{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:56:07Z","timestamp":1790646967652,"version":"4.1.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23 HL093065"],"award-info":[{"award-number":["K23 HL093065"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["British Journal of Anaesthesia"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1093\/bja\/aex095","type":"journal-article","created":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T20:12:38Z","timestamp":1490040758000},"page":"40-49","source":"Crossref","is-referenced-by-count":52,"title":["Prolonged concurrent hypotension and low bispectral index (\u2018double low\u2019) are associated with mortality, serious complications, and prolonged hospitalization after cardiac surgery"],"prefix":"10.1016","volume":"119","author":[{"given":"A.","family":"Maheshwari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.J.","family":"McCormick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.I.","family":"Sessler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.L.","family":"Reich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.J.","family":"Mascha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.G.","family":"Castillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.A.","family":"Levin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.E.","family":"Duncan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/bja\/aex095_bib1","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1097\/ALN.0b013e3181d5e0a3","article-title":"Association of perioperative risk factors and cumulative duration of low bispectral index with intermediate-term mortality after cardiac surgery in the B-Unaware Trial","volume":"112","author":"Kertai","year":"2010","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aex095_bib2","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1097\/ALN.0b013e31820c2b57","article-title":"Bispectral index monitoring, duration of bispectral index below 45, patient risk factors, and intermediate-term mortality after noncardiac surgery in the B-Unaware Trial","volume":"114","author":"Kertai","year":"2011","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aex095_bib3","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1213\/ane.0b013e31818f603c","article-title":"Mortality within 2\u2009years after surgery in relation to low intraoperative bispectral index values and preexisting malignant disease","volume":"108","author":"Lindholm","year":"2009","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aex095_bib4","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.bpa.2005.10.004","article-title":"Processed EEG and patient outcome","volume":"20","author":"Monk","year":"2006","journal-title":"Best Pract Res Clin Anaesthesiol"},{"key":"10.1093\/bja\/aex095_bib5","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1213\/01.ANE.0000147519.82841.5E","article-title":"Anesthetic management and one-year mortality after noncardiac surgery","volume":"100","author":"Monk","year":"2005","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aex095_bib6","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/S0022-5223(95)70053-6","article-title":"Improvement of outcomes after coronary artery bypass. A randomized trial comparing intraoperative high versus low mean arterial pressure","volume":"110","author":"Gold","year":"1995","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1093\/bja\/aex095_bib7","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1097\/00003246-199802000-00016","article-title":"Perioperative determinants of morbidity and mortality in elderly patients undergoing cardiac surgery","volume":"26","author":"Rady","year":"1998","journal-title":"Crit Care Med"},{"key":"10.1093\/bja\/aex095_bib8","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1213\/00000539-199910000-00002","article-title":"Intraoperative hemodynamic predictors of mortality, stroke, and myocardial infarction after coronary artery bypass surgery","volume":"89","author":"Reich","year":"1999","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aex095_bib9","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1097\/ALN.0b013e31825683dc","article-title":"Hospital stay and mortality are increased in patients having a \u201ctriple low\u201d of low blood pressure, low bispectral index, and low minimum alveolar concentration of volatile anaesthesia","volume":"116","author":"Sessler","year":"2012","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aex095_bib10","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1097\/ALN.0000000000000822","article-title":"Concurrence of intraoperative hypotension, low minimum alveolar concentration, and low bispectral index is associated with postoperative death","volume":"123","author":"Willingham","year":"2015","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aex095_bib11","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/ALN.0000000000000281","article-title":"Cumulative duration of \u201ctriple low\u201d state of low blood pressure, low bispectral index, and low minimum alveolar concentration of volatile anesthesia is not associated with increased mortality","volume":"121","author":"Kertai","year":"2014","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aex095_bib12","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1097\/ALN.0000000000001296","article-title":"Effectiveness of an electronic alert for hypotension and low bispectral index on 90-day postoperative mortality: a prospective, randomized trial","volume":"125","author":"McCormick","year":"2016","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aex095_bib13","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1001\/jama.1992.03480170070031","article-title":"Stratification of morbidity and mortality outcome by preoperative risk factors in coronary artery bypass patients. A clinical severity score","volume":"267","author":"Higgins","year":"1992","journal-title":"JAMA"},{"key":"10.1093\/bja\/aex095_bib14","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1080\/01621459.1995.10476562","article-title":"Efficiency and power of tests for multiple binary outcomes","volume":"90","author":"Legler","year":"1995","journal-title":"J Am Stat Assoc"},{"key":"10.1093\/bja\/aex095_bib15","doi-asserted-by":"crossref","first-page":"2890","DOI":"10.1002\/sim.4066","article-title":"Factors affecting power of tests for multiple binary outcomes","volume":"29","author":"Higgins","year":"2010","journal-title":"Stat Med"},{"key":"10.1093\/bja\/aex095_bib16","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1161\/01.STR.0000236024.68020.3a","article-title":"Watershed strokes after cardiac surgery: diagnosis, etiology, and outcome","volume":"37","author":"Gottesman","year":"2006","journal-title":"Stroke"},{"key":"10.1093\/bja\/aex095_bib17","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0952-8180(02)00510-X","article-title":"The interaction between fentanyl and propofol during emergence from anaesthesia: monitoring with the EEG-bispectral index","volume":"15","author":"Mi","year":"2003","journal-title":"J Clin Anesth"},{"key":"10.1093\/bja\/aex095_bib18","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1213\/01.ane.0000278117.31134.34","article-title":"The effect of neuromuscular block and noxious stimulation on hypnosis monitoring during sevoflurane anaesthesia","volume":"105","author":"Ekman","year":"2007","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aex095_bib19","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.athoracsur.2015.03.036","article-title":"Hypotension after cardiac operations based on autoregulation monitoring leads to brain cellular injury","volume":"100","author":"Hori","year":"2015","journal-title":"Ann Thorac Surg"},{"key":"10.1093\/bja\/aex095_bib20","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1213\/01.ANE.0000139347.64944.95","article-title":"The detection of cerebral hypoperfusion with bispectral index monitoring during general anaesthesia","volume":"100","author":"Morimoto","year":"2005","journal-title":"Anesth Analg"}],"container-title":["British Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091217337376?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091217337376?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/bja\/article-pdf\/119\/1\/40\/17941750\/aex095.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T23:52:15Z","timestamp":1635205935000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0007091217337376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["S0007091217337376"],"URL":"https:\/\/doi.org\/10.1093\/bja\/aex095","relation":{},"ISSN":["0007-0912"],"issn-type":[{"value":"0007-0912","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]}}}