{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T20:24:31Z","timestamp":1785270271571,"version":"3.55.0"},"reference-count":73,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T00:00:00Z","timestamp":1717113600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Medical and Health Innovation Project of the Chinese Academy of Medical Sciences","award":["2021-I2M-1-052"],"award-info":[{"award-number":["2021-I2M-1-052"]}]},{"name":"Central Research Institute Fund of the Chinese Academy of Medical Sciences","award":["2018PT32015"],"award-info":[{"award-number":["2018PT32015"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Hypertrophic scarring is a disease of abnormal skin fibrosis caused by excessive fibroblast proliferation. Existing drugs have not achieved satisfactory therapeutic effects.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To explore the molecular pathogenesis of hypertrophic scars and screen effective drugs for their treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Existing human hypertrophic scar RNA sequencing data were utilized to search for hypertrophic scar-related gene modules and key genes through weighted gene co-expression network analysis (WGCNA). Candidate compounds were screened in a compound library. Potential drugs were screened by molecular docking and verified in human hypertrophic scar fibroblasts and a mouse mechanical force hypertrophic scar model.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>WGCNA showed that hypertrophic scar-associated gene modules influence focal adhesion, the transforming growth factor (TGF)-\u03b2 signalling pathway and other biologic pathways. Integrin \u03b21 (ITGB1) is the hub protein. Among the candidate compounds obtained by computer virtual screening and molecular docking, crizotinib, sorafenib and SU11274 can inhibit the proliferation and migration of human hypertrophic scar fibroblasts and profibrotic gene expression. Crizotinib had the best effect on hypertrophic scar attenuation in mouse models. At the same time, mouse ITGB1 small interfering RNA can also inhibit mouse scar hyperplasia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>ITGB1 and TGF-\u03b2 signalling pathways are important for hypertrophic scar formation. Crizotinib could be a potential treatment drug for hypertrophic scars.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjd\/ljae234","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T22:21:04Z","timestamp":1717194064000},"page":"592-604","source":"Crossref","is-referenced-by-count":19,"title":["Using network pharmacology to discover potential drugs for hypertrophic scars"],"prefix":"10.1093","volume":"191","author":[{"given":"Yi","family":"Zhang","sequence":"first","affiliation":[{"name":"Research Center of Plastic Surgery Hospital, Chinese Academy of Medical Science and Peking Union Medical College , Beijing , P.R. China"},{"name":"Key Laboratory of External Tissue and Organ Regeneration, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu","family":"Li","sequence":"additional","affiliation":[{"name":"Research Center of Plastic Surgery Hospital, Chinese Academy of Medical Science and Peking Union Medical College , Beijing , P.R. China"},{"name":"Key Laboratory of External Tissue and Organ Regeneration, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Yu","sequence":"additional","affiliation":[{"name":"Research Center of Plastic Surgery Hospital, Chinese Academy of Medical Science and Peking Union Medical College , Beijing , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Lv","sequence":"additional","affiliation":[{"name":"Research Center of Plastic Surgery Hospital, Chinese Academy of Medical Science and Peking Union Medical College , Beijing , P.R. China"},{"name":"Key Laboratory of External Tissue and Organ Regeneration, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Li","sequence":"additional","affiliation":[{"name":"Research Center of Plastic Surgery Hospital, Chinese Academy of Medical Science and Peking Union Medical College , Beijing , P.R. China"},{"name":"Key Laboratory of External Tissue and Organ Regeneration, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianzhao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Science and Peking Union Medical College , Beijing , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Science and Peking Union Medical College , Beijing , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[{"name":"Research Center of Plastic Surgery Hospital, Chinese Academy of Medical Science and Peking Union Medical College , Beijing , P.R. China"},{"name":"Key Laboratory of External Tissue and Organ Regeneration, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8195-7992","authenticated-orcid":false,"given":"Zhigang","family":"Yang","sequence":"additional","affiliation":[{"name":"Research Center of Plastic Surgery Hospital, Chinese Academy of Medical Science and Peking Union Medical College , Beijing , P.R. China"},{"name":"Key Laboratory of External Tissue and Organ Regeneration, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Fu","sequence":"additional","affiliation":[{"name":"Research Center of Plastic Surgery Hospital, Chinese Academy of Medical Science and Peking Union Medical College , Beijing , P.R. China"},{"name":"Key Laboratory of External Tissue and Organ Regeneration, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1359-4237","authenticated-orcid":false,"given":"Ran","family":"Xiao","sequence":"additional","affiliation":[{"name":"Research Center of Plastic Surgery Hospital, Chinese Academy of Medical Science and Peking Union Medical College , Beijing , P.R. China"},{"name":"Key Laboratory of External Tissue and Organ Regeneration, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,31]]},"reference":[{"key":"2024091723514005500_ljae234-B1","doi-asserted-by":"crossref","first-page":"787","DOI":"10.12688\/f1000research.18293.1","article-title":"Toward understanding scarless skin wound healing and pathological scarring","volume":"8","author":"Karppinen","year":"2019","journal-title":"F1000Res"},{"key":"2024091723514005500_ljae234-B2","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.biopha.2016.09.010","article-title":"Growth factor pathways in hypertrophic scars: molecular pathogenesis and therapeutic implications","volume":"84","author":"Lian","year":"2016","journal-title":"Biomed Pharmacother"},{"key":"2024091723514005500_ljae234-B3","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.burns.2013.11.010","article-title":"New molecular medicine-based scar management strategies","volume":"40","author":"Arno","year":"2014","journal-title":"Burns"},{"key":"2024091723514005500_ljae234-B4","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/wrr.12432","article-title":"Current concepts related to hypertrophic scarring in burn injuries","volume":"24","author":"Chiang","year":"2016","journal-title":"Wound Repair Regen"},{"key":"2024091723514005500_ljae234-B5","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1524-4725.2008.34406.x","article-title":"Hypertrophic scars and keloids \u2013 a review of their pathophysiology, risk factors, and therapeutic management","volume":"35","author":"Wolfram","year":"2009","journal-title":"Dermatol Surg"},{"key":"2024091723514005500_ljae234-B6","first-page":"312","article-title":"S2k guidelines for the therapy of pathological scars (hypertrophic scars and keloids) \u2013 update 2020","volume":"19","author":"Nast","year":"2021","journal-title":"J Dtsch Dermatol Ges"},{"key":"2024091723514005500_ljae234-B7","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/jcp.25879","article-title":"TGF\u03b2 signaling and the control of myofibroblast differentiation: implications for chronic inflammatory disorders","volume":"233","author":"Carthy","year":"2018","journal-title":"J Cell Physiol"},{"key":"2024091723514005500_ljae234-B8","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1083\/jcb.122.1.103","article-title":"Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts","volume":"122","author":"Desmouli\u00e8re","year":"1993","journal-title":"J Cell Biol"},{"key":"2024091723514005500_ljae234-B9","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1002\/cphy.c140067","article-title":"Physiological implications of myocardial scar structure","volume":"5","author":"Richardson","year":"2015","journal-title":"Compr Physiol"},{"key":"2024091723514005500_ljae234-B10","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1111\/ijd.12436","article-title":"Scar prevention and remodeling: a review of the medical, surgical, topical and light treatment approaches","volume":"53","author":"Kerwin","year":"2014","journal-title":"Int J Dermatol"},{"key":"2024091723514005500_ljae234-B11","doi-asserted-by":"crossref","first-page":"4109","DOI":"10.1002\/jcp.29302","article-title":"Molecular mechanism of myofibroblast formation and strategies for clinical drugs treatments in hypertrophic scars","volume":"235","author":"Zhu","year":"2020","journal-title":"J Cell Physiol"},{"key":"2024091723514005500_ljae234-B12","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jaad.2011.08.035","article-title":"Cutaneous scarring: Pathophysiology, molecular mechanisms, and scar reduction therapeutics Part II. Strategies to reduce scar formation after dermatologic procedures","volume":"66","author":"Tziotzios","year":"2012","journal-title":"J Am Acad Dermatol"},{"key":"2024091723514005500_ljae234-B13","doi-asserted-by":"crossref","first-page":"113","DOI":"10.2119\/molmed.2009.00153","article-title":"Hypertrophic scarring and keloids: pathomechanisms and current and emerging treatment strategies","volume":"17","author":"Gauglitz","year":"2011","journal-title":"Mol Med"},{"key":"2024091723514005500_ljae234-B14","doi-asserted-by":"crossref","DOI":"10.1093\/burnst\/tkz003","article-title":"Strategies to prevent hypertrophic scar formation: a review of therapeutic interventions based on molecular evidence","volume":"8","author":"Shirakami","year":"2020","journal-title":"Burns Trauma"},{"key":"2024091723514005500_ljae234-B15","first-page":"721","article-title":"New paradigm for drug discovery based on network pharmacology","volume-title":"Chin J New Drugs Clin Rem","author":"Pan","year":"2009"},{"key":"2024091723514005500_ljae234-B16","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1186\/1471-2105-7-268","article-title":"Genome wide prediction of protein function via a generic knowledge discovery approach based on evidence integration","volume":"7","author":"Xiong","year":"2006","journal-title":"BMC Bioinformatics"},{"key":"2024091723514005500_ljae234-B17","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/nchembio.118","article-title":"Network pharmacology: the next paradigm in drug discovery","volume":"4","author":"Hopkins","year":"2008","journal-title":"Nat Chem Biol"},{"key":"2024091723514005500_ljae234-B18","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinformatics"},{"key":"2024091723514005500_ljae234-B19","doi-asserted-by":"crossref","first-page":"943","DOI":"10.2146\/ajhp120261","article-title":"Crizotinib for the treatment of non-small-cell lung cancer","volume":"70","author":"Timm","year":"2013","journal-title":"Am J Health Syst Pharm"},{"key":"2024091723514005500_ljae234-B20","doi-asserted-by":"crossref","first-page":"100768","DOI":"10.1016\/j.currproblcancer.2021.100768","article-title":"Inflammatory myofibroblastic tumor: molecular landscape, targeted therapeutics, and remaining challenges","volume":"45","author":"Mahajan","year":"2021","journal-title":"Curr Probl Cancer"},{"key":"2024091723514005500_ljae234-B21"},{"key":"2024091723514005500_ljae234-B22","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/j.cell.2017.10.049","article-title":"A next generation connectivity map: L1000 platform and the first 1,000,000 profiles","volume":"171","author":"Subramanian","year":"2017","journal-title":"Cell"},{"key":"2024091723514005500_ljae234-B23","doi-asserted-by":"crossref","first-page":"3250","DOI":"10.1096\/fj.07-8218com","article-title":"Mechanical load initiates hypertrophic scar formation through decreased cellular apoptosis","volume":"21","author":"Aarabi","year":"2007","journal-title":"FASEB J"},{"key":"2024091723514005500_ljae234-B24","doi-asserted-by":"crossref","first-page":"144","DOI":"10.3389\/fmolb.2019.00144","article-title":"Adhesions assemble! \u2013 Autoinhibition as a major regulatory mechanism of integrin-mediated adhesion","volume":"6","author":"Khan","year":"2019","journal-title":"Front Mol Biosci"},{"key":"2024091723514005500_ljae234-B25","first-page":"3563","article-title":"Ginsberg M","volume":"113","author":"Liu","year":"2000","journal-title":"Integrin cytoplasmic domain-binding proteins J Cell Sci"},{"key":"2024091723514005500_ljae234-B26","doi-asserted-by":"crossref","first-page":"E65-8","DOI":"10.1038\/ncb0402-e65","article-title":"Networks and crosstalk: integrin signalling spreads","volume":"4","author":"Schwartz","year":"2002","journal-title":"Nat Cell Biol"},{"key":"2024091723514005500_ljae234-B27","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1242\/jcs.041624","article-title":"Mechanisms that regulate adaptor binding to beta-integrin cytoplasmic tails","volume":"122","author":"Legate","year":"2009","journal-title":"J Cell Sci"},{"key":"2024091723514005500_ljae234-B28","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1083\/jcb.201609037","article-title":"Integrin-mediated mechanotransduction","volume":"215","author":"Sun","year":"2016","journal-title":"J Cell Biol"},{"key":"2024091723514005500_ljae234-B29","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/embor.2009.276","article-title":"Integrin-TGF-beta crosstalk in fibrosis, cancer and wound healing","volume":"11","author":"Margadant","year":"2010","journal-title":"EMBO Rep"},{"key":"2024091723514005500_ljae234-B30","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.diff.2013.02.003","article-title":"The role of focal adhesion complexes in fibroblast mechanotransduction during scar formation","volume":"86","author":"Rustad","year":"2013","journal-title":"Differentiation"},{"key":"2024091723514005500_ljae234-B31","doi-asserted-by":"crossref","first-page":"897","DOI":"10.3390\/ijms22020897","article-title":"Molecular changes underlying hypertrophic scarring following burns involve specific deregulations at all wound healing stages (inflammation, proliferation and maturation)","volume":"22","author":"\u010coma","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2024091723514005500_ljae234-B32","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.burns.2008.06.020","article-title":"Potential cellular and molecular causes of hypertrophic scar formation","volume":"35","author":"van der Veer","year":"2009","journal-title":"Burns"},{"key":"2024091723514005500_ljae234-B33","doi-asserted-by":"crossref","first-page":"606","DOI":"10.3390\/ijms18030606","article-title":"Keloid and hypertrophic scars are the result of chronic inflammation in the reticular dermis","volume":"18","author":"Ogawa","year":"2017","journal-title":"Int J Mol Sci"},{"key":"2024091723514005500_ljae234-B34","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/iwj.13286","article-title":"Biological approaches for hypertrophic scars","volume":"17","author":"Lingzhi","year":"2020","journal-title":"Int Wound J"},{"key":"2024091723514005500_ljae234-B35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-386035-4.00001-X","article-title":"Circulating fibrocytes \u2013 biology and mechanisms in wound healing and scar formation","volume":"291","author":"Grieb","year":"2011","journal-title":"Int Rev Cell Mol Biol"},{"key":"2024091723514005500_ljae234-B36","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1093\/jbcr\/irz158","article-title":"Hypertrophic scarring: current knowledge of predisposing factors, cellular and molecular mechanisms","volume":"41","author":"Nabai","year":"2020","journal-title":"J Burn Care Res"},{"key":"2024091723514005500_ljae234-B37","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00441-014-2064-9","article-title":"Integrin-mediated adhesion and mechano-sensing in cutaneous wound healing","volume":"360","author":"Kenny","year":"2015","journal-title":"Cell Tissue Res"},{"key":"2024091723514005500_ljae234-B38","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s00403-012-1278-5","article-title":"Mechanosignaling pathways in cutaneous scarring","volume":"304","author":"Huang","year":"2012","journal-title":"Arch Dermatol Res"},{"key":"2024091723514005500_ljae234-B39","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/s41580-022-00531-5","article-title":"Organization, dynamics and mechanoregulation of integrin-mediated cell-ECM adhesions","volume":"24","author":"Kanchanawong","year":"2023","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2024091723514005500_ljae234-B40","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s00441-016-2446-2","article-title":"Integrin-mediated regulation of epidermal wound functions","volume":"365","author":"DiPersio","year":"2016","journal-title":"Cell Tissue Res"},{"key":"2024091723514005500_ljae234-B41","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s41038-017-0080-1","article-title":"Current progress in understanding the molecular pathogenesis of burn scar contracture","volume":"5","author":"Tan","year":"2017","journal-title":"Burns Trauma"},{"key":"2024091723514005500_ljae234-B42","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1126\/science.1092053","article-title":"Cell migration: integrating signals from front to back","volume":"302","author":"Ridley","year":"2003","journal-title":"Science"},{"key":"2024091723514005500_ljae234-B43","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1242\/jcs.188672","article-title":"The integrin-collagen connection \u2013 a glue for tissue repair?","volume":"129","author":"Zeltz","year":"2016","journal-title":"J Cell Sci"},{"key":"2024091723514005500_ljae234-B44","doi-asserted-by":"crossref","first-page":"4031","DOI":"10.1242\/jcs.112.22.4031","article-title":"Differential subcellular localization of DNA-dependent protein kinase components Ku and DNA-PKcs during mitosis","volume":"112","author":"Koike","year":"1999","journal-title":"J Cell Sci"},{"key":"2024091723514005500_ljae234-B45","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/jcb.20810","article-title":"CCN2, connective tissue growth factor, stimulates collagen deposition by gingival fibroblasts via module 3 and alpha6- and beta1 integrins","volume":"98","author":"Heng","year":"2006","journal-title":"J Cell Biochem"},{"key":"2024091723514005500_ljae234-B46","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1242\/jcs.113.2.259","article-title":"Altered synthesis of laminin 1 and absence of basement membrane component deposition in (beta)1 integrin-deficient embryoid bodies","volume":"113","author":"Aumailley","year":"2000","journal-title":"J Cell Sci"},{"key":"2024091723514005500_ljae234-B47","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.matbio.2014.11.004","article-title":"The \u03b14\u03b21 integrin and the EDA domain of fibronectin regulate a profibrotic phenotype in dermal fibroblasts","volume":"41","author":"Shinde","year":"2015","journal-title":"Matrix Biol"},{"key":"2024091723514005500_ljae234-B48","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1038\/jid.2015.24","article-title":"Reduced granulation tissue and wound strength in the absence of \u03b111\u03b21 integrin","volume":"135","author":"Schulz","year":"2015","journal-title":"J Invest Dermatol"},{"key":"2024091723514005500_ljae234-B49","doi-asserted-by":"crossref","first-page":"12384","DOI":"10.1074\/jbc.M208544200","article-title":"Myofibroblast differentiation by transforming growth factor-beta1 is dependent on cell adhesion and integrin signaling via focal adhesion kinase","volume":"278","author":"Thannickal","year":"2003","journal-title":"J Biol Chem"},{"key":"2024091723514005500_ljae234-B50","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1146\/annurev-immunol-032713-120257","article-title":"TGF-\u03b2 activation and function in immunity","volume":"32","author":"Travis","year":"2014","journal-title":"Annu Rev Immunol"},{"key":"2024091723514005500_ljae234-B51","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.tibs.2010.08.002","article-title":"TGF\u03b2: a sleeping giant awoken by integrins","volume":"36","author":"Worthington","year":"2011","journal-title":"Trends Biochem Sci"},{"key":"2024091723514005500_ljae234-B52","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.matbio.2015.05.005","article-title":"Latent TGF-\u03b2-binding proteins","volume":"47","author":"Robertson","year":"2015","journal-title":"Matrix Biol"},{"key":"2024091723514005500_ljae234-B53","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.tcb.2019.10.002","article-title":"Controlling immunity and inflammation through integrin-dependent regulation of TGF-\u03b2","volume":"30","author":"Nolte","year":"2020","journal-title":"Trends Cell Biol"},{"key":"2024091723514005500_ljae234-B54","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.3892\/ijmm.2014.1912","article-title":"Effects of integrin \u03b1\u03bd\u03b23 on differentiation and collagen synthesis induced by connective tissue growth factor in human hypertrophic scar fibroblasts","volume":"34","author":"Hu","year":"2014","journal-title":"Int J Mol Med"},{"key":"2024091723514005500_ljae234-B55","first-page":"213","article-title":"Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis","volume":"119","author":"Kim","year":"2009","journal-title":"J Clin Invest"},{"key":"2024091723514005500_ljae234-B56","doi-asserted-by":"crossref","first-page":"4230","DOI":"10.1242\/jcs.03492","article-title":"MAP-kinase activity necessary for TGFbeta1-stimulated mesangial cell type I collagen expression requires adhesion-dependent phosphorylation of FAK tyrosine 397","volume":"120","author":"Hayashida","year":"2007","journal-title":"J Cell Sci"},{"key":"2024091723514005500_ljae234-B57","doi-asserted-by":"crossref","first-page":"46707","DOI":"10.1074\/jbc.M106176200","article-title":"Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of\u00a0p38MAPK and epithelial plasticity","volume":"276","author":"Bhowmick","year":"2001","journal-title":"J Biol Chem"},{"key":"2024091723514005500_ljae234-B58","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/sj.jid.5701042","article-title":"Integrin alpha3beta1 potentiates TGFbeta-mediated induction of MMP-9 in immortalized keratinocytes","volume":"128","author":"Lamar","year":"2008","journal-title":"J Invest Dermatol"},{"key":"2024091723514005500_ljae234-B59","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1165\/rcmb.2012-0050OC","article-title":"Matrix stiffness-induced myofibroblast differentiation is mediated by intrinsic mechanotransduction","volume":"47","author":"Huang","year":"2012","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2024091723514005500_ljae234-B60","doi-asserted-by":"crossref","first-page":"12564","DOI":"10.1038\/ncomms12564","article-title":"Mechanosensing by the \u03b16-integrin confers an invasive fibroblast phenotype and mediates lung fibrosis","volume":"7","author":"Chen","year":"2016","journal-title":"Nat Commun"},{"key":"2024091723514005500_ljae234-B61","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/ncb0807-858","article-title":"Functional atlas of the integrin adhesome","volume":"9","author":"Zaidel-Bar","year":"2007","journal-title":"Nat Cell Biol"},{"key":"2024091723514005500_ljae234-B62","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ceb.2017.12.014","article-title":"Mechanosensing at integrin-mediated cell-matrix adhesions: from molecular to integrated mechanisms","volume":"50","author":"Gauthier","year":"2018","journal-title":"Curr Opin Cell Biol"},{"key":"2024091723514005500_ljae234-B63","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1089\/wound.2012.0365","article-title":"\u03b2Integrin 1: a mechanosignaling sensor essential for connective tissue deposition by fibroblasts","volume":"2","author":"Leask","year":"2013","journal-title":"Adv Wound Care"},{"key":"2024091723514005500_ljae234-B64","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1038\/jid.2012.438","article-title":"Integrin \u03b21 is required for dermal homeostasis","volume":"133","author":"Liu","year":"2013","journal-title":"J\u00a0Invest Dermatol"},{"key":"2024091723514005500_ljae234-B65","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1093\/rheumatology\/kes234","article-title":"Focal adhesion kinase and reactive oxygen species contribute to the persistent fibrotic phenotype of lesional scleroderma fibroblasts","volume":"51","author":"Shi-wen","year":"2012","journal-title":"Rheumatology (Oxford)"},{"key":"2024091723514005500_ljae234-B66","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/0092-8674(91)90191-Z","article-title":"Integrin alpha 2 beta 1 (VLA-2) mediates reorganization and contraction of collagen matrices by human cells","volume":"67","author":"Schiro","year":"1991","journal-title":"Cell"},{"key":"2024091723514005500_ljae234-B67","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1083\/jcb.142.2.587","article-title":"Integrin alpha1beta1 mediates a unique collagen-dependent proliferation pathway in vivo","volume":"142","author":"Pozzi","year":"1998","journal-title":"J Cell Biol"},{"key":"2024091723514005500_ljae234-B68","doi-asserted-by":"crossref","first-page":"10434","DOI":"10.1074\/jbc.M109.078766","article-title":"The fibroblast integrin alpha11beta1 is induced in a mechanosensitive manner involving activin A and regulates myofibroblast differentiation","volume":"285","author":"Carracedo","year":"2010","journal-title":"J Biol Chem"},{"key":"2024091723514005500_ljae234-B69","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1034\/j.1600-0625.2002.110404.x","article-title":"Integrin expression in the dermis during scar formation in humans","volume":"11","author":"Noszczyk","year":"2002","journal-title":"Exp Dermatol"},{"key":"2024091723514005500_ljae234-B70","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1083\/jcb.115.5.1427","article-title":"Integrin alpha 2 beta 1 is upregulated in fibroblasts and highly aggressive melanoma cells in three-dimensional collagen lattices and mediates the reorganization of collagen I fibrils","volume":"115","author":"Klein","year":"1991","journal-title":"J Cell Biol"},{"key":"2024091723514005500_ljae234-B71","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1083\/jcb.131.6.1903","article-title":"Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by alpha 1 beta 1 and alpha 2 beta 1 integrins","volume":"131","author":"Langholz","year":"1995","journal-title":"J Cell Biol"},{"key":"2024091723514005500_ljae234-B72","doi-asserted-by":"crossref","first-page":"99","DOI":"10.2165\/11207680-000000000-00000","article-title":"Crizotinib: in locally advanced or metastatic non-small cell lung cancer","volume":"72","author":"Curran Monique","year":"2012","journal-title":"Drugs"},{"key":"2024091723514005500_ljae234-B73","doi-asserted-by":"crossref","first-page":"4408","DOI":"10.1158\/0008-5472.CAN-06-4443","article-title":"An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms","volume":"67","author":"Zou Helen","year":"2007","journal-title":"Cancer Res"}],"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bjd\/advance-article-pdf\/doi\/10.1093\/bjd\/ljae234\/58619026\/ljae234.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjd\/article-pdf\/191\/4\/592\/59122406\/ljae234.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjd\/article-pdf\/191\/4\/592\/59122406\/ljae234.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T23:52:09Z","timestamp":1726617129000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/article\/191\/4\/592\/7686090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,31]]},"references-count":73,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,5,31]]},"published-print":{"date-parts":[[2024,9,18]]}},"URL":"https:\/\/doi.org\/10.1093\/bjd\/ljae234","relation":{},"ISSN":["0007-0963","1365-2133"],"issn-type":[{"value":"0007-0963","type":"print"},{"value":"1365-2133","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,10]]},"published":{"date-parts":[[2024,5,31]]}}}