{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T11:29:12Z","timestamp":1778066952860,"version":"3.51.4"},"reference-count":157,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:00:00Z","timestamp":1719187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000296","name":"British Skin Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000296","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by recurrent inflammatory lesions, which affect skin and hair follicles in intertriginous areas. HS has a multifactorial aetiology resulting in barrier dysfunction associated with aberrant immune activation. There is increased evidence for the role of inflammasomes in the pathophysiology of inflammatory skin diseases, including HS. Inflammasomes are multiprotein complexes activated following exposure to danger signals, including microbial ligands and components of damaged host cells. Inflammasome activation induces many signalling cascades and subsequent cleavage of proinflammatory cytokines\u00a0\u2013 most notably interleukin (IL)-1\u03b2 \u2013 which have a role in HS pathogenesis. Limited immunotherapies are approved for treating moderate-to-severe HS, with variable response rates influenced by disease heterogeneity. Inflammasomes represent attractive targets to suppress multiple inflammatory pathways in HS, including IL-1\u03b2 and IL-17. This review aims to summarize the role of inflammasomes in HS and to evaluate evidence for inflammasomes as therapeutic targets for HS treatment.<\/jats:p>","DOI":"10.1093\/bjd\/ljae262","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T16:12:04Z","timestamp":1719245524000},"page":"670-679","source":"Crossref","is-referenced-by-count":9,"title":["Inflammasomes: emerging therapeutic targets in hidradenitis suppurativa?"],"prefix":"10.1093","volume":"191","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0183-1781","authenticated-orcid":false,"given":"Ciara","family":"Campbell","sequence":"first","affiliation":[{"name":"Discipline of Anatomy, Trinity College Dublin , Dublin ,","place":["Ireland"]},{"name":"Department of Medicine, Harvard Medical School, Brigham and Women's Hospital , Boston, MA ,","place":["USA"]},{"name":"School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay M","family":"Mayatra","sequence":"additional","affiliation":[{"name":"Discipline of Anatomy, Trinity College Dublin , Dublin ,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashish J","family":"Neve","sequence":"additional","affiliation":[{"name":"Conway Institute, University College Dublin , Dublin ,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0670-6659","authenticated-orcid":false,"given":"Jean M","family":"Fletcher","sequence":"additional","affiliation":[{"name":"School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin"},{"name":"School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1737-0046","authenticated-orcid":false,"given":"Daniel\u00a0G W","family":"Johnston","sequence":"additional","affiliation":[{"name":"Discipline of Anatomy, Trinity College Dublin , Dublin ,","place":["Ireland"]},{"name":"Charles Institute of Dermatology, University College Dublin , Dublin ,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,6,24]]},"reference":[{"key":"2024102112264874900_ljae262-B1","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1111\/exd.14451","article-title":"Hidradenitis suppurativa: a folliculotropic disease of innate immune barrier dysfunction?","volume":"30","author":"Johnston","year":"2021","journal-title":"Exp 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