{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T09:13:04Z","timestamp":1769073184048,"version":"3.49.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Urticaria has been tentatively linked to cancer, but epidemiological evidence supporting this link is sparse and conflicting. We conducted a population-based cohort study using healthcare databases covering the Danish population (January 1980\u2013December 2022). We followed 87 507 people for a median of 10.1 years after their first hospital contact for urticaria.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To examine associations of a hospital diagnosis of urticaria with incident cancer.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We computed the absolute risk of cancer and standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) standardized to Danish national cancer rates. In a cross-sectional analysis, we examined whether the extent of cancer spread differed between people with vs. without a previous urticaria diagnosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The overall SIR for all types of cancer was 1.09 (95% CI 1.06\u20131.11) based on 7788 observed vs. 7161 expected cases. The risk for any cancer was 0.7% (95% CI 0.6\u20130.7) for the first year of follow-up. Cancer was diagnosed in 588 people with urticaria during the first year of follow-up (SIR 1.49, 95% CI 1.38\u20131.62) and in 7200 people thereafter (SIR 1.06, 95% CI 1.04\u20131.09). During the first year of follow-up, we found strong associations with haematological cancers (e.g. non-Hodgkin lymphoma; SIR 2.91, 95% CI 1.92\u20134.23). Cancer stage was similar in people with vs. without a previous urticaria diagnosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>At the time of urticaria diagnosis, or in the first year afterward, we found a large increase in the risk of cancer. In subsequent years, a persistent 6% increase in risk remained. Diagnostic efforts may partly explain the elevated short-term risk, but occult cancer may promote urticaria, or cancer and urticaria share common risk factors.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjd\/ljae264","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T20:03:06Z","timestamp":1719432186000},"page":"706-712","source":"Crossref","is-referenced-by-count":2,"title":["Urticaria and the risk of cancer: a Danish population-based cohort study"],"prefix":"10.1093","volume":"191","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9243-9736","authenticated-orcid":false,"given":"Sissel B T","family":"S\u00f8rensen","sequence":"first","affiliation":[{"name":"Department of Dermatology, Aarhus University Hospital , Aarhus ,","place":["Denmark"]},{"name":"Department of Rheumatology, Aarhus University Hospital , Aarhus ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8577-048X","authenticated-orcid":false,"given":"D\u00f3ra K","family":"Farkas","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Aarhus University Hospital and Aarhus University , Aarhus ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6485-3158","authenticated-orcid":false,"given":"Christian","family":"Vestergaard","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Aarhus University Hospital , Aarhus ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5527-0698","authenticated-orcid":false,"given":"Sigrun A J","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Aarhus University Hospital , Aarhus ,","place":["Denmark"]},{"name":"Department of Clinical Epidemiology, Aarhus University Hospital and Aarhus University , Aarhus ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3768-4146","authenticated-orcid":false,"given":"Lise\u00a0Maria","family":"Lindahl","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Aarhus University Hospital , Aarhus ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2551-410X","authenticated-orcid":false,"given":"Kathryn E","family":"Mansfield","sequence":"additional","affiliation":[{"name":"Department of Non-communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine , London ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7022-7441","authenticated-orcid":false,"given":"Sinead M","family":"Langan","sequence":"additional","affiliation":[{"name":"Department of Non-communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine , London ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4299-7040","authenticated-orcid":false,"given":"Henrik T","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Aarhus University Hospital and Aarhus University , Aarhus ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,6,27]]},"reference":[{"key":"2024102112264113900_ljae264-B1","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1111\/j.1365-2230.2010.03840.x","article-title":"Epidemiology of urticaria: a representative cross-sectional population survey","volume":"35","author":"Zuberbier","year":"2010","journal-title":"Clin Exp Dermatol"},{"key":"2024102112264113900_ljae264-B2","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.jaip.2016.09.029","article-title":"Prevalence of inducible urticaria in patients with chronic spontaneous urticaria: associated risk factors","volume":"5","author":"S\u00e1nchez","year":"2017","journal-title":"J Allergy Clin Immunol Pract"},{"key":"2024102112264113900_ljae264-B3","first-page":"317","article-title":"Unmet clinical needs in chronic spontaneous urticaria. 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