{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T13:56:01Z","timestamp":1789826161770,"version":"4.0.1"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T00:00:00Z","timestamp":1688947200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital, Hsin-Chu branch","doi-asserted-by":"publisher","award":["111-HCH004"],"award-info":[{"award-number":["111-HCH004"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital, Hsin-Chu branch","doi-asserted-by":"publisher","award":["111-HCH108"],"award-info":[{"award-number":["111-HCH108"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology of Taiwan","doi-asserted-by":"publisher","award":["110-2314-B-002-191"],"award-info":[{"award-number":["110-2314-B-002-191"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology of Taiwan","doi-asserted-by":"publisher","award":["111-2314-B-002-244"],"award-info":[{"award-number":["111-2314-B-002-244"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Stevens\u2013Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) not only cause acute, devastating mucocutaneous reactions but also have long-lasting implications on survivors\u2019 lives.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To quantify the lifetime burden of SJS\/TEN.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The cumulative incidence rate (CIR), life expectancy (LE), loss-of-life expectancy (LoLE) and lifetime healthcare expenditure (HE) for SJS\/TEN were estimated over the period from 2008 to 2019 using data from the National Health Insurance Research Database of Taiwan and life tables of vital statistics.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In this nationwide cohort of 6552 incident SJS\/TEN cases, a trend towards a decrease in the CIR was observed between 2008 and 2019. Compared with the general population, patients with SJS\/TEN experience a tremendous loss of 9.43 (1.06) [mean (SEM)] years of LE after diagnosis of SJS\/TEN. Male patients with SJS\/TEN had higher LoLE [10.74 (1.22) vs. 7.69 (1.43) years] and annual HE than females. Younger age at diagnosis of SJS\/TEN was associated with longer LE but greater LoLE and higher lifetime HE. Patients with intensive care unit admission on diagnosis, malignancy, diabetes mellitus, end-stage renal disease and SJS\/TEN-associated sequelae experienced substantially greater LoLE and HE per life year.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Patients with SJS\/TEN suffer substantial loss-of-LE and HE, particularly young patients, compared with the general population. These data provide a reference estimate of the lifetime burden of SJS\/TEN to help health authorities evaluate the cost-effectiveness of future preventive and treatment strategies to minimize the burden of SJS\/TEN.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjd\/ljad234","type":"journal-article","created":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T11:32:13Z","timestamp":1688988733000},"page":"553-560","source":"Crossref","is-referenced-by-count":22,"title":["Lifetime risk, life expectancy, loss-of-life expectancy and lifetime healthcare expenditure for Stevens\u2013Johnson syndrome\/toxic epidermal necrolysis in Taiwan: follow-up of a nationwide cohort from 2008 to 2019"],"prefix":"10.1093","volume":"189","author":[{"given":"Ying-Ming","family":"Chiu","sequence":"first","affiliation":[{"name":"Department of Allergy, Immunology, and Rheumatology, Tungs\u2019 Taichung MetroHarbor Hospital , Taichung , Taiwan"},{"name":"Department of Nursing, Jen Teh Junior College 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