{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:15:07Z","timestamp":1787008507621,"version":"build-2736575974"},"reference-count":18,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T00:00:00Z","timestamp":1512345600000},"content-version":"vor","delay-in-days":1374,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["bjanaesthesia.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["British Journal of Anaesthesia"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1093\/bja\/aet340","type":"journal-article","created":{"date-parts":[[2013,10,23]],"date-time":"2013-10-23T20:35:29Z","timestamp":1382560529000},"page":"485-490","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Efficacy of palonosetron for the prevention of postoperative nausea and vomiting: a randomized, double-blinded, placebo-controlled trial"],"prefix":"10.1016","volume":"112","author":[{"given":"H.R.","family":"Chun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.S.","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.Y.","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.J.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.H.","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.I.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/bja\/aet340_bib1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1097\/00000542-199207000-00023","article-title":"Postoperative nausea and vomiting. Its etiology, treatment, and prevention","volume":"77","author":"Watcha","year":"1992","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aet340_bib2","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1097\/00000542-199909000-00022","article-title":"A simplified risk score for predicting postoperative nausea and vomiting: conclusions from cross-validations between two centers","volume":"91","author":"Apfel","year":"1999","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aet340_bib3","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1093\/bja\/aep209","article-title":"Comparison of ramosetron with ondansetron for prevention of postoperative nausea and vomiting in patients undergoing gynaecological surgery","volume":"103","author":"Kim","year":"2009","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aet340_bib4","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1097\/01.aco.0000247340.61815.38","article-title":"Pharmacology, pharmacogenetics, and clinical efficacy of 5-hydroxytryptamine type 3 receptor antagonists for postoperative nausea and vomiting","volume":"19","author":"Ho","year":"2006","journal-title":"Curr Opin Anaesthesiol"},{"key":"10.1093\/bja\/aet340_bib5","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1111\/j.1476-5381.1995.tb13282.x","article-title":"The interaction of RS 25259-197, a potent and selective antagonist, with 5-HT3 receptors, in vitro","volume":"114","author":"Wong","year":"1995","journal-title":"Br J Pharmacol"},{"key":"10.1093\/bja\/aet340_bib6","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1177\/0091270004264641","article-title":"Pharmacokinetic and safety evaluation of palonosetron, a 5-hydroxytryptamine-3 receptor antagonist, in U.S. and Japanese healthy subjects","volume":"44","author":"Stoltz","year":"2004","journal-title":"J Clin Pharmacol"},{"key":"10.1093\/bja\/aet340_bib7","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ejphar.2009.10.002","article-title":"Palonosetron triggers 5-HT3 receptor internalization and causes prolonged inhibition of receptor function","volume":"626","author":"Rojas","year":"2010","journal-title":"Eur J Pharmacol"},{"key":"10.1093\/bja\/aet340_bib8","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1093\/annonc\/mdl137","article-title":"A phase III, double-blind, randomized trial of palonosetron compared with ondansetron in preventing chemotherapy-induced nausea and vomiting following highly emetogenic chemotherapy","volume":"17","author":"Aapro","year":"2006","journal-title":"Ann Oncol"},{"key":"10.1093\/bja\/aet340_bib9","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1002\/cncr.11817","article-title":"Improved prevention of moderately emetogenic chemotherapy-induced nausea and vomiting with palonosetron, a pharmacologically novel 5-HT3 receptor antagonist: results of a phase III, single-dose trial versus dolasetron","volume":"98","author":"Eisenberg","year":"2003","journal-title":"Cancer"},{"key":"10.1093\/bja\/aet340_bib10","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S1470-2045(08)70313-9","article-title":"Palonosetron plus dexamethasone versus granisetron plus dexamethasone for prevention of nausea and vomiting during chemotherapy: a double-blind, double-dummy, randomised, comparative phase III trial","volume":"10","author":"Saito","year":"2009","journal-title":"Lancet Oncol"},{"key":"10.1093\/bja\/aet340_bib11","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1213\/ane.0b013e31817abcd3","article-title":"A randomized, double-blind study to evaluate the efficacy and safety of three different doses of palonosetron versus placebo in preventing postoperative nausea and vomiting over a 72-hour period","volume":"107","author":"Kovac","year":"2008","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aet340_bib12","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1213\/ane.0b013e31817b5ebb","article-title":"A randomized, double-blind study to evaluate the efficacy and safety of three different doses of palonosetron versus placebo for preventing postoperative nausea and vomiting","volume":"107","author":"Candiotti","year":"2008","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aet340_bib13","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/00000539-200207000-00042","article-title":"Small-dose dexamethasone reduces nausea and vomiting after laparoscopic cholecystectomy: a comparison of tropisetron with saline","volume":"95","author":"Wang","year":"2002","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aet340_bib14","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/00000542-199907000-00018","article-title":"Can postoperative nausea and vomiting be predicted?","volume":"91","author":"Sinclair","year":"1999","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aet340_bib15","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1097\/ALN.0b013e318267ef31","article-title":"Who is at risk for postdischarge nausea and vomiting after ambulatory surgery?","volume":"117","author":"Apfel","year":"2012","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aet340_bib16","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1213\/01.ANE.0000180204.64588.EC","article-title":"Postoperative nausea and vomiting are strongly influenced by postoperative opioid use in a dose-related manner","volume":"101","author":"Roberts","year":"2005","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aet340_bib17","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1093\/bja\/88.5.659","article-title":"Volatile anaesthetics may be the main cause of early but not delayed postoperative vomiting: a randomized controlled trial of factorial design","volume":"88","author":"Apfel","year":"2002","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aet340_bib18","doi-asserted-by":"crossref","first-page":"405","DOI":"10.4097\/kjae.2011.61.5.405","article-title":"Ramosetron for the prevention of postoperative nausea and vomiting (PONV): a meta-analysis","volume":"61","author":"Kim","year":"2011","journal-title":"Korean J Anesthesiol"}],"container-title":["British Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091217318597?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091217318597?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/bja\/article-pdf\/112\/3\/485\/681972\/aet340.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T18:35:51Z","timestamp":1757788551000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0007091217318597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["S0007091217318597"],"URL":"https:\/\/doi.org\/10.1093\/bja\/aet340","relation":{},"ISSN":["0007-0912"],"issn-type":[{"value":"0007-0912","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy of palonosetron for the prevention of postoperative nausea and vomiting: a randomized, double-blinded, placebo-controlled trial","name":"articletitle","label":"Article Title"},{"value":"British Journal of Anaesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/bja\/aet340","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 The Author(s). Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}