{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:34:59Z","timestamp":1790948099987,"version":"4.1.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science and Technology Program of Guangzhou, China","award":["SL2022A04J01934"],"award-info":[{"award-number":["SL2022A04J01934"]}]},{"name":"President Foundation of The Third Affiliated Hospital of Southern Medical University","award":["YP2021008"],"award-info":[{"award-number":["YP2021008"]}]},{"name":"President Foundation of The Third Affiliated Hospital of Southern Medical University","award":["YM2021007"],"award-info":[{"award-number":["YM2021007"]}]},{"name":"President Foundation of The Third Affiliated Hospital of Southern Medical University","award":["YY2021001"],"award-info":[{"award-number":["YY2021001"]}]},{"name":"Guangzhou Science and Technology Program Project","award":["202201010926"],"award-info":[{"award-number":["202201010926"]}]},{"DOI":"10.13039\/501100021171","name":"Guangdong Basic and Applied Basic Research Foundation","doi-asserted-by":"publisher","award":["2022A1515111144"],"award-info":[{"award-number":["2022A1515111144"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171785"],"award-info":[{"award-number":["82171785"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371772"],"award-info":[{"award-number":["82371772"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Psoriasis is a common chronic inflammatory disease with an unclear aetiology. Keratinocytes in psoriasis are susceptible to exogenous triggers that induce inflammatory cell death.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To investigate whether gasdermin E (GSDME)-mediated pyroptosis in keratinocytes contributes to the pathogenesis of psoriasis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Skin samples from patients with psoriasis and from healthy controls were collected to evaluate the expression of GSDME, cleaved caspase-3 and inflammatory factors. We then analysed the data series GSE41662 to further compare the expression of GSDME between lesional and nonlesional skin samples in those with psoriasis. In vivo, a caspase-3 inhibitor and GSDME-deficient mice (Gsdme\u2013\/\u2013) were used to block caspase-3\/GSDME activation in an imiquimod-induced psoriasis model. Skin inflammation, disease severity and pyroptosis-related proteins were analysed. In vitro, tumour necrosis factor (TNF)-\u03b1-induced caspase-3\/GSDME-mediated pyroptosis in the HACAT cell line was explored.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Our analysis of the GSE41662 data series found that GSDME was upregulated in psoriasis lesions vs. normal skin. High levels of inflammatory cytokines such as interleukin (IL)-1\u03b2, IL-6 and TNF-\u03b1 were also found in psoriasis lesions. In mice in the Gsdme\u2013\/\u2013 and caspase-3 inhibitor groups, the severity of skin inflammation was attenuated and GSDME and cleaved caspase-3 levels decreased after imiquimod treatment. Similarly, IL-1\u03b2, IL-6 and TNF-\u03b1 expression was decreased in the Gsdme\u2013\/\u2013 and caspase-3 inhibitor groups. In vitro, TNF-\u03b1 induced HACAT cell pyroptosis through caspase-3\/GSDME pathway activation, which was suppressed by blocking caspase-3 or silencing Gsdme.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our study provides a novel explanation of TNF-\u03b1\/caspase-3\/GSDME-mediated keratinocyte pyroptosis in the initiation and \u00adacceleration of skin inflammation and the progression of psoriasis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjd\/ljae179","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T11:45:09Z","timestamp":1713872709000},"page":"385-396","source":"Crossref","is-referenced-by-count":32,"title":["Gasdermin E-mediated keratinocyte pyroptosis participates in the pathogenesis of psoriasis by promoting skin inflammation"],"prefix":"10.1093","volume":"191","author":[{"given":"Yingfei","family":"Li","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology, The Third Affiliated Hospital, Southern Medical University , Guangzhou , China"},{"name":"Department of Rheumatology and Immunology, Academy of Orthopedics, Guangdong Province, Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, The Third Affiliated Hospital of Southern Medical University , Guangzhou , China"},{"name":"Department of Clinical Immunology, Center for Orthopaedic Surgery, The Third Affiliated Hospital of Southern Medical University , Guangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"He","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, The Third Affiliated Hospital, Southern Medical University , Guangzhou , China"},{"name":"Department of Rheumatology and Immunology, Academy of Orthopedics, Guangdong Province, Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, The Third Affiliated Hospital of Southern Medical University , Guangzhou , China"},{"name":"Department of Clinical Immunology, Center for Orthopaedic Surgery, The Third Affiliated Hospital of Southern Medical University , Guangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, The Third Affiliated Hospital, Southern Medical University , Guangzhou , China"},{"name":"Department of Rheumatology and Immunology, Academy of Orthopedics, Guangdong Province, Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, The Third Affiliated Hospital of Southern Medical University , Guangzhou , China"},{"name":"Department of Clinical Immunology, Center for Orthopaedic Surgery, The Third Affiliated Hospital of Southern Medical University , Guangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongmei","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, The Third Affiliated Hospital, Southern Medical University , Guangzhou , China"},{"name":"Department of Rheumatology and Immunology, Academy of Orthopedics, Guangdong Province, Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, The Third Affiliated Hospital of Southern Medical University , Guangzhou , China"},{"name":"Department of Clinical Immunology, Center for Orthopaedic Surgery, The Third Affiliated Hospital of Southern Medical University , Guangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenchao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, The Third Affiliated Hospital, Southern Medical University , Guangzhou , China"},{"name":"Department of Rheumatology and Immunology, Academy of Orthopedics, Guangdong Province, Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, The Third Affiliated Hospital of Southern Medical University , Guangzhou , China"},{"name":"Department of Clinical Immunology, Center for Orthopaedic Surgery, The Third Affiliated Hospital of Southern Medical University , Guangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, The Third Affiliated Hospital, Southern Medical University , Guangzhou , China"},{"name":"Department of Rheumatology and Immunology, Academy of Orthopedics, Guangdong Province, Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, The Third Affiliated Hospital of Southern Medical University , Guangzhou , China"},{"name":"Department of Clinical Immunology, Center for Orthopaedic Surgery, The Third Affiliated Hospital of Southern Medical University , Guangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingbo","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Academy of Orthopedics, Guangdong Province, Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, The Third Affiliated Hospital of Southern Medical University , Guangzhou , China"},{"name":"Department of Clinical Immunology, Center for Orthopaedic Surgery, The Third Affiliated Hospital of Southern Medical University , Guangzhou , China"},{"name":"Department of Anesthesiology, The Third Affiliated Hospital of Southern Medical University , Guangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baozhu","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, The Third Affiliated Hospital, Southern Medical University , Guangzhou , 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Orthopaedic Surgery, The Third Affiliated Hospital of Southern Medical University , Guangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingliang","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, The Third Affiliated Hospital, Southern Medical University , Guangzhou , China"},{"name":"Department of Rheumatology and Immunology, Academy of Orthopedics, Guangdong Province, Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, The Third Affiliated Hospital of Southern Medical University , Guangzhou , China"},{"name":"Department of Clinical Immunology, Center for Orthopaedic Surgery, The Third Affiliated Hospital of Southern Medical University , Guangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, The Third Affiliated Hospital, Southern 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Clinical Immunology, Center for Orthopaedic Surgery, The Third Affiliated Hospital of Southern Medical University , Guangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, The Third Affiliated Hospital, Southern Medical University , Guangzhou , China"},{"name":"Department of Rheumatology and Immunology, Academy of Orthopedics, Guangdong Province, Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, The Third Affiliated Hospital of Southern Medical University , Guangzhou , China"},{"name":"Department of Clinical Immunology, Center for Orthopaedic Surgery, The Third Affiliated Hospital of Southern Medical University , Guangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruilin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, The Third 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