{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T02:31:48Z","timestamp":1784687508113,"version":"3.55.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["British Journal of Anaesthesia"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1093\/bja\/aex134","type":"journal-article","created":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T11:14:52Z","timestamp":1492514092000},"page":"901-909","source":"Crossref","is-referenced-by-count":20,"title":["Pharmacokinetics and pharmacodynamics of propofol: changes in patients with frontal brain tumours"],"prefix":"10.1016","volume":"118","author":[{"given":"M.M.","family":"Sahinovic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.J.","family":"Eleveld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Miyabe-Nishiwaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.M.R.F.","family":"Struys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.R.","family":"Absalom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/bja\/aex134_bib1","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1227\/01.neu.0000303996.74526.30","article-title":"Total intravenous anesthesia: advantages for intracranial surgery","volume":"61","author":"Cole","year":"2007","journal-title":"Neurosurgery"},{"key":"10.1093\/bja\/aex134_bib2","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1097\/00000542-200302000-00010","article-title":"Intracranial pressure and cerebral hemodynamic in patients with cerebral tumors: a randomized prospective study of patients subjected to craniotomy in propofol-fentanyl, isoflurane-fentanyl, or sevoflurane-fentanyl anesthesia","volume":"98","author":"Petersen","year":"2003","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aex134_bib3","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1097\/00000542-199805000-00006","article-title":"The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers","volume":"88","author":"Schnider","year":"1998","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aex134_bib4","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/bja\/67.1.41","article-title":"Pharmacokinetic model driven infusion of propofol in children","volume":"67","author":"Marsh","year":"1991","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aex134_bib5","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1097\/00000542-199906000-00012","article-title":"Propofol requirement is decreased in patients with large supratentorial brain tumor","volume":"90","author":"Chan","year":"1999","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aex134_bib6","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/ANA.0b013e318262282f","article-title":"Fentanyl co-administration decreases the induction dose requirement of propofol in patients with supratentorial tumors and not in patients with spinal lesions","volume":"24","author":"Bansal","year":"2012","journal-title":"J Neurosurg Anesthesiol"},{"key":"10.1093\/bja\/aex134_bib7","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jclinane.2007.09.011","article-title":"Brain tumors may alter the relationship between bispectral index values and propofol concentrations during induction of anesthesia","volume":"20","author":"Ferreira","year":"2008","journal-title":"J Clin Anesth"},{"key":"10.1093\/bja\/aex134_bib8","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1093\/bja\/aet342","article-title":"Bispectral index values and propofol concentrations at loss and return of consciousness in patients with frontal brain tumours and control patients","volume":"112","author":"Sahinovic","year":"2014","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aex134_bib9","series-title":"Committee for Standards and Practice Parameters. 10.28.15 Standards for basic anesthetic monitoring","year":"2015"},{"key":"10.1093\/bja\/aex134_bib10","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1136\/bmj.1.6072.1321-a","article-title":"Detecting wakefulness during general anaesthesia for caesarean section","volume":"1","author":"Tunstall","year":"1977","journal-title":"Br Med J"},{"key":"10.1093\/bja\/aex134_bib11","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.jchromb.2007.01.001","article-title":"Gas chromatography-mass spectrometric assay for propofol in cerebrospinal fluid of traumatic brain patients","volume":"852","author":"Peeters","year":"2007","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"10.1093\/bja\/aex134_bib12","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1023\/B:JOPA.0000012999.36063.4e","article-title":"Simultaneous vs. sequential analysis for population PK\/PD data II: robustness of methods","volume":"30","author":"Zhang","year":"2003","journal-title":"J Pharmacokinet Pharmacodyn"},{"key":"10.1093\/bja\/aex134_bib13","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1097\/ALN.0b013e3181b799c1","article-title":"Early phase pharmacokinetics but not pharmacodynamics are influenced by propofol infusion rate","volume":"111","author":"Masui","year":"2009","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aex134_bib14","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1213\/01.ane.0000287269.06170.0f","article-title":"Estimation of optimal modeling weights for a Bayesian-based closed-loop system for propofol administration using the bispectral index as a controlled variable: a simulation study","volume":"105","author":"De Smet","year":"2007","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aex134_bib15","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/BF01143186","article-title":"Measuring the predictive performance of computer-controlled infusion pumps","volume":"20","author":"Varvel","year":"1992","journal-title":"J Pharmacokinet Biopharm"},{"key":"10.1093\/bja\/aex134_bib16","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1365-2044.1988.tb09059.x","article-title":"Total intravenous anaesthesia with propofol and alfentanil by computer-assisted infusion","volume":"43","author":"Sch\u00fcttler","year":"1988","journal-title":"Anaesthesia"},{"key":"10.1093\/bja\/aex134_bib17","series-title":"Miller's Anesthesia","first-page":"439","article-title":"Intravenous drug delivery systems","author":"Glass","year":"2005"},{"key":"10.1093\/bja\/aex134_bib18","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1213\/ANE.0000000000000165","article-title":"A general purpose pharmacokinetic model for propofol","volume":"118","author":"Eleveld","year":"2014","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aex134_bib19","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1146\/annurev.pharmtox.48.113006.094708","article-title":"Mechanism-based concepts of size and maturity in pharmacokinetics","volume":"48","author":"Anderson","year":"2008","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1093\/bja\/aex134_bib20","doi-asserted-by":"crossref","first-page":"254","DOI":"10.2174\/157015910792246254","article-title":"Antiepileptic drug interactions'principles and clinical implications","volume":"8","author":"Johannessen","year":"2010","journal-title":"Curr Neuropharmacol"},{"key":"10.1093\/bja\/aex134_bib21","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1097\/00000542-200603000-00016","article-title":"Time delay of index calculation: analysis of cerebral state, bispectral, and Narcotrend indices","volume":"104","author":"Pilge","year":"2006","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aex134_bib22","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/00000542-200607000-00009","article-title":"Cerebral state index during propofol anesthesia: a comparison with the bispectral index and the A-line ARX index","volume":"105","author":"Jensen","year":"2006","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aex134_bib23","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1093\/bja\/aep198","article-title":"Time delay of electroencephalogram index calculation: analysis of cerebral state, bispectral, and Narcotrend indices using perioperatively recorded electroencephalographic signals","volume":"103","author":"Zanner","year":"2009","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aex134_bib24","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1093\/bja\/88.2.184","article-title":"Bispectral index monitoring during electroconvulsive therapy under propofol anaesthesia","volume":"88","author":"Gunawardane","year":"2002","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aex134_bib25","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1093\/bja\/aet410","article-title":"Bilateral bispectral index monitoring during and after electroconvulsive therapy compared with magnetic seizure therapy for treatment-resistant depression","volume":"112","author":"Soehle","year":"2014","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aex134_bib26","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1213\/01.ANE.0000059223.78879.0F","article-title":"Low baseline Bispectral Index of the electroencephalogram in patients with dementia","volume":"96","author":"Renna","year":"2003","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aex134_bib27","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1097\/00000539-200212000-00020","article-title":"Bispectral index monitoring: a comparison between normal children and children with quadriplegic cerebral palsy","volume":"95","author":"Choudhry","year":"2002","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aex134_bib28","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1097\/ACO.0b013e32833a1d2f","article-title":"Population pharmacokinetics and pharmacodynamics in anesthesia, intensive care and pain medicine","volume":"23","author":"Heeremans","year":"2010","journal-title":"Curr Opin Anaesthesiol"},{"issue":"Suppl 1","key":"10.1093\/bja\/aex134_bib29","doi-asserted-by":"crossref","first-page":"23S","DOI":"10.1016\/S0952-8180(97)00117-7","article-title":"Pharmacokinetic and pharmacodynamic interactions between opioids and propofol","volume":"9","author":"Vuyk","year":"1997","journal-title":"J Clin Anesth"},{"key":"10.1093\/bja\/aex134_bib30","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1093\/bja\/aew312","article-title":"Pharmacokinetic and pharmacodynamic interactions in anaesthesia. A review of current knowledge and how it can be used to optimize anaesthetic drug administration","volume":"118","author":"Van Den Berg","year":"2017","journal-title":"Br J Anaesth"}],"container-title":["British Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091217300557?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091217300557?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/bja\/article-pdf\/118\/6\/901\/17650454\/aex134.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T13:39:02Z","timestamp":1653313142000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0007091217300557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["S0007091217300557"],"URL":"https:\/\/doi.org\/10.1093\/bja\/aex134","relation":{},"ISSN":["0007-0912"],"issn-type":[{"value":"0007-0912","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]}}}