{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T03:44:28Z","timestamp":1779335068856,"version":"3.51.4"},"reference-count":33,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T00:00:00Z","timestamp":1512345600000},"content-version":"vor","delay-in-days":1282,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["bjanaesthesia.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["British Journal of Anaesthesia"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1093\/bja\/aeu132","type":"journal-article","created":{"date-parts":[[2014,4,25]],"date-time":"2014-04-25T22:37:27Z","timestamp":1398465447000},"page":"1055-1064","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":78,"title":["Dexmedetomidine reduces intestinal and hepatic injury after hepatectomy with inflow occlusion under general anaesthesia: a randomized controlled trial"],"prefix":"10.1016","volume":"112","author":[{"given":"Z.X.","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.Y.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.P.","family":"Hua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.Q.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.H.","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.X.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1093\/bja\/aeu132_bib1","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1097\/01.SLA.0000072371.95588.DA","article-title":"Influence of transfusions on perioperative and long-term outcome in patients following hepatic resection for colorectal metastases","volume":"237","author":"Kooby","year":"2003","journal-title":"Ann Surg"},{"key":"10.1093\/bja\/aeu132_bib2","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1159\/000108325","article-title":"European survey on the application of vascular clamping in liver surgery","volume":"24","author":"van der Bilt","year":"2007","journal-title":"Dig Surg"},{"key":"10.1093\/bja\/aeu132_bib3","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1001\/archsurg.1996.01430160100022","article-title":"Multiple-system organ damage resulting from prolonged hepatic inflow interruption","volume":"131","author":"Liu","year":"1996","journal-title":"Arch Surg"},{"key":"10.1093\/bja\/aeu132_bib4","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1056\/NEJMra065156","article-title":"Strategies for safer liver surgery and partial liver transplantation","volume":"356","author":"Clavien","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1093\/bja\/aeu132_bib5","doi-asserted-by":"crossref","first-page":"e30539","DOI":"10.1371\/journal.pone.0030539","article-title":"Total intermittent Pringle maneuver during liver resection can induce intestinal epithelial cell damage and endotoxemia","volume":"7","author":"Dello","year":"2012","journal-title":"Plos One"},{"key":"10.1093\/bja\/aeu132_bib6","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1007\/s00595-010-4363-4","article-title":"Mechanical intestinal cleansing and antibiotic prophylaxis for preventing bacterial translocation during the Pringle maneuver in rabbits","volume":"41","author":"Erenoglu","year":"2011","journal-title":"Surg Today"},{"key":"10.1093\/bja\/aeu132_bib7","doi-asserted-by":"crossref","first-page":"520","DOI":"10.2741\/1816","article-title":"Role of the gut in the development of injury- and shock induced SIRS and MODS: the gut-lymph hypothesis, a review","volume":"11","author":"Deitch","year":"2006","journal-title":"Front Biosci"},{"key":"10.1093\/bja\/aeu132_bib8","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1089\/109629600750018141","article-title":"Pathogenesis of multiple organ dysfunction syndrome: gut origin, protection, and decontamination","volume":"1","author":"Rotstein","year":"2000","journal-title":"Surg Infect"},{"key":"10.1093\/bja\/aeu132_bib9","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1097\/00000542-200511000-00011","article-title":"Effects of dexmedetomidine on hippocampal focal adhesion kinase tyrosine phosphorylation in physiologic and ischemic conditions","volume":"103","author":"Dahmani","year":"2005","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aeu132_bib10","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1080\/08860220802546487","article-title":"Effect of dexmedetomidine on ischemia\u2013reperfusion injury in rat kidney: a histopathologic study","volume":"31","author":"Kocoglu","year":"2009","journal-title":"Renal Fail"},{"key":"10.1093\/bja\/aeu132_bib11","first-page":"524","article-title":"The effect of the alpha 2-agonist dexmedetomidine and the N-methyl-d-aspartate antagonist S(+)-ketamine on the expression of apoptosis-regulating proteins after incomplete cerebral ischemia and reperfusion in rats","volume":"96","author":"Engelhard","year":"2003","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aeu132_bib12","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.resuscitation.2007.01.032","article-title":"The cardioprotective effect of dexmedetomidine on global ischaemia in isolated rat hearts","volume":"74","author":"Okada","year":"2007","journal-title":"Resuscitation"},{"key":"10.1093\/bja\/aeu132_bib13","doi-asserted-by":"crossref","first-page":"687","DOI":"10.2174\/138945009788982423","article-title":"Dexmedetomidine use in general anaesthesia","volume":"10","author":"Arcangeli","year":"2009","journal-title":"Curr Drug Targets"},{"key":"10.1093\/bja\/aeu132_bib14","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ijsu.2012.12.003","article-title":"The protective effects of dexmedetomidine on the liver and remote organs against hepatic ischemia reperfusion injury in rats","volume":"11","author":"Tufek","year":"2013","journal-title":"Int J Surg"},{"key":"10.1093\/bja\/aeu132_bib15","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.jss.2012.11.034","article-title":"The effects of dexmedetomidine on liver ischemia\u2013reperfusion injury in rats","volume":"183","author":"Sahin","year":"2013","journal-title":"J Surg Res"},{"key":"10.1093\/bja\/aeu132_bib16","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1213\/ANE.0b013e318253631c","article-title":"Dexmedetomidine prevents alterations of intestinal microcirculation that are induced by surgical stress and pain in a novel rat model","volume":"115","author":"Yeh","year":"2012","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aeu132_bib17","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1097\/ALN.0b013e3182503964","article-title":"Dexmedetomidine administration before, but not after, ischemia attenuates intestinal injury induced by intestinal ischemia\u2013reperfusion in rats","volume":"116","author":"Zhang","year":"2012","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aeu132_bib18","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1159\/000171432","article-title":"Diamine oxidase: an overview of historical, biochemical and functional aspects","volume":"12","author":"Wolvekamp","year":"1994","journal-title":"Digest Dis (Basel, Switzerland)"},{"key":"10.1093\/bja\/aeu132_bib19","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1213\/ANE.0b013e3181effda8","article-title":"A comparison of liver function after hepatectomy with inflow occlusion between sevoflurane and propofol anesthesia","volume":"111","author":"Song","year":"2010","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aeu132_bib20","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1213\/ane.0b013e318172c47c","article-title":"Dexmedetomidine infusion during laparoscopic bariatric surgery: the effect on recovery outcome variables","volume":"106","author":"Tufanogullari","year":"2008","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aeu132_bib21","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1097\/ALN.0b013e31825681cb","article-title":"Effect of perioperative systemic \u03b12 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials","volume":"116","author":"Blaudszun","year":"2012","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aeu132_bib22","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1007\/BF03021622","article-title":"Intraoperative infusion of dexmedetomidine reduces perioperative analgesic requirements","volume":"53","author":"Gurbet","year":"2006","journal-title":"Can J Anaesth"},{"key":"10.1093\/bja\/aeu132_bib23","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1097\/ALN.0b013e3182850da5","article-title":"Limb remote ischemic preconditioning for intestinal and pulmonary protection during elective open infrarenal abdominal aortic aneurysm repair: a randomized controlled trial","volume":"118","author":"Li","year":"2013","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aeu132_bib24","doi-asserted-by":"crossref","first-page":"R90","DOI":"10.1186\/cc6958","article-title":"Gastrointestinal failure score in critically ill patients: a prospective observational study","volume":"12","author":"Reintam","year":"2008","journal-title":"Crit Care"},{"key":"10.1093\/bja\/aeu132_bib25","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1007\/BF03011261","article-title":"Study design in clinical research: sample size estimation and power analysis","volume":"43","author":"Lerman","year":"1996","journal-title":"Can J Anaesth"},{"key":"10.1093\/bja\/aeu132_bib26","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s00534-002-0720-z","article-title":"Current progress in the understanding of and therapeutic strategies for ischemia and reperfusion injury of the liver","volume":"10","author":"Arii","year":"2003","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"10.1093\/bja\/aeu132_bib27","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1097\/01.sla.0000246834.07130.5d","article-title":"A prospective, randomized, controlled trial comparing intermittent portal triad clamping versus ischemic preconditioning with continuous clamping for major liver resection","volume":"244","author":"Petrowsky","year":"2006","journal-title":"Ann Surg"},{"key":"10.1093\/bja\/aeu132_bib28","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1002\/bjs.7176","article-title":"Hepatic ischaemia\u2013reperfusion injury from bench to bedside","volume":"97","author":"Bahde","year":"2010","journal-title":"Br J Surg"},{"key":"10.1093\/bja\/aeu132_bib29","doi-asserted-by":"crossref","first-page":"e55","DOI":"10.1016\/j.jss.2008.11.843","article-title":"Immediate but not delayed postconditioning during reperfusion attenuates acute lung injury induced by intestinal ischemia\/reperfusion in rats: comparison with ischemic preconditioning","volume":"157","author":"Liu","year":"2009","journal-title":"J Surg Res"},{"key":"10.1093\/bja\/aeu132_bib30","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1007\/s00134-009-1428-1","article-title":"Immediate postconditioning during reperfusion attenuates intestinal injury","volume":"35","author":"Liu","year":"2009","journal-title":"Intensive Care Med"},{"key":"10.1093\/bja\/aeu132_bib31","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1007\/BF03018493","article-title":"Central dexmedetomidine attenuates cardiac dysfunction in a rodent model of intracranial hypertension","volume":"51","author":"Hall","year":"2004","journal-title":"Can J Anaesth"},{"key":"10.1093\/bja\/aeu132_bib32","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/1479-5876-11-141","article-title":"Dexmedetomidine protects against renal ischemia and reperfusion injury by inhibiting the JAK\/STAT signaling activation","volume":"11","author":"Si","year":"2013","journal-title":"J Transl Med"},{"key":"10.1093\/bja\/aeu132_bib33","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/cc10283","article-title":"Dexmedetomidine provides renoprotection against ischemia\u2013reperfusion injury in mice","volume":"15","author":"Gu","year":"2011","journal-title":"Crit Care"}],"container-title":["British Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091217307924?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091217307924?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/bja\/article-pdf\/112\/6\/1055\/18258192\/aeu132.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T18:31:56Z","timestamp":1757788316000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0007091217307924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["S0007091217307924"],"URL":"https:\/\/doi.org\/10.1093\/bja\/aeu132","relation":{},"ISSN":["0007-0912"],"issn-type":[{"value":"0007-0912","type":"print"}],"subject":[],"published":{"date-parts":[[2014,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dexmedetomidine reduces intestinal and hepatic injury after hepatectomy with inflow occlusion under general anaesthesia: a randomized controlled trial","name":"articletitle","label":"Article Title"},{"value":"British Journal of Anaesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/bja\/aeu132","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 The Author(s). Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}