{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T10:52:01Z","timestamp":1792839121459,"version":"4.5.0"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T00:00:00Z","timestamp":1512345600000},"content-version":"vor","delay-in-days":2560,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["bjanaesthesia.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["British Journal of Anaesthesia"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1093\/bja\/aeq312","type":"journal-article","created":{"date-parts":[[2010,12,10]],"date-time":"2010-12-10T03:28:13Z","timestamp":1291951693000},"page":"i16-i23","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":294,"special_numbering":"S1","title":["Dose adjustment of anaesthetics in the morbidly obese"],"prefix":"10.1016","volume":"105","author":[{"given":"J","family":"Ingrande","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.J.M.","family":"Lemmens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/bja\/aeq312_bib1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1093\/bja\/85.1.91","article-title":"Obesity in anaesthesia and intensive care","volume":"85","author":"Adams","year":"2000","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aeq312_bib2","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1093\/bja\/70.3.349","article-title":"Perioperative management of the obese patient","volume":"70","author":"Shenkman","year":"1993","journal-title":"Br J Anaesth"},{"issue":"Suppl. 1","key":"10.1093\/bja\/aeq312_bib3","doi-asserted-by":"crossref","first-page":"i23","DOI":"10.1093\/bja\/aep294","article-title":"Obesity, obstructive sleep apnoea, and diabetes mellitus: anaesthetic implications","volume":"103","author":"Candiotti","year":"2009","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aeq312_bib4","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1111\/j.1365-2044.2005.04229.x","article-title":"Obesity: basic science and medical aspects relevant to anaesthetists","volume":"60","author":"Cheah","year":"2005","journal-title":"Anaesthesia"},{"key":"10.1093\/bja\/aeq312_bib5","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2165\/11318100-000000000-00000","article-title":"Effect of obesity on the pharmacokinetics of drugs in humans","volume":"49","author":"Hanley","year":"2010","journal-title":"Clin Pharmacokinet"},{"key":"10.1093\/bja\/aeq312_bib6","doi-asserted-by":"crossref","first-page":"215","DOI":"10.2165\/00003088-200039030-00004","article-title":"Effects of obesity on pharmacokinetics implications for drug therapy","volume":"39","author":"Cheymol","year":"2000","journal-title":"Clin Pharmacokinet"},{"key":"10.1093\/bja\/aeq312_bib7","first-page":"99","article-title":"Lean body mass in obesity","volume":"7","author":"Forbes","year":"1983","journal-title":"Int J Obes"},{"key":"10.1093\/bja\/aeq312_bib8","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1097\/00000542-200311000-00013","article-title":"Using front-end kinetics to optimize target-controlled drug infusions","volume":"99","author":"Avram","year":"2003","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aeq312_bib9","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1365-2125.2004.02157.x","article-title":"What is the best size descriptor to use for pharmacokinetic studies in the obese?","volume":"58","author":"Green","year":"2004","journal-title":"Br J Clin Pharmacol"},{"key":"10.1093\/bja\/aeq312_bib10","doi-asserted-by":"crossref","first-page":"292","DOI":"10.2165\/00003088-199426040-00005","article-title":"Lean body mass as a predictor of drug dosage. Implications for drug therapy","volume":"26","author":"Morgan","year":"1994","journal-title":"Clin Pharmacokinet"},{"key":"10.1093\/bja\/aeq312_bib11","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.2165\/00003088-200544100-00004","article-title":"Quantification of lean bodyweight","volume":"44","author":"Janmahasatian","year":"2005","journal-title":"Clin Pharmacokinet"},{"key":"10.1093\/bja\/aeq312_bib12","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1345\/aph.19381","article-title":"The origin of the \u2018ideal\u2019 body weight equations","volume":"34","author":"Pai","year":"2000","journal-title":"Ann Pharmacother"},{"key":"10.1093\/bja\/aeq312_bib13","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1056\/NEJM198710223171717","article-title":"Simplified calculation of body-surface area","volume":"317","author":"Mosteller","year":"1987","journal-title":"N Engl J Med"},{"key":"10.1093\/bja\/aeq312_bib14","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1161\/01.CIR.103.6.820","article-title":"Relations of stroke volume and cardiac output to body composition: the strong heart study","volume":"103","author":"Collis","year":"2001","journal-title":"Circulation"},{"key":"10.1093\/bja\/aeq312_bib15","first-page":"57","article-title":"Increased glomerular filtration rate and adrenocortical function in obese women","volume":"4","author":"Stokholm","year":"1980","journal-title":"Int J Obes"},{"key":"10.1093\/bja\/aeq312_bib16","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/0002-9343(88)90310-5","article-title":"Predicting creatinine clearance and renal drug clearance in obese patients from estimated fat-free body mass","volume":"84","author":"Salazar","year":"1988","journal-title":"Am J Med"},{"key":"10.1093\/bja\/aeq312_bib17","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1067\/mcp.2002.129306","article-title":"Caution when lean body weight is used as a size descriptor for obese subjects","volume":"72","author":"Green","year":"2002","journal-title":"Clin Pharmacol Ther"},{"key":"10.1093\/bja\/aeq312_bib18","doi-asserted-by":"crossref","first-page":"397","DOI":"10.2165\/00003088-200948060-00005","article-title":"Pharmacokinetic model-driven remifentanil administration in the morbidly obese: the \u2018critical weight\u2019 and the \u2018fictitious height\u2019, a possible solution to an unsolved problem?","volume":"48","author":"La Colla","year":"2009","journal-title":"Clin Pharmacokinet"},{"key":"10.1093\/bja\/aeq312_bib19","doi-asserted-by":"crossref","first-page":"131","DOI":"10.2165\/11317690-000000000-00000","article-title":"Predictive performance of the \u2018Minto\u2019 remifentanil pharmacokinetic parameter set in morbidly obese patients ensuing from a new method for calculating lean body mass","volume":"49","author":"La Colla","year":"2010","journal-title":"Clin Pharmacokinet"},{"key":"10.1093\/bja\/aeq312_bib20","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1211\/0022357991773320","article-title":"Prediction of clearance, volume of distribution and half-life by allometric scaling and by use of plasma concentrations predicted from pharmacokinetic constants: a comparative study","volume":"51","author":"Mahmood","year":"1999","journal-title":"J Pharm Pharmacol"},{"key":"10.1093\/bja\/aeq312_bib21","author":"Abernethy"},{"key":"10.1093\/bja\/aeq312_bib22","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1097\/FTD.0b013e318042d3c4","article-title":"Prediction of drug clearance in children: impact of allometric exponents, body weight, and age","volume":"29","author":"Mahmood","year":"2007","journal-title":"Ther Drug Monit"},{"key":"10.1093\/bja\/aeq312_bib23","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1093\/bja\/aeq195","article-title":"Influence of obesity on propofol pharmacokinetics: derivation of a pharmacokinetic model","volume":"105","author":"Cortinez","year":"2010","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aeq312_bib24","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1111\/j.1476-5381.2009.00267.x","article-title":"To scale or not to scale: the principles of dose extrapolation","volume":"157","author":"Sharma","year":"2009","journal-title":"Br J Pharmacol"},{"key":"10.1093\/bja\/aeq312_bib25","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1097\/00000542-198204000-00007","article-title":"Thiopental disposition in lean and obese patients undergoing surgery","volume":"56","author":"Jung","year":"1982","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aeq312_bib26","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1097\/00000542-199710000-00024","article-title":"Computer simulation of the effects of alterations in blood flows and body composition on thiopental pharmacokinetics in humans","volume":"87","author":"Wada","year":"1997","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aeq312_bib27","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1213\/00000539-199909000-00002","article-title":"Cardiac output is a determinant of the initial concentrations of propofol after short-infusion administration","volume":"89","author":"Upton","year":"1999","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aeq312_bib28","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1097\/00000542-199304000-00008","article-title":"Propofol infusion for maintenance of anesthesia in morbidly obese patients receiving nitrous oxide. A clinical and pharmacokinetic study","volume":"78","author":"Servin","year":"1993","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aeq312_bib29","series-title":"Anesth Analg","article-title":"Lean body weight scalar for the anesthetic induction dose of propofol in morbidly obese subjects","author":"Ingrande","year":"2010"},{"key":"10.1093\/bja\/aeq312_bib30","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1213\/ane.0b013e318172c47c","article-title":"Dexmedetomidine infusion during laparoscopic bariatric surgery: the effect on recovery outcome variables","volume":"106","author":"Tufanogullari","year":"2008","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aeq312_bib31","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jclinane.2005.05.009","article-title":"Fentanyl or dexmedetomidine combined with desflurane for bariatric surgery","volume":"18","author":"Feld","year":"2006","journal-title":"J Clin Anesth"},{"key":"10.1093\/bja\/aeq312_bib32","first-page":"45","article-title":"Single-dose etomidate for rapid sequence intubation may impact outcome after severe injury","volume":"67","author":"Warner","year":"2009","journal-title":"J Trauma"},{"key":"10.1093\/bja\/aeq312_bib33","doi-asserted-by":"crossref","unstructured":"DC Ray, AW Hay, DW McKeown, Induction drug and outcome of patients admitted to the intensive care unit after emergency laparotomy, Eur J Anaesthesiol, 27, 481, 5, doi:10.1006\/anbo.1998.0725.","DOI":"10.1097\/EJA.0b013e3283333a61"},{"key":"10.1093\/bja\/aeq312_bib34","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0140-6736(09)60949-1","article-title":"Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial","volume":"374","author":"Jabre","year":"2009","journal-title":"Lancet"},{"key":"10.1093\/bja\/aeq312_bib35","first-page":"7","article-title":"Acute pain management: a new area of liability for anesthesiologist","volume":"71","author":"Bird","year":"2007","journal-title":"ASA Newsl"},{"key":"10.1093\/bja\/aeq312_bib36","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1177\/1479972308096978","article-title":"Obesity and respiratory diseases","volume":"5","author":"Murugan","year":"2008","journal-title":"Chron Respir Dis"},{"key":"10.1093\/bja\/aeq312_bib37","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jclinane.2004.01.009","article-title":"Anesthesia in the obese patient: pharmacokinetic considerations","volume":"17","author":"Casati","year":"2005","journal-title":"J Clin Anesth"},{"key":"10.1093\/bja\/aeq312_bib38","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1097\/00000542-199711000-00010","article-title":"Difficult or impossible ventilation after sufentanil-induced anesthesia is caused primarily by vocal cord closure","volume":"87","author":"Bennett","year":"1997","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aeq312_bib39","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1093\/bja\/55.9.825","article-title":"Comparison of decreases in ventilation caused by enflurane and fentanyl during anaesthesia","volume":"55","author":"Drummond","year":"1983","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aeq312_bib40","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.mcna.2010.02.007","article-title":"Opioid medication and sleep-disordered breathing","volume":"94","author":"Yue","year":"2010","journal-title":"Med Clin North Am"},{"key":"10.1093\/bja\/aeq312_bib41","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/ALN.0b013e318190b501","article-title":"Respiratory and sleep effects of remifentanil in volunteers with moderate obstructive sleep apnea","volume":"110","author":"Bernards","year":"2009","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aeq312_bib42","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/00001503-200402000-00005","article-title":"Obesity, sleep apnea, the airway and anesthesia","volume":"17","author":"Benumof","year":"2004","journal-title":"Curr Opin Anaesthesiol"},{"key":"10.1093\/bja\/aeq312_bib43","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1097\/00000542-199012000-00005","article-title":"Pharmacokinetics of fentanyl administered by computer-controlled infusion pump","volume":"73","author":"Shafer","year":"1990","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aeq312_bib44","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0022-3565(25)22695-7","article-title":"Decreased fentanyl and alfentanil dose requirements with age. A simultaneous pharmacokinetic and pharmacodynamic evaluation","volume":"240","author":"Scott","year":"1987","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1093\/bja\/aeq312_bib45","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/clpt.1980.138","article-title":"Intravenous fentanyl kinetics","volume":"28","author":"McClain","year":"1980","journal-title":"Clin Pharmacol Ther"},{"key":"10.1093\/bja\/aeq312_bib46","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1093\/bja\/aei195","article-title":"Pharmacokinetic mass of fentanyl for postoperative analgesia in lean and obese patients","volume":"95","author":"Shibutani","year":"2005","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aeq312_bib47","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1097\/00000542-199803000-00016","article-title":"Application of physiologic models to predict the influence of changes in body composition and blood flows on the pharmacokinetics of fentanyl and alfentanil in patients","volume":"88","author":"Bjorkman","year":"1998","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aeq312_bib48","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1213\/00000539-199112000-00019","article-title":"Pharmacokinetics of sufentanil in obese patients","volume":"73","author":"Schwartz","year":"1991","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aeq312_bib49","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/00000542-200301000-00014","article-title":"Performance of target-controlled sufentanil infusion in obese patients","volume":"98","author":"Slepchenko","year":"2003","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aeq312_bib50","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/00000542-199101000-00010","article-title":"Pharmacokinetics, pharmacodynamics, and rational opioid selection","volume":"74","author":"Shafer","year":"1991","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aeq312_bib51","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1097\/00000542-199809000-00004","article-title":"Remifentanil pharmacokinetics in obese versus lean patients","volume":"89","author":"Egan","year":"1998","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aeq312_bib52","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1213\/ane.0b013e3181888127","article-title":"Obesity modestly affects inhaled anesthetic kinetics in humans","volume":"107","author":"Lemmens","year":"2008","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aeq312_bib53","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1097\/00000542-199103000-00017","article-title":"Kinetics of desflurane, isoflurane, and halothane in humans","volume":"74","author":"Yasuda","year":"1991","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aeq312_bib54","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1152\/jappl.1967.23.5.621","article-title":"Measurement of adipose tissue blood flow and perfusion in man by uptake of 85Kr","volume":"23","author":"Lesser","year":"1967","journal-title":"J Appl Physiol"},{"key":"10.1093\/bja\/aeq312_bib55","first-page":"523","article-title":"Wash-in and wash-out curves of sevoflurane and isoflurane in morbidly obese patients","volume":"68","author":"Torri","year":"2002","journal-title":"Minerva Anesthesiol"},{"key":"10.1093\/bja\/aeq312_bib56","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.1210\/jc.2008-2508","article-title":"Body mass index is associated with increased creatinine clearance by a mechanism independent of body fat distribution","volume":"94","author":"Gerchman","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1093\/bja\/aeq312_bib57","doi-asserted-by":"crossref","unstructured":"W Druml, B Metnitz, E Schaden, P Bauer, PG Metnitz, Impact of body mass on incidence and prognosis of acute kidney injury requiring renal replacement therapy, Intens Care Med, 36, 1221, 8, doi:10.1093\/aob\/mci007.","DOI":"10.1007\/s00134-010-1844-2"},{"key":"10.1093\/bja\/aeq312_bib58","doi-asserted-by":"crossref","first-page":"21","DOI":"10.7326\/0003-4819-144-1-200601030-00006","article-title":"Body mass index and risk for end-stage renal disease","volume":"144","author":"Hsu","year":"2006","journal-title":"Ann Intern Med"},{"key":"10.1093\/bja\/aeq312_bib59","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1097\/00000539-200112000-00036","article-title":"Long-duration low-flow sevoflurane and isoflurane effects on postoperative renal and hepatic function","volume":"93","author":"Kharasch","year":"2001","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aeq312_bib60","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0952-8180(01)00330-0","article-title":"Randomized comparison of isoflurane and sevoflurane for laparoscopic gastric banding in morbidly obese patients","volume":"13","author":"Torri","year":"2001","journal-title":"J Clin Anesth"},{"key":"10.1093\/bja\/aeq312_bib61","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1213\/01.ANE.0000136472.01079.95","article-title":"Emergence and recovery characteristics of desflurane versus sevoflurane in morbidly obese adult surgical patients: a prospective, randomized study","volume":"99","author":"Strum","year":"2004","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aeq312_bib62","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1093\/bja\/aeg236","article-title":"Optimization of desflurane administration in morbidly obese patients: a comparison with sevoflurane using an \u2018inhalation bolus\u2019 technique","volume":"91","author":"De Baerdemaeker","year":"2003","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aeq312_bib63","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/bja\/aem197","article-title":"Faster wash-out and recovery for desflurane vs sevoflurane in morbidly obese patients when no premedication is used","volume":"99","author":"La Colla","year":"2007","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aeq312_bib64","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.jclinane.2004.12.015","article-title":"Choice of volatile anesthetic for the morbidly obese patient: sevoflurane or desflurane","volume":"17","author":"Arain","year":"2005","journal-title":"J Clin Anesth"},{"key":"10.1093\/bja\/aeq312_bib65","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jclinane.2006.04.003","article-title":"Desflurane versus sevoflurane for laparoscopic gastroplasty in morbidly obese patients","volume":"19","author":"Vallejo","year":"2007","journal-title":"J Clin Anesth"},{"key":"10.1093\/bja\/aeq312_bib66","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1097\/00000542-198207000-00014","article-title":"Weight, pseudocholinesterase activity, and succinylcholine requirement","volume":"57","author":"Bentley","year":"1982","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aeq312_bib67","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1213\/01.ane.0000194876.00551.0e","article-title":"The dose of succinylcholine in morbid obesity","volume":"102","author":"Lemmens","year":"2006","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aeq312_bib68","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1097\/00000542-197806000-00012","article-title":"Pancuronium bromide requirement during anesthesia for the morbidly obese","volume":"48","author":"Tsueda","year":"1978","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aeq312_bib69","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1213\/00000539-198812000-00004","article-title":"Pharmacodynamics of vecuronium and atracurium in the obese surgical patient","volume":"67","author":"Weinstein","year":"1988","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aeq312_bib70","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1213\/00000539-199204000-00008","article-title":"Pharmacokinetics and pharmacodynamics of vecuronium in the obese surgical patient","volume":"74","author":"Schwartz","year":"1992","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aeq312_bib71","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1213\/01.ANE.0000120081.99080.C2","article-title":"The pharmacodynamic effects of rocuronium when dosed according to real body weight or ideal body weight in morbidly obese patients","volume":"99","author":"Leykin","year":"2004","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aeq312_bib72","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1097\/00003643-199908000-00002","article-title":"Pharmacokinetics of rocuronium bromide in obese female patients","volume":"16","author":"Puhringer","year":"1999","journal-title":"Eur J Anaesthesiol"},{"key":"10.1093\/bja\/aeq312_bib73","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1213\/01.ANE.0000132781.62934.37","article-title":"The effects of cisatracurium on morbidly obese women","volume":"99","author":"Leykin","year":"2004","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aeq312_bib74","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1213\/00000539-199611000-00031","article-title":"Anthropometric variables as predictors for duration of action of atracurium-induced neuromuscular block","volume":"83","author":"Kirkegaard-Nielsen","year":"1996","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aeq312_bib75","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/bja\/67.1.41","article-title":"Pharmacokinetic model driven infusion of propofol in children","volume":"67","author":"Marsh","year":"1991","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aeq312_bib76","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/EJA.0b013e328326f7d0","article-title":"No adjustment vs. adjustment formula as input weight for propofol target-controlled infusion in morbidly obese patients","volume":"26","author":"La Colla","year":"2009","journal-title":"Eur J Anaesthesiol"},{"key":"10.1093\/bja\/aeq312_bib77","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1097\/00000542-199805000-00006","article-title":"The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers","volume":"88","author":"Schnider","year":"1998","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aeq312_bib78","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1093\/bja\/aep143","article-title":"Pharmacokinetic models for propofol\u2014defining and illuminating the devil in the detail","volume":"103","author":"Absalom","year":"2009","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aeq312_bib79","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/00000542-199701000-00004","article-title":"Influence of age and gender on the pharmacokinetics and pharmacodynamics of remifentanil. I. Model development","volume":"86","author":"Minto","year":"1997","journal-title":"Anesthesiology"}],"container-title":["British Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091217333913?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091217333913?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/bja\/article-pdf\/105\/suppl_1\/i16\/646621\/aeq312.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T18:42:37Z","timestamp":1757788957000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0007091217333913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":79,"alternative-id":["S0007091217333913"],"URL":"https:\/\/doi.org\/10.1093\/bja\/aeq312","relation":{},"ISSN":["0007-0912"],"issn-type":[{"value":"0007-0912","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dose adjustment of anaesthetics in the morbidly obese","name":"articletitle","label":"Article Title"},{"value":"British Journal of Anaesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/bja\/aeq312","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 The Author(s). Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}