{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T17:09:51Z","timestamp":1785344991419,"version":"3.55.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T00:00:00Z","timestamp":1512345600000},"content-version":"vor","delay-in-days":1739,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["bjanaesthesia.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["British Journal of Anaesthesia"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1093\/bja\/aes416","type":"journal-article","created":{"date-parts":[[2012,11,19]],"date-time":"2012-11-19T21:36:45Z","timestamp":1353361005000},"page":"388-396","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":69,"title":["Bispectral index-guided induction of general anaesthesia in patients undergoing major abdominal surgery using propofol or etomidate: a double-blind, randomized, clinical trial"],"prefix":"10.1016","volume":"110","author":[{"given":"A.","family":"M\u00f6ller Petrun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kamenik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/bja\/aes416_bib1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/sj.bjp.0706441","article-title":"Molecular targets underlying general anaesthesia","volume":"147","author":"Franks","year":"2006","journal-title":"Br J Pharmacol"},{"key":"10.1093\/bja\/aes416_bib2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1053\/j.sane.2005.04.002","article-title":"Intravenous (non-opioid) anaesthesia","volume":"24","author":"White","year":"2005","journal-title":"Semin Anesth Perioperat Med Pain"},{"key":"10.1093\/bja\/aes416_bib3","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1097\/ALN.0b013e3181ff72b5","article-title":"Clinical and molecular pharmacology of etomidate","volume":"114","author":"Stuart","year":"2011","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aes416_bib4","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1097\/00000542-199205000-00010","article-title":"Sympathetic response to induction of anaesthesia in humans with propofol or etomidate","volume":"76","author":"Ebert","year":"1992","journal-title":"Anaesthesiology"},{"key":"10.1093\/bja\/aes416_bib5","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1213\/01.ANE.0000175214.38450.91","article-title":"Predictors of hypotension after induction of general anaesthesia","volume":"101","author":"Reich","year":"2005","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aes416_bib6","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1383\/anes.5.9.317.49897","article-title":"Intravenous induction agents","volume":"5","author":"Fryer","year":"2004","journal-title":"Anaesth Intensive Care Med"},{"key":"10.1093\/bja\/aes416_bib7","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1111\/j.1365-2044.1993.tb07412.x","article-title":"Effects of thiopentone, etomidate and propofol of beat-to-beat cardiovascular signals in man","volume":"48","author":"Scheffer","year":"1993","journal-title":"Anaesthesia"},{"issue":"Suppl.)","key":"10.1093\/bja\/aes416_bib8","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1365-2044.1988.tb09064.x","article-title":"Effects of propofol on cardiovascular dynamics on coronary blood flow in geriatric patients. A comparison with etomidate","volume":"43","author":"Larsen","year":"1988","journal-title":"Anaesthesia"},{"issue":"uppl.)","key":"10.1093\/bja\/aes416_bib9","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1365-2044.1988.tb09065.x","article-title":"Effects of thiopentone, etomidate, and propofol on the haemodynamic response to tracheal intubation","volume":"43","author":"Harris","year":"1988","journal-title":"Anaesthesia"},{"key":"10.1093\/bja\/aes416_bib10","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1365-2044.1988.tb09014.x","article-title":"Which intravenous induction agent for day surgery? A comparison of propofol, thiopentone, methohexital and etomidate","volume":"43","author":"Heath","year":"1988","journal-title":"Anaesthesia"},{"key":"10.1093\/bja\/aes416_bib11","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/j.1365-2044.1989.tb11333.x","article-title":"The effects of speed of injection on induction with propofol. A comparison with etomidate","volume":"44","author":"Gillies","year":"1989","journal-title":"Anaesthesia"},{"key":"10.1093\/bja\/aes416_bib12","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1365-2044.1991.tb09349.x","article-title":"Echocardiographic assessment of the haemodynamic effects of propofol: a comparison with etomidate and thiopentone","volume":"46","author":"Gauss","year":"1991","journal-title":"Anaesthesia"},{"key":"10.1093\/bja\/aes416_bib13","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1111\/j.1365-2044.1986.tb12740.x","article-title":"Comparison of induction characteristics of four intravenous anaesthetic agents","volume":"46","author":"McCollum","year":"1986","journal-title":"Anaesthesia"},{"key":"10.1093\/bja\/aes416_bib14","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/S0003-4975(02)04059-6","article-title":"PulseCO: a less-invasive method to monitor cardiac output from arterial pressure after cardiac surgery","volume":"74","author":"Hamilton","year":"2002","journal-title":"Ann Thorac Surg"},{"key":"10.1093\/bja\/aes416_bib15","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1213\/01.ane.0000268140.02147.ed","article-title":"The reliability of pulse contour-derived cardiac output during hemorrhage and after vasopressor administration","volume":"105","author":"Bein","year":"2007","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aes416_bib16","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s10877-007-9093-9","article-title":"Effects of vasodilation on cardiac output measured by PulseCO","volume":"21","author":"Yamashita","year":"2007","journal-title":"J Clin Monit Comput"},{"key":"10.1093\/bja\/aes416_bib17","doi-asserted-by":"crossref","first-page":"R76","DOI":"10.1186\/cc10065","article-title":"Uncalibrated pulse power analysis fails to reliably measure cardiac output in patients undergoing coronary artery bypass surgery","volume":"15","author":"Broch","year":"2011","journal-title":"Crit Care"},{"key":"10.1093\/bja\/aes416_bib18","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.bpa.2005.08.004","article-title":"Update on bispectral index monitoring","volume":"20","author":"Johansen","year":"2006","journal-title":"Best Pract Clin Res Anesthesiol"},{"key":"10.1093\/bja\/aes416_bib19","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1053\/j.sane.2006.09.007","article-title":"Monitoring consciousness: EEG-based measures of anesthestic depth","volume":"25","author":"Mashour","year":"2006","journal-title":"Semin Anesth Perioperat Med Pain"},{"key":"10.1093\/bja\/aes416_bib20","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1097\/ALN.0b013e3181b799c1","article-title":"Early phase pharmacokinetics but not pharmakodynamics are influenced by propofol infusion rate","volume":"111","author":"Masui","year":"2001","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aes416_bib21","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1097\/00000542-200603000-00016","article-title":"Time delay of index calculation: analysis of cerebral state, bispectral, and narcotrend indices","volume":"104","author":"Pilge","year":"2006","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aes416_bib22","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1093\/bja\/82.3.333","article-title":"Effect-site modelling of propofol using auditory evoked potentials","volume":"82","author":"White","year":"1999","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aes416_bib23","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1097\/01.anes.0000278902.15505.f8","article-title":"Influence of administration rate on propofol plasma-effect site equilibration","volume":"107","author":"Struys","year":"2007","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aes416_bib24","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1177\/0091270010369242","article-title":"Population pharmacokinetics pharmacodynamics of brief etomidate infusion in healthy volunteers","volume":"51","author":"Kaneda","year":"2011","journal-title":"J Clin Pharmacol"},{"key":"10.1093\/bja\/aes416_bib25","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0952-8180(96)00041-4","article-title":"Propofol infusion for induction and maintenance of anaesthesia in elderly patients: recovery and haemodynamic profiles","volume":"8","author":"Chan","year":"1996","journal-title":"J Clin Anesth"},{"issue":"uppl)","key":"10.1093\/bja\/aes416_bib26","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1365-2044.1983.tb15182.x","article-title":"Etomidate infusion: its use in anaesthesia for general surgery","volume":"38","author":"Scorgie","year":"1983","journal-title":"Anaesthesia"},{"key":"10.1093\/bja\/aes416_bib27","doi-asserted-by":"crossref","first-page":"217","DOI":"10.4103\/0971-9784.69057","article-title":"A randomized trial of anaesthetic induction agents in patients with coronary artery disease and left ventricular dysfunction","volume":"13","author":"Singh","year":"2010","journal-title":"Ann Card Anaesth"},{"key":"10.1093\/bja\/aes416_bib28","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/1053-0770(92)90193-B","article-title":"Propofol\/fentanyl versus etomidate\/fentanyl for the induction of anaesthesia in patients with aortic insufficiency and coronary artery disease","volume":"6","author":"Haessler","year":"1992","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1093\/bja\/aes416_bib29","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/j.1399-6576.2006.01206.x","article-title":"Propofol causes more hypotension than etomidate in patients with severe aortic stenosis: a double-blind, randomized study comparing propofol and etomidate","volume":"51","author":"Bendel","year":"2007","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1093\/bja\/aes416_bib30","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/bja\/aeg175","article-title":"Bispectral index changes following etomidate induction of general anaesthesia and orotracheal intubation","volume":"91","author":"Lallemand","year":"2003","journal-title":"Br J Anaesth"}],"container-title":["British Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091217327642?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091217327642?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/bja\/article-pdf\/110\/3\/388\/18256194\/aes416.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T18:40:20Z","timestamp":1757788820000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0007091217327642"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["S0007091217327642"],"URL":"https:\/\/doi.org\/10.1093\/bja\/aes416","relation":{},"ISSN":["0007-0912"],"issn-type":[{"value":"0007-0912","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bispectral index-guided induction of general anaesthesia in patients undergoing major abdominal surgery using propofol or etomidate: a double-blind, randomized, clinical trial","name":"articletitle","label":"Article Title"},{"value":"British Journal of Anaesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/bja\/aes416","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 The Author(s). Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}