{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:39:46Z","timestamp":1790782786653,"version":"4.1.0"},"reference-count":140,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T00:00:00Z","timestamp":1512345600000},"content-version":"vor","delay-in-days":1617,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["bjanaesthesia.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["British Journal of Anaesthesia"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1093\/bja\/aet128","type":"journal-article","created":{"date-parts":[[2013,6,23]],"date-time":"2013-06-23T19:27:51Z","timestamp":1372015671000},"page":"26-37","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":540,"title":["Neuroinflammation and the generation of neuropathic pain"],"prefix":"10.1016","volume":"111","author":[{"given":"A","family":"Ellis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.L.H.","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/bja\/aet128_bib1","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/nature07201","article-title":"Origin and physiological roles of inflammation","volume":"454","author":"Medzhitov","year":"2008","journal-title":"Nature"},{"key":"10.1093\/bja\/aet128_bib2","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nri2294","article-title":"Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators","volume":"8","author":"Serhan","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"10.1093\/bja\/aet128_bib3","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S1474-4422(12)70134-5","article-title":"The role of the immune system in the generation of neuropathic pain","volume":"11","author":"Calvo","year":"2012","journal-title":"Lancet Neurol"},{"key":"10.1093\/bja\/aet128_bib4","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1038\/nn1992","article-title":"The neuropathic pain triad: neurons, immune cells and glia","volume":"10","author":"Scholz","year":"2007","journal-title":"Nat Neurosci"},{"key":"10.1093\/bja\/aet128_bib5","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/nrn1700","article-title":"Role of the immune system in chronic pain","volume":"6","author":"Marchand","year":"2005","journal-title":"Nat Rev Neurosci"},{"key":"10.1093\/bja\/aet128_bib6","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1212\/01.wnl.0000282763.29778.59","article-title":"Neuropathic pain: redefinition and a grading system for clinical and research purposes","volume":"70","author":"Treede","year":"2008","journal-title":"Neurology"},{"key":"10.1093\/bja\/aet128_bib7","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1212\/01.WNL.0000137047.85868.D6","article-title":"The prevalence of pain in multiple sclerosis: a multicenter cross-sectional study","volume":"63","author":"Solaro","year":"2004","journal-title":"Neurology"},{"key":"10.1093\/bja\/aet128_bib8","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1212\/WNL.0b013e3181f88345","article-title":"Pain in Guillain-Barre syndrome: a long-term follow-up study","volume":"75","author":"Ruts","year":"2010","journal-title":"Neurology"},{"key":"10.1093\/bja\/aet128_bib9","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.neuron.2011.11.031","article-title":"A central role for the ERK-signaling pathway in controlling Schwann cell plasticity and peripheral nerve regeneration in vivo","volume":"73","author":"Napoli","year":"2012","journal-title":"Neuron"},{"key":"10.1093\/bja\/aet128_bib10","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.pneurobio.2012.05.005","article-title":"Specificity of peripheral nerve regeneration: interactions at the axon level","volume":"98","author":"Allodi","year":"2012","journal-title":"Prog Neurobiol"},{"key":"10.1093\/bja\/aet128_bib11","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S0306-4522(00)00396-1","article-title":"Hyperalgesia due to nerve injury: role of neutrophils","volume":"101","author":"Perkins","year":"2000","journal-title":"Neuroscience"},{"key":"10.1093\/bja\/aet128_bib12","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0304-3959(03)00261-6","article-title":"Inflammation and hyperalgesia induced by nerve injury in the rat: a key role of mast cells","volume":"105","author":"Zuo","year":"2003","journal-title":"Pain"},{"key":"10.1093\/bja\/aet128_bib13","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.brainres.2011.06.022","article-title":"Detailed characterization of neuro-immune responses following neuropathic injury in mice","volume":"1405","author":"Kim","year":"2011","journal-title":"Brain Res"},{"key":"10.1093\/bja\/aet128_bib14","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1159\/000125048","article-title":"Role of histamine H3 and H4 receptors in mechanical hyperalgesia following peripheral nerve injury","volume":"14","author":"Smith","year":"2007","journal-title":"Neuroimmunomodulation"},{"key":"10.1093\/bja\/aet128_bib15","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/j.intimp.2010.08.012","article-title":"Neutrophils: Cinderella of innate immune system","volume":"10","author":"Kumar","year":"2010","journal-title":"Int Immunopharmacol"},{"key":"10.1093\/bja\/aet128_bib16","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.neuroscience.2004.08.035","article-title":"T lymphocytes play a role in neuropathic pain following peripheral nerve injury in rats","volume":"129","author":"Moalem","year":"2004","journal-title":"Neuroscience"},{"key":"10.1093\/bja\/aet128_bib17","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1172\/JCI112815","article-title":"Secretory products of macrophages","volume":"79","author":"Nathan","year":"1987","journal-title":"J Clin Invest"},{"key":"10.1093\/bja\/aet128_bib18","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0304-3959(99)00306-1","article-title":"Depletion of macrophages reduces axonal degeneration and hyperalgesia following nerve injury","volume":"86","author":"Liu","year":"2000","journal-title":"Pain"},{"key":"10.1093\/bja\/aet128_bib19","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/ni.1802","article-title":"Autoimmunity: increasing suspects in the CD4+ T cell lineup","volume":"11","author":"Palmer","year":"2010","journal-title":"Nat Immunol"},{"key":"10.1093\/bja\/aet128_bib20","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/jlb.61.2.216","article-title":"Regulation of cytokine expression in macrophages and the Langerhans cell-like line XS52 by calcitonin gene-related peptide","volume":"61","author":"Torii","year":"1997","journal-title":"J Leukoc Biol"},{"key":"10.1093\/bja\/aet128_bib21","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.jpain.2005.06.004","article-title":"Evaluation of the time course of plasma extravasation in the skin by digital image analysis","volume":"6","author":"Gonzalez","year":"2005","journal-title":"J Pain"},{"key":"10.1093\/bja\/aet128_bib22","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1152\/jn.00855.2002","article-title":"Similar electrophysiological changes in axotomized and neighboring intact dorsal root ganglion neurons","volume":"89","author":"Ma","year":"2003","journal-title":"J Neurophysiol"},{"key":"10.1093\/bja\/aet128_bib23","doi-asserted-by":"crossref","first-page":"7746","DOI":"10.1523\/JNEUROSCI.22-17-07746.2002","article-title":"Degeneration of myelinated efferent fibers induces spontaneous activity in uninjured C-fiber afferents","volume":"22","author":"Wu","year":"2002","journal-title":"J Neurosci"},{"key":"10.1093\/bja\/aet128_bib24","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/0006-8993(89)90928-1","article-title":"Prostaglandin effects after elimination of indirect hyperalgesic mechanisms in the skin of the rat","volume":"492","author":"Taiwo","year":"1989","journal-title":"Brain Res"},{"key":"10.1093\/bja\/aet128_bib25","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1046\/j.1460-9568.1998.00139.x","article-title":"Endogenous nerve growth factor regulates the sensitivity of nociceptors in the adult rat","volume":"10","author":"Bennett","year":"1998","journal-title":"Eur J Neurosci"},{"key":"10.1093\/bja\/aet128_bib26","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0306-4522(97)00147-4","article-title":"Tumour necrosis factor-alpha induces ectopic activity in nociceptive primary afferent fibres","volume":"81","author":"Sorkin","year":"1997","journal-title":"Neuroscience"},{"key":"10.1093\/bja\/aet128_bib27","doi-asserted-by":"crossref","first-page":"14062","DOI":"10.1523\/JNEUROSCI.3795-08.2008","article-title":"Nociceptors are interleukin-1beta sensors","volume":"28","author":"Binshtok","year":"2008","journal-title":"J Neurosci"},{"key":"10.1093\/bja\/aet128_bib28","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.neuron.2007.07.016","article-title":"Nociceptors\u2013noxious stimulus detectors","volume":"55","author":"Woolf","year":"2007","journal-title":"Neuron"},{"key":"10.1093\/bja\/aet128_bib29","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1111\/j.1469-7793.2001.00813.x","article-title":"Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide","volume":"534","author":"Vellani","year":"2001","journal-title":"J Physiol"},{"key":"10.1093\/bja\/aet128_bib30","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0304-3959(02)00034-9","article-title":"Activation of protein kinase C sensitizes human VR1 to capsaicin and to moderate decreases in pH at physiological temperatures in Xenopus oocytes","volume":"98","author":"Crandall","year":"2002","journal-title":"Pain"},{"key":"10.1093\/bja\/aet128_bib31","doi-asserted-by":"crossref","first-page":"25665","DOI":"10.1074\/jbc.M311515200","article-title":"Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity","volume":"279","author":"Morenilla-Palao","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1093\/bja\/aet128_bib32","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/35050121","article-title":"Induction of vanilloid receptor channel activity by protein kinase C","volume":"408","author":"Premkumar","year":"2000","journal-title":"Nature"},{"key":"10.1093\/bja\/aet128_bib33","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.pneurobio.2007.06.005","article-title":"Neural plasticity after peripheral nerve injury and regeneration","volume":"82","author":"Navarro","year":"2007","journal-title":"Prog Neurobiol"},{"key":"10.1093\/bja\/aet128_bib34","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1046\/j.0953-816x.2001.01591.x","article-title":"VR1 protein expression increases in undamaged DRG neurons after partial nerve injury","volume":"13","author":"Hudson","year":"2001","journal-title":"Eur J Neurosci"},{"key":"10.1093\/bja\/aet128_bib35","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.pain.2004.11.018","article-title":"Medium and large injured dorsal root ganglion cells increase TRPV-1, accompanied by increased alpha2C-adrenoceptor co-expression and functional inhibition by clonidine","volume":"113","author":"Ma","year":"2005","journal-title":"Pain"},{"key":"10.1093\/bja\/aet128_bib36","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S0306-4522(03)00491-3","article-title":"Glial cell line-derived neurotrophic factor normalizes neurochemical changes in injured dorsal root ganglion neurons and prevents the expression of experimental neuropathic pain","volume":"121","author":"Wang","year":"2003","journal-title":"Neuroscience"},{"key":"10.1093\/bja\/aet128_bib37","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0304-3959(98)00111-0","article-title":"Change in mRNAs for neuropeptides and the GABA(A) receptor in dorsal root ganglion neurons in a rat experimental neuropathic pain model","volume":"78","author":"Fukuoka","year":"1998","journal-title":"Pain"},{"key":"10.1093\/bja\/aet128_bib38","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0304-3959(02)00067-2","article-title":"VR1, but not P2X(3), increases in the spared L4 DRG in rats with L5 spinal nerve ligation","volume":"99","author":"Fukuoka","year":"2002","journal-title":"Pain"},{"key":"10.1093\/bja\/aet128_bib39","doi-asserted-by":"crossref","first-page":"4891","DOI":"10.1523\/JNEUROSCI.21-13-04891.2001","article-title":"Brain-derived neurotrophic factor increases in the uninjured dorsal root ganglion neurons in selective spinal nerve ligation model","volume":"21","author":"Fukuoka","year":"2001","journal-title":"J Neurosci"},{"key":"10.1093\/bja\/aet128_bib40","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/neu.20094","article-title":"Voltage-gated sodium channels and pain pathways","volume":"61","author":"Wood","year":"2004","journal-title":"J Neurobiol"},{"key":"10.1093\/bja\/aet128_bib41","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1038\/35082088","article-title":"Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition","volume":"411","author":"Chuang","year":"2001","journal-title":"Nature"},{"key":"10.1093\/bja\/aet128_bib42","doi-asserted-by":"crossref","first-page":"12533","DOI":"10.1523\/JNEUROSCI.2840-11.2011","article-title":"Functional recovery after peripheral nerve injury is dependent on the pro-inflammatory cytokines IL-1beta and TNF: implications for neuropathic pain","volume":"31","author":"Nadeau","year":"2011","journal-title":"J Neurosci"},{"key":"10.1093\/bja\/aet128_bib43","doi-asserted-by":"crossref","first-page":"9363","DOI":"10.1523\/JNEUROSCI.1447-08.2008","article-title":"Requirement of myeloid cells for axon regeneration","volume":"28","author":"Barrette","year":"2008","journal-title":"J Neurosci"},{"key":"10.1093\/bja\/aet128_bib44","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jneuroim.2006.12.009","article-title":"Neutrophils invade lumbar dorsal root ganglia after chronic constriction injury of the sciatic nerve","volume":"184","author":"Morin","year":"2007","journal-title":"J Neuroimmunol"},{"key":"10.1093\/bja\/aet128_bib45","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.bbi.2006.10.013","article-title":"Immune cell involvement in dorsal root ganglia and spinal cord after chronic constriction or transection of the rat sciatic nerve","volume":"21","author":"Hu","year":"2007","journal-title":"Brain Behav Immun"},{"key":"10.1093\/bja\/aet128_bib46","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0306-4522(02)00065-9","article-title":"Macrophage and lymphocyte invasion of dorsal root ganglia after peripheral nerve lesions in the rat","volume":"112","author":"Hu","year":"2002","journal-title":"Neuroscience"},{"key":"10.1093\/bja\/aet128_bib47","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.neures.2004.01.004","article-title":"Enhanced production of monocyte chemoattractant protein-1 in the dorsal root ganglia in a rat model of neuropathic pain: possible involvement in the development of neuropathic pain","volume":"48","author":"Tanaka","year":"2004","journal-title":"Neurosci Res"},{"key":"10.1093\/bja\/aet128_bib48","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1111\/j.1349-7006.2008.00877.x","article-title":"Up-regulation of matrix metalloproteinase-3 in the dorsal root ganglion of rats with paclitaxel-induced neuropathy","volume":"99","author":"Nishida","year":"2008","journal-title":"Cancer Sci"},{"key":"10.1093\/bja\/aet128_bib49","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.expneurol.2006.07.022","article-title":"Intravenous paclitaxel administration in the rat induces a peripheral sensory neuropathy characterized by macrophage infiltration and injury to sensory neurons and their supporting cells","volume":"203","author":"Peters","year":"2007","journal-title":"Exp Neurol"},{"key":"10.1093\/bja\/aet128_bib50","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/j.1582-4934.2008.00333.x","article-title":"Improved outcome of EAN, an animal model of GBS, through amelioration of peripheral and central inflammation by minocycline","volume":"13","author":"Zhang","year":"2009","journal-title":"J Cell Mol Med"},{"key":"10.1093\/bja\/aet128_bib51","doi-asserted-by":"crossref","first-page":"10","DOI":"10.2174\/157339908783502361","article-title":"Role of inflammation in diabetic nephropathy","volume":"4","author":"Fornoni","year":"2008","journal-title":"Curr Diabetes Rev"},{"key":"10.1093\/bja\/aet128_bib52","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1042\/CS20080394","article-title":"Pathogenic perspectives for the role of inflammation in diabetic nephropathy","volume":"116","author":"Rivero","year":"2009","journal-title":"Clin Sci"},{"key":"10.1093\/bja\/aet128_bib53","doi-asserted-by":"crossref","first-page":"7","DOI":"10.4239\/wjd.v3.i1.7","article-title":"Pathophysiological role and therapeutic implications of inflammation in diabetic nephropathy","volume":"3","author":"Luis-Rodriguez","year":"2012","journal-title":"World J Diabetes"},{"key":"10.1093\/bja\/aet128_bib54","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1212\/WNL.53.1.20","article-title":"Matrix metalloproteinases in inflammatory demyelination: targets for treatment","volume":"53","author":"Kieseier","year":"1999","journal-title":"Neurology"},{"key":"10.1093\/bja\/aet128_bib55","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1159\/000110788","article-title":"Effect of bradykinin receptor antagonists on vincristine- and streptozotocin-induced hyperalgesia in a rat model of chemotherapy-induced and diabetic neuropathy","volume":"81","author":"Bujalska","year":"2008","journal-title":"Pharmacology"},{"key":"10.1093\/bja\/aet128_bib56","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s11916-008-0029-y","article-title":"Status of immune mediators in painful neuropathies","volume":"12","author":"Uceyler","year":"2008","journal-title":"Curr Pain Headache Rep"},{"key":"10.1093\/bja\/aet128_bib57","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/1744-8069-6-74","article-title":"Peripheral nerve injury and TRPV1-expressing primary afferent C-fibers cause opening of the blood-brain barrier","volume":"6","author":"Beggs","year":"2010","journal-title":"Mol Pain"},{"key":"10.1093\/bja\/aet128_bib58","doi-asserted-by":"crossref","first-page":"10819","DOI":"10.1523\/JNEUROSCI.1642-11.2011","article-title":"Peripheral nerve injury alters blood-spinal cord barrier functional and molecular integrity through a selective inflammatory pathway","volume":"31","author":"Echeverry","year":"2011","journal-title":"J Neurosci"},{"key":"10.1093\/bja\/aet128_bib59","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1002\/eji.200737485","article-title":"CNS-infiltrating CD4+ T lymphocytes contribute to murine spinal nerve transection-induced neuropathic pain","volume":"38","author":"Cao","year":"2008","journal-title":"Eur J Immunol"},{"key":"10.1093\/bja\/aet128_bib60","doi-asserted-by":"crossref","first-page":"14415","DOI":"10.1523\/JNEUROSCI.4569-09.2009","article-title":"T-cell infiltration and signaling in the adult dorsal spinal cord is a major contributor to neuropathic pain-like hypersensitivity","volume":"29","author":"Costigan","year":"2009","journal-title":"J Neurosci"},{"key":"10.1093\/bja\/aet128_bib61","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1533-2500.2010.00367.x","article-title":"The role of glia and the immune system in the development and maintenance of neuropathic pain","volume":"10","author":"Vallejo","year":"2010","journal-title":"Pain Pract"},{"key":"10.1093\/bja\/aet128_bib62","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1038\/nn.3155","article-title":"P2X4R+ microglia drive neuropathic pain","volume":"15","author":"Beggs","year":"2012","journal-title":"Nat Neurosci"},{"key":"10.1093\/bja\/aet128_bib63","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.expneurol.2011.08.018","article-title":"The mechanisms of microgliosis and pain following peripheral nerve injury","volume":"234","author":"Calvo","year":"2012","journal-title":"Exp Neurol"},{"key":"10.1093\/bja\/aet128_bib64","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.pain.2007.05.023","article-title":"IL-1ra alleviates inflammatory hyperalgesia through preventing phosphorylation of NMDA receptor NR-1 subunit in rats","volume":"135","author":"Zhang","year":"2008","journal-title":"Pain"},{"key":"10.1093\/bja\/aet128_bib65","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.pain.2007.11.019","article-title":"Low-dose methotrexate reduces peripheral nerve injury-evoked spinal microglial activation and neuropathic pain behavior in rats","volume":"138","author":"Scholz","year":"2008","journal-title":"Pain"},{"key":"10.1093\/bja\/aet128_bib66","doi-asserted-by":"crossref","first-page":"4017","DOI":"10.1523\/JNEUROSCI.23-10-04017.2003","article-title":"p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain","volume":"23","author":"Jin","year":"2003","journal-title":"J Neurosci"},{"key":"10.1093\/bja\/aet128_bib67","doi-asserted-by":"crossref","first-page":"8032","DOI":"10.1073\/pnas.0810420106","article-title":"IFN-gamma receptor signaling mediates spinal microglia activation driving neuropathic pain","volume":"106","author":"Tsuda","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1093\/bja\/aet128_bib68","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1097\/01.anes.0000270759.11086.e7","article-title":"Nerve conduction blockade in the sciatic nerve prevents but does not reverse the activation of p38 mitogen-activated protein kinase in spinal microglia in the rat spared nerve injury model","volume":"107","author":"Wen","year":"2007","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aet128_bib69","doi-asserted-by":"crossref","first-page":"5437","DOI":"10.1523\/JNEUROSCI.5169-09.2010","article-title":"Neuregulin-ErbB signaling promotes microglial proliferation and chemotaxis contributing to microgliosis and pain after peripheral nerve injury","volume":"30","author":"Calvo","year":"2010","journal-title":"J Neurosci"},{"key":"10.1093\/bja\/aet128_bib70","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1007\/s12031-009-9224-5","article-title":"Effect of memantine on the levels of neuropeptides and microglial cells in the brain regions of rats with neuropathic pain","volume":"39","author":"Takeda","year":"2009","journal-title":"J Mol Neurosci"},{"key":"10.1093\/bja\/aet128_bib71","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.1097\/00001756-200111160-00012","article-title":"Long-term trans-synaptic glial responses in the human thalamus after peripheral nerve injury","volume":"12","author":"Banati","year":"2001","journal-title":"Neuroreport"},{"key":"10.1093\/bja\/aet128_bib72","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.bbi.2008.08.004","article-title":"Spinal cord histopathological alterations in a patient with longstanding complex regional pain syndrome","volume":"23","author":"Del Valle","year":"2009","journal-title":"Brain Behav Immun"},{"key":"10.1093\/bja\/aet128_bib73","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1124\/jpet.103.052407","article-title":"Inhibition of microglial activation attenuates the development but not existing hypersensitivity in a rat model of neuropathy","volume":"306","author":"Raghavendra","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1093\/bja\/aet128_bib74","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.pain.2005.02.009","article-title":"Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation","volume":"115","author":"Ledeboer","year":"2005","journal-title":"Pain"},{"key":"10.1093\/bja\/aet128_bib75","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/nature01786","article-title":"P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury","volume":"424","author":"Tsuda","year":"2003","journal-title":"Nature"},{"key":"10.1093\/bja\/aet128_bib76","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2012.05.020","article-title":"Involvement of CX3CR1 in bone cancer pain through the activation of microglia p38 MAPK pathway in the spinal cord","volume":"1465","author":"Hu","year":"2012","journal-title":"Brain Res"},{"key":"10.1093\/bja\/aet128_bib77","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.neuron.2012.02.008","article-title":"Deconstructing the neuropathic pain phenotype to reveal neural mechanisms","volume":"73","author":"von Hehn","year":"2012","journal-title":"Neuron"},{"key":"10.1093\/bja\/aet128_bib78","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1002\/j.1532-2149.2012.00140.x","article-title":"The correlation between pain-related behaviour and spinal microgliosis in four distinct models of peripheral neuropathy","volume":"16","author":"Blackbeard","year":"2012","journal-title":"Eur J Pain"},{"key":"10.1093\/bja\/aet128_bib79","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.pain.2012.12.023","article-title":"Ethologically relevant behavioural changes and peripheral nerve neuropathology in a rat model of HIV antiretroviral drug stavudine induced peripheral neuropathy","volume":"154","author":"Huang","year":"2013","journal-title":"Pain"},{"key":"10.1093\/bja\/aet128_bib80","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.neuroscience.2010.12.052","article-title":"The response of spinal microglia to chemotherapy-evoked painful peripheral neuropathies is distinct from that evoked by traumatic nerve injuries","volume":"176","author":"Zheng","year":"2011","journal-title":"Neuroscience"},{"key":"10.1093\/bja\/aet128_bib81","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.neulet.2008.09.009","article-title":"Up-regulation of tumor necrosis factor-alpha in spinal cord contributes to vincristine-induced mechanical allodynia in mice","volume":"445","author":"Kiguchi","year":"2008","journal-title":"Neurosci Lett"},{"key":"10.1093\/bja\/aet128_bib82","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.neulet.2006.02.058","article-title":"Propentofylline attenuates vincristine-induced peripheral neuropathy in the rat","volume":"400","author":"Sweitzer","year":"2006","journal-title":"Neurosci Lett"},{"key":"10.1093\/bja\/aet128_bib83","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1742-2094-7-36","article-title":"Key role for spinal dorsal horn microglial kinin B1 receptor in early diabetic pain neuropathy","volume":"7","author":"Talbot","year":"2010","journal-title":"J Neuroinflammation"},{"key":"10.1093\/bja\/aet128_bib84","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.ejpain.2008.09.010","article-title":"Gabapentin reverses microglial activation in the spinal cord of streptozotocin-induced diabetic rats","volume":"13","author":"Wodarski","year":"2009","journal-title":"Eur J Pain"},{"key":"10.1093\/bja\/aet128_bib85","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.brainres.2010.10.044","article-title":"Spinal astrocytic activation contributes to mechanical allodynia in a mouse model of type 2 diabetes","volume":"1368","author":"Liao","year":"2011","journal-title":"Brain Res"},{"key":"10.1093\/bja\/aet128_bib86","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.neuroscience.2004.06.008","article-title":"Potassium buffering in the central nervous system","volume":"129","author":"Kofuji","year":"2004","journal-title":"Neuroscience"},{"key":"10.1093\/bja\/aet128_bib87","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.pain.2006.02.034","article-title":"The tetrapartite synapse: path to CNS sensitization and chronic pain","volume":"122","author":"De Leo","year":"2006","journal-title":"Pain"},{"key":"10.1093\/bja\/aet128_bib88","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.brainres.2008.05.004","article-title":"A comparison of spinal Iba1 and GFAP expression in rodent models of acute and chronic pain","volume":"1219","author":"Romero-Sandoval","year":"2008","journal-title":"Brain Res"},{"key":"10.1093\/bja\/aet128_bib89","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.neuint.2003.06.002","article-title":"Quantitative real-time RT-PCR assessment of spinal microglial and astrocytic activation markers in a rat model of neuropathic pain","volume":"45","author":"Tanga","year":"2004","journal-title":"Neurochem Int"},{"key":"10.1093\/bja\/aet128_bib90","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1006\/exnr.1999.7065","article-title":"The effect of site and type of nerve injury on spinal glial activation and neuropathic pain behavior","volume":"157","author":"Colburn","year":"1999","journal-title":"Exp Neurol"},{"key":"10.1093\/bja\/aet128_bib91","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.neuroscience.2006.02.070","article-title":"Role of astrocytic S100beta in behavioral hypersensitivity in rodent models of neuropathic pain","volume":"140","author":"Tanga","year":"2006","journal-title":"Neuroscience"},{"key":"10.1093\/bja\/aet128_bib92","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/glia.20207","article-title":"Astrocyte activation and reactive gliosis","volume":"50","author":"Pekny","year":"2005","journal-title":"Glia"},{"key":"10.1093\/bja\/aet128_bib93","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/S0166-2236(97)01139-9","article-title":"Reactive astrocytes: cellular and molecular cues to biological function","volume":"20","author":"Ridet","year":"1997","journal-title":"Trends Neurosci"},{"key":"10.1093\/bja\/aet128_bib94","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.pain.2009.02.006","article-title":"Profiling of dynamically changed gene expression in dorsal root ganglia post peripheral nerve injury and a critical role of injury-induced glial fibrillary acidic protein in maintenance of pain behaviors [corrected]","volume":"143","author":"Kim","year":"2009","journal-title":"Pain"},{"key":"10.1093\/bja\/aet128_bib95","doi-asserted-by":"crossref","first-page":"5189","DOI":"10.1523\/JNEUROSCI.3338-07.2008","article-title":"Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord","volume":"28","author":"Kawasaki","year":"2008","journal-title":"J Neurosci"},{"key":"10.1093\/bja\/aet128_bib96","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1002\/glia.21042","article-title":"Cathepsin S release from primary cultured microglia is regulated by the P2X7 receptor","volume":"58","author":"Clark","year":"2010","journal-title":"Glia"},{"key":"10.1093\/bja\/aet128_bib97","doi-asserted-by":"crossref","first-page":"6945","DOI":"10.1523\/JNEUROSCI.0828-09.2009","article-title":"The liberation of fractalkine in the dorsal horn requires microglial cathepsin S","volume":"29","author":"Clark","year":"2009","journal-title":"J Neurosci"},{"key":"10.1093\/bja\/aet128_bib98","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/nature04223","article-title":"BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain","volume":"438","author":"Coull","year":"2005","journal-title":"Nature"},{"key":"10.1093\/bja\/aet128_bib99","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1038\/nature01868","article-title":"Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain","volume":"424","author":"Coull","year":"2003","journal-title":"Nature"},{"key":"10.1093\/bja\/aet128_bib100","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.pain.2007.10.016","article-title":"Loose ligation of the sciatic nerve is associated with TrkB receptor-dependent decreases in KCC2 protein levels in the ipsilateral spinal dorsal horn","volume":"137","author":"Miletic","year":"2008","journal-title":"Pain"},{"key":"10.1093\/bja\/aet128_bib101","doi-asserted-by":"crossref","first-page":"11263","DOI":"10.1523\/JNEUROSCI.2308-08.2008","article-title":"Up-regulation of P2X4 receptors in spinal microglia after peripheral nerve injury mediates BDNF release and neuropathic pain","volume":"28","author":"Ulmann","year":"2008","journal-title":"J Neurosci"},{"key":"10.1093\/bja\/aet128_bib102","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.pain.2010.02.042","article-title":"Inhibition of microglial P2X4 receptors attenuates morphine tolerance, Iba1, GFAP and mu opioid receptor protein expression while enhancing perivascular microglial ED2","volume":"150","author":"Horvath","year":"2010","journal-title":"Pain"},{"key":"10.1093\/bja\/aet128_bib103","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/nn.3295","article-title":"Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl(-) homeostasis","volume":"16","author":"Ferrini","year":"2013","journal-title":"Nat Neurosci"},{"key":"10.1093\/bja\/aet128_bib104","doi-asserted-by":"crossref","first-page":"10482","DOI":"10.1523\/JNEUROSCI.3593-08.2008","article-title":"Supraspinal glial-neuronal interactions contribute to descending pain facilitation","volume":"28","author":"Wei","year":"2008","journal-title":"J Neurosci"},{"key":"10.1093\/bja\/aet128_bib105","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1038\/ni1276","article-title":"Resolution of inflammation: the beginning programs the end","volume":"6","author":"Serhan","year":"2005","journal-title":"Nat Immunol"},{"key":"10.1093\/bja\/aet128_bib106","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/89759","article-title":"Lipid mediator class switching during acute inflammation: signals in resolution","volume":"2","author":"Levy","year":"2001","journal-title":"Nat Immunol"},{"key":"10.1093\/bja\/aet128_bib107","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s11481-012-9394-8","article-title":"Resolvin E1 inhibits neuropathic pain and spinal cord microglial activation following peripheral nerve injury","volume":"8","author":"Xu","year":"2012","journal-title":"J Neuroimmune Pharmacol"},{"key":"10.1093\/bja\/aet128_bib108","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD005582.pub4","article-title":"Corticosteroids for preventing postherpetic neuralgia","author":"Han","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1093\/bja\/aet128_bib109","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1056\/NEJM200011233432102","article-title":"Intrathecal methylprednisolone for intractable postherpetic neuralgia","volume":"343","author":"Kotani","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1093\/bja\/aet128_bib110","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s12630-009-9237-0","article-title":"Treatment of complex regional pain syndrome: a review of the evidence","volume":"57","author":"Tran de","year":"2010","journal-title":"Canadian J Anaesth"},{"key":"10.1093\/bja\/aet128_bib111","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.ejpain.2009.11.004","article-title":"Efficacy and safety of a single intrathecal methylprednisolone bolus in chronic complex regional pain syndrome","volume":"14","author":"Munts","year":"2010","journal-title":"Eur J Pain"},{"key":"10.1093\/bja\/aet128_bib112","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1097\/BSD.0b013e31819afdc4","article-title":"Tumor necrosis alpha-blocking agent (etanercept): a triple blind randomized controlled trial of its use in treatment of sciatica","volume":"23","author":"Okoro","year":"2010","journal-title":"J Spinal Disord Tech"},{"key":"10.1093\/bja\/aet128_bib113","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.1097\/01.brs.0000190815.13764.64","article-title":"The treatment of disc herniation-induced sciatica with infliximab: results of a randomized, controlled, 3-month follow-up study","volume":"30","author":"Korhonen","year":"2005","journal-title":"Spine"},{"key":"10.1093\/bja\/aet128_bib114","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.tins.2011.08.005","article-title":"Emerging roles of resolvins in the resolution of inflammation and pain","volume":"34","author":"Ji","year":"2011","journal-title":"Trends Neurosci"},{"key":"10.1093\/bja\/aet128_bib115","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.expneurol.2011.11.006","article-title":"Propentofylline, a CNS glial modulator does not decrease pain in post-herpetic neuralgia patients: in vitro evidence for differential responses in human and rodent microglia and macrophages","volume":"234","author":"Landry","year":"2012","journal-title":"Exp Neurol"},{"key":"10.1093\/bja\/aet128_bib116","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.ejpain.2011.04.005","article-title":"Clinical trial of the p38 MAP kinase inhibitor dilmapimod in neuropathic pain following nerve injury","volume":"15","author":"Anand","year":"2011","journal-title":"Eur J Pain"},{"key":"10.1093\/bja\/aet128_bib117","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/ni1158","article-title":"Mast cells in the development of adaptive immune responses","volume":"6","author":"Galli","year":"2005","journal-title":"Nat Immunol"},{"key":"10.1093\/bja\/aet128_bib118","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/35093019","article-title":"Molecular mechanisms of nociception","volume":"413","author":"Julius","year":"2001","journal-title":"Nature"},{"key":"10.1093\/bja\/aet128_bib119","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.neures.2008.08.004","article-title":"Contribution of TRPV1 to the bradykinin-evoked nociceptive behavior and excitation of cutaneous sensory neurons","volume":"62","author":"Katanosaka","year":"2008","journal-title":"Neurosci Res"},{"key":"10.1093\/bja\/aet128_bib120","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1038\/ni1113","article-title":"The complement system in regulation of adaptive immunity","volume":"5","author":"Carroll","year":"2004","journal-title":"Nat Immunol"},{"key":"10.1093\/bja\/aet128_bib121","doi-asserted-by":"crossref","first-page":"8699","DOI":"10.1523\/JNEUROSCI.2018-07.2007","article-title":"Complement induction in spinal cord microglia results in anaphylatoxin C5a-mediated pain hypersensitivity","volume":"27","author":"Griffin","year":"2007","journal-title":"J Neurosci"},{"key":"10.1093\/bja\/aet128_bib122","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4049\/jimmunol.1101029","article-title":"Regulation of immune responses by prostaglandin E2","volume":"188","author":"Kalinski","year":"2012","journal-title":"J Immunol"},{"key":"10.1093\/bja\/aet128_bib123","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ejpain.2011.05.005","article-title":"LipoxinA(4) induced antinociception and decreased expression of NF-kappaB and pro-inflammatory cytokines after chronic dorsal root ganglia compression in rats","volume":"16","author":"Sun","year":"2012","journal-title":"Eur J Pain"},{"key":"10.1093\/bja\/aet128_bib124","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1038\/nn1997","article-title":"Microglia: active sensor and versatile effector cells in the normal and pathologic brain","volume":"10","author":"Hanisch","year":"2007","journal-title":"Nat Neurosci"},{"key":"10.1093\/bja\/aet128_bib125","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s10571-009-9390-6","article-title":"Spinal astrogliosis in pain models: cause and effects","volume":"29","author":"Hald","year":"2009","journal-title":"Cell Mol Neurobiol"},{"key":"10.1093\/bja\/aet128_bib126","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1742-2094-7-27","article-title":"TNF-alpha and neuropathic pain\u2013a review","volume":"7","author":"Leung","year":"2010","journal-title":"J Neuroinflammation"},{"key":"10.1093\/bja\/aet128_bib127","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.brainresrev.2008.12.020","article-title":"Role of interleukin-1beta during pain and inflammation","volume":"60","author":"Ren","year":"2009","journal-title":"Brain Res Rev"},{"key":"10.1093\/bja\/aet128_bib128","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/0006-8993(94)91466-4","article-title":"Intracerebroventricular injection of interleukin-1 beta enhances nociceptive neuronal responses of the trigeminal nucleus caudalis in rats","volume":"656","author":"Oka","year":"1994","journal-title":"Brain Res"},{"key":"10.1093\/bja\/aet128_bib129","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/00004647-200101000-00009","article-title":"Neuronal MCP-1 expression in response to remote nerve injury","volume":"21","author":"Flugel","year":"2001","journal-title":"J Cereb Blood flow Metab"},{"key":"10.1093\/bja\/aet128_bib130","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1046\/j.1460-9568.2001.01425.x","article-title":"Influence of injury and cytokines on synthesis of monocyte chemoattractant protein-1 mRNA in peripheral nervous tissue","volume":"13","author":"Subang","year":"2001","journal-title":"Eur J Neurosci"},{"key":"10.1093\/bja\/aet128_bib131","doi-asserted-by":"crossref","first-page":"4096","DOI":"10.1523\/JNEUROSCI.3623-08.2009","article-title":"JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain","volume":"29","author":"Gao","year":"2009","journal-title":"J Neurosci"},{"key":"10.1093\/bja\/aet128_bib132","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.ejpain.2008.04.017","article-title":"CCL2 is a key mediator of microglia activation in neuropathic pain states","volume":"13","author":"Thacker","year":"2009","journal-title":"Eur J Pain"},{"key":"10.1093\/bja\/aet128_bib133","doi-asserted-by":"crossref","first-page":"7947","DOI":"10.1073\/pnas.1331358100","article-title":"Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2","volume":"100","author":"Abbadie","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1093\/bja\/aet128_bib134","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.coph.2011.10.007","article-title":"Chemokines and cytokines in neuroinflammation leading to neuropathic pain","volume":"12","author":"Kiguchi","year":"2012","journal-title":"Curr Opin Pharmacol"},{"key":"10.1093\/bja\/aet128_bib135","doi-asserted-by":"crossref","first-page":"10655","DOI":"10.1073\/pnas.0610811104","article-title":"Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain","volume":"104","author":"Clark","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1093\/bja\/aet128_bib136","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nm1723","article-title":"Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain","volume":"14","author":"Kawasaki","year":"2008","journal-title":"Nat Med"},{"key":"10.1093\/bja\/aet128_bib137","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.mcn.2005.10.011","article-title":"TNFalpha-induced MMP-9 promotes macrophage recruitment into injured peripheral nerve","volume":"31","author":"Shubayev","year":"2006","journal-title":"Mol Cell Neurosci"},{"key":"10.1093\/bja\/aet128_bib138","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.mcn.2008.08.008","article-title":"MMPs initiate Schwann cell-mediated MBP degradation and mechanical nociception after nerve damage","volume":"39","author":"Kobayashi","year":"2008","journal-title":"Mol Cell Neurosci"},{"key":"10.1093\/bja\/aet128_bib139","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1007\/BF03402069","article-title":"Neurotrophic factors regulate cathepsin S in macrophages and microglia: a role in the degradation of myelin basic protein and amyloid beta peptide","volume":"5","author":"Liuzzo","year":"1999","journal-title":"Mol Med"},{"key":"10.1093\/bja\/aet128_bib140","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.pain.2006.11.017","article-title":"Role of the cysteine protease cathepsin S in neuropathic hyperalgesia","volume":"130","author":"Barclay","year":"2007","journal-title":"Pain"}],"container-title":["British Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000709121732963X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000709121732963X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/bja\/article-pdf\/111\/1\/26\/18256240\/aet128.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T18:41:46Z","timestamp":1757788906000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000709121732963X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":140,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["S000709121732963X"],"URL":"https:\/\/doi.org\/10.1093\/bja\/aet128","relation":{},"ISSN":["0007-0912"],"issn-type":[{"value":"0007-0912","type":"print"}],"subject":[],"published":{"date-parts":[[2013,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuroinflammation and the generation of neuropathic pain","name":"articletitle","label":"Article Title"},{"value":"British Journal of Anaesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/bja\/aet128","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 The Author(s). Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}