{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T15:13:09Z","timestamp":1781277189736,"version":"3.54.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T00:00:00Z","timestamp":1670803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>A previous validation study showed a very low sensitivity and higher specificity associated with Hanifin and Rajka criteria (H&amp;R) and the UK Working Party criteria (UKWP) in diagnosing AD vs. the Chinese criteria of atopic dermatitis (AD) for children (CCAD). However, their diagnostic efficacy in adult and elderly Chinese populations remains unknown.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To validate the diagnostic efficacy of three sets of AD criteria in adult and elderly Chinese populations in a hospital setting.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A total of 1034 patients (aged 19\u201395\u2005years) from five university hospital dermatological clinics were recruited. Medical history, dermatological examination, AD diagnosis and evaluation of AD severity were done by dermatologists. Each patient was investigated by two dermatologist panels, one to establish a clinical diagnosis, and the other to identify and record the major or minor signs of H&amp;R criteria, UKWP criteria and CCAD. Taking clinical diagnosis as the reference, the diagnostic efficacy of three sets of diagnostic criteria was evaluated. The \u03c72 test or rank sum test were used for between-groups comparisons.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>CCAD had a higher sensitivity (84.0%), especially among mild and moderate cases of AD (72.7% and 90.3%, respectively), than the H&amp;R (58.0%; P &amp;lt; 0.001) and UKWP criteria (56.0%; P &amp;lt; 0.001) in diagnosing AD. The specificity of CCAD (92.7%) was slightly lower than the H&amp;R (97.3%; P &amp;lt; 0.001) or UKWP criteria (97.4%; P &amp;lt; 0.001). The CCAD had the highest Youden index (0.77), accuracy rate (0.90) and Kappa value (0.76) of the three sets of diagnostic criteria.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Consistent with results in a population of Chinese children, although the H&amp;R and UKWP criteria had a high specificity for diagnosing AD, their low sensitivity limited their use in adult and elderly Chinese patients. Based on the high sensitivity and favourable diagnostic efficacy, the CCAD is proposed for AD diagnosis in adult and elderly Chinese populations, especially for cases of mild and moderate AD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjd\/ljac097","type":"journal-article","created":{"date-parts":[[2023,1,14]],"date-time":"2023-01-14T00:30:31Z","timestamp":1673656231000},"page":"420-426","source":"Crossref","is-referenced-by-count":12,"title":["Validation of diagnostic criteria for atopic dermatitis and proposal of novel diagnostic criteria for adult and elderly Chinese populations: a multicentre, prospective, clinical setting-based study"],"prefix":"10.1093","volume":"188","author":[{"given":"Wanbo","family":"Yue","sequence":"first","affiliation":[{"name":"Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine , Shanghai , China"},{"name":"Institute of Dermatology, Shanghai Jiaotong University School of Medicine , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daian","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine , Shanghai , China"},{"name":"Institute of Dermatology, Shanghai Jiaotong University School of Medicine , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine , Shanghai , China"},{"name":"Institute of Dermatology, Shanghai Jiaotong University School of Medicine , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihang","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine , Shanghai , China"},{"name":"Institute of Dermatology, Shanghai Jiaotong University School of Medicine , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangshang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Huashan Hospital Fudan University , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiumei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College Hospital of Skin Diseases and Institute of Dermatology , Nanjing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Pei","sequence":"additional","affiliation":[{"name":"Dermatology Hospital of Southern Medical University , Guangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sisi","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Third Military Medical University Southwest Hospital , Chongqing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongju","family":"Pan","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Engineering Technology Research and Development Center for External Drugs , Guangdong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Liao","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Engineering Technology Research and Development Center for External Drugs , Guangdong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Huashan Hospital Fudan University , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College Hospital of Skin Diseases and Institute of Dermatology , Nanjing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunsheng","family":"Liang","sequence":"additional","affiliation":[{"name":"Dermatology Hospital of Southern Medical University , Guangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Third Military Medical University Southwest Hospital , Chongqing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhirong","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine , Shanghai , China"},{"name":"Institute of Dermatology, Shanghai Jiaotong University School of Medicine , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine , Shanghai , China"},{"name":"Institute of Dermatology, Shanghai Jiaotong University School of Medicine , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifeng","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine , Shanghai , China"},{"name":"Institute of Dermatology, Shanghai Jiaotong University School of Medicine , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,12,12]]},"reference":[{"key":"2023100620082651200_ljac097-B1","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0140-6736(20)31286-1","article-title":"Atopic 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Br J Dermatol"},{"key":"2023100620082651200_ljac097-B6","doi-asserted-by":"crossref","first-page":"29751","DOI":"10.1038\/srep29751","article-title":"Prevalence of atopic dermatitis in Chinese children aged 1\u20137 ys","volume":"6","author":"Guo","year":"2016","journal-title":"Sci Rep"},{"key":"2023100620082651200_ljac097-B7","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1111\/jdv.15979","article-title":"Development and validation of new diagnostic criteria for atopic dermatitis in children of China","volume":"34","author":"Cheng","year":"2020","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2023100620082651200_ljac097-B8","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1111\/j.1468-3083.2010.03953.x","article-title":"Clinical features of atopic dermatitis in a hospital-based setting in China","volume":"25","author":"Shi","year":"2011","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2023100620082651200_ljac097-B9","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1111\/jdv.16346","article-title":"Distinct clinical features and serum cytokine pattern of elderly atopic dermatitis in China","volume":"34","author":"Wang","year":"2020","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2023100620082651200_ljac097-B10","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/bjd.19580","article-title":"The global burden of atopic dermatitis: lessons from the Global Burden of Disease Study 1990\u20132017","volume":"184","author":"Laughter","year":"2021","journal-title":"Br J Dermatol"},{"issue":"Suppl. 1","key":"2023100620082651200_ljac097-B11","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/ggi.12771","article-title":"Atopic dermatitis in older adults: a viewpoint from geriatric dermatology","volume":"16","author":"Tanei","year":"2016","journal-title":"Geriatr Gerontol Int"},{"key":"2023100620082651200_ljac097-B12","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.jaad.2013.10.010","article-title":"Guidelines of care for the management of atopic dermatitis: section 1. 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