{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:41:59Z","timestamp":1787762519465,"version":"build-2784847793"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Celltrion Pharm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,16]]},"abstract":"<jats:title>Lay Summary<\/jats:title>\n                  <jats:p>Beh\u00e7et disease (BD) is a multisystem vasculitis (inflammation of the blood vessels) of unknown origin that commonly results in oral and genital ulcers, uveitis (eye inflammation) and skin lesions. BD is most prevalent in people from the Mediterranean to East Asia, affecting 0.4% of people in this area. Most lesions go away with time, but more severe forms that involve the cardiovascular and neurological systems can lead to death. It is estimated that people with BD have 1.4 times the risk of dying than the general population.<\/jats:p>\n                  <jats:p>Using large insurance databases in Korea, we investigated the risk of death in people with BD versus age- and sex-matched controls (i.e. people without the disease) from the general population. We found that patients with BD had a 28% greater risk of death than controls over 11.9\u2005years of follow-up, with the highest risk being in first year after diagnosis. Top causes of death in people with BD included cancer, and cardiovascular, gastrointestinal, neurological, genitourinary, respiratory and infectious disease. Further analyses of the data showed that the risk of death in BD is affected by age and sex. In particular, younger patients were more susceptible to death as a result of cardiovascular disease and women were more susceptible to dying of gastrointestinal disease.<\/jats:p>\n                  <jats:p>Our study suggests that there could be an increased risk of death within the first year of being diagnosed with BD and highlights how BD is a systemic disease (i.e. the involvement of any internal organ system could lead to an increase in mortality). Finally, there were unique patterns of cause-specific deaths across subgroups of people with BD.<\/jats:p>","DOI":"10.1093\/bjd\/ljae051","type":"journal-article","created":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T16:09:23Z","timestamp":1707149363000},"page":"858-866","source":"Crossref","is-referenced-by-count":11,"title":["All-cause and cause-specific mortality in patients with Beh\u00e7et disease versus the general population"],"prefix":"10.1093","volume":"190","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4625-8571","authenticated-orcid":false,"given":"Se Rim","family":"Choi","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital , Seongnam, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Shin","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital , Seongnam, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You-Jung","family":"Ha","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital , Seongnam, Korea"},{"name":"Department of Internal Medicine, Seoul National University College of Medicine , Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun Jong","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital , Seongnam, Korea"},{"name":"Department of Internal Medicine, Seoul National University College of Medicine , Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0703-1208","authenticated-orcid":false,"given":"Eun Bong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University College of Medicine , Seoul, Korea"},{"name":"Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital , Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun-So","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Ajou University School of Medicine , Suwon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Ha","family":"Kang","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital , Seongnam, Korea"},{"name":"Department of Internal Medicine, Seoul National University College of Medicine , Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,2,6]]},"reference":[{"key":"2024072405354109100_ljae051-B1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41572-021-00301-1","article-title":"Beh\u00e7et syndrome","volume":"7","author":"Yazici","year":"2021","journal-title":"Nat Rev Dis Primers"},{"key":"2024072405354109100_ljae051-B2","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1093\/rheumatology\/33.1.48","article-title":"Pulmonary arterial aneurysms in Beh\u00e7et\u2019s syndrome: a report of 24 cases","volume":"33","author":"Hamuryudan","year":"1994","journal-title":"Br J Rheumatol"},{"key":"2024072405354109100_ljae051-B3","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1093\/brain\/122.11.2171","article-title":"Clinical patterns of neurological involvement in Beh\u00e7et\u2019s disease: evaluation of 200 patients. 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