{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T19:47:45Z","timestamp":1778874465869,"version":"3.51.4"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:00:00Z","timestamp":1692835200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100004423","name":"World Health Organization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004423","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Lymphatic filariasis (LF) is a neglected tropical disease presenting mainly as lymphoedema (elephantiasis). At present, LF is not effectively treated. Integrative medicine (IM) treatment for lymphoedema uses a combination of Indian traditional medicine, Ayurveda, alongside yoga exercises, compression therapy, antibiotics and antifungal treatments, providing a useful combination where resources are limited and different practices are in use.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To assess the effectiveness of the IM in the existing clinical practice of lower-limb lymphoedema management and to determine whether the treatment outcomes align with the World Health Organization (WHO) global goal of LF management.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Institutional data from electronic medical records of all 1698 patients with LF between 2010 and 2019 were retrospectively analysed using pre- and post-treatment comparisons and the National Institute for Health and Care Excellence guidelines for clinical audit. The primary treatment outcomes evaluated were limb volume, bacterial entry points (BEEPs), episodes of cellulitis, and health-related quality of life (HRQoL). Secondary outcomes included the influence of the patient\u2019s sex, duration of illness, education and employment status on volume reduction. Multiple regression analysis, t-test, \u03c72-test, analysis of variance, Mann\u2013Whitney U-test and the Kruskal\u2013Wallis test were used to assess the association between IM and patients\u2019 treatment outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Limb volume reduced by 24.5% [95% confidence interval (CI) 22.47\u201326.61; n = 1660] following an intensive supervised care period (mean 14.84\u2005days, n = 1660). Limb volume further reduced by 1.42% (95% CI 0.76\u20132.07; n = 1259) at the first follow-up visit (mean 81.45\u2005days), and by 2.3% between the first and second follow-up visits (mean 231.32\u2005days) (95% CI 1.26\u20133.34; n = 796). BEEPs were reduced upon follow-up; excoriations (78.4%) and intertrigo (26.7%) were reduced at discharge and further improvements was achieved at the follow-up visits. In total, 4% of patients exhibited new BEEPs at the first follow-up [eczema (3.9%), folliculitis (6.5%), excoriations (11.9%) and intertrigo (15.4%); 4 of 7 BEEPs were recorded]. HRQoL, measured using the disease-specific Lymphatic Filariasis Specific Quality of Life Questionnaire, showed an average score of 73.9 on admission, which increased by 17.8 at the first follow-up and 18.6 at the second follow-up. No patients developed new cellulitis episodes at the first follow-up, and only five patients (5.3%) developed new episodes of cellulitis at the second follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>IM for lower-limb lymphoedema successfully reduces limb volume and episodes of cellulitis, and also reduces BEEPs, leading to improved HRQoL. IM aligns with the LF treatment goals of the WHO and is a low-cost, predominantly self-care management protocol. IM has the potential to change care models and improve the lives of patients with lymphoedema.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjd\/ljad310","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T20:24:34Z","timestamp":1692735874000},"page":"94-104","source":"Crossref","is-referenced-by-count":8,"title":["Self-care treatment for lymphoedema of lymphatic filariasis using integrative medicine"],"prefix":"10.1093","volume":"190","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0495-0244","authenticated-orcid":false,"given":"Saravu R","family":"Narahari","sequence":"first","affiliation":[{"name":"Institute of Applied Dermatology , Kasaragod, Kerala , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhur G","family":"Aggithaya","sequence":"additional","affiliation":[{"name":"Institute of Applied Dermatology , Kasaragod, Kerala , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terence 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