{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:40:59Z","timestamp":1787506859041,"version":"build-2736575974"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR078688"],"award-info":[{"award-number":["R01AR078688"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR083553"],"award-info":[{"award-number":["R01AR083553"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AR079089"],"award-info":[{"award-number":["R21AR079089"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R33AR076803"],"award-info":[{"award-number":["R33AR076803"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Henry Ford Immunology Research Program","award":["T71016"],"award-info":[{"award-number":["T71016"]}]},{"name":"Henry Ford Immunology Research Program","award":["T71017"],"award-info":[{"award-number":["T71017"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition with a greater prevalence and disease burden in patients who identify as African American and those with a family history of HS, suggesting a strong genetic component to its pathogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the relationship between plasma inflammatory protein expression, HS disease severity and genetic ancestry in a diverse cohort of patients with HS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a case\u2013control, single-centre study of patients with HS and age-, sex- and ethnicity-matched healthy control participants. We profiled circulating inflammatory proteins using Olink\u00ae high-throughput proteomics and determined genetic ancestry from whole-genome sequencing data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Using linear regression, we identified novel proteins associated with HS, after adjusting for age, sex and ethnicity. Our analysis also revealed differences in the inflammatory proteome linked to disease severity. Specifically, we found that plasma levels of interleukin (IL)-6 can distinguish between different Hurley stages, indicating that IL-6 may serve as a marker of disease severity. Additionally, we found variations in inflammatory protein levels based on genetic ancestry: patients with predominantly African ancestry exhibited higher levels of inflammatory proteins associated with neutrophilic inflammation, while those with predominantly European ancestry showed increased levels of T helper 1-related inflammatory proteins.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although we were unable to account for treatment status or comorbidities that may influence the level of inflammatory cytokines, genetic ancestry and disease severity may influence the plasma inflammatory profile in patients with HS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjd\/ljaf012","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T23:15:57Z","timestamp":1735946157000},"page":"1063-1071","source":"Crossref","is-referenced-by-count":6,"title":["High-throughput proteomics identifies inflammatory proteins associated with disease severity and genetic ancestry in patients with hidradenitis suppurativa"],"prefix":"10.1093","volume":"192","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5648-5962","authenticated-orcid":false,"given":"Peter M","family":"Dimitrion","sequence":"first","affiliation":[{"name":"Center for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health , Detroit, MI ,","place":["USA"]},{"name":"Immunology Research Program, Henry Ford Cancer Institute, Henry Ford Health , Detroit, MI ,","place":["USA"]},{"name":"Cancer Biology Graduate Program, School of Medicine, Wayne State University , Detroit, MI ,","place":["USA"]},{"name":"Department of Dermatology, Henry Ford Health , Detroit, MI ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8861-7640","authenticated-orcid":false,"given":"Rachel","family":"Krevh","sequence":"additional","affiliation":[{"name":"Center for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health , Detroit, MI ,","place":["USA"]},{"name":"Immunology Research Program, Henry Ford Cancer Institute, Henry Ford Health , Detroit, MI ,","place":["USA"]},{"name":"Department of Dermatology, Henry Ford Health , Detroit, MI ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3576-855X","authenticated-orcid":false,"given":"Jesse","family":"Veenstra","sequence":"additional","affiliation":[{"name":"Center for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health , Detroit, MI ,","place":["USA"]},{"name":"Immunology Research Program, Henry Ford Cancer Institute, Henry Ford Health , Detroit, MI ,","place":["USA"]},{"name":"Department of Dermatology, Henry Ford Health , Detroit, MI ,","place":["USA"]},{"name":"Center for Bioinformatics, Department of Public Health Sciences, Henry Ford Health , Detroit, MI ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5389-134X","authenticated-orcid":false,"given":"James","family":"Ge","sequence":"additional","affiliation":[{"name":"Center for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health , Detroit, MI ,","place":["USA"]},{"name":"Immunology Research Program, Henry Ford Cancer Institute, Henry Ford Health , Detroit, MI ,","place":["USA"]},{"name":"Department of Dermatology, Henry Ford Health , Detroit, MI ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2086-5418","authenticated-orcid":false,"given":"Aamir","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Henry Ford Health , Detroit, MI ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7095-1555","authenticated-orcid":false,"given":"Deangelo","family":"Ferguson","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Henry Ford Health , Detroit, MI ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0761-8551","authenticated-orcid":false,"given":"Aakash","family":"Hans","sequence":"additional","affiliation":[{"name":"Center for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health , Detroit, MI ,","place":["USA"]},{"name":"Immunology Research Program, Henry Ford Cancer Institute, Henry Ford Health , Detroit, MI ,","place":["USA"]},{"name":"Department of Dermatology, Henry Ford Health , Detroit, MI ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5699-4671","authenticated-orcid":false,"given":"Bobby","family":"Zuniga","sequence":"additional","affiliation":[{"name":"Center for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health , Detroit, MI ,","place":["USA"]},{"name":"Immunology Research Program, Henry Ford Cancer Institute, Henry Ford Health , Detroit, MI ,","place":["USA"]},{"name":"Department of Dermatology, Henry Ford Health , Detroit, MI ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7618-4567","authenticated-orcid":false,"given":"Kermanjot","family":"Sidhu","sequence":"additional","affiliation":[{"name":"Center for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health , Detroit, MI ,","place":["USA"]},{"name":"Immunology Research Program, Henry Ford Cancer Institute, Henry Ford Health , Detroit, MI ,","place":["USA"]},{"name":"Department of Dermatology, Henry Ford Health , Detroit, MI ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6951-2894","authenticated-orcid":false,"given":"Steven","family":"Daveluy","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Wayne State University , Detroit, MI ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3137-5601","authenticated-orcid":false,"given":"Iltefat","family":"Hamzavi","sequence":"additional","affiliation":[{"name":"Center for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health , Detroit, MI ,","place":["USA"]},{"name":"Department of Dermatology, Henry Ford Health , Detroit, MI ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7028-3865","authenticated-orcid":false,"given":"Li","family":"Zhou","sequence":"additional","affiliation":[{"name":"Center for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health , Detroit, MI ,","place":["USA"]},{"name":"Immunology Research Program, Henry Ford Cancer Institute, Henry Ford Health , Detroit, MI ,","place":["USA"]},{"name":"Department of Dermatology, Henry Ford Health , Detroit, MI ,","place":["USA"]},{"name":"Department of Medicine, College of Human Medicine, Michigan State University , East Lansing, MI ,","place":["USA"]},{"name":"Henry Ford Health + Michigan State University Health Sciences , Detroit, MI ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9973-3057","authenticated-orcid":false,"given":"Indra","family":"Adrianto","sequence":"additional","affiliation":[{"name":"Center for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health , Detroit, MI ,","place":["USA"]},{"name":"Immunology Research Program, Henry Ford Cancer Institute, Henry Ford Health , Detroit, MI ,","place":["USA"]},{"name":"Center for Bioinformatics, Department of Public Health Sciences, Henry Ford Health , Detroit, MI ,","place":["USA"]},{"name":"Department of Medicine, College of Human Medicine, Michigan State University , East Lansing, MI ,","place":["USA"]},{"name":"Henry Ford Health + Michigan State University Health Sciences , Detroit, MI ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1411-6827","authenticated-orcid":false,"given":"Qing-Sheng","family":"Mi","sequence":"additional","affiliation":[{"name":"Center for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health , Detroit, MI ,","place":["USA"]},{"name":"Immunology Research Program, Henry Ford Cancer Institute, Henry Ford Health , Detroit, MI ,","place":["USA"]},{"name":"Cancer Biology Graduate Program, School of Medicine, Wayne State University , Detroit, MI ,","place":["USA"]},{"name":"Department of Dermatology, Henry Ford Health , Detroit, MI ,","place":["USA"]},{"name":"Department of Medicine, College of Human Medicine, Michigan State University , East Lansing, MI ,","place":["USA"]},{"name":"Henry Ford Health + Michigan State University Health Sciences , Detroit, MI ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,1,8]]},"reference":[{"key":"2025052713001734000_ljaf012-B1","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1001\/jamadermatol.2021.1677","article-title":"Prevalence of hidradenitis suppurativa: a systematic review and meta-regression analysis","volume":"157","author":"Jfri","year":"2021","journal-title":"JAMA Dermatol"},{"key":"2025052713001734000_ljaf012-B2","doi-asserted-by":"crossref","first-page":"918858","DOI":"10.3389\/fgene.2022.918858","article-title":"Recent advances in hidradenitis suppurativa: role of race, genetics, and immunology","volume":"13","author":"Vellaichamy","year":"2022","journal-title":"Front Genet"},{"key":"2025052713001734000_ljaf012-B3","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/ijd.16428","article-title":"African American race is a risk factor for severe hidradenitis suppurativa","volume":"62","author":"Ulschmid","year":"2023","journal-title":"Int J Dermatol"},{"key":"2025052713001734000_ljaf012-B4","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/j.jaci.2022.02.003","article-title":"Insights into hidradenitis suppurativa","volume":"149","author":"van Straalen","year":"2022","journal-title":"J Allergy Clin Immunol"},{"key":"2025052713001734000_ljaf012-B5","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.jaad.2021.07.035","article-title":"The inflammatory proteome of hidradenitis suppurativa skin is more expansive than that of psoriasis vulgaris","volume":"86","author":"Navrazhina","year":"2022","journal-title":"J Am Acad Dermatol"},{"key":"2025052713001734000_ljaf012-B6","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1016\/j.jid.2021.02.742","article-title":"In-depth analysis of the hidradenitis suppurativa serum proteome identifies distinct inflammatory subtypes","volume":"141","author":"Navrazhina","year":"2021","journal-title":"J Invest Dermatol"},{"key":"2025052713001734000_ljaf012-B7","doi-asserted-by":"publisher","DOI":"10.1101\/2023.01.27.525867","article-title":"Dysregulated CD38 expression in blood and skin immune cells of patients with hidradenitis suppurativa","author":"Dimitrion","year":"2023","journal-title":"bioRxiv"},{"key":"2025052713001734000_ljaf012-B8","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1111\/bjd.14038","article-title":"Diagnostic delay in hidradenitis suppurativa is a global problem","volume":"173","author":"Saunte","year":"2015","journal-title":"Br J Dermatol"},{"key":"2025052713001734000_ljaf012-B9","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1111\/bjd.20642","article-title":"Large-scale serum analysis identifies unique systemic biomarkers in psoriasis and hidradenitis suppurativa","volume":"186","author":"Navrazhina","year":"2022","journal-title":"Br J Dermatol"},{"key":"2025052713001734000_ljaf012-B10","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.jid.2021.01.023","article-title":"Insights from gamma-secretase: functional genetics of hidradenitis suppurativa","volume":"141","author":"Vellaichamy","year":"2021","journal-title":"J\u00a0Invest Dermatol"},{"key":"2025052713001734000_ljaf012-B11","doi-asserted-by":"crossref","first-page":"e139932","DOI":"10.1172\/jci.insight.139932","article-title":"Immunopathogenesis of hidradenitis suppurativa and response to anti-TNF-alpha therapy","volume":"5","author":"Lowe","year":"2020","journal-title":"JCI Insight"},{"key":"2025052713001734000_ljaf012-B12","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.jid.2021.05.036","article-title":"Altered skin and gut microbiome in hidradenitis suppurativa","volume":"142","author":"McCarthy","year":"2022","journal-title":"J Invest Dermatol"},{"key":"2025052713001734000_ljaf012-B13","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1001\/jamadermatol.2021.4926","article-title":"Identification of biomarkers and critical evaluation of biomarker validation in hidradenitis suppurativa: a systematic review","volume":"158","author":"Sarkissian S","year":"2022","journal-title":"JAMA Dermatol"},{"key":"2025052713001734000_ljaf012-B14","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1056\/NEJMoa1504370","article-title":"Two phase 3 trials of adalimumab for hidradenitis suppurativa","volume":"375","author":"Kimball","year":"2016","journal-title":"N Engl J Med"},{"key":"2025052713001734000_ljaf012-B15","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1080\/13557858.1997.9961813","article-title":"Why are African Americans under-represented in medical research studies? Impediments to participation","volume":"2","author":"Shavers-Hornaday","year":"1997","journal-title":"Ethn Health"},{"key":"2025052713001734000_ljaf012-B16","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1001\/jamadermatol.2017.0201","article-title":"Sex- and age-adjusted population analysis of prevalence estimates for hidradenitis suppurativa in the United States","volume":"153","author":"Garg","year":"2017","journal-title":"JAMA Dermatol"},{"key":"2025052713001734000_ljaf012-B17","article-title":"Improving representation in clinical trials and research: building research equity for women and underrepresented groups","author":"National Academies of Sciences, Engineering, and Medicine; Policy and Global Affairs; Committee on Women in Science, Engineering, and Medicine"},{"key":"2025052713001734000_ljaf012-B18","doi-asserted-by":"crossref","first-page":"117269","DOI":"10.1016\/j.jns.2020.117269","article-title":"Inclusion of ethnoracial populations and diversity remains a key challenge in Alzheimer's disease biofluid-based biomarker studies","volume":"421","author":"Babulal","year":"2021","journal-title":"J Neurol Sci"},{"key":"2025052713001734000_ljaf012-B19","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1038\/s41588-022-01213-w","article-title":"Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis","volume":"54","author":"Ishigaki","year":"2022","journal-title":"Nat Genet"},{"key":"2025052713001734000_ljaf012-B20","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1126\/science.abg0928","article-title":"Genetic ancestry effects on the response to viral infection are pervasive but cell type specific","volume":"374","author":"Randolph","year":"2021","journal-title":"Science"},{"key":"2025052713001734000_ljaf012-B21","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1101\/gr.107524.110","article-title":"The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data","volume":"20","author":"McKenna","year":"2010","journal-title":"Genome Res"},{"key":"2025052713001734000_ljaf012-B22","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1534\/g3.118.200925","article-title":"GRAF-pop: a fast distance-based method to infer subject ancestry from multiple genotype datasets without principal components analysis","volume":"9","author":"Jin","year":"2019","journal-title":"G3 (Bethesda)"},{"key":"2025052713001734000_ljaf012-B23","doi-asserted-by":"crossref","first-page":"e0179106","DOI":"10.1371\/journal.pone.0179106","article-title":"Quickly identifying identical and closely related subjects in large databases using genotype data","volume":"12","author":"Jin","year":"2017","journal-title":"PLOS ONE"},{"key":"2025052713001734000_ljaf012-B24","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.jaad.2019.08.090","article-title":"Hidradenitis suppurativa: Epidemiology, clinical presentation, and pathogenesis","volume":"82","author":"Goldburg","year":"2020","journal-title":"J Am Acad Dermatol"},{"key":"2025052713001734000_ljaf012-B25","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41572-020-0149-1","article-title":"Hidradenitis suppurativa","volume":"6","author":"Sabat","year":"2020","journal-title":"Nat Rev Dis Primers"},{"key":"2025052713001734000_ljaf012-B26","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1177\/1203475420972348","article-title":"Race-specific prevalence of hidradenitis suppurativa","volume":"25","author":"Sachdeva","year":"2021","journal-title":"J Cutan Med Surg"},{"key":"2025052713001734000_ljaf012-B27","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.3390\/cells10051184","article-title":"The role of BANK1 in B cell signaling and disease","volume":"10","author":"Gomez Hernandez","year":"2021","journal-title":"Cells"},{"key":"2025052713001734000_ljaf012-B28","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1093\/bjd\/ljad184","article-title":"Targeting the NLRP3 inflammasome reduces inflammation in hidradenitis suppurativa skin","volume":"189","author":"Moran","year":"2023","journal-title":"Br J Dermatol"},{"key":"2025052713001734000_ljaf012-B29","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1038\/s41423-023-01037-6","article-title":"Mass cytometry uncovers a distinct peripheral immune profile and upregulated CD38 expression in patients with hidradenitis suppurativa","volume":"20","author":"Dimitrion","year":"2023","journal-title":"Cell Mol Immunol"},{"key":"2025052713001734000_ljaf012-B30","first-page":"e169870","article-title":"Tertiary lymphoid structures sustain cutaneous B cell activity in hidradenitis suppurativa","volume":"9","author":"Lowe","year":"2024","journal-title":"JCI Insight"},{"key":"2025052713001734000_ljaf012-B31","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.jaci.2022.10.034","article-title":"Neutrophilic granulocyte-derived B-cell activating factor supports B cells in skin lesions in hidradenitis suppurativa","volume":"151","author":"Sabat","year":"2023","journal-title":"J Allergy Clin Immunol"},{"key":"2025052713001734000_ljaf012-B32","doi-asserted-by":"crossref","first-page":"e139930","DOI":"10.1172\/jci.insight.139930","article-title":"Contribution of plasma cells and B cells to hidradenitis suppurativa pathogenesis","volume":"5","author":"Gudjonsson","year":"2020","journal-title":"JCI Insight"},{"key":"2025052713001734000_ljaf012-B33","doi-asserted-by":"crossref","first-page":"eaav5908","DOI":"10.1126\/scitranslmed.aav5908","article-title":"Neutrophil extracellular traps, B cells, and type I interferons contribute to immune dysregulation in hidradenitis suppurativa","volume":"11","author":"Byrd","year":"2019","journal-title":"Sci Transl Med"},{"key":"2025052713001734000_ljaf012-B34","doi-asserted-by":"crossref","first-page":"665873","DOI":"10.3389\/fmed.2021.665873","article-title":"Single-cell RNA sequencing reveals cellular and transcriptional changes associated with M1 macrophage polarization in hidradenitis suppurativa","volume":"8","author":"Mariottoni","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"2025052713001734000_ljaf012-B35","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1016\/j.jid.2021.09.031","article-title":"Transcriptome analysis reveals intrinsic proinflammatory signaling in healthy African American skin","volume":"142","author":"Klopot","year":"2022","journal-title":"J Invest Dermatol"},{"key":"2025052713001734000_ljaf012-B36","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/s41423-020-00608-1","article-title":"Interleukin-6 mediates neutrophil mobilization from bone marrow in pulmonary hypertension","volume":"18","author":"Florentin","year":"2021","journal-title":"Cell Mol Immunol"},{"key":"2025052713001734000_ljaf012-B37","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.4049\/jimmunol.181.3.2189","article-title":"IL-6 regulates neutrophil trafficking during acute inflammation via STAT3","volume":"181","author":"Fielding","year":"2008","journal-title":"J\u00a0Immunol"},{"key":"2025052713001734000_ljaf012-B38","doi-asserted-by":"crossref","first-page":"EVIDoa2300155","DOI":"10.1056\/EVIDoa2300155","article-title":"Brepocitinib, zimlovisertib, and ropsacitinib in hidradenitis suppurativa","volume":"3","author":"Kimball","year":"2024","journal-title":"NEJM Evid"},{"key":"2025052713001734000_ljaf012-B39","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/s41392-021-00791-1","article-title":"The JAK\/STAT signaling pathway: from bench to clinic","volume":"6","author":"Hu","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"2025052713001734000_ljaf012-B40","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1001\/jamadermatol.2023.2217","article-title":"Genetic variants associated with hidradenitis suppurativa","volume":"159","author":"Sun","year":"2023","journal-title":"JAMA Dermatol"}],"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bjd\/advance-article-pdf\/doi\/10.1093\/bjd\/ljaf012\/61382169\/ljaf012.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjd\/article-pdf\/192\/6\/1063\/61382169\/ljaf012.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjd\/article-pdf\/192\/6\/1063\/61382169\/ljaf012.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T13:02:12Z","timestamp":1748350932000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/article\/192\/6\/1063\/7945752"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,8]]},"references-count":40,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,1,8]]},"published-print":{"date-parts":[[2025,5,19]]}},"URL":"https:\/\/doi.org\/10.1093\/bjd\/ljaf012","relation":{},"ISSN":["0007-0963","1365-2133"],"issn-type":[{"value":"0007-0963","type":"print"},{"value":"1365-2133","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,6]]},"published":{"date-parts":[[2025,1,8]]}}}