{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:26:03Z","timestamp":1792700763283,"version":"4.5.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T00:00:00Z","timestamp":1512345600000},"content-version":"vor","delay-in-days":2073,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["bjanaesthesia.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["British Journal of Anaesthesia"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1093\/bja\/aer492","type":"journal-article","created":{"date-parts":[[2012,2,4]],"date-time":"2012-02-04T03:10:23Z","timestamp":1328325023000},"page":"662-669","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Short small-interfering RNAs produce interferon-\u03b1-mediated analgesia"],"prefix":"10.1016","volume":"108","author":[{"given":"P.H.","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.J.","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Berta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.Z.","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.R.","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/bja\/aer492_bib1","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.immuni.2006.08.014","article-title":"Complex modulation of cell type-specific signaling in response to type I interferons","volume":"25","author":"van Boxel-Dezaire","year":"2006","journal-title":"Immunity"},{"key":"10.1093\/bja\/aer492_bib2","doi-asserted-by":"crossref","first-page":"12136","DOI":"10.1523\/JNEUROSCI.3402-08.2008","article-title":"Interferon-gamma is a critical modulator of CB(2) cannabinoid receptor signaling during neuropathic pain","volume":"28","author":"Racz","year":"2008","journal-title":"J Neurosci"},{"key":"10.1093\/bja\/aer492_bib3","doi-asserted-by":"crossref","first-page":"8032","DOI":"10.1073\/pnas.0810420106","article-title":"IFN-gamma receptor signaling mediates spinal microglia activation driving neuropathic pain","volume":"106","author":"Tsuda","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1093\/bja\/aer492_bib4","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/35078107","article-title":"Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells","volume":"411","author":"Elbashir","year":"2001","journal-title":"Nature"},{"key":"10.1093\/bja\/aer492_bib5","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nature03121","article-title":"Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs","volume":"432","author":"Soutschek","year":"2004","journal-title":"Nature"},{"key":"10.1093\/bja\/aer492_bib6","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1471-4159.2006.04082.x","article-title":"RNA interference in pain research","volume":"99","author":"Rohl","year":"2006","journal-title":"J Neurochem"},{"key":"10.1093\/bja\/aer492_bib7","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2174\/1876386300902010057","article-title":"Therapeutic potential of RNA interference in pain medicine","volume":"2","author":"Tan","year":"2009","journal-title":"Open Pain J"},{"key":"10.1093\/bja\/aer492_bib8","doi-asserted-by":"crossref","first-page":"16773","DOI":"10.1073\/pnas.0801793105","article-title":"Activation of P2X7 receptors in glial satellite cells reduces pain through downregulation of P2X3 receptors in nociceptive neurons","volume":"105","author":"Chen","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1093\/bja\/aer492_bib9","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nm1723","article-title":"Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain","volume":"14","author":"Kawasaki","year":"2008","journal-title":"Nat Med"},{"key":"10.1093\/bja\/aer492_bib10","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/sj.gt.3302376","article-title":"Gene knockdown with intrathecal siRNA of NMDA receptor NR2B subunit reduces formalin-induced nociception in the rat","volume":"12","author":"Tan","year":"2005","journal-title":"Gene Ther"},{"key":"10.1093\/bja\/aer492_bib11","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nbt1081","article-title":"Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA","volume":"23","author":"Judge","year":"2005","journal-title":"Nat Biotechnol"},{"key":"10.1093\/bja\/aer492_bib12","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/ncb1038","article-title":"Activation of the interferon system by short-interfering RNAs","volume":"5","author":"Sledz","year":"2003","journal-title":"Nat Cell Biol"},{"key":"10.1093\/bja\/aer492_bib13","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","article-title":"Ethical guidelines for investigations of experimental pain in conscious animals","volume":"16","author":"Zimmermann","year":"1983","journal-title":"Pain"},{"key":"10.1093\/bja\/aer492_bib14","doi-asserted-by":"crossref","first-page":"e1000412","DOI":"10.1371\/journal.pbio.1000412","article-title":"Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research","volume":"8","author":"Kilkenny","year":"2010","journal-title":"PLoS Biol"},{"key":"10.1093\/bja\/aer492_bib15","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.pain.2004.12.022","article-title":"ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model","volume":"114","author":"Zhuang","year":"2005","journal-title":"Pain"},{"key":"10.1093\/bja\/aer492_bib16","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev.pa.20.040180.002301","article-title":"Efficient analysis of experimental observations","volume":"20","author":"Dixon","year":"1980","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1093\/bja\/aer492_bib17","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.neulet.2005.12.046","article-title":"Mu- but not delta- and kappa-opioid receptor mediates the nucleus submedius interferon-alpha-evoked antinociception in the rat","volume":"397","author":"Wang","year":"2006","journal-title":"Neurosci Lett"},{"key":"10.1093\/bja\/aer492_bib18","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1146\/annurev.biochem.67.1.227","article-title":"How cells respond to interferons","volume":"67","author":"Stark","year":"1998","journal-title":"Annu Rev Biochem"},{"key":"10.1093\/bja\/aer492_bib19","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/ng1173","article-title":"Induction of an interferon response by RNAi vectors in mammalian cells","volume":"34","author":"Bridge","year":"2003","journal-title":"Nat Genet"},{"key":"10.1093\/bja\/aer492_bib20","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nm1191","article-title":"Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7","volume":"11","author":"Hornung","year":"2005","journal-title":"Nat Med"},{"key":"10.1093\/bja\/aer492_bib21","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1038\/nbt1122","article-title":"Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs","volume":"23","author":"Morrissey","year":"2005","journal-title":"Nat Biotechnol"},{"key":"10.1093\/bja\/aer492_bib22","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0304-3940(95)11452-3","article-title":"Microglial localization of alpha-interferon receptor in human brain tissues","volume":"189","author":"Yamada","year":"1995","journal-title":"Neurosci Lett"},{"key":"10.1093\/bja\/aer492_bib23","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/ana.410240211","article-title":"Multiple sclerosis: involvement of interferons in lesion pathogenesis","volume":"24","author":"Traugott","year":"1988","journal-title":"Ann Neurol"},{"key":"10.1093\/bja\/aer492_bib24","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1083\/jcb.102.6.2244","article-title":"Astrocytes produce interferon that enhances the expression of H-2 antigens on a subpopulation of brain cells","volume":"102","author":"Tedeschi","year":"1986","journal-title":"J Cell Biol"},{"key":"10.1093\/bja\/aer492_bib25","doi-asserted-by":"crossref","first-page":"3916","DOI":"10.4049\/jimmunol.173.6.3916","article-title":"Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs","volume":"173","author":"Olson","year":"2004","journal-title":"J Immunol"},{"key":"10.1093\/bja\/aer492_bib26","doi-asserted-by":"crossref","first-page":"7835","DOI":"10.1073\/pnas.0602460103","article-title":"Neurons produce type I interferon during viral encephalitis","volume":"103","author":"Delhaye","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1093\/bja\/aer492_bib27","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0197-0186(99)00124-2","article-title":"Analgesic effect of interferon-alpha via mu opioid receptor in the rat","volume":"36","author":"Jiang","year":"2000","journal-title":"Neurochem Int"},{"key":"10.1093\/bja\/aer492_bib28","doi-asserted-by":"crossref","first-page":"PL227","DOI":"10.1016\/0024-3205(92)90555-4","article-title":"Human recombinant interferon alpha inhibits naloxone binding to rat brain membranes","volume":"50","author":"Menzies","year":"1992","journal-title":"Life Sci"},{"key":"10.1093\/bja\/aer492_bib29","doi-asserted-by":"crossref","first-page":"5189","DOI":"10.1523\/JNEUROSCI.3338-07.2008","article-title":"Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord","volume":"28","author":"Kawasaki","year":"2008","journal-title":"J Neurosci"},{"key":"10.1093\/bja\/aer492_bib30","doi-asserted-by":"crossref","first-page":"4096","DOI":"10.1523\/JNEUROSCI.3623-08.2009","article-title":"JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain","volume":"29","author":"Gao","year":"2009","journal-title":"J Neurosci"},{"key":"10.1093\/bja\/aer492_bib31","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.tins.2004.12.002","article-title":"Neuropathic pain and spinal microglia: a big problem from molecules in \u2018small\u2019 glia","volume":"28","author":"Tsuda","year":"2005","journal-title":"Trends Neurosci"},{"key":"10.1093\/bja\/aer492_bib32","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s12264-010-6023-5","article-title":"Interleukin-1beta with learning and memory","volume":"26","author":"Huang","year":"2010","journal-title":"Neurosci Bull"},{"key":"10.1093\/bja\/aer492_bib33","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nrn2533","article-title":"Pathological and protective roles of glia in chronic pain","volume":"10","author":"Milligan","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"10.1093\/bja\/aer492_bib34","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/glia.20738","article-title":"Astrocytes are very sensitive to develop innate immune responses to lipid-carried short interfering RNA","volume":"57","author":"Gorina","year":"2009","journal-title":"Glia"}],"container-title":["British Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091217322754?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091217322754?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/bja\/article-pdf\/108\/4\/662\/715420\/aer492.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,22]],"date-time":"2022-10-22T10:48:48Z","timestamp":1666435728000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0007091217322754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S0007091217322754"],"URL":"https:\/\/doi.org\/10.1093\/bja\/aer492","relation":{},"ISSN":["0007-0912"],"issn-type":[{"value":"0007-0912","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Short small-interfering RNAs produce interferon-\u03b1-mediated analgesia","name":"articletitle","label":"Article Title"},{"value":"British Journal of Anaesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/bja\/aer492","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 The Author(s). Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}