{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T11:43:29Z","timestamp":1776771809834,"version":"3.51.2"},"reference-count":28,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T00:00:00Z","timestamp":1512345600000},"content-version":"vor","delay-in-days":1678,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["bjanaesthesia.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["British Journal of Anaesthesia"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1093\/bja\/aes503","type":"journal-article","created":{"date-parts":[[2013,2,7]],"date-time":"2013-02-07T20:49:58Z","timestamp":1360270198000},"page":"831-836","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["What is the ED95 of prilocaine for femoral nerve block using ultrasound?"],"prefix":"10.1016","volume":"110","author":[{"given":"P.K.","family":"Gupta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Chevret","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Zohar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.M.","family":"Hopkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1093\/bja\/aes503_bib1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/BF03011989","article-title":"Postoperative analgesia with \u20183-in-1' femoral nerve block after prosthetic hip surgery","volume":"45","author":"Fournier","year":"1998","journal-title":"Can J Anaesth"},{"key":"10.1093\/bja\/aes503_bib2","first-page":"206","article-title":"Long saphenous vein stripping under local anaesthesia","volume":"63","author":"Taylor","year":"1981","journal-title":"Ann R Coll Surg Engl"},{"issue":"Suppl. 2","key":"10.1093\/bja\/aes503_bib3","first-page":"ii411","article-title":"Single injection of femoral nerve block for bilateral total knee arthroplasty for post-operative pain management","volume":"108","author":"Rasiah","year":"2012","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aes503_bib4","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/bja\/aeq112","article-title":"Analgesia and functional outcome after total knee arthroplasty: periarticular infiltration vs continuous femoral nerve block","volume":"105","author":"Carli","year":"2010","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aes503_bib5","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1093\/bja\/aem373","article-title":"Epidural analgesia compared with peripheral nerve blockade after major knee surgery: a systematic review and meta-analysis of randomized trials","volume":"100","author":"Fowler","year":"2008","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aes503_bib6","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/bja\/62.5.515","article-title":"Evaluation of \u20183 in 1' lumbar plexus block in patients having muscle biopsy","volume":"62","author":"Madej","year":"1989","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aes503_bib7","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2307\/2531628","article-title":"Continual reassessment method: a practical design for phase 1 clinical trials in cancer","volume":"46","author":"O\u2019Quigley","year":"1990","journal-title":"Biometrics"},{"key":"10.1093\/bja\/aes503_bib8","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1177\/1740774508098788","article-title":"Adaptive designs for dose-finding in non-cancer phase II trials: influence of early unexpected outcomes","volume":"5","author":"Resche-Rigon","year":"2008","journal-title":"Clin Trials"},{"key":"10.1093\/bja\/aes503_bib9","first-page":"1","article-title":"Using the continual reassessment method to estimate the minimum effective dose in phase II dose-finding studies: a case study","volume":"0","author":"Zohar","year":"2011","journal-title":"Clin Trials"},{"key":"10.1093\/bja\/aes503_bib10","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1002\/sim.920","article-title":"The continual reassessment method: comparison of Bayesian stopping rules for dose-ranging studies","volume":"20","author":"Zohar","year":"2001","journal-title":"Stat Med"},{"key":"10.1093\/bja\/aes503_bib11","series-title":"R: A Language and Environment for Statistical Computing","year":"2009"},{"key":"10.1093\/bja\/aes503_bib12","series-title":"Introduction to Statistical Analysis","author":"Dixon","year":"1957"},{"key":"10.1093\/bja\/aes503_bib13","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1080\/01621459.1948.10483254","article-title":"A method for obtaining and analyzing sensitivity data","volume":"43","author":"Dixon","year":"1948","journal-title":"J Am Stat Assoc"},{"key":"10.1093\/bja\/aes503_bib14","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1080\/01621459.1965.10480843","article-title":"The up-and-down method for small samples","volume":"60","author":"Dixon","year":"1965","journal-title":"J Am Stat Assoc"},{"key":"10.1093\/bja\/aes503_bib15","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/j.1365-2710.2005.00678.x","article-title":"Minimum effective dose of midazolam for sedation of mechanically ventilated neonates","volume":"30","author":"Treluyer","year":"2005","journal-title":"J Clin Pharm Thera"},{"key":"10.1093\/bja\/aes503_bib16","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1365-2710.2005.00630.x","article-title":"Dose-finding study of ibuprofen in patent ductus arteriosus using the continual reassessment method","volume":"30","author":"Desfrere","year":"2005","journal-title":"J Clin Pharm Ther"},{"key":"10.1093\/bja\/aes503_bib17","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1215\/15228517-2008-030","article-title":"Phase I and pharmacokinetic study of karenitecin in patients with recurrent malignant gliomas","volume":"10","author":"Grossman","year":"2008","journal-title":"Neuro Oncol"},{"key":"10.1093\/bja\/aes503_bib18","doi-asserted-by":"crossref","first-page":"3323","DOI":"10.1200\/JCO.2004.10.116","article-title":"Platelet-derived growth factor receptor inhibitor imatinib mesylate and docetaxel: a modular phase I trial in androgen-independent prostate cancer","volume":"22","author":"Mathew","year":"2004","journal-title":"J Clin Oncol"},{"key":"10.1093\/bja\/aes503_bib19","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1023\/B:DRUG.0000011790.31292.ef","article-title":"A phase I trial of daily oral 4'- N-benzoyl-staurosporine in combination with protracted continuous infusion 5-fluorouracil in patients with advanced solid malignancies","volume":"22","author":"Eder","year":"2004","journal-title":"Invest New Drugs"},{"key":"10.1093\/bja\/aes503_bib20","doi-asserted-by":"crossref","DOI":"10.1097\/ALN.0b013e31829764cf","article-title":"Application of the continual reassessment method to dose-finding studies in regional anesthesia: an estimate of the ED95 dose for 0.5% bupivacaine for ultrasound-guided supraclavicular block","author":"Kant","year":"2013","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aes503_bib21","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1093\/bja\/aen384","article-title":"Ultrasound guidance compared with electrical neurostimulation for peripheral nerve block: a systematic review and meta-analysis of randomized controlled trials","volume":"102","author":"Abrahams","year":"2009","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aes503_bib22","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1097\/AAP.0b013e31819aab1","article-title":"Real-time ultrasound visualization of intravascular injection of local anesthetic during a peripheral nerve block","volume":"34","author":"Baciarello","year":"2009","journal-title":"Reg Anesth Pain Med"},{"key":"10.1093\/bja\/aes503_bib23","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1093\/bja\/aei036","article-title":"Deep venous thrombosis revealed during ultrasound-guided femoral nerve block","volume":"94","author":"Sutin","year":"2005","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aes503_bib24","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1093\/bja\/aem100","article-title":"Effects of ultrasound guidance on the minimum effective anaesthetic volume required to block the femoral nerve","volume":"98","author":"Casati","year":"2007","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aes503_bib25","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1093\/bja\/aeq069","article-title":"Fifteen years of ultrasound guidance in regional anaesthesia: part 1","volume":"104","author":"Marhofer","year":"2010","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aes503_bib26","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1093\/bja\/aeq086","article-title":"Fifteen years of ultrasound guidance in regional anaesthesia: Part 2\u2014recent developments in block techniques","volume":"104","author":"Marhofer","year":"2010","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aes503_bib27","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1093\/bja\/aeq017","article-title":"Effect of body mass index on the ED50 volume of bupivacaine 0.5% for supraclavicular brachial plexus block","volume":"104","author":"Gupta","year":"2010","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aes503_bib28","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1097\/00000542-200610000-00024","article-title":"Nerve puncture and apparent intraneural injection during ultrasound-guided axillary block does not invariably result in neurologic injury","volume":"105","author":"Bigeleisen","year":"2006","journal-title":"Anesthesiology"}],"container-title":["British Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000709121732682X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000709121732682X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/bja\/article-pdf\/110\/5\/831\/18256524\/aes503.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T18:40:13Z","timestamp":1757788813000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000709121732682X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["S000709121732682X"],"URL":"https:\/\/doi.org\/10.1093\/bja\/aes503","relation":{},"ISSN":["0007-0912"],"issn-type":[{"value":"0007-0912","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"What is the ED95 of prilocaine for femoral nerve block using ultrasound?","name":"articletitle","label":"Article Title"},{"value":"British Journal of Anaesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/bja\/aes503","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 The Author(s). Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}