{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T17:43:57Z","timestamp":1747676637690,"version":"3.37.3"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T00:00:00Z","timestamp":1671580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,30]]},"abstract":"<jats:p>We report two cases of cutaneous mpox virus infection (formerly known as monkeypox), one of which presented with unusual clinical findings, and demonstrate their histopathological, RNA in situ hybridization (ISH) and ultrastructural characteristics. We observed in two patients with polymerase chain reaction-confirmed mpox virus infection squamous syringometaplasia of the eccrine ducts, a finding that can aid in recognizing this disease and is explained by the demonstration of viral mRNA within eccrine epithelium by ISH.<\/jats:p>","DOI":"10.1093\/bjd\/ljac146","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T14:21:23Z","timestamp":1674224483000},"page":"574-576","source":"Crossref","is-referenced-by-count":5,"title":["Inguinal patch in mpox (monkeypox) virus infection and eccrine syringometaplasia: report of two cases with <i>in situ<\/i> hybridization and electron microscopy findings"],"prefix":"10.1093","volume":"188","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5444-0349","authenticated-orcid":false,"given":"Simon F","family":"Roy","sequence":"first","affiliation":[{"name":"Department of Dermatology, Yale University School of Medicine , New Haven , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Sarhan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Yale University School of Medicine , New Haven , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1586-2151","authenticated-orcid":false,"given":"Xinran","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Cellular & Molecular Imaging, Yale University School of Medicine , New Haven, CT , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6494-7250","authenticated-orcid":false,"given":"Michael J","family":"Murphy","sequence":"additional","affiliation":[{"name":"Yale University School of Medicine , New Haven, CT , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4011-8308","authenticated-orcid":false,"given":"Christopher G","family":"Bunick","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Yale University School of Medicine , New Haven , USA"},{"name":"Program in Translational Biomedicine, Yale University School of Medicine , New Haven, CT , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1010-6354","authenticated-orcid":false,"given":"Keith A","family":"Choate","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Yale University School of Medicine , New Haven , USA"},{"name":"Department of Pathology, Yale University School of Medicine , New Haven, CT , USA"},{"name":"Department of Genetics, Yale University School of Medicine , New Haven, CT , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0975-4071","authenticated-orcid":false,"given":"William B","family":"Damsky","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Yale University School of Medicine , New Haven , USA"},{"name":"Department of Pathology, Yale University School of Medicine , New Haven, CT , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8142-6481","authenticated-orcid":false,"given":"Jennifer M","family":"McNiff","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Yale University School of Medicine , New Haven , USA"},{"name":"Department of Pathology, Yale University School of Medicine , New Haven, CT , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,12,21]]},"reference":[{"key":"2023100916155176100_ljac146-B1","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/bjd.21790","article-title":"Monkeypox outbreak in Spain: clinical and epidemiological findings in a prospective cross-sectional study of 185 cases","volume":"187","author":"Catal\u00e0","year":"2022","journal-title":"Br J Dermatol"},{"key":"2023100916155176100_ljac146-B2","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1056\/NEJMoa2207323","article-title":"Monkeypox virus infection in humans across 16 countries \u2013 April\u2013June 2022","volume":"387","author":"Thornhill","year":"2022","journal-title":"N Engl J Med"},{"key":"2023100916155176100_ljac146-B3","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jmoldx.2011.08.002","article-title":"RNAscope: a novel in situ RNA analysis platform for formalin-fixed, paraffin-embedded tissues","volume":"14","author":"Wang","year":"2012","journal-title":"J Mol Diagn"},{"key":"2023100916155176100_ljac146-B4","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.0303-6987.2005.00254.x","article-title":"Monkeypox virus: histologic, immunohistochemical and electron-microscopic findings","volume":"32","author":"Bayer-Garner","year":"2005","journal-title":"J Cutan Pathol"},{"key":"2023100916155176100_ljac146-B5","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/0035-9203(85)90333-5","article-title":"The histopathology and electron microscopy of a human monkeypox lesion","volume":"79","author":"Stagles","year":"1985","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"2023100916155176100_ljac146-B6","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1056\/NEJMicm2206893","article-title":"Monkeypox genital lesions","volume":"387","author":"Patrocinio-Jesus","year":"2022","journal-title":"N Engl J Med"},{"key":"2023100916155176100_ljac146-B7","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1016\/j.jaad.2020.09.018","article-title":"Adenopathy and extensive skin patch overlying a plasmacytoma (AESOP): two morphologic variants can be outlined","volume":"85","author":"Marzolf","year":"2021","journal-title":"J Am Acad Dermatol"}],"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bjd\/advance-article-pdf\/doi\/10.1093\/bjd\/ljac146\/49170692\/ljac146.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjd\/article-pdf\/188\/4\/574\/51960922\/ljac146.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjd\/article-pdf\/188\/4\/574\/51960922\/ljac146.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T16:22:29Z","timestamp":1696868549000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/article\/188\/4\/574\/6951610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,21]]},"references-count":7,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,12,21]]},"published-print":{"date-parts":[[2023,3,30]]}},"URL":"https:\/\/doi.org\/10.1093\/bjd\/ljac146","relation":{},"ISSN":["0007-0963","1365-2133"],"issn-type":[{"type":"print","value":"0007-0963"},{"type":"electronic","value":"1365-2133"}],"subject":[],"published-other":{"date-parts":[[2023,4,1]]},"published":{"date-parts":[[2022,12,21]]}}}