{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:22:06Z","timestamp":1740126126078,"version":"3.37.3"},"reference-count":4,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T00:00:00Z","timestamp":1681689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,17]]},"abstract":"<jats:p>We read with great interest \u2018Chronic activation of Toll-like receptor 2 induces an ichthyotic skin phenotype\u2019 by Tagoe et al.1 Their findings expand our recent understanding of how certain kinds of autoinflammation contribute to the pathogenesis of ichthyosis. Inspired by the report by Tagoe et al., we suggest that their unique autosomal recessive congenital ichthyosis in vitro models have several characteristics in common with autoinflammatory keratinization diseases.<\/jats:p>","DOI":"10.1093\/bjd\/ljad122","type":"journal-article","created":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T16:16:49Z","timestamp":1681748209000},"page":"252-252","source":"Crossref","is-referenced-by-count":1,"title":["Ichthyotic skin phenotype induced by the chronic activation of Toll-like receptor 2, and autoinflammation"],"prefix":"10.1093","volume":"189","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5958-2875","authenticated-orcid":false,"given":"Takuya","family":"Takeichi","sequence":"first","affiliation":[{"name":"Department of Dermatology, Nagoya University Graduate School of Medicine , Nagoya , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2329-8375","authenticated-orcid":false,"given":"Yoshinao","family":"Muro","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Nagoya University Graduate School of Medicine , Nagoya , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5863-9315","authenticated-orcid":false,"given":"Masashi\u00a0","family":"Akiyama","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Nagoya University Graduate School of Medicine , Nagoya , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,4,17]]},"reference":[{"key":"2023100915280277000_ljad122-B1","doi-asserted-by":"crossref","DOI":"10.1093\/bjd\/ljad095","article-title":"Chronic activation of Toll-like receptor 2 induces an ichthyotic skin phenotype","volume":"189","author":"Tagoe","year":"2023","journal-title":"Br J Dermatol"},{"key":"2023100915280277000_ljad122-B2","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/j.jaci.2017.05.019","article-title":"Autoinflammatory keratinization diseases","volume":"140","author":"Akiyama","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"2023100915280277000_ljad122-B3","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/jid.2013.374","article-title":"Identifying a hyperkeratosis signature in autosomal recessive congenital ichthyosis: Mdm2 inhibition prevents hyperkeratosis in a rat ARCI model","volume":"134","author":"Youssef","year":"2014","journal-title":"J Invest Dermatol"},{"key":"2023100915280277000_ljad122-B4","doi-asserted-by":"crossref","DOI":"10.1172\/JCI140869","article-title":"Tankyrase represses autoinflammation through the attenuation of TLR2 signaling","volume":"132","author":"Matsumoto","year":"2022","journal-title":"J Clin Invest"}],"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bjd\/advance-article-pdf\/doi\/10.1093\/bjd\/ljad122\/50518025\/ljad122.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjd\/article-pdf\/189\/2\/252\/51959909\/ljad122.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjd\/article-pdf\/189\/2\/252\/51959909\/ljad122.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T15:32:33Z","timestamp":1696865553000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/article\/189\/2\/252\/7126696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,17]]},"references-count":4,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,4,17]]},"published-print":{"date-parts":[[2023,7,17]]}},"URL":"https:\/\/doi.org\/10.1093\/bjd\/ljad122","relation":{},"ISSN":["0007-0963","1365-2133"],"issn-type":[{"type":"print","value":"0007-0963"},{"type":"electronic","value":"1365-2133"}],"subject":[],"published-other":{"date-parts":[[2023,8]]},"published":{"date-parts":[[2023,4,17]]}}}