{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:46:06Z","timestamp":1790358366734,"version":"4.1.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T00:00:00Z","timestamp":1693785600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002999","name":"Dutch Ministry of Health, Welfare and Sport","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002999","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Dutch Ministry of Economic Affairs"},{"DOI":"10.13039\/501100005075","name":"University Medical Center Groningen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005075","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University Groningen and the Northern Provinces of the Netherlands"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Hidradenitis suppurativa (HS) is a chronic, devastating, multifactorial skin disease. Patients generally develop HS after puberty and the prevalence of the disease is assumed to decrease with higher age. Data outside the usual age range are limited, especially for elderly patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To investigate the prevalence, clinical characteristics and associated comorbidities among the elderly HS population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Data were collected through a population-wide survey-based study within the Lifelines Cohort Study in the Netherlands. The clinical characteristics of elderly patients with HS (\u2265 60\u2005years) were compared with an adult population (&amp;lt; 60\u2005years) with HS. The comorbidities in elderly patients with HS were compared with those of a non-HS sex- and age-matched elderly population in a 1 : 4 ratio. HS in the elderly was defined as active HS in patients aged 60\u2005years and older. Within the HS elderly group, two subgroups were defined, late-onset HS (HS developed after 60\u2005years of age) and persistent HS (HS developed from a younger age but continuing after 60\u2005years of age).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Within the Lifelines cohort 209 elderly patients with HS were identified as well as an adult (&amp;lt; 60\u2005years) group with HS (n = 793) and a non-HS sex- and age-matched control elderly group (n = 810). The prevalence of HS among the elderly bootstrap analysis population was 0.8% [95% confidence interval (CI) 0.4\u20131.2]. A significantly higher age of HS symptom onset was found compared with the adult HS group: respectively, 40 vs. 23\u2005years (odds ratio 1.056, 95% CI 1.05\u20131.07). Among the elderly HS cohort (in the Discussion, the HS tarda cohort) a female : male ratio of 1.7 : 1.0 and a higher family history for HS were found. Moreover, elderly patients with HS had a significantly higher risk of having HS-associated comorbidities compared with the sex- and age-matched controls.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The prevalence of HS in the elderly is not rare. Among the elderly a shift from female predominance towards a lower female\u00a0: male ratio in HS is observed. In addition, HS in the elderly showed significant variation in age of onset and involved body areas. Moreover, elderly patients with HS were more susceptible to multimorbidity. Finally, we propose defining HS in the elderly as \u2018HS tarda\u2019 and subdividing it as late-onset and persistent HS tarda.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjd\/ljad317","type":"journal-article","created":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T17:18:46Z","timestamp":1693761526000},"page":"105-113","source":"Crossref","is-referenced-by-count":16,"title":["Hidradenitis suppurativa tarda: defining an understudied elderly population"],"prefix":"10.1093","volume":"190","author":[{"given":"Deveny A Y","family":"van der Weijden","sequence":"first","affiliation":[{"name":"Departments of Dermatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8905-6263","authenticated-orcid":false,"given":"Nicole D K","family":"Koerts","sequence":"additional","affiliation":[{"name":"Departments of Dermatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6056-7795","authenticated-orcid":false,"given":"Barbara C","family":"van Munster","sequence":"additional","affiliation":[{"name":"Internal Medicine and Geriatrics, University of Groningen, University Medical Center Groningen , Groningen , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hessel H","family":"van der Zee","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Erasmus Medical Center , Rotterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8559-3674","authenticated-orcid":false,"given":"Barbara","family":"Horv\u00e1th","sequence":"additional","affiliation":[{"name":"Departments of Dermatology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,9,4]]},"reference":[{"key":"2024090210030824100_ljad317-B1","volume-title":"Hidradenitis Suppurativa. Treasure Island","author":"Ballard","year":"2023"},{"key":"2024090210030824100_ljad317-B2","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1111\/bjd.19435","article-title":"The epidemiology of hidradenitis suppurativa","volume":"183","author":"Ingram","year":"2020","journal-title":"Br J Dermatol"},{"key":"2024090210030824100_ljad317-B3","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1111\/bjd.20954","article-title":"New insights in hidradenitis suppurativa from a population-based Dutch cohort: prevalence, smoking behaviour, socioeconomic status and comorbidities","volume":"186","author":"Prens","year":"2022","journal-title":"Br J Dermatol"},{"key":"2024090210030824100_ljad317-B4","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1111\/jdv.16520","article-title":"Hidradenitis suppurativa in paediatric patients: a retrospective monocentric study in Germany and review of the literature","volume":"34","author":"Vaiopoulos","year":"2020","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2024090210030824100_ljad317-B5","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1056\/NEJMcp1014163","article-title":"Hidradenitis suppurativa","volume":"366","author":"Jemec","year":"2012","journal-title":"N Engl J Med"},{"key":"2024090210030824100_ljad317-B6","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1111\/bjd.17537","article-title":"British Association of Dermatologists guidelines for the management of hidradenitis suppurativa (acne inversa) 2018","volume":"180","author":"Ingram","year":"2019","journal-title":"Br J Dermatol"},{"key":"2024090210030824100_ljad317-B7","first-page":"477","article-title":"Symptoms of menopause in peri and postmenopausal women and their attitude towards them","volume":"29","author":"Inayat","year":"2017","journal-title":"J Ayub Med Coll Abbottabad"},{"key":"2024090210030824100_ljad317-B8","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.jaad.2014.11.017","article-title":"Correlation of early-onset hidradenitis suppurativa with stronger genetic susceptibility and more widespread involvement","volume":"72","author":"Deckers","year":"2015","journal-title":"J Am Acad Dermatol"},{"key":"2024090210030824100_ljad317-B9","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1001\/jamadermatol.2021.2865","article-title":"Differences between children and adults with hidradenitis suppurativa","volume":"157","author":"Hallock","year":"2021","journal-title":"JAMA Dermatol"},{"key":"2024090210030824100_ljad317-B10","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1001\/jamadermatol.2022.5390","article-title":"Hidradenitis suppurativa in older adults","volume":"159","author":"Blum","year":"2023","journal-title":"JAMA Dermatol"},{"key":"2024090210030824100_ljad317-B11","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.2174\/0929867326666190717152739","article-title":"From healthy aging to frailty: in search of the underlying mechanisms","volume":"26","author":"Brivio","year":"2019","journal-title":"Curr Med Chem"},{"key":"2024090210030824100_ljad317-B12","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/j.1365-2133.2010.09773.x","article-title":"Questionnaire-based diagnosis of hidradenitis suppurativa: specificity, sensitivity and positive predictive value of specific diagnostic questions","volume":"163","author":"Esmann","year":"2010","journal-title":"Br J Dermatol"},{"key":"2024090210030824100_ljad317-B13","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1111\/bjd.12787","article-title":"The prevalence of inverse recurrent suppuration: a population-based study of possible hidradenitis suppurativa","volume":"170","author":"Vinding","year":"2014","journal-title":"Br J Dermatol"},{"key":"2024090210030824100_ljad317-B14","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1046\/j.1468-3083.2000.00087.x","article-title":"The natural history of hidradenitis suppurativa","volume":"14","author":"von der Werth","year":"2000","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2024090210030824100_ljad317-B15","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1001\/jamadermatol.2019.0478","article-title":"Distribution of self-reported hidradenitis suppurativa age at onset","volume":"155","author":"Naik","year":"2019","journal-title":"JAMA Dermatol"},{"key":"2024090210030824100_ljad317-B16","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1093\/bjd\/ljac121","article-title":"Association between age at symptom onset and disease severity in older patients with hidradenitis suppurativa","volume":"188","author":"Jiang","year":"2023","journal-title":"Br J Dermatol"},{"issue":"Suppl. 4","key":"2024090210030824100_ljad317-B17","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.jid.2020.11.014","article-title":"Regulation of the wound healing response during aging","volume":"141","author":"Ding","year":"2021","journal-title":"J Invest Dermatol"},{"key":"2024090210030824100_ljad317-B18","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1080\/14740338.2020.1728253","article-title":"Safety concerns with current treatments for psoriasis in the elderly","volume":"19","author":"Di Caprio","year":"2020","journal-title":"Expert Opin Drug Saf"},{"key":"2024090210030824100_ljad317-B19","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1093\/ageing\/afab138","article-title":"Multimorbidity patterns and risk of frailty in older community-dwelling adults: a population-based cohort study","volume":"50","author":"Tazzeo","year":"2021","journal-title":"Age Ageing"},{"key":"2024090210030824100_ljad317-B20","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.jaad.2019.08.090","article-title":"Hidradenitis suppurativa: epidemiology, clinical presentation, and pathogenesis","volume":"82","author":"Goldburg","year":"2020","journal-title":"J Am Acad Dermatol"},{"key":"2024090210030824100_ljad317-B21","doi-asserted-by":"crossref","first-page":"e30169","DOI":"10.1097\/MD.0000000000030169","article-title":"Risk factors for frailty in older adults","volume":"101","author":"Wang","year":"2022","journal-title":"Medicine (Baltimore"},{"key":"2024090210030824100_ljad317-B22","doi-asserted-by":"crossref","first-page":"e323\u201332","DOI":"10.1016\/S2468-2667(18)30091-4","article-title":"Frailty and pre-frailty in \u00admiddle-aged and older adults and its association with multi-morbidity and mortality: a prospective analysis of 493 737 UK Biobank participants","volume":"3","author":"Hanlon","year":"2018","journal-title":"Lancet Public Health"}],"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bjd\/advance-article-pdf\/doi\/10.1093\/bjd\/ljad317\/54035798\/ljad317.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjd\/article-pdf\/190\/1\/105\/58992344\/ljad317.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjd\/article-pdf\/190\/1\/105\/58992344\/ljad317.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T12:40:32Z","timestamp":1725280832000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/article\/190\/1\/105\/7259837"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,4]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,9,4]]},"published-print":{"date-parts":[[2023,12,20]]}},"URL":"https:\/\/doi.org\/10.1093\/bjd\/ljad317","relation":{},"ISSN":["0007-0963","1365-2133"],"issn-type":[{"value":"0007-0963","type":"print"},{"value":"1365-2133","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,1]]},"published":{"date-parts":[[2023,9,4]]}}}