{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T16:17:07Z","timestamp":1785687427022,"version":"3.56.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T00:00:00Z","timestamp":1512345600000},"content-version":"vor","delay-in-days":2955,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"British Journal of Anaesthesia and Royal College of Anaesthetists, London, UK"},{"name":"Higher Education Funding Council for England (HEFCE) Clinical Senior Lectureship"}],"content-domain":{"domain":["bjanaesthesia.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["British Journal of Anaesthesia"],"published-print":{"date-parts":[[2009,11]]},"DOI":"10.1093\/bja\/aep223","type":"journal-article","created":{"date-parts":[[2009,8,21]],"date-time":"2009-08-21T20:26:33Z","timestamp":1250886393000},"page":"701-710","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Differential effects of halothane and sevoflurane on hypoxia-induced intracellular calcium transients of neonatal rat carotid body type I cells"],"prefix":"10.1016","volume":"103","author":[{"given":"J.J.","family":"Pandit","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.J.","family":"Buckler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/bja\/aep223_bib1","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1046\/j.1365-2044.2002.02604.x","article-title":"The variable effect of low-dose volatile anaesthetics on the acute ventilatory response to hypoxia in humans: a quantitative review","volume":"57","author":"Pandit","year":"2002","journal-title":"Anaesthesia"},{"key":"10.1093\/bja\/aep223_bib2","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1097\/00000542-197810000-00004","article-title":"Ventilatory responses to hypoxia and hypercapnia during halothane sedation and anesthesia in man","volume":"49","author":"Knill","year":"1978","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aep223_bib3","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/BF03006447","article-title":"Ventilation and chemoreflexes during enflurane sedation and anaesthesia in man","volume":"26","author":"Knill","year":"1979","journal-title":"Can Anaesth Soc J"},{"key":"10.1093\/bja\/aep223_bib4","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/BF03015231","article-title":"Chemical regulation of ventilation during isoflurane sedation and anaesthesia in humans","volume":"30","author":"Knill","year":"1983","journal-title":"Can Anaesth Soc J"},{"key":"10.1093\/bja\/aep223_bib5","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1097\/00000542-199404000-00004","article-title":"Effects of subanesthetic halothane on the ventilatory responses to hypercapnia and hypoxia in healthy volunteers","volume":"80","author":"Dahan","year":"1994","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aep223_bib6","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1097\/00000542-200412000-00022","article-title":"Effect of pain and audiovisual stimulation on the depression of acute hypoxic ventilatory response by low dose halothane in humans","volume":"101","author":"Pandit","year":"2004","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aep223_bib7","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/00000542-199608000-00011","article-title":"Acute pain and central nervous system arousal do not restore impaired hypoxic ventilatory response during sevoflurane sedation","volume":"85","author":"Sarton","year":"1996","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aep223_bib8","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1093\/bja\/83.2.210","article-title":"Effects of subanaesthetic sevoflurane on ventilation. 2: Response to acute and sustained hypoxia in humans","volume":"83","author":"Pandit","year":"1999","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aep223_bib9","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1093\/bja\/49.10.957","article-title":"Depression of hypoxic ventilatory response by halothane, enflurane and isoflurane in dogs","volume":"49","author":"Hirshman","year":"1977","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aep223_bib10","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1007\/BF03009263","article-title":"Effects of halothane on arterial blood gas equilibrium in the intact rat and chemodenervated rat","volume":"40","author":"Gaudy","year":"1993","journal-title":"Can J Anaesth"},{"key":"10.1093\/bja\/aep223_bib11","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/00000542-198209000-00002","article-title":"Halothane depresses the response of carotid body chemoreceptors to hypoxia and hypercapnia in the cat","volume":"57","author":"Davies","year":"1982","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aep223_bib12","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1093\/bja\/62.1.33","article-title":"Effect of halothane, enflurane and isoflurane on carotid body chemoreceptor activity in the rabbit and the cat","volume":"62","author":"Ponte","year":"1989","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aep223_bib13","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1093\/bja\/aeh124","article-title":"Influence of volatile anaesthetics on hypercapnoeic ventilatory responses in mice with blunted respiratory drive","volume":"92","author":"Groeben","year":"2004","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aep223_bib14","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1053\/j.sane.2007.03.001","article-title":"Volatile anesthetics and the hypoxic ventilatory response: effects, clinical implications, and future research","volume":"26","author":"Pandit","year":"2007","journal-title":"Semin Anesth Perioper Med Pain"},{"key":"10.1093\/bja\/aep223_bib15","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1469-7793.2000.00135.x","article-title":"An oxygen-, acid- and anaesthetic-sensitive TASK-like background potassium channel in rat arterial chemoreceptor cells","volume":"525","author":"Buckler","year":"2000","journal-title":"J Physiol"},{"key":"10.1093\/bja\/aep223_bib16","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1113\/jphysiol.1997.sp021890","article-title":"A novel oxygen-sensitive potassium current in rat carotid body type I cells","volume":"498","author":"Buckler","year":"1997","journal-title":"J Physiol"},{"key":"10.1093\/bja\/aep223_bib17","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1113\/jphysiol.1994.sp020143","article-title":"Effects of hypoxia on membrane potential and intracellular calcium in rat neonatal carotid body type I cells","volume":"476","author":"Buckler","year":"1994","journal-title":"J Physiol"},{"key":"10.1093\/bja\/aep223_bib18","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1146\/annurev.physiol.63.1.259","article-title":"Cellular mechanisms of oxygen sensing","volume":"63","author":"L\u00f3pez-Barneo","year":"2001","journal-title":"Annu Rev Physiol"},{"key":"10.1093\/bja\/aep223_bib19","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1056\/NEJMra050002","article-title":"Acute oxygen-sensing mechanisms","volume":"353","author":"Weir","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1093\/bja\/aep223_bib20","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1113\/expphysiol.2005.031922","article-title":"O2 sensing at the mammalian carotid body: why multiple O2 sensors and multiple transmitters?","volume":"91","author":"Prabhakar","year":"2006","journal-title":"Exp Physiol"},{"key":"10.1093\/bja\/aep223_bib21","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1097\/00000542-199607000-00009","article-title":"Ventilatory response to hypoxia in humans: influences of subanesthetic desflurane","volume":"85","author":"Dahan","year":"1996","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aep223_bib22","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1097\/00000542-199905000-00011","article-title":"Sevoflurane-induced reduction of hypoxic drive is sex-independent","volume":"90","author":"Sarton","year":"1999","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aep223_bib23","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0034-5687(99)00015-8","article-title":"Background leak K+-currents and oxygen sensing in carotid body type I cells","volume":"115","author":"Buckler","year":"1999","journal-title":"Respir Physiol"},{"key":"10.1093\/bja\/aep223_bib24","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/BF00374499","article-title":"Effects of acidic stimuli on intracellular calcium in type I cells of the neonatal rat carotid body","volume":"425","author":"Buckler","year":"1993","journal-title":"Pfl\u00fcgers Arch"},{"key":"10.1093\/bja\/aep223_bib25","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/BF00586988","article-title":"Local oxygen tension field in the glomus caroticum of the cat and its change at changing arterial PO2","volume":"329","author":"Acker","year":"1971","journal-title":"Pfl\u00fcgers Arch"},{"key":"10.1093\/bja\/aep223_bib26","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1146\/annurev.ph.51.030189.004155","article-title":"PO2 chemoreception in arterial chemoreceptors","volume":"51","author":"Acker","year":"1989","journal-title":"Annu Rev Physiol"},{"key":"10.1093\/bja\/aep223_bib27","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1152\/jappl.1993.75.3.1035","article-title":"Contribution of in vivo microvascular PO2 in the cat carotid body chemotransduction","volume":"75","author":"Lahiri","year":"1993","journal-title":"J Appl Physiol"},{"key":"10.1093\/bja\/aep223_bib28","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1007\/BF03008350","article-title":"Kinetics of dissolution of gaseous halothane in Krebs\u2013Ringer\u2019s solution","volume":"39","author":"Millman","year":"1992","journal-title":"Can J Anaesth"},{"key":"10.1093\/bja\/aep223_bib29","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1097\/00000542-196711000-00009","article-title":"Minimum alveolar concentrations of methoxyflurane, halothane, ether and cyclopropane in man: correlation with theories of anesthesia","volume":"28","author":"Saidman","year":"1967","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aep223_bib30","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1093\/bja\/aeg132","article-title":"Age-related iso-MAC charts for isoflurane, sevoflurane and desflurane in man","volume":"91","author":"Nickalls","year":"2003","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aep223_bib31","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1213\/01.ANE.0000139651.82022.1D","article-title":"Determining minimum alveolar concentration of halothane in rats: the effect of increment change in halothane concentration and number of crossovers","volume":"99","author":"Leon","year":"2004","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aep223_bib32","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1097\/00003643-199707000-00003","article-title":"The minimum alveolar concentration of sevoflurane in rats","volume":"14","author":"Kashimoto","year":"1997","journal-title":"Eur J Anaesthesiol"},{"key":"10.1093\/bja\/aep223_bib33","doi-asserted-by":"crossref","first-page":"L36","DOI":"10.1152\/ajplung.2000.279.1.L36","article-title":"Interactions between hypoxia and hypercapnic acidosis on calcium signalling in carotid body type I cells","volume":"279","author":"Dasso","year":"2000","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1093\/bja\/aep223_bib34","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1213\/01.ANE.0000142112.30807.5C","article-title":"Sorptive loss of volatile and gaseous anesthetics from in vitro drug application systems","volume":"100","author":"Suzuki","year":"2005","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aep223_bib35","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1097\/00000542-200105000-00023","article-title":"Comparison of volatile anesthetic actions on intracellular calcium stores of vascular smooth muscle","volume":"94","author":"Akata","year":"2001","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aep223_bib36","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1093\/bja\/62.6.669","article-title":"Inhalation anaesthetics decrease calcium content of cardiac sarcoplasmic reticulum","volume":"62","author":"Katsuoka","year":"1989","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aep223_bib37","doi-asserted-by":"crossref","first-page":"279","DOI":"10.2170\/jjphysiol.45.279","article-title":"Different effects of removing extracellular Ca2+ on cytosolic Ca2+ response to anoxia of sensory neurons and carotid chemoreceptor cells from newborn rabbits","volume":"45","author":"Sato","year":"1995","journal-title":"Jpn J Physiol"},{"key":"10.1093\/bja\/aep223_bib38","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1152\/jappl.1991.71.3.1062","article-title":"Dependency of hypoxic chemotransduction in cat carotid body on voltage-gated calcium channels","volume":"71","author":"Shirahata","year":"1991","journal-title":"J Appl Physiol"},{"key":"10.1093\/bja\/aep223_bib39","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1113\/jphysiol.1995.sp020606","article-title":"Ca2+-activated K+ channels in isolated type I cells of the neonatal rat carotid body","volume":"483","author":"Wyatt","year":"1995","journal-title":"J Physiol"},{"key":"10.1093\/bja\/aep223_bib40","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1113\/jphysiol.2003.058131","article-title":"The effect of mitochondrial inhibitors on membrane currents in isolated neonatal rat carotid body type I cells","volume":"556","author":"Wyatt","year":"2004","journal-title":"J Physiol"},{"key":"10.1093\/bja\/aep223_bib41","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1113\/jphysiol.2002.018382","article-title":"Molecular identification of Kv\u03b1, subunits that contribute to the oxygen-sensitive K+ current of chemoreceptor cells of the rabbit carotid body","volume":"542","author":"Sanchez","year":"2002","journal-title":"J Physiol"},{"key":"10.1093\/bja\/aep223_bib42","doi-asserted-by":"crossref","first-page":"L271","DOI":"10.1152\/ajplung.1990.258.6.L271","article-title":"Cellular basis of transduction in carotid chemoreceptors","volume":"258","author":"Biscoe","year":"1990","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1093\/bja\/aep223_bib43","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S1569-9048(03)00048-X","article-title":"Variation in human ventilatory control\u2014genetic influence on the hypoxic ventilatory response","volume":"135","author":"Weil","year":"2003","journal-title":"Respir Physiol Neurobiol"},{"key":"10.1093\/bja\/aep223_bib44","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0034-5687(92)90004-G","article-title":"Effects of different levels of end-tidal PO2 on ventilation during isocapnia in humans","volume":"88","author":"Bascom","year":"1992","journal-title":"Respir Physiol"},{"key":"10.1093\/bja\/aep223_bib45","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1213\/00000539-199907000-00038","article-title":"Ventilatory responses to acute and sustained hypoxia during sevoflurane anesthesia in women","volume":"89","author":"Sj\u00f6gren","year":"1999","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aep223_bib46","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/8084","article-title":"Inhalational anesthetics activate two-pore-domain background K+ channels","volume":"2","author":"Patel","year":"1999","journal-title":"Nat Neurosci"},{"key":"10.1093\/bja\/aep223_bib47","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1124\/mi.3.4.205","article-title":"The TASK family: two-pore domain background K+ channels","volume":"3","author":"Bayliss","year":"2003","journal-title":"Mol Interv"},{"key":"10.1093\/bja\/aep223_bib48","doi-asserted-by":"crossref","first-page":"C1319","DOI":"10.1152\/ajpcell.00100.2007","article-title":"Differential effects of volatile and intravenous anesthetics on the activity of human TASK-1","volume":"293","author":"Putzke","year":"2007","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1093\/bja\/aep223_bib49","first-page":"A170","article-title":"Volatile anesthetic regulation of TASK tandem pore potassium channels","volume":"105","author":"Cotten","year":"2006","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aep223_bib50","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/j.1749-6632.1999.tb11296.x","article-title":"Functional and molecular aspects of voltage-gated K+ channel beta subunits","volume":"868","author":"Pongs","year":"1999","journal-title":"Ann N Y Acad Sci"},{"key":"10.1093\/bja\/aep223_bib51","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/BF02110699","article-title":"High-conductance calcium-activated potassium channels; structure, pharmacology, and function","volume":"28","author":"Kaczorowski","year":"1996","journal-title":"J Bioenerg Biomembr"},{"key":"10.1093\/bja\/aep223_bib52","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1152\/jn.1997.78.5.2467","article-title":"Ca2+ current in rabbit carotid body glomus cells is conducted by multiple types of high-voltage-activated Ca2+ channels","volume":"78","author":"Overholt","year":"1997","journal-title":"J Neurophysiol"},{"key":"10.1093\/bja\/aep223_bib53","doi-asserted-by":"crossref","first-page":"S56","DOI":"10.1038\/sj.bjp.0706442","article-title":"A short history of voltage-gated calcium channels","volume":"147","author":"Dolphin","year":"2006","journal-title":"Br J Pharmacol"},{"key":"10.1093\/bja\/aep223_bib54","doi-asserted-by":"crossref","first-page":"C51","DOI":"10.1152\/ajpcell.2000.279.1.C51","article-title":"Intracellular Ca2+ stores in chemoreceptor cells of the rabbit carotid body: significance for chemoreception","volume":"279","author":"Vicario","year":"2000","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1093\/bja\/aep223_bib55","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1113\/jphysiol.2002.035782","article-title":"The plasma membrane calcium-ATPase as a major mechanism for intracellular calcium regulation in neurones from the rat superior cervical ganglion","volume":"550","author":"Wanaverbecq","year":"2003","journal-title":"J Physiol"},{"key":"10.1093\/bja\/aep223_bib56","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1093\/bja\/aeg040","article-title":"Differential interaction of anaesthetics and antiepileptic drugs with neuronal Na+ channels, Ca2+ channels, and GABAA receptors","volume":"90","author":"Lingamaneni","year":"2003","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aep223_bib57","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1097\/01.anes.0000265155.01815.6d","article-title":"Myocardial depressant effects of desflurane: mechanical and electrophysiologic actions in vitro","volume":"106","author":"Park","year":"2007","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aep223_bib58","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1097\/00000542-200501000-00019","article-title":"Effect of propofol on carotid body chemosensitivity and cholinergic chemotransduction","volume":"102","author":"Jonsson","year":"2005","journal-title":"Anesthesiology"}],"container-title":["British Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091217339090?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091217339090?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/bja\/article-pdf\/103\/5\/701\/18252351\/aep223.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,22]],"date-time":"2022-10-22T07:18:01Z","timestamp":1666423081000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0007091217339090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":58,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["S0007091217339090"],"URL":"https:\/\/doi.org\/10.1093\/bja\/aep223","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1165255.628199","asserted-by":"object"}]},"ISSN":["0007-0912"],"issn-type":[{"value":"0007-0912","type":"print"}],"subject":[],"published":{"date-parts":[[2009,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential effects of halothane and sevoflurane on hypoxia-induced intracellular calcium transients of neonatal rat carotid body type I cells","name":"articletitle","label":"Article Title"},{"value":"British Journal of Anaesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/bja\/aep223","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}