{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T09:51:15Z","timestamp":1747907475544,"version":"3.37.3"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T00:00:00Z","timestamp":1687910400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,15]]},"abstract":"<jats:p>The European Medicines Agency (EMA) advises that all medicines containing soya-derived excipients should be labelled as contraindicated in peanut-allergic individuals. This is despite evidence of very little cross-reactivity between soya and peanut allergies. It is highly unlikely that patients with peanut allergy are at risk of a cross-reactive soya oil-based allergic reaction to soya protein in isotretinoin. This cross-sectional study has demonstrated the absence of IgE-sensitization to isotretinoin in peanut-allergic children and adolescents. Isotretinoin does not need to be avoided by peanut-allergic patients and we would encourage the EMA to alter their advice regarding soybean oil-containing medications to reflect this.<\/jats:p>","DOI":"10.1093\/bjd\/ljad214","type":"journal-article","created":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T15:25:53Z","timestamp":1687965953000},"page":"481-482","source":"Crossref","is-referenced-by-count":2,"title":["No evidence of isotretinoin sensitization in peanut-allergic children: a cross-sectional study"],"prefix":"10.1093","volume":"189","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6014-6345","authenticated-orcid":false,"given":"Emma","family":"Ruth","sequence":"first","affiliation":[{"name":"Children\u2019s Health Ireland , Dublin , Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fionnuala","family":"Heraghty","sequence":"additional","affiliation":[{"name":"Children\u2019s Health Ireland , Dublin , Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niamh","family":"Flynn","sequence":"additional","affiliation":[{"name":"Children\u2019s Health Ireland , Dublin , Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Triona","family":"McGlynn","sequence":"additional","affiliation":[{"name":"Children\u2019s Health Ireland , Dublin , Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9862-5161","authenticated-orcid":false,"given":"Paul J","family":"Turner","sequence":"additional","affiliation":[{"name":"National Heart & Lung Institute, Imperial College London , London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3764-0461","authenticated-orcid":false,"given":"Maeve","family":"Kelleher","sequence":"additional","affiliation":[{"name":"Children\u2019s Health Ireland , Dublin , Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7136-9364","authenticated-orcid":false,"given":"Aideen","family":"Byrne","sequence":"additional","affiliation":[{"name":"Children\u2019s Health Ireland , Dublin , Ireland"},{"name":"Trinity College Dublin , Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4997-9857","authenticated-orcid":false,"given":"Jonathan","family":"O\u2019B. 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