{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T05:34:10Z","timestamp":1789882450417,"version":"4.0.1"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T00:00:00Z","timestamp":1512345600000},"content-version":"vor","delay-in-days":1829,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["bjanaesthesia.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["British Journal of Anaesthesia"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1093\/bja\/aes389","type":"journal-article","created":{"date-parts":[[2012,12,14]],"date-time":"2012-12-14T03:50:30Z","timestamp":1355457030000},"page":"i39-i46","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":73,"special_numbering":"S1","title":["Haemostatic resuscitation"],"prefix":"10.1016","volume":"109","author":[{"given":"R.P.","family":"Dutton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/bja\/aes389_bib1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.atc.2006.11.007","article-title":"Current concepts in hemorrhagic shock","volume":"25","author":"Dutton","year":"2007","journal-title":"Anesthesiol Clin North Am"},{"key":"10.1093\/bja\/aes389_bib2","doi-asserted-by":"crossref","first-page":"S55","DOI":"10.1097\/00003246-199302001-00011","article-title":"Vasoactive mediators and splanchnic perfusion","volume":"21","author":"Reilly","year":"1993","journal-title":"Crit Care Med"},{"key":"10.1093\/bja\/aes389_bib3","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1002\/bjs.6697","article-title":"Cellular mechanisms of injury after major trauma","volume":"96","author":"Chaudry","year":"2009","journal-title":"Br J Surg"},{"key":"10.1093\/bja\/aes389_bib4","first-page":"1211","article-title":"Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis","volume":"64","author":"Brohi","year":"2008","journal-title":"J Trauma"},{"key":"10.1093\/bja\/aes389_bib5","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1177\/1076029611426138","article-title":"Disseminated intravascular coagulation (DIC) at an early phase of trauma continuously proceeds to DIC at a late phase of trauma","volume":"18","author":"Murakami","year":"2012","journal-title":"Clin Appl Thromb Hemost"},{"key":"10.1093\/bja\/aes389_bib6","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1097\/01.TA.0000069184.82147.06","article-title":"Acute traumatic coagulopathy","volume":"54","author":"Brohi","year":"2003","journal-title":"J Trauma"},{"key":"10.1093\/bja\/aes389_bib7","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1537-2995.2008.01944.x","article-title":"The prevalence of abnormal results of conventional coagulation tests on admission to a trauma centre","volume":"49","author":"Hess","year":"2009","journal-title":"Transfusion"},{"key":"10.1093\/bja\/aes389_bib8","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/01.TA.0000075338.21177.EF","article-title":"Early coagulopathy predicts mortality in trauma","volume":"55","author":"MacLeod","year":"2003","journal-title":"J Trauma"},{"key":"10.1093\/bja\/aes389_bib9","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1097\/00005373-199705000-00016","article-title":"Predicting life-threatening coagulopathy in the massively transfused trauma patient: hypothermia and acidoses revisited","volume":"42","author":"Cosgriff","year":"1997","journal-title":"J Trauma"},{"key":"10.1093\/bja\/aes389_bib10","first-page":"639","article-title":"Comparison of cardiorespiratory effects of crystalline hemoglobin, whole blood, albumin, and Ringer\u2019s lactate in the resuscitation of hemorrhagic shock in dogs","volume":"83","author":"Nees","year":"1978","journal-title":"Surgery"},{"key":"10.1093\/bja\/aes389_bib11","first-page":"618","article-title":"The preventive treatment of wound shock","volume":"70","author":"Cannon","year":"1918","journal-title":"J Am Med Assoc"},{"key":"10.1093\/bja\/aes389_bib12","first-page":"851","article-title":"Fundamentals of physiologic control of arterial haemorrhage","volume":"58","author":"Shaftan","year":"1965","journal-title":"Surgery"},{"key":"10.1093\/bja\/aes389_bib13","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1097\/ALN.0b013e3181863117","article-title":"A rational approach to perioperative fluid management","volume":"109","author":"Chappell","year":"2008","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aes389_bib14","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1097\/00003246-200001000-00012","article-title":"Human neutrophil activation and increased adhesion by various resuscitation fluids","volume":"28","author":"Rhee","year":"2000","journal-title":"Crit Care Med"},{"key":"10.1093\/bja\/aes389_bib15","series-title":"Trauma Anesthesia: Basic and Clinical Aspects","first-page":"55","article-title":"Shock management","author":"Dutton","year":"2008"},{"key":"10.1093\/bja\/aes389_bib16","first-page":"33","article-title":"Haemostatic resuscitation during surgery improves survival in patients with traumatic-induced coagulopathy","volume":"67","author":"Duchesne","year":"2009","journal-title":"J Trauma"},{"key":"10.1093\/bja\/aes389_bib17","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1097\/00005373-199310000-00014","article-title":"Lactate clearance and survival following injury","volume":"35","author":"Abramson","year":"1993","journal-title":"J Trauma"},{"key":"10.1093\/bja\/aes389_bib18","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1097\/00005373-199911000-00028","article-title":"The golden hour and the silver day: detection and correction of occult hypoperfusion within 24 hours improves outcome from major trauma","volume":"47","author":"Blow","year":"1999","journal-title":"J Trauma"},{"key":"10.1093\/bja\/aes389_bib19","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1080\/10903120801907570","article-title":"Tourniquets: a review of current use with proposals for expanded prehospital use","volume":"12","author":"Doyle","year":"2008","journal-title":"Prehosp Emerg Care"},{"key":"10.1093\/bja\/aes389_bib20","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1097\/00005373-199309000-00008","article-title":"\u2018Damage control\u2019: an approach for improved survival in exsanguinating penetrating abdominal injury","volume":"35","author":"Rotondo","year":"1993","journal-title":"J Trauma"},{"key":"10.1093\/bja\/aes389_bib21","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1097\/00005373-200004000-00006","article-title":"External fixation as a bridge to intramedullary nailing for patients with multiple injuries and with femur fractures: damage control orthopedics","volume":"48","author":"Scalea","year":"2000","journal-title":"J Trauma"},{"key":"10.1093\/bja\/aes389_bib22","first-page":"CD007438","article-title":"Damage control surgery for abdominal trauma","volume":"20","author":"Cirocchi","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1093\/bja\/aes389_bib23","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1097\/00005373-199902000-00003","article-title":"Controlled resuscitation for uncontrolled hemorrhagic shock","volume":"46","author":"Burris","year":"1999","journal-title":"J Trauma"},{"key":"10.1093\/bja\/aes389_bib24","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0196-0644(05)80195-7","article-title":"Effect of blood pressure on haemorrhage volume and survival in a near-fatal haemorrhage model incorporating a vascular injury","volume":"22","author":"Stern","year":"1993","journal-title":"Ann Emerg Med"},{"key":"10.1093\/bja\/aes389_bib25","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0300-9572(95)00829-I","article-title":"Uncontrolled hemorrhagic shock outcome model in rats","volume":"29","author":"Capone","year":"1995","journal-title":"Resuscitation"},{"key":"10.1093\/bja\/aes389_bib26","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1097\/00005373-199804000-00026","article-title":"Resuscitation after uncontrolled venous haemorrhage: does increased resuscitation volume improve regional perfusion?","volume":"44","author":"Smail","year":"1998","journal-title":"J Trauma"},{"key":"10.1093\/bja\/aes389_bib27","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/S0196-0644(97)70352-4","article-title":"Effect of immediate fluid resuscitation on the rate, volume, and duration of pulmonary vascular haemorrhage in a sheep model of penetrating thoracic trauma","volume":"29","author":"Sakles","year":"1997","journal-title":"Ann Emerg Med"},{"key":"10.1093\/bja\/aes389_bib28","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1097\/00003246-199602001-00003","article-title":"Resuscitation from severe haemorrhage","volume":"24","author":"Shoemaker","year":"1996","journal-title":"Crit Care Med"},{"key":"10.1093\/bja\/aes389_bib29","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1056\/NEJM199410273311701","article-title":"Immediate versus delayed resuscitation for hypotensive patients with penetrating torso injuries","volume":"331","author":"Bickell","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1093\/bja\/aes389_bib30","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1097\/00005373-200206000-00020","article-title":"Hypotensive resuscitation during active haemorrhage: impact on in-hospital mortality","volume":"52","author":"Dutton","year":"2002","journal-title":"J Trauma"},{"key":"10.1093\/bja\/aes389_bib31","first-page":"652","article-title":"Hypotensive resuscitation strategy reduces transfusion requirements and severe postoperative coagulopathy in trauma patients with hemorrhagic shock: preliminary results of a randomized controlled trial","volume":"70","author":"Morrison","year":"2011","journal-title":"J Trauma"},{"key":"10.1093\/bja\/aes389_bib32","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1097\/ALN.0b013e3181fe3fe7","article-title":"Ideal permissive hypotension to resuscitate uncontrolled hemorrhagic shock and the tolerance time in rats","volume":"114","author":"Li","year":"2011","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aes389_bib33","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1097\/00005373-199302000-00006","article-title":"The role of secondary brain injury in determining outcome from severe head injury","volume":"34","author":"Chesnut","year":"1993","journal-title":"J Trauma"},{"key":"10.1093\/bja\/aes389_bib34","first-page":"527","article-title":"Battlefield resuscitation","volume":"15","author":"Dawes","year":"2009","journal-title":"Curr Opin Crit Care"},{"key":"10.1093\/bja\/aes389_bib35","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.suc.2006.09.008","article-title":"Lessons learned from modern military surgery","volume":"87","author":"Beekley","year":"2007","journal-title":"Surg Clin North Am"},{"key":"10.1093\/bja\/aes389_bib36","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1177\/000313481107700222","article-title":"Damage control resuscitation: from emergency department to the operating room","volume":"77","author":"Duchesne","year":"2011","journal-title":"Am Surg"},{"key":"10.1093\/bja\/aes389_bib37","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1001\/archsurg.2011.287","article-title":"Military Application of Tranexamic Acid in Trauma Emergency Resuscitation (MATTERs) Study","volume":"147","author":"Morrison","year":"2012","journal-title":"Arch Surg"},{"key":"10.1093\/bja\/aes389_bib38","first-page":"1177","article-title":"Damage control hematology: the impact of a trauma exsanguination protocol on survival and blood product utilization","volume":"64","author":"Cotton","year":"2008","journal-title":"J Trauma"},{"key":"10.1093\/bja\/aes389_bib39","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1097\/01.ta.0000198373.97217.94","article-title":"Safety of uncrossmatched type-O red cells for resuscitation from hemorrhagic shock","volume":"59","author":"Dutton","year":"2005","journal-title":"J Trauma"},{"key":"10.1093\/bja\/aes389_bib40","first-page":"272","article-title":"Review of current blood transfusions strategies in a mature level I trauma centre: were we wrong for the last 60 years?","volume":"65","author":"Duchesne","year":"2008","journal-title":"J Trauma"},{"issue":"4 Suppl.","key":"10.1093\/bja\/aes389_bib41","first-page":"S69","article-title":"Warm fresh whole blood is independently associated with improved survival for patients with combat-related traumatic injuries","volume":"66","author":"Spinella","year":"2009","journal-title":"J Trauma"},{"key":"10.1093\/bja\/aes389_bib42","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0887-7963(03)00022-1","article-title":"Treating coagulopathy in trauma patients","volume":"17","author":"Armand","year":"2003","journal-title":"Transfus Med Rev"},{"key":"10.1093\/bja\/aes389_bib43","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1111\/j.1537-2995.2004.03409.x","article-title":"Blood transfusion use rates in the care of acute trauma","volume":"44","author":"Como","year":"2004","journal-title":"Transfusion"},{"key":"10.1093\/bja\/aes389_bib44","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1365-2141.2004.04868.x","article-title":"Efficacy of standard dose and 30 ml\/kg fresh frozen plasma in correcting laboratory parameters of haemostasis in critically ill patients","volume":"125","author":"Chowdary","year":"2004","journal-title":"Br J Haematol"},{"key":"10.1093\/bja\/aes389_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/bja\/aeq001","article-title":"Haemodilution-induced profibrinolytic state is mitigated by fresh-frozen plasma: implications for early haemostatic intervention in massive haemorrhage","volume":"104","author":"Bolliger","year":"2010","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aes389_bib46","first-page":"805","article-title":"The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital","volume":"63","author":"Borgman","year":"2007","journal-title":"J Trauma"},{"key":"10.1093\/bja\/aes389_bib47","first-page":"358","article-title":"The relationship of blood product ratio to mortality: survival benefit or survival bias?","volume":"66","author":"Snyder","year":"2009","journal-title":"J Trauma"},{"key":"10.1093\/bja\/aes389_bib48","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1097\/ALN.0b013e318245c47b","article-title":"Prevalence of survivor bias in observational studies on fresh frozen plasma:erythrocyte ratios in trauma requiring massive transfusion","volume":"116","author":"Ho","year":"2012","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aes389_bib49","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1111\/j.1537-2995.2010.03050.x","article-title":"Blood product use in trauma resuscitation: plasma deficit versus plasma ratio as predictors of mortality in trauma","volume":"51","author":"de Biasi","year":"2011","journal-title":"Transfusion"},{"key":"10.1093\/bja\/aes389_bib50","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1757-7241-20-47","article-title":"Current management of massive haemorrhage in trauma","volume":"20","author":"Johansson","year":"2012","journal-title":"Scand J Trauma Resusc Emerg Med"},{"key":"10.1093\/bja\/aes389_bib51","doi-asserted-by":"crossref","first-page":"R55","DOI":"10.1186\/cc8948","article-title":"Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEM)-guided administration of fibrinogen concentrate and prothrombin complex concentrate","volume":"4","author":"Sch\u00f6chl","year":"2010","journal-title":"Crit Care"},{"key":"10.1093\/bja\/aes389_bib52","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/S0140-6736(11)60278-X","article-title":"The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial","volume":"377","author":"Roberts","year":"2011","journal-title":"Lancet"},{"key":"10.1093\/bja\/aes389_bib53","first-page":"489","article-title":"Results of the CONTROL trial: efficacy and safety of recombinant activated factor vii in the management of refractory traumatic haemorrhage","volume":"69","author":"Hauser","year":"2010","journal-title":"J Trauma"},{"key":"10.1093\/bja\/aes389_bib54","series-title":"Miller\u2019s Anesthesia","first-page":"2277","article-title":"Anesthesia for trauma","author":"Dutton","year":"2010"},{"key":"10.1093\/bja\/aes389_bib55","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1056\/NEJMoa1012452","article-title":"Liberal or restrictive transfusion in high-risk patients after hip surgery","volume":"365","author":"Carson","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1093\/bja\/aes389_bib56","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1097\/01.ta.0000203581.75241.f1","article-title":"Understanding combat casualty care statistics","volume":"60","author":"Holcomb","year":"2006","journal-title":"J Trauma"},{"key":"10.1093\/bja\/aes389_bib57","first-page":"620","article-title":"Trauma mortality in mature trauma systems: are we doing better? an analysis of trauma mortality patterns, 1997\u20132008","volume":"69","author":"Dutton","year":"2010","journal-title":"J Trauma"},{"issue":"Suppl. 1)","key":"10.1093\/bja\/aes389_bib58","first-page":"21","article-title":"Resuscitative strategies to maintain homeostasis during damage control surgery","volume":"99","author":"Dutton","year":"2012","journal-title":"Br J Surg"}],"container-title":["British Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091217315799?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091217315799?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/bja\/article-pdf\/109\/suppl_1\/i39\/826614\/aes389.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T18:35:22Z","timestamp":1757788522000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0007091217315799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":58,"alternative-id":["S0007091217315799"],"URL":"https:\/\/doi.org\/10.1093\/bja\/aes389","relation":{},"ISSN":["0007-0912"],"issn-type":[{"value":"0007-0912","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Haemostatic resuscitation","name":"articletitle","label":"Article Title"},{"value":"British Journal of Anaesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/bja\/aes389","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 The Author(s). Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}