{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:51:48Z","timestamp":1789051908389,"version":"build-2803163510"},"reference-count":65,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T00:00:00Z","timestamp":1512345600000},"content-version":"vor","delay-in-days":1678,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["bjanaesthesia.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["British Journal of Anaesthesia"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1093\/bja\/aes501","type":"journal-article","created":{"date-parts":[[2013,1,18]],"date-time":"2013-01-18T23:58:55Z","timestamp":1358553535000},"page":"764-772","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":87,"title":["Long-term safety and efficacy of a pasteurized nanofiltrated prothrombin complex concentrate (Beriplex P\/N): a pharmacovigilance study"],"prefix":"10.1016","volume":"110","author":[{"given":"A.A.","family":"Hanke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Joch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"G\u00f6rlinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/bja\/aes501_bib1","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1111\/j.1538-7836.2006.01944.x","article-title":"Urgent reversal of warfarin with prothrombin complex concentrate: where are the evidence-based data?","volume":"4","author":"Kessler","year":"2006","journal-title":"J Thromb Haemost"},{"key":"10.1093\/bja\/aes501_bib2","doi-asserted-by":"crossref","first-page":"401S","DOI":"10.1378\/chest.126.3_suppl.401S","article-title":"Antithrombotic therapy for venous thromboembolic disease: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy","volume":"126","author":"Buller","year":"2004","journal-title":"Chest"},{"key":"10.1093\/bja\/aes501_bib3","doi-asserted-by":"crossref","first-page":"457S","DOI":"10.1378\/chest.126.3_suppl.457S","article-title":"Antithrombotic therapy in valvular heart disease\u2014native and prosthetic: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy","volume":"126","author":"Salem","year":"2004","journal-title":"Chest"},{"key":"10.1093\/bja\/aes501_bib4","doi-asserted-by":"crossref","first-page":"429S","DOI":"10.1378\/chest.126.3_suppl.429S","article-title":"Antithrombotic therapy in atrial fibrillation: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy","volume":"126","author":"Singer","year":"2004","journal-title":"Chest"},{"key":"10.1093\/bja\/aes501_bib5","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1055\/s-2008-1066025","article-title":"Survival of heparins, oral anticoagulants, and aspirin after the year 2010","volume":"34","author":"Fareed","year":"2008","journal-title":"Semin Thromb Hemost"},{"key":"10.1093\/bja\/aes501_bib6","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1001\/archinte.160.7.967","article-title":"Quality of anticoagulation management among patients with atrial fibrillation: results of a review of medical records from 2 communities","volume":"160","author":"Samsa","year":"2000","journal-title":"Arch Intern Med"},{"key":"10.1093\/bja\/aes501_bib7","doi-asserted-by":"crossref","first-page":"287S","DOI":"10.1378\/chest.126.3_suppl.287S","article-title":"Hemorrhagic complications of anticoagulant treatment: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy","volume":"126","author":"Levine","year":"2004","journal-title":"Chest"},{"key":"10.1093\/bja\/aes501_bib8","first-page":"312","article-title":"The incidence of bleeding complications associated with warfarin treatment in general practice in the United Kingdom","volume":"53","author":"Hallowell","year":"2003","journal-title":"Br J Gen Pract"},{"key":"10.1093\/bja\/aes501_bib9","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0002-9343(93)90285-W","article-title":"Anticoagulant-related bleeding: clinical epidemiology, prediction, and prevention","volume":"95","author":"Landefeld","year":"1993","journal-title":"Am J Med"},{"key":"10.1093\/bja\/aes501_bib10","doi-asserted-by":"crossref","first-page":"511","DOI":"10.7326\/0003-4819-118-7-199304010-00005","article-title":"Risk factors for complications of chronic anticoagulation. A multicenter study. Warfarin Optimized Outpatient Follow-up Study Group","volume":"118","author":"Fihn","year":"1993","journal-title":"Ann Intern Med"},{"key":"10.1093\/bja\/aes501_bib11","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1212\/01.wnl.0000250340.05202.8b","article-title":"The increasing incidence of anticoagulant-associated intracerebral hemorrhage","volume":"68","author":"Flaherty","year":"2007","journal-title":"Neurology"},{"key":"10.1093\/bja\/aes501_bib12","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0140-6736(96)01109-9","article-title":"Bleeding complications of oral anticoagulant treatment: an inception-cohort, prospective collaborative study (ISCOAT). Italian Study on Complications of Oral Anticoagulant Therapy","volume":"348","author":"Palareti","year":"1996","journal-title":"Lancet"},{"key":"10.1093\/bja\/aes501_bib13","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.amjmed.2006.07.034","article-title":"Death and disability from warfarin-associated intracranial and extracranial hemorrhages","volume":"120","author":"Fang","year":"2007","journal-title":"Am J Med"},{"key":"10.1093\/bja\/aes501_bib14","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1046\/j.1525-1497.1998.00096.x","article-title":"Risk of major hemorrhage for outpatients treated with warfarin","volume":"13","author":"McMahan","year":"1998","journal-title":"J Gen Intern Med"},{"key":"10.1093\/bja\/aes501_bib15","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1136\/jcp.2003.008904","article-title":"Warfarin reversal","volume":"57","author":"Hanley","year":"2004","journal-title":"J Clin Pathol"},{"key":"10.1093\/bja\/aes501_bib16","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1111\/j.1742-1241.2008.01859.x","article-title":"Biochemical comparison of seven commercially available prothrombin complex concentrates","volume":"62","author":"Kalina","year":"2008","journal-title":"Int J Clin Pract"},{"key":"10.1093\/bja\/aes501_bib17","doi-asserted-by":"crossref","first-page":"204S","DOI":"10.1378\/chest.126.3_suppl.204S","article-title":"The pharmacology and management of the vitamin K antagonists: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy","volume":"126","author":"Ansell","year":"2004","journal-title":"Chest"},{"key":"10.1093\/bja\/aes501_bib18","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1365-2141.2005.05856.x","article-title":"Guidelines on oral anticoagulation (warfarin): third edition\u20142005 update","volume":"132","author":"Baglin","year":"2006","journal-title":"Br J Haematol"},{"key":"10.1093\/bja\/aes501_bib19","doi-asserted-by":"crossref","first-page":"R52","DOI":"10.1186\/cc8943","article-title":"Management of bleeding following major trauma: an updated European guideline","volume":"14","author":"Rossaint","year":"2010","journal-title":"Crit Care"},{"key":"10.1093\/bja\/aes501_bib20","doi-asserted-by":"crossref","first-page":"e44S","DOI":"10.1378\/chest.11-2292","article-title":"Oral anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines","volume":"141","author":"Ageno","year":"2012","journal-title":"Chest"},{"key":"10.1093\/bja\/aes501_bib21","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1097\/ALN.0b013e31823497dd","article-title":"First-line therapy with coagulation factor concentrates combined with point-of-care coagulation testing is associated with decreased allogeneic blood transfusion in cardiovascular surgery: a retrospective, single-center cohort study","volume":"115","author":"Gorlinger","year":"2011","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aes501_bib22","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1097\/00042737-200301000-00004","article-title":"Efficacy and safety of a prothrombin complex concentrate with two virus-inactivation steps in patients with severe liver damage","volume":"15","author":"Lorenz","year":"2003","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1093\/bja\/aes501_bib23","doi-asserted-by":"crossref","first-page":"R191","DOI":"10.1186\/cc8186","article-title":"Prothrombin complex concentrate in surgical patients: retrospective evaluation of vitamin K antagonist reversal and treatment of severe bleeding","volume":"13","author":"Schick","year":"2009","journal-title":"Crit Care"},{"key":"10.1093\/bja\/aes501_bib24","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s12028-009-9310-0","article-title":"Prothrombin complex concentrates for oral anticoagulant therapy-related intracranial hemorrhage: a review of the literature","volume":"12","author":"Bershad","year":"2010","journal-title":"Neurocrit Care"},{"key":"10.1093\/bja\/aes501_bib25","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/ajh.21046","article-title":"Role of prothrombin complex concentrates in reversing warfarin anticoagulation: a review of the literature","volume":"83","author":"Leissinger","year":"2008","journal-title":"Am J Hematol"},{"key":"10.1093\/bja\/aes501_bib26","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1080\/02688690050175265","article-title":"Prothrombin complex concentrate for oral anticoagulant reversal in neurosurgical emergencies","volume":"14","author":"Cartmill","year":"2000","journal-title":"Br J Neurosurg"},{"key":"10.1093\/bja\/aes501_bib27","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1046\/j.1365-2141.2001.03214.x","article-title":"Beriplex P\/N reverses severe warfarin-induced overanticoagulation immediately and completely in patients presenting with major bleeding","volume":"115","author":"Evans","year":"2001","journal-title":"Br J Haematol"},{"key":"10.1093\/bja\/aes501_bib28","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1161\/01.STR.0000221786.81354.d6","article-title":"Hematoma growth and outcome in treated neurocritical care patients with intracerebral hemorrhage related to oral anticoagulant therapy: comparison of acute treatment strategies using vitamin K, fresh frozen plasma, and prothrombin complex concentrates","volume":"37","author":"Huttner","year":"2006","journal-title":"Stroke"},{"key":"10.1093\/bja\/aes501_bib29","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.thromres.2004.04.004","article-title":"Efficacy and safety of a prothrombin complex concentrate (Octaplex) for rapid reversal of oral anticoagulation","volume":"113","author":"Lubetsky","year":"2004","journal-title":"Thromb Res"},{"key":"10.1093\/bja\/aes501_bib30","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1055\/s-0038-1655992","article-title":"Emergency oral anticoagulant reversal: the relative efficacy of infusions of fresh frozen plasma and clotting factor concentrate on correction of the coagulopathy","volume":"77","author":"Makris","year":"1997","journal-title":"Thromb Haemost"},{"key":"10.1093\/bja\/aes501_bib31","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1111\/j.1538-7836.2008.02904.x","article-title":"Prothrombin complex concentrate (Beriplex P\/N) for emergency anticoagulation reversal: a prospective multinational clinical trial","volume":"6","author":"Pabinger","year":"2008","journal-title":"J Thromb Haemost"},{"key":"10.1093\/bja\/aes501_bib32","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s00277-009-0830-7","article-title":"Impact of infusion speed on the safety and effectiveness of prothrombin complex concentrate: a prospective clinical trial of emergency anticoagulation reversal","volume":"89","author":"Pabinger","year":"2010","journal-title":"Ann Hematol"},{"key":"10.1093\/bja\/aes501_bib33","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1046\/j.0007-1048.2001.03295.x","article-title":"Rapid reversal of oral anticoagulation with warfarin by a prothrombin complex concentrate (Beriplex): efficacy and safety in 42 patients","volume":"116","author":"Preston","year":"2002","journal-title":"Br J Haematol"},{"key":"10.1093\/bja\/aes501_bib34","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.thromres.2007.02.009","article-title":"Prothrombin complex concentrate (Octaplex) in patients requiring immediate reversal of oral anticoagulation","volume":"121","author":"Riess","year":"2007","journal-title":"Thromb Res"},{"key":"10.1093\/bja\/aes501_bib35","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1007\/s00134-007-0528-z","article-title":"Ultra-rapid management of oral anticoagulant therapy-related surgical intracranial hemorrhage","volume":"33","author":"Vigue","year":"2007","journal-title":"Intensive Care Med"},{"key":"10.1093\/bja\/aes501_bib36","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0049-3848(02)00402-4","article-title":"Correction of INR by prothrombin complex concentrate and vitamin K in patients with warfarin related hemorrhagic complication","volume":"108","author":"Yasaka","year":"2003","journal-title":"Thromb Res"},{"key":"10.1093\/bja\/aes501_bib37","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1007\/s00134-007-0765-1","article-title":"The headache over warfarin in British neurosurgical intensive care units: a national survey of current practice","volume":"33","author":"Appelboam","year":"2007","journal-title":"Intensive Care Med"},{"key":"10.1093\/bja\/aes501_bib38","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1016\/S0049-3848(99)00079-1","article-title":"Thrombogenicity of prothrombin complex concentrates","volume":"95","author":"Kohler","year":"1999","journal-title":"Thromb Res"},{"key":"10.1093\/bja\/aes501_bib39","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1055\/s-0037-1615219","article-title":"Thromboembolic complications associated with the use of prothrombin complex and factor IX concentrates","volume":"80","author":"Kohler","year":"1998","journal-title":"Thromb Haemost"},{"key":"10.1093\/bja\/aes501_bib40","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/cc9311","article-title":"Prothrombin complex concentrates: evaluation of safety and thrombogenicity","volume":"15","author":"S\u00f8rensen","year":"2011","journal-title":"Crit Care"},{"key":"10.1093\/bja\/aes501_bib41","unstructured":"PubMed Advanced Search Builder Available from www.ncbi.nlm.nih.gov\/pubmed\/advanced (accessed 30 March 2012)."},{"key":"10.1093\/bja\/aes501_bib42","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1160\/TH07-04-0263","article-title":"Perioperative myocardial infarction in a patient receiving low-dose prothrombin complex concentrates","volume":"98","author":"Bagot","year":"2007","journal-title":"Thromb Haemost"},{"issue":"Suppl. 2)","key":"10.1093\/bja\/aes501_bib43","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1016\/S0049-3848(08)70005-7","article-title":"Warfarin-reversal: results of a phase III study with pasteurised, nanofiltrated prothrombin complex concentrate","volume":"122","author":"Pabinger-Fasching","year":"2008","journal-title":"Thromb Res"},{"key":"10.1093\/bja\/aes501_bib44","doi-asserted-by":"crossref","first-page":"34","DOI":"10.5414\/IBP30034","article-title":"Omentuminfarkt und Portalvenenthrombose im Rahmen der Gabe von PPSB","volume":"30","author":"Sakka","year":"2005","journal-title":"Intensiv und Notfallbehandlung"},{"key":"10.1093\/bja\/aes501_bib45","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1097\/MBC.0b013e32834cb343","article-title":"Observational study of fibrinogen concentrate in massive hemorrhage: evaluation of a multicenter register","volume":"22","author":"Weiss","year":"2011","journal-title":"Blood Coagul Fibrinol"},{"key":"10.1093\/bja\/aes501_bib46","first-page":"609","article-title":"The dangers of prothrombin complex concentrate administration after heart surgery","volume":"19","author":"White","year":"2008","journal-title":"Blood Coagul Fibrinol"},{"key":"10.1093\/bja\/aes501_bib47","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1097\/MBC.0b013e3282010d7a","article-title":"Successful emergency reversal of phenprocoumon anticoagulation with prothrombin complex concentrate: a prospective clinical study","volume":"18","author":"Lorenz","year":"2007","journal-title":"Blood Coagul Fibrinol"},{"key":"10.1093\/bja\/aes501_bib48","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.thromres.2005.08.005","article-title":"Individualized dosing regimen for prothrombin complex concentrate more effective than standard treatment in the reversal of oral anticoagulant therapy: an open, prospective randomized controlled trial","volume":"118","author":"van Aart","year":"2006","journal-title":"Thromb Res"},{"key":"10.1093\/bja\/aes501_bib49","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1159\/000337723","article-title":"Thromboelastometry based early goal-directed coagulation management reduces blood transfusion requirements, adverse events, and costs in acute type A aortic dissection: a pilot study","volume":"39","author":"Hanke","year":"2012","journal-title":"Transfus Med Hemother"},{"key":"10.1093\/bja\/aes501_bib50","doi-asserted-by":"crossref","first-page":"R105","DOI":"10.1186\/cc6987","article-title":"Prothrombin complex concentrate (Beriplex P\/N) in severe bleeding: experience in a large tertiary hospital","volume":"12","author":"Bruce","year":"2008","journal-title":"Crit Care"},{"key":"10.1093\/bja\/aes501_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.thromres.2012.05.029","article-title":"Emergency reversal of anticoagulation: the real use of prothrombin complex concentrates: a prospective multicenter two year French study from 2006 to 2008","author":"Desmettre","year":"2012","journal-title":"Thromb Res"},{"key":"10.1093\/bja\/aes501_bib52","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1007\/s11938-007-0046-7","article-title":"Coagulopathy in liver disease","volume":"10","author":"Blonski","year":"2007","journal-title":"Curr Treat Options Gastroenterol"},{"key":"10.1093\/bja\/aes501_bib53","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1017\/S0265021508004675","article-title":"Prothrombin complex concentrates: a brief review","volume":"25","author":"Samama","year":"2008","journal-title":"Eur J Anaesthesiol"},{"key":"10.1093\/bja\/aes501_bib54","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1097\/01.mbc.0000114437.81125.2b","article-title":"Identification of prothrombin as a major thrombogenic agent in prothrombin complex concentrates","volume":"15","author":"Dusel","year":"2004","journal-title":"Blood Coagul Fibrinol"},{"key":"10.1093\/bja\/aes501_bib55","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1046\/j.1365-2141.2001.02908.x","article-title":"The management of coumarin-induced over-anticoagulation Annotation","volume":"114","author":"Makris","year":"2001","journal-title":"Br J Haematol"},{"key":"10.1093\/bja\/aes501_bib56","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1160\/TH11-01-0052","article-title":"Safety of prothrombin complex concentrates for rapid anticoagulation reversal of vitamin K antagonists. A meta-analysis","volume":"106","author":"Dentali","year":"2011","journal-title":"Thromb Haemost"},{"key":"10.1093\/bja\/aes501_bib57","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1182\/blood-2009-09-241851","article-title":"The new oral anticoagulants","volume":"115","author":"Garcia","year":"2010","journal-title":"Blood"},{"key":"10.1093\/bja\/aes501_bib58","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.thromres.2011.07.024","article-title":"Thromboembolic safety and efficacy of prothrombin complex concentrates in the emergency reversal of warfarin coagulopathy","volume":"129","author":"Majeed","year":"2012","journal-title":"Thromb Res"},{"key":"10.1093\/bja\/aes501_bib59","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1097\/ALN.0b013e318264c644","article-title":"Point-of-care testing: a prospective, randomized clinical trial of efficacy in coagulopathic cardiac surgery patients","volume":"117","author":"Weber","year":"2012","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aes501_bib60","doi-asserted-by":"crossref","first-page":"S468","DOI":"10.1016\/j.amepre.2009.12.019","article-title":"Assessing emerging infectious threats to blood safety for the blood disorders community","volume":"38","author":"Trimble","year":"2010","journal-title":"Am J Prev Med"},{"issue":"Suppl. 2","key":"10.1093\/bja\/aes501_bib61","doi-asserted-by":"crossref","first-page":"P-M-100","DOI":"10.1111\/j.1538-7836.2007.tb01022.x","article-title":"Effective pathogen reduction for a plasma-derived prothrombin complex concentrate through multiple dedicated measures","volume":"5","author":"Nowak","year":"2007","journal-title":"J Thromb Haemost"},{"key":"10.1093\/bja\/aes501_bib62","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1160\/TH07-05-0367","article-title":"Pharmacokinetics of Beriplex P\/N prothrombin complex concentrate in healthy volunteers","volume":"98","author":"Ostermann","year":"2007","journal-title":"Thromb Haemost"},{"key":"10.1093\/bja\/aes501_bib63","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.tmrv.2006.08.002","article-title":"Anticoagulants and their reversal","volume":"21","author":"Schulman","year":"2007","journal-title":"Transfus Med Rev"},{"key":"10.1093\/bja\/aes501_bib64","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1365-2044.2009.06188.x","article-title":"Use of rotation thromboelastometry (ROTEM) to achieve successful treatment of polytrauma with fibrinogen concentrate and prothrombin complex concentrate","volume":"65","author":"Schochl","year":"2010","journal-title":"Anaesthesia"},{"key":"10.1093\/bja\/aes501_bib65","doi-asserted-by":"crossref","first-page":"R55","DOI":"10.1186\/cc8948","article-title":"Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEM\u00ae)-guided administration of fibrinogen concentrate and prothrombin complex concentrate","volume":"14","author":"Sch\u00f6chl","year":"2010","journal-title":"Crit Care"}],"container-title":["British Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091217326740?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091217326740?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/bja\/article-pdf\/110\/5\/764\/940375\/aes501.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T18:40:48Z","timestamp":1757788848000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0007091217326740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":65,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["S0007091217326740"],"URL":"https:\/\/doi.org\/10.1093\/bja\/aes501","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718002375.793475371","asserted-by":"object"}]},"ISSN":["0007-0912"],"issn-type":[{"value":"0007-0912","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-term safety and efficacy of a pasteurized nanofiltrated prothrombin complex concentrate (Beriplex P\/N): a pharmacovigilance study","name":"articletitle","label":"Article Title"},{"value":"British Journal of Anaesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/bja\/aes501","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 The Author(s). Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}