{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:46:07Z","timestamp":1784547967503,"version":"3.55.0"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The involvement of visible areas in vitiligo has been found to be correlated with increased psychiatric morbidity. Although multiple tools have been developed to assess vitiligo, no cutoff for improvement or worsening of vitiligo from a patient\u2019s perspective has been established.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To determine the minimal clinically important difference (MCID) of the Self-Assessment Vitiligo Extent Score (SA-VES) in patients with vitiligo and to evaluate, from the patient\u2019s perspective, the importance of the change in the involvement of visible areas (face and hands) in patients\u2019 overall perception of disease worsening or improving.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a cross-sectional study in the context of the ComPaRe e-cohort. Adult patients with vitiligo were invited to answer online questionnaires. They completed the SA-VES twice, 1\u2005year apart. In addition, patients answered a 5-point Likert anchor question aimed at assessing their perception of the evolution of the extent of their vitiligo. The MCID was calculated using distribution- and anchor-based approaches. Using ordinal logistic regression, the change of vitiliginous lesions on the face or hands was compared to the overall extent of vitiligo (patches on all body areas).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In total, 244 patients with vitiligo were included in the analyses; 20 (8%) were found to have an improvement in their vitiligo. The MCID in worsened patients was equal to a 1.3% body surface area [95% confidence interval (CI) 1.01\u20131.43] increase in the SA-VES. For participants with improved vitiligo, the MCID was equal to a decrease in total SA-VES of 1.3% (95% CI 0.867\u20131.697). Patients\u2019 perceptions of change in their vitiligo was increased sevenfold when it affected the face vs. the rest of the body.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Changes in the facial SA-VES were highly correlated with patients\u2019 impressions of the extent of vitiligo.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjd\/ljad109","type":"journal-article","created":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T08:41:50Z","timestamp":1680338510000},"page":"188-194","source":"Crossref","is-referenced-by-count":17,"title":["Facial involvement is reflective of patients\u2019 global perception of vitiligo extent"],"prefix":"10.1093","volume":"189","author":[{"given":"Samar","family":"Merhi","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris-Est Cr\u00e9teil, EpiDermE \u2013 Epidemiology in Dermatology and Evaluation of Therapeutics , Creteil , France"},{"name":"Faculty of Nursing and Health Sciences, Notre Dame University \u2013 Louaize (NDU) , Zouk Mosbeh , Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Salameh","sequence":"additional","affiliation":[{"name":"School of Medicine, Lebanese American University , Byblos , Lebanon"},{"name":"Institut National de Sant\u00e9 Publique d'\u00c9pid\u00e9miologie Clinique et de Toxicologie-Liban (INSPECT-LB) , Beirut , Lebanon"},{"name":"Department of Primary Care and Population Health, University of Nicosia Medical School , Nicosia , Cyprus"},{"name":"Faculty of Pharmacy, Lebanese University , Hadat , Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mounya","family":"Abboud","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Est Cr\u00e9teil, EpiDermE \u2013 Epidemiology in Dermatology and Evaluation of Therapeutics , Creteil , 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