{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:06:52Z","timestamp":1762430812293,"version":"3.44.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T00:00:00Z","timestamp":1512345600000},"content-version":"vor","delay-in-days":1343,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Department of Anaesthesiology, University of Regensburg"}],"content-domain":{"domain":["bjanaesthesia.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["British Journal of Anaesthesia"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1093\/bja\/aet353","type":"journal-article","created":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T23:02:41Z","timestamp":1383087761000},"page":"735-741","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Lipid emulsion pretreatment has different effects on mepivacaine and bupivacaine cardiac toxicity in an isolated rat heart model"],"prefix":"10.1016","volume":"112","author":[{"given":"C.","family":"Aumeier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Kasdorf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Gruber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Busse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.H.","family":"Wiese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Zink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.M.","family":"Graf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.A.","family":"Zausig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1093\/bja\/aet353_bib1","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1097\/00000542-199804000-00028","article-title":"Pretreatment or resuscitation with a lipid infusion shifts the dose\u2013response to bupivacaine-induced asystole in rats","volume":"88","author":"Weinberg","year":"1998","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aet353_bib2","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1097\/CCM.0b013e3181961a12","article-title":"Lipid emulsion is superior to vasopressin in a rodent model of resuscitation from toxin-induced cardiac arrest","volume":"37","author":"Di Gregorio","year":"2009","journal-title":"Crit Care Med"},{"key":"10.1093\/bja\/aet353_bib3","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1213\/01.ane.0000248220.01320.58","article-title":"The effects of lipid infusion on myocardial function and bioenergetics in l-bupivacaine toxicity in the isolated rat heart","volume":"104","author":"Stehr","year":"2007","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aet353_bib4","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1097\/ALN.0b013e31816d91d2","article-title":"Resuscitation with lipid versus epinephrine in a rat model of bupivacaine overdose","volume":"108","author":"Weinberg","year":"2008","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aet353_bib5","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1213\/ane.0b013e3181af7fb3","article-title":"Lipid emulsion improves recovery from bupivacaine-induced cardiac arrest, but not from ropivacaine- or mepivacaine-induced cardiac arrest","volume":"109","author":"Zausig","year":"2009","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aet353_bib6","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1097\/AAP.0b013e3181d22fcd","article-title":"ASRA practice advisory on local anesthetic systemic toxicity","volume":"35","author":"Neal","year":"2010","journal-title":"Reg Anesth Pain Med"},{"key":"10.1093\/bja\/aet353_bib7","first-page":"698","article-title":"Empfehlungen zur Lipidbehandlung bei der Intoxikation mit Lokalan\u00e4sthetika","volume":"11","author":"Volk","year":"2009","journal-title":"Anaesth Intensiv"},{"key":"10.1093\/bja\/aet353_bib8","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1111\/j.1365-2044.2009.05974.x","article-title":"The lipid resuscitation story: past and future","volume":"64","author":"Weinberg","year":"2009","journal-title":"Anaesthesia"},{"key":"10.1093\/bja\/aet353_bib9","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.annemergmed.2007.06.004","article-title":"Use of lipid emulsion in the resuscitation of a patient with prolonged cardiovascular collapse after overdose of bupropion and lamotrigine","volume":"51","author":"Sirianni","year":"2008","journal-title":"Ann Emerg Med"},{"key":"10.1093\/bja\/aet353_bib10","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1213\/ane.0b013e31816a6c09","article-title":"Lipid infusion therapy: translation to clinical practice","volume":"106","author":"Weinberg","year":"2008","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aet353_bib11","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1097\/00003246-200910000-00042","article-title":"Is it \u2018lipid sink,\u2019 hemodilution, or both?","volume":"37","author":"Zausig","year":"2009","journal-title":"Crit Care Med"},{"key":"10.1093\/bja\/aet353_bib12","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/EJA.0b013e32834c7c42","article-title":"What limits the effect of lipid emulsion therapy?","volume":"29","author":"Zausig","year":"2012","journal-title":"Eur J Anaesthesiol"},{"key":"10.1093\/bja\/aet353_bib13","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1007\/s00216-009-3435-z","article-title":"Interaction of a commercial lipid dispersion and local anesthetics in human plasma: implications for drug trapping by \u2018lipid-sinks\u2019","volume":"396","author":"Laine","year":"2010","journal-title":"Anal Bioanal Chem"},{"key":"10.1093\/bja\/aet353_bib14","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1097\/ALN.0b013e318194b252","article-title":"Binding of long-lasting local anesthetics to lipid emulsions","volume":"110","author":"Mazoit","year":"2009","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aet353_bib15","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1007\/s00540-009-0755-2","article-title":"Failure of lipid emulsion to reverse neurotoxicity after an ultrasound-guided axillary block with ropivacaine and mepivacaine","volume":"23","author":"Calenda","year":"2009","journal-title":"J Anesth"},{"key":"10.1093\/bja\/aet353_bib16","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1213\/ANE.0b013e31822c10b8","article-title":"The effect of lipid emulsion infusion on postmortem ropivacaine concentrations in swine: endeavoring to comprehend a soldier\u2019s death","volume":"114","author":"Buckenmaier","year":"2012","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aet353_bib17","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1097\/AAP.0b013e31819340be","article-title":"Early use of lipid emulsion to treat incipient mepivacaine intoxication","volume":"34","author":"Charbonneau","year":"2009","journal-title":"Reg Anesth Pain Med"},{"key":"10.1093\/bja\/aet353_bib18","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1097\/SHK.0b013e3181cd877b","article-title":"Direct cardiac effects of dobutamine, dopamine, epinephrine, and levosimendan in isolated septic rat hearts","volume":"34","author":"Zausig","year":"2010","journal-title":"Shock"},{"key":"10.1093\/bja\/aet353_bib19","doi-asserted-by":"crossref","first-page":"R144","DOI":"10.1186\/cc8038","article-title":"Cardiac effects of induction agents in the septic rat heart","volume":"13","author":"Zausig","year":"2009","journal-title":"Crit Care"},{"key":"10.1093\/bja\/aet353_bib20","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1097\/ALN.0b013e3181fc63ed","article-title":"Lipid emulsion reverses bupivacaine-induced asystole in isolated rat hearts: concentration\u2013response and time\u2013response relationships","volume":"113","author":"Chen","year":"2010","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aet353_bib21","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/j.resuscitation.2010.08.015","volume":"81","author":"Soar","year":"2010","journal-title":"Resuscitation"},{"key":"10.1093\/bja\/aet353_bib22","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1007\/s00101-003-0617-5","article-title":"Toxicology of local anesthetics. Clinical, therapeutic and pathological mechanisms","volume":"52","author":"Zink","year":"2003","journal-title":"Anaesthesist"},{"key":"10.1093\/bja\/aet353_bib23","first-page":"1096","article-title":"Insulin reverses bupivacaine-induced cardiac depression in dogs","volume":"91","author":"Cho","year":"2000","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aet353_bib24","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1213\/ANE.0b013e31826c8095","article-title":"Myocardial accumulation of bupivacaine and ropivacaine is associated with reversible effects on mitochondria and reduced myocardial function","volume":"116","author":"Hiller","year":"2013","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aet353_bib25","first-page":"343","article-title":"Alteration of lipid fatty acid profile and cationic fluxes in ventricular cardiomyocytes from omega3-depleted rats","volume":"24","author":"Peltier","year":"2009","journal-title":"Int J Mol Med"},{"key":"10.1093\/bja\/aet353_bib26","first-page":"741","article-title":"Acute in vivo administration of a fish oil-containing emulsion improves post-ischemic cardiac function in n-3-depleted rats","volume":"18","author":"Peltier","year":"2006","journal-title":"Int J Mol Med"},{"key":"10.1093\/bja\/aet353_bib27","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1097\/ALN.0b013e318238be73","article-title":"Lipid resuscitation of bupivacaine toxicity: long-chain triglyceride emulsion provides benefits over long- and medium-chain triglyceride emulsion","volume":"115","author":"Li","year":"2011","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aet353_bib28","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.clnu.2006.01.021","article-title":"ESPEN guidelines on enteral nutrition: intensive care","volume":"25","author":"Kreymann","year":"2006","journal-title":"Clin Nutr"},{"key":"10.1093\/bja\/aet353_bib29","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1213\/ane.0b013e3181683dd7","article-title":"Reversal of central nervous system and cardiac toxicity after local anesthetic intoxication by lipid emulsion injection","volume":"106","author":"Litz","year":"2008","journal-title":"Anesth Analg"}],"container-title":["British Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091217308929?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091217308929?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/bja\/article-pdf\/112\/4\/735\/629984\/aet353.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T18:32:52Z","timestamp":1757788372000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0007091217308929"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["S0007091217308929"],"URL":"https:\/\/doi.org\/10.1093\/bja\/aet353","relation":{},"ISSN":["0007-0912"],"issn-type":[{"type":"print","value":"0007-0912"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lipid emulsion pretreatment has different effects on mepivacaine and bupivacaine cardiac toxicity in an isolated rat heart model","name":"articletitle","label":"Article Title"},{"value":"British Journal of Anaesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/bja\/aet353","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1093\/bja\/aet327","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"https:\/\/doi.org\/10.1093\/bja\/aeu010","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 The Author(s). Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}