{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T09:11:22Z","timestamp":1782810682469,"version":"3.54.5"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T00:00:00Z","timestamp":1715644800000},"content-version":"vor","delay-in-days":69,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"several public"},{"DOI":"10.13039\/501100010234","name":"Swedish Asthma and Allergy Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010234","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research Foundation"},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Swedish Heart-Lung Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006128","name":"Swedish Order of Freemasons","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006128","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007687","name":"Swedish Society of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005744","name":"Foundation for Pediatric Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005744","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004337","name":"Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>In the general population randomized controlled trial PreventADALL, frequent emollient bath additives from 2 weeks of age did not prevent atopic dermatitis, while the effect on skin barrier function throughout infancy is not established.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The primary aim of this exploratory substudy was to assess the effect of mineral-based oil baths on transepidermal water loss (TEWL) and dry skin through infancy, and secondarily to explore if filaggrin (FLG) mutations modified the effect.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Overall, 2153 infants were included and randomized to either the \u2018Skin intervention\u2019 (SI) group (n = 995) (oil bath 4 times weekly from 2 weeks through 8\u2005months) or \u2018No skin intervention\u2019 (NSI) group (n = 1158), with TEWL measurements at 3, 6 and\/or 12\u2005months of age. Information on FLG mutation status was available for 1683 of these infants. Effects of the skin intervention on TEWL and dry skin through infancy were assessed by mixed-effects regression modelling. Background characteristics and protocol adherence were collected from electronic questionnaires, birth records and weekly diaries.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The TEWL (95% confidence interval) was on average 0.42\u2005g m\u20132 h\u20131 (0.13\u20130.70, P = 0.004) higher in the SI group compared with the NSI group through the first year of life, with significantly higher levels at 3\u2005months [8.6 (8.3\u20139.0) vs. 7.6 (7.3\u20137.9)], but similar at 6 and 12\u2005months. Dry skin was observed significantly more often in the NSI group compared with the SI group at 3\u2005months (59% vs. 51%) and at 6\u2005months of age (63% vs. 53%), while at 12\u2005months of age, the difference was no longer significant. At 3\u2005months, the TEWL of FLG mutation carriers was similar to the TEWL in the SI group. No interaction between SI and FLG mutation was found in the first year of life.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Infants given frequent oil baths from 2 weeks of age had reduced skin barrier function through infancy compared with controls, largely attributed to higher TEWL at 3\u2005months of age, while the skin at 3 and 6\u2005months appeared less dry in infants subjected to the skin intervention.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjd\/ljae091","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T07:31:20Z","timestamp":1715671880000},"page":"49-57","source":"Crossref","is-referenced-by-count":6,"title":["Frequent oil baths and skin barrier during infancy in the PreventADALL study"],"prefix":"10.1093","volume":"191","author":[{"given":"Eva Maria","family":"Rehbinder","sequence":"first","affiliation":[{"name":"Department of Dermatology, Oslo University Hospital , Oslo , Norway"},{"name":"Faculty of Medicine, Institute of Clinical Medicine, University of Oslo , Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"W\u00e4rnberg Gerdin","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Karolinska Institutet , Stockholm , Sweden"},{"name":"Astrid Lindgren Children\u2019s Hospital, Karolinska University Hospital , Stockholm , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Hoyer","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Karolinska Institutet , Stockholm , Sweden"},{"name":"Astrid Lindgren Children\u2019s Hospital, Karolinska University Hospital , Stockholm , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Bradley","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital , Stockholm , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin\u00a0C","family":"L\u00f8drup Carlsen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Clinical Medicine, University of Oslo , Oslo , Norway"},{"name":"Divisions of Paediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berit","family":"Granum","sequence":"additional","affiliation":[{"name":"Department of Chemical Toxicology, Norwegian Institute of Public Health , Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunilla","family":"Hedlin","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Karolinska Institutet , Stockholm , Sweden"},{"name":"Astrid Lindgren Children\u2019s Hospital, Karolinska University Hospital , Stockholm , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine Monceyron","family":"Jonassen","sequence":"additional","affiliation":[{"name":"Center for Laboratory Medicine, \u00d8stfold Hospital Trust , Kalnes , Norway"},{"name":"Department of Virology, Norwegian Institute of Public Health , Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marissa","family":"Leblanc","sequence":"additional","affiliation":[{"name":"Oslo Centre for Biostatistics and Epidemiology; University of Oslo , Oslo , Norway"},{"name":"Norwegian Institute of Public Health , Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Nordlund","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Karolinska Institutet , Stockholm , Sweden"},{"name":"Astrid Lindgren Children\u2019s Hospital, Karolinska University Hospital , Stockholm , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Knut","family":"Rudi","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences , \u00c5s , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e5vard O","family":"Skjerven","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Clinical Medicine, University of Oslo , Oslo , Norway"},{"name":"Divisions of Paediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Cathrine","family":"Staff","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Clinical Medicine, University of Oslo , Oslo , Norway"},{"name":"Divisions of Obstetrics and Gynaecology; 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