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Growing evidence suggests the involvement of stromal cells in the inflammatory process.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the roles of stromal cells, including fibroblasts, vascular endothelial cells (VECs) and vascular smooth muscle cells (VSMCs), in the psoriatic inflammatory microenvironment, and the possible underlying mechanisms involved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used a combination of single-cell, spatial transcriptome and bulk RNA sequencing of lesional and nonlesional skin samples from patients with psoriasis vulgaris (PV) and healthy skin samples from unaffected individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>By analysing transcriptomes from 364 098 single cells, we uncovered WNT5A+ (Wnt-5a) fibroblasts, ITIH5+ (inter-\u03b1-trypsin inhibitor heavy chain 5) VECs and VCAN+ (versican) VSMCs, with significantly increased proportions of these cells in the papillary dermis of lesional psoriatic skin. We defined eight unique subclusters of fibroblasts in the skin and observed a shift of WIF1+ (Wnt inhibitory factor 1) fibroblasts toward WNT5A+ fibroblasts, with abnormal activation of the noncanonical Wnt signalling pathway and increased angiogenic and proinflammatory capabilities. VSMCs were able to undergo phenotypic transformation from a contractile to a synthetic phenotype during the development of psoriatic inflammation. ITIH5+ VECs and VCAN+ VSMCs were found to have an essential role in regulating angiogenesis and vascular remodelling in the pathological changes seen in PV. Ligand receptor analyses found that WNT5A+ fibroblasts are extensively implicated in interactions with various skin cell types, especially TIH5+ VECs and VCAN+ VSMCs in the papillary dermis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Interactions of stromal cells in the papillary dermis were identified as possible pathogenic elements in PV. Improving the inflammatory microenvironment by targeting stromal cells might be a potential treatment strategy in PV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjd\/ljae459","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T15:26:17Z","timestamp":1732029977000},"page":"672-683","source":"Crossref","is-referenced-by-count":11,"title":["Multitranscriptome analysis reveals stromal cells in the papillary dermis to promote angiogenesis in psoriasis vulgaris"],"prefix":"10.1093","volume":"192","author":[{"given":"Bo","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Dermatology, The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital; Medical Center of Soochow University) , Suzhou, Jiangsu ,","place":["China"]},{"name":"Department of Dermatology, The First Affiliated Hospital of Anhui Medical University , Hefei ,","place":["China"]},{"name":"Dermatology Center in Boao Super Hospital , Qionghai, Hainan Province ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4630-0765","authenticated-orcid":false,"given":"Junpu","family":"Mei","sequence":"additional","affiliation":[{"name":"BGI Research , Sanya ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qijun","family":"Liao","sequence":"additional","affiliation":[{"name":"BGI Research , Shenzhen ,","place":["China"]},{"name":"Institute of Intelligent Medical Research (IIMR), BGI Genomics , Shenzhen ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The First Affiliated Hospital of Anhui Medical University , Hefei ,","place":["China"]},{"name":"The Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education , Hefei 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