{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T03:09:44Z","timestamp":1792206584716,"version":"4.4.0"},"reference-count":71,"publisher":"Oxford University Press (OUP)","issue":"Supplement_1","license":[{"start":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:00:00Z","timestamp":1738540800000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["K01AR075111"],"award-info":[{"award-number":["K01AR075111"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR080796"],"award-info":[{"award-number":["R01AR080796"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition with many unmet needs. It is characterized by significant clinical heterogeneity, which suggests that a diagnosis of HS captures multiple distinct disease entities and that research aimed at identifying medically relevant HS subtypes will improve its management. Precision medicine is an approach to disease management that uses information encoded in a patient\u2019s genome, and operationalized in clinical presentations and drug responses, to identify disease subtypes. Prior research aimed at identifying HS subtypes has largely focused on phenotypic classifications derived from clinical features of cutaneous lesions. Limitations of existing HS taxonomies emphasize a need for a more nuanced understanding of disease subtypes. Evidence that has emerged from initial genetic studies of HS suggests the presence of at least three HS subtypes, each of which has different clinical implications in terms of disease risks and drug responses. These preliminary findings are instructive in terms of expanding our definitions of HS phenotypes to not only include characteristics of skin lesions, but also disease comorbidities and molecular and cellular phenotypes. Here we provide a comprehensive review of HS phenotype and genotype knowledge, and propose a strategic framework for implementing precision medicine in HS management. Future research should focus on expanding phenotype assessments to include data on multiple scales. Iterative research designs performed with phenotype and genotype data from large diverse cohorts are needed to rigorously define clinically relevant HS subtypes.<\/jats:p>","DOI":"10.1093\/bjd\/ljae399","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T15:31:46Z","timestamp":1728919906000},"page":"i22-i29","source":"Crossref","is-referenced-by-count":15,"title":["Leveraging genotypes and phenotypes to implement precision medicine in hidradenitis suppurativa management"],"prefix":"10.1093","volume":"192","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1573-1653","authenticated-orcid":false,"given":"Lynn","family":"Petukhova","sequence":"first","affiliation":[{"name":"The Ronald O. Perelman Department of Dermatology, NYU Grossman School of Medicine, NYU Langone Health , New York, NY ,","place":["USA"]},{"name":"Department of Population Health, NYU Grossman School of Medicine, NYU Langone Health , New York, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1703-6854","authenticated-orcid":false,"given":"Annelise","family":"Colvin","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of California San Francisco , San Francisco, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8905-6263","authenticated-orcid":false,"given":"Nicole D K","family":"Koerts","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Medical Center Groningen, University of Groningen , Groningen ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8559-3674","authenticated-orcid":false,"given":"Barbara","family":"Horv\u00e1th","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Medical Center Groningen, University of Groningen , Groningen ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,2,3]]},"reference":[{"key":"2025020309491321900_ljae399-B1","doi-asserted-by":"crossref","first-page":"635","DOI":"10.7326\/M18-0425","article-title":"Precision medicine in internal medicine","volume":"170","author":"Kiryluk","year":"2019","journal-title":"Ann Intern Med"},{"key":"2025020309491321900_ljae399-B2","doi-asserted-by":"crossref","first-page":"100006","DOI":"10.1016\/j.gim.2023.100006","article-title":"Returning integrated genomic risk and clinical recommendations: the eMERGE 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