{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:22:33Z","timestamp":1740126153397,"version":"3.37.3"},"reference-count":149,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T00:00:00Z","timestamp":1693612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Regulatory elements, particularly enhancers, play a crucial role in disease susceptibility and progression. Enhancers are DNA sequences that activate gene expression and can be affected by epigenetic modifications, interactions with transcription factors (TFs) or changes to the enhancer DNA sequence itself. Altered enhancer activity impacts gene expression and contributes to disease. In this review, we define enhancers and the experimental techniques used to identify and characterize them. We also discuss recent studies that examine how enhancers contribute to atopic dermatitis (AD) and psoriasis. Articles in the PubMed database were identified (from 1 January 2010 to 28 February 2023) that were relevant to enhancer variants, enhancer-associated TFs and enhancer histone modifications in psoriasis or AD. Most enhancers associated with these conditions regulate genes affecting epidermal homeostasis or immune function. These discoveries present potential therapeutic targets to complement existing treatment options for AD and psoriasis.<\/jats:p>","DOI":"10.1093\/bjd\/ljad321","type":"journal-article","created":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T13:48:46Z","timestamp":1693662526000},"page":"10-19","source":"Crossref","is-referenced-by-count":0,"title":["The role of enhancers in psoriasis and atopic dermatitis"],"prefix":"10.1093","volume":"190","author":[{"given":"Jennifer Y","family":"Sui","sequence":"first","affiliation":[{"name":"Department of Dermatology, University of California San Diego School of Medicine , CA , USA"},{"name":"Division of Pediatric and Adolescent Dermatology, Rady Children\u2019s Hospital of San Diego , CA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1511-3804","authenticated-orcid":false,"given":"Dawn Z","family":"Eichenfield","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of California San Diego School of Medicine , CA , USA"},{"name":"Division of Pediatric and Adolescent Dermatology, Rady Children\u2019s Hospital of San Diego , CA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0740-0125","authenticated-orcid":false,"given":"Bryan K","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of California San Diego School of Medicine , CA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,9,2]]},"reference":[{"key":"2023122107175411900_ljad321-B1","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/s41576-019-0128-0","article-title":"Long-range enhancer\u2013promoter contacts in gene expression control","volume":"20","author":"Schoenfelder","year":"2019","journal-title":"Nat Rev 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