{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T14:54:12Z","timestamp":1777992852161,"version":"3.51.4"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Institute of Health Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"name":"patient advocacy groups DEBRA-Spain and Berritxuak"},{"name":"Spanish Ministry of Science and Innovation and European Regional Development Fund"},{"DOI":"10.13039\/501100019725","name":"DEBRA Austria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011960","name":"DEBRA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011960","id-type":"DOI","asserted-by":"publisher"}]},{"name":"EB-LOPPET"},{"name":"EB Research Network"},{"name":"UC3M-PhD research training scholarship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,16]]},"abstract":"<jats:p>Recessive dystrophic epidermolysis bullosa (RDEB) is a blistering genodermatosis due to biallelic loss-of-function variants in the type VII collagen (C7) gene (COL7A1). We report the impact of inflammation\/autoimmunity on the gut (and other organs) in the nine children with RDEB recruited to an early-phase clinical trial of systemic cell therapy (NCT04153630). This pilot study provides evidence that autoimmunity may play an important role in sustaining chronic inflammation and the coexistence of coeliac disease, which, in turn, could exacerbate anaemia\/malnutrition and progression in RDEB. Testing this hypothesis in a larger cohort including children and adults with RDEB and other epidermolysis bullosa\u00a0(EB) subtypes is warranted so that targeted interventions may improve outcomes.<\/jats:p>","DOI":"10.1093\/bjd\/ljad313","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T15:21:54Z","timestamp":1693581714000},"page":"774-776","source":"Crossref","is-referenced-by-count":2,"title":["Gluten-sensitive enteropathy in recessive dystrophic epidermolysis bullosa"],"prefix":"10.1093","volume":"189","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7486-7120","authenticated-orcid":false,"given":"Rosa","family":"Saced\u00f3n","sequence":"first","affiliation":[{"name":"Departamento de Biolog\u00eda Celular, Facultad de Medicina, Universidad Complutense , Madrid"},{"name":"Instituto de Investigaci\u00f3n Sanitaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8033-7444","authenticated-orcid":false,"given":"M Carmen","family":"de Arriba","sequence":"additional","affiliation":[{"name":"Departamento de Bioingenier\u00eda, Universidad Carlos III de Madrid; 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Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras-ISCIII; Instituto de Investigaci\u00f3n Sanitaria Fundaci\u00f3n Jim\u00e9nez Diaz; Centro de Investigaciones Energ\u00e9ticas, Medioambientales y Tecnol\u00f3gicas , Madrid"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8598-8537","authenticated-orcid":false,"given":"Marta","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Departamento de Bioingenier\u00eda, Universidad Carlos III de Madrid; Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras-ISCIII; Instituto de Investigaci\u00f3n Sanitaria Fundaci\u00f3n Jim\u00e9nez Diaz; Centro de Investigaciones Energ\u00e9ticas, Medioambientales y Tecnol\u00f3gicas , Madrid"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4601-7150","authenticated-orcid":false,"given":"Nora","family":"Butta","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda y Hemoterapia, Instituto de Investigaci\u00f3n Sanitaria del Hospital Universitario La Paz (IdiPAZ); 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