{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T05:12:29Z","timestamp":1788585149161,"version":"build-2803163510"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:00:00Z","timestamp":1715731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"La Ligue contre le cancer du Haut-Rhin"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Basal cell carcinoma (BCC) is the most frequent malignancy reported in populations with fair skin. In most countries, BCCs are only partially or not at all recorded, and incidence data are lacking.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>This study assessed the current incidence rates and trends in the only two French d\u00e9partements where BCCs have been recorded for several decades.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This regional population-based study thus used data from two French cancer registries (Doubs and Haut-Rhin) where first-time BCC diagnoses were recorded. The European age-standardized incidence rates (EASR) were calculated per 100 000 person-years (PY). The trends and the annual percentages of change were assessed using joinpoint analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In all, 48 989 patients were diagnosed with a first BCC in the study period. The median age at diagnosis was 69\u2005years and the BCCs were mainly located on the head and neck (68.8%). In the Doubs area between 1980 and 2016, the EASR of BCC increased from 59.9 to 183.1 per 100 000 PY. The annual increase for men was 5.73% before 1999 and 1.49% thereafter, and among women 4.56% before 2001 and 1.31% thereafter. In the Haut-Rhin area, the EASR increased from 139.2 in 1991 to 182.8 per 100 000 PY in 2019. Among men, the EASR increased annually by 2.31% before 2000, and by 0.29% after 2000; among women, it increased by 0.95% over the entire period (1991\u20132019). In the most recent period and for these two d\u00e9partements, the age-specific incidence rates of BCC for men and women were close before the age of 60\u2005years, except for the 40\u201349-year age group, where the rates were significantly higher among women. For patients aged 60\u2005years and over, men had much higher rates of BCC.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>BCC incidence has increased since 1980 and is still rising, particularly among men and the elderly. A slowing was observed from 2000, which could be explained by a shift in the management of BCCs and by the possible efficacy of prevention actions. This study provides insight into the BCC burden in France and highlights the need to maintain effective prevention strategies, as incidence is still increasing.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjd\/ljae201","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T16:04:36Z","timestamp":1715789076000},"page":"519-528","source":"Crossref","is-referenced-by-count":9,"title":["Incidence and trends of first basal cell carcinomas in\u00a0France between 1980 and 2019: a regional population-based registry study"],"prefix":"10.1093","volume":"191","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5320-8073","authenticated-orcid":false,"given":"Karima","family":"Hammas","sequence":"first","affiliation":[{"name":"Registre des cancers du Haut-Rhin, Groupe hospitalier de la r\u00e9gion de Mulhouse et Sud-Alsace (GHRMSA) , F-68000 Mulhouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charl\u00e9e","family":"Nardin","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Franche Comt\u00e9 , EFS, Inserm UMR RIGHT, F-25000 Besan\u00e7on , France"},{"name":"Service de Dermatologie, Centre Hospitalier Universitaire , F-25000 Besan\u00e7on , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9verine","family":"Boyer","sequence":"additional","affiliation":[{"name":"Registre des cancers du Haut-Rhin, Groupe hospitalier de la r\u00e9gion de Mulhouse et Sud-Alsace (GHRMSA) , F-68000 Mulhouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Michel","sequence":"additional","affiliation":[{"name":"Service de Dermatologie, Groupe hospitalier de la r\u00e9gion de Mulhouse et Sud-Alsace (GHRMSA) , F-68000 Mulhouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Aubin","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Franche Comt\u00e9 , EFS, Inserm UMR RIGHT, F-25000 Besan\u00e7on , France"},{"name":"Service de Dermatologie, Centre Hospitalier Universitaire , F-25000 Besan\u00e7on , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Sophie","family":"Woronoff","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Franche Comt\u00e9 , EFS, Inserm UMR RIGHT, F-25000 Besan\u00e7on , France"},{"name":"Registre des tumeurs du Doubs, Centre Hospitalier Universitaire , F-25000 Besan\u00e7on , France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,15]]},"reference":[{"key":"2024091723522707100_ljae201-B1","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1111\/j.1365-2133.2012.10830.x","article-title":"A systematic review of worldwide incidence of nonmelanoma skin cancer","volume":"166","author":"Lomas","year":"2012","journal-title":"Br J Dermatol"},{"key":"2024091723522707100_ljae201-B2","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.jaad.2018.03.060","article-title":"Basal cell carcinoma: epidemiology; 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