{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T16:55:15Z","timestamp":1782579315702,"version":"3.54.5"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T00:00:00Z","timestamp":1698105600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Operational Programme \u2018Competitiveness, Entrepreneurship & Innovation\u2019"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Coexisting long-term conditions (LTCs) in psoriasis and their potential causal associations with the disease are not well \u00adestablished.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To determine distinct clusters of LTCs in people with psoriasis and the potential bidirectional causal association between these LTCs and psoriasis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Using latent class analysis, cross-sectional data from people with psoriasis from the UK Biobank were analysed to identify distinct psoriasis-related comorbidity profiles. Linkage disequilibrium score regression (LDSR) was applied to compute the genetic correlation between psoriasis and LTCs. Two-sample bidirectional Mendelian randomization (MR) analysis assessed the potential causal direction using independent genetic variants that reached genome-wide significance (P &amp;lt; 5 \u00d7 10\u20138).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Five comorbidity clusters were identified in a population of 10 873 people with psoriasis. LDSR revealed that psoriasis was positively genetically correlated with heart failure [genetic correlation (rg) = 0.23, P = 8.8 \u00d7 10\u22128], depression (rg = 0.12, P = 2.7 \u00d7 10\u22125), coronary artery disease (CAD; rg = 0.15, P = 2 \u00d7 10\u22124) and type 2 diabetes (rg = 0.19, P = 3 \u00d7 10\u22123). Genetic liability to CAD was associated with an increased risk of psoriasis [inverse variance weighted (IVW) odds ratio (ORIVW) 1.159, 95% confidence interval (CI) 1.055\u20131.274; P = 2 \u00d7 10\u22123]. The MR pleiotropy residual sum and outlier (MR-PRESSO; ORMR-PRESSO 1.13, 95% CI 1.042\u20131.228; P = 6 \u00d7 10\u22123) and the MR-robust adjusted profile score (RAPS) (ORMR-RAPS 1.149, 95% CI 1.062\u20131.242; P = 5 \u00d7 10\u22124) approaches corroborate the IVW findings. The weighted median (WM) generated similar and consistent effect estimates but was not statistically significant (ORWM 1.076, 95% CI 0.949\u20131.221; P = 0.25). Evidence for a suggestive increased risk was detected for CAD (ORIVW 1.031, 95% CI 1.003\u20131.059; P = 0.03) and heart failure (ORIVW 1.019, 95% CI 1.005\u20131.033; P = 9 \u00d7 10\u22123) in those with a genetic liability to psoriasis; however, MR sensitivity analyses did not reach statistical significance.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Five distinct clusters of psoriasis comorbidities were observed with these findings to offer opportunities for an integrated approach to comorbidity prevention and treatment. Coexisting LTCs share with psoriasis common genetic and nongenetic risk factors, and aggressive lifestyle modification in these people is anticipated to have an impact beyond psoriasis risk. Genetically predicted CAD is possibly associated with an increased risk of psoriasis, altering our prior knowledge.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjd\/ljad410","type":"journal-article","created":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T19:31:22Z","timestamp":1698175882000},"page":"364-373","source":"Crossref","is-referenced-by-count":18,"title":["Multiple long-term conditions in people with psoriasis: a\u00a0latent class and bidirectional Mendelian randomization analysis"],"prefix":"10.1093","volume":"190","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0836-9385","authenticated-orcid":false,"given":"Christos V","family":"Chalitsios","sequence":"first","affiliation":[{"name":"Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina , Ioannina , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devendra","family":"Meena","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and 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