{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T07:55:34Z","timestamp":1783238134701,"version":"3.54.6"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T00:00:00Z","timestamp":1688601600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Jubil\u00e4umsstiftung von SwissLife"},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["IZLIZ3_200253"],"award-info":[{"award-number":["IZLIZ3_200253"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008307","name":"Promedica Stiftung","doi-asserted-by":"publisher","award":["1406\/M & 1412\/M"],"award-info":[{"award-number":["1406\/M & 1412\/M"]}],"id":[{"id":"10.13039\/501100008307","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002002","name":"Cancer Research Foundation","doi-asserted-by":"publisher","award":["KFS-4243-08-2017"],"award-info":[{"award-number":["KFS-4243-08-2017"]}],"id":[{"id":"10.13039\/100002002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002002","name":"Cancer Research Foundation","doi-asserted-by":"publisher","award":["PPRC-2019-20"],"award-info":[{"award-number":["PPRC-2019-20"]}],"id":[{"id":"10.13039\/100002002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["692180-STREAMH2020-TWINN-2015"],"award-info":[{"award-number":["692180-STREAMH2020-TWINN-2015"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"Polish National Science Centre","doi-asserted-by":"publisher","award":["2015\/19\/B\/NZ6\/02862"],"award-info":[{"award-number":["2015\/19\/B\/NZ6\/02862"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003043","name":"EMBO","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003043","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Extracorporeal photopheresis (ECP) has emerged as a systemic first-line immunomodulatory therapy in leukaemic cutaneous T-cell lymphoma (L-CTCL) and is now beginning to be utilized in other T-cell-mediated diseases. Although ECP has been used for nearly 30\u2005years, its mechanisms of action are not sufficiently understood, and biomarkers for response are scarce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We aimed to investigate the immunomodulatory effects of ECP on cytokine secretion patterns in patients with L-CTCL, to help elucidate its mechanism of action.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 25 patients with L-CTCL and 15 healthy donors (HDs) were enrolled in this retrospective cohort study. Concentrations of 22 cytokines were simultaneously quantified by using multiplex bead-based immunoassays. Neoplastic cells in patients\u2019 blood were evaluated by flow cytometry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Firstly, we observed a distinct cytokine profile pattern difference between L-CTCLs and HDs. There was a significant loss of tumour necrosis factor (TNF)-\u03b1, and significant increase of interleukins (IL)-9, IL-12 and IL-13 in the sera of patients with L-CTCL compared with HDs. Secondly, patients with L-CTCL who received ECP were classified as treatment responders and nonresponders according to the quantitative reduction of malignant burden in their blood. We evaluated cytokine levels in culture supernatants from patients\u2019 peripheral blood mononuclear cells (PBMCs) at baseline and 27 weeks after ECP initiation. Strikingly, PBMCs purified from ECP responders released statistically higher concentrations of innate immune cytokines IL-1\u03b1, IL-1\u03b2, granulocyte\u2013macrophage colony-stimulating factor (GM-CSF) and TNF-\u03b1 in comparison with ECP nonresponders. In parallel, responders showed clearance of erythema, reduction of malignant clonal T cells in the blood, and a potent boost of relevant innate immune cytokines in individual patients with L-CTCL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Taken together, our results demonstrate that ECP stimulates the innate immune network, and facilitates redirection of the tumour-biased immunosuppressive microenvironment towards proactive antitumour immune responses. The alterations of IL-1\u03b1, IL-1\u03b2, GM-CSF and TNF-\u03b1 can be used as biomarkers of response to ECP in patients with L-CTCL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjd\/ljad220","type":"journal-article","created":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T11:33:09Z","timestamp":1688556789000},"page":"603-611","source":"Crossref","is-referenced-by-count":12,"title":["Boost of innate immunity cytokines as biomarkers of response to extracorporeal photopheresis in patients with leukaemic cutaneous T-cell lymphoma"],"prefix":"10.1093","volume":"189","author":[{"given":"Yi-Chien","family":"Tsai","sequence":"first","affiliation":[{"name":"Department of Dermatology, Lausanne University Hospital (CHUV) , and\u00a0Faculty of Biology and Medicine, University of Lausanne, Lausanne ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Schlaepfer","sequence":"additional","affiliation":[{"name":"Departments of 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,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjana","family":"Urosevic-Maiwald","sequence":"additional","affiliation":[{"name":"Haut\u00e4rzte-Zentrum am Z\u00fcrisse , Z\u00fcrich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfram","family":"Hoetzenecker","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Hospital Linz , Linz ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Pascolo","sequence":"additional","affiliation":[{"name":"Departments of Dermatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Iselin","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Lausanne University Hospital (CHUV) , and\u00a0Faculty of Biology and Medicine, University of Lausanne, Lausanne 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