation in man","volume":"59","author":"Leslie","year":"2003","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1093\/bja\/aen164_bib13","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1113\/jphysiol.1980.sp013413","article-title":"Thermoregulatory and rhythm-generating mechanisms governing the sudomotor and vasoconstrictor outflow in human cutaneous nerves","volume":"306","author":"Bini","year":"1980","journal-title":"J Physiol"},{"key":"10.1093\/bja\/aen164_bib14","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1067\/mjh.2002.123842","article-title":"Blunted vasodilatory responses in the cutaneous microcirculation of cigarette smokers","volume":"144","author":"Pellaton","year":"2002","journal-title":"Am Heart J"},{"key":"10.1093\/bja\/aen164_bib15","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1471-0528.1996.tb09517.x","article-title":"Laser Doppler-recorded reactive hyperaemia in the forearm skin during the menstrual cycle","volume":"103","author":"Bungum","year":"1996","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1093\/bja\/aen164_bib16","first-page":"121","article-title":"The influence of Emla cream on cutaneous microcirculation","volume":"28","author":"Hafner","year":"2003","journal-title":"Clin Hemorheol Microcirc"},{"key":"10.1093\/bja\/aen164_bib17","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1113\/jphysiol.2001.013060","article-title":"Evidence that the human cutaneous venoarteriolar response is not mediated by adrenergic mechanisms","volume":"538","author":"Crandall","year":"2002","journal-title":"J Physiol"},{"key":"10.1093\/bja\/aen164_bib18","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1006\/mvre.1999.2205","article-title":"Effects on skin blood flow by provocation during local analgesia","volume":"59","author":"Arildsson","year":"2000","journal-title":"Microvasc Res"},{"key":"10.1093\/bja\/aen164_bib19","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1113\/jphysiol.1993.sp019466","article-title":"The cutaneous vascular axon reflex in humans characterized by laser Doppler perfusion imaging","volume":"460","author":"Wardell","year":"1993","journal-title":"J Physiol"},{"key":"10.1093\/bja\/aen164_bib20","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1093\/bja\/57.10.1006","article-title":"Comparison of the vasoactivity of amide and ester local anaesthetics. An intradermal study","volume":"57","author":"Willatts","year":"1985","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aen164_bib21","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0378-3782(96)81348-X","article-title":"Skin blood flow and topical local anaesthetic absorption in preterm infants","volume":"45","author":"Barker","year":"1996","journal-title":"Early Hum Dev"}],"container-title":["British Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091217341922?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091217341922?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/bja\/article-pdf\/101\/3\/320\/671814\/aen164.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T18:46:40Z","timestamp":1757789200000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0007091217341922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["S0007091217341922"],"URL":"https:\/\/doi.org\/10.1093\/bja\/aen164","relation":{},"ISSN":["0007-0912"],"issn-type":[{"type":"print","value":"0007-0912"}],"subject":[],"published":{"date-parts":[[2008,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transient hyperaemic response to assess vascular reactivity of skin: effect of topical anaesthesia","name":"articletitle","label":"Article Title"},{"value":"British Journal of Anaesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/bja\/aen164","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}