{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T01:07:01Z","timestamp":1787879221488,"version":"build-2784847793"},"reference-count":101,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Tongji Hospital Foundation","award":["2021A09"],"award-info":[{"award-number":["2021A09"]}]},{"name":"Horizontal project funding","award":["2024068"],"award-info":[{"award-number":["2024068"]}]},{"name":"Horizontal project funding","award":["2024100"],"award-info":[{"award-number":["2024100"]}]},{"name":"Ningxia Medical University Key Research Project","award":["XZ2024040"],"award-info":[{"award-number":["XZ2024040"]}]},{"name":"Ningxia Medical University General Research Project","award":["XY2024138"],"award-info":[{"award-number":["XY2024138"]}]},{"name":"Autonomous Region Youth Science and Technology Talent Development Project"},{"name":"Ningxia Association for Science and Technology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Skin diseases encompass a diverse range of conditions with significant psychological and physiological impacts. N6-methyladenosine (m6A) RNA methylation is a key epitranscriptomic modification that regulates gene expression by influencing RNA stability, splicing, translation, export and degradation. Recent studies have highlighted the crucial role of m6A modification in the pathogenesis and progression of various skin diseases. m6A modification affects critical biologic processes of the skin, such as inflammation, immune response and cellular ageing. This review systematically explores the landscape of m6A modification in nontumour skin diseases, elucidating its regulatory roles and therapeutic implications, including wound healing, scar and keloid, skin ageing, psoriasis, systemic lupus erythematosus, acne vulgaris, rosacea, chronic actinic dermatitis and scleroderma. The intricate mechanisms of m6A modification can lead to the development of novel diagnostic biomarkers and therapeutic strategies, ultimately improving patient outcomes.<\/jats:p>","DOI":"10.1093\/bjd\/ljaf087","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T08:54:03Z","timestamp":1741596843000},"page":"983-994","source":"Crossref","is-referenced-by-count":2,"title":["The landscape of <i>N<\/i> \u00a06-methyladenosine RNA methylation in skin diseases"],"prefix":"10.1093","volume":"192","author":[{"given":"Qi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Plastic and Cosmetic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guozhen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Spinal Surgery, General Hospital of Ningxia Medical University , Yinchuan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Jing","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Ningxia Key Laboratory of Vascular Injury and Repair, Ningxia Medical University , Yinchuan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sis","family":"Aghayants","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Renmin Hospital of Wuhan University , Wuhan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangjing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Yinchuan Hospital of Traditional Chinese Medicine, Affiliated to Ningxia Medical University , Yinchuan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0497-4627","authenticated-orcid":false,"given":"Yucheng","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Pathology, The First People\u2019s Hospital of Shizuishan, Affiliated to Ningxia Medical University , Shizuishan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,3,10]]},"reference":[{"key":"2025052712572294200_ljaf087-B1","doi-asserted-by":"crossref","first-page":"101264","DOI":"10.1016\/j.plipres.2023.101264","article-title":"The heterogeneity and complexity of skin surface lipids in human skin health and disease","volume":"93","author":"Mijaljica","year":"2024","journal-title":"Prog Lipid Res"},{"key":"2025052712572294200_ljaf087-B2","doi-asserted-by":"crossref","first-page":"101252","DOI":"10.1016\/j.plipres.2023.101252","article-title":"The skin barrier: an extraordinary interface with an exceptional lipid organization","volume":"92","author":"Bouwstra","year":"2023","journal-title":"Prog Lipid Res"},{"key":"2025052712572294200_ljaf087-B3","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-19383-8","article-title":"Spatially and cell-type resolved quantitative proteomic atlas of healthy human skin","volume":"11","author":"Dyring-Andersen","year":"2020","journal-title":"Nat Commun"},{"key":"2025052712572294200_ljaf087-B4","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.jaad.2021.06.013","article-title":"Interpretation of genomic sequence variants in heritable skin diseases: a primer for clinicians","volume":"89","author":"Uitto","year":"2023","journal-title":"J Am Acad Dermatol"},{"key":"2025052712572294200_ljaf087-B5","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s13045-019-0805-7","article-title":"The interplay between m6A RNA methylation and noncoding RNA in 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