{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T19:28:01Z","timestamp":1783366081414,"version":"3.54.6"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T00:00:00Z","timestamp":1746144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Clinician Scientist School L\u00fcbeck","award":["CS01-2022"],"award-info":[{"award-number":["CS01-2022"]}]},{"name":"Cluster of Excellence Precision Medicine in Chronic Inflammation","award":["EXC 2167"],"award-info":[{"award-number":["EXC 2167"]}]},{"name":"Cluster of Excellence Precision Medicine in Chronic Inflammation","award":["LU 877\/25-1"],"award-info":[{"award-number":["LU 877\/25-1"]}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Schleswig-Holstein Excellence-Chair Program"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,17]]},"abstract":"<jats:p>Prurigo nodularis (PN) is a chronic skin disorder. Emerging, although limited, evidence suggests an association between PN and psychiatric comorbidities. Furthermore, the temporal relationship between PN and the onset of psychiatric conditions remains unclear. To address these unresolved, clinically relevant questions, retrospective cohort studies were conducted. Here, patients with PN exhibited significantly higher risks of suicidal ideations, depressive disorders and schizophrenia compared with matched controls. These findings underscore the importance of integrating mental health screening and support into the care of patients with PN.<\/jats:p>","DOI":"10.1093\/bjd\/ljaf164","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T08:53:00Z","timestamp":1746175980000},"page":"343-345","source":"Crossref","is-referenced-by-count":3,"title":["Increased risk of psychiatric disease in patients with prurigo nodularis"],"prefix":"10.1093","volume":"193","author":[{"given":"Salam","family":"Alfarsi","sequence":"first","affiliation":[{"name":"L\u00fcbeck Institute of Experimental Dermatology, University of L\u00fcbeck , L\u00fcbeck ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Recke","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University-Hospital Schleswig-Holstein (UKSH) , L\u00fcbeck ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn","family":"Gaffal","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University-Hospital Schleswig-Holstein (UKSH) , L\u00fcbeck ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan P","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Psychosomatics and Psychotherapy, University of L\u00fcbeck , L\u00fcbeck ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henner","family":"Zirpel","sequence":"additional","affiliation":[{"name":"Institute and Comprehensive Center for Inflammation Medicine, University of L\u00fcbeck , L\u00fcbeck ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9971-9151","authenticated-orcid":false,"given":"Khalaf","family":"Kridin","sequence":"additional","affiliation":[{"name":"L\u00fcbeck Institute of Experimental Dermatology, University of L\u00fcbeck , L\u00fcbeck ,","place":["Germany"]},{"name":"Faculty of Medicine, Bar-Ilan University , Safed ,","place":["Israel"]},{"name":"Unit of Dermatology and Skin Research Laboratory, Galilee Medical Center , Nahariya ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8513-550X","authenticated-orcid":false,"given":"Diamant","family":"Thaci","sequence":"additional","affiliation":[{"name":"Institute and Comprehensive Center for Inflammation Medicine, University of L\u00fcbeck , L\u00fcbeck ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0863-7148","authenticated-orcid":false,"given":"Henning","family":"Olbrich","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University-Hospital Schleswig-Holstein (UKSH) , L\u00fcbeck ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Bieber","sequence":"additional","affiliation":[{"name":"L\u00fcbeck Institute of Experimental Dermatology, University of L\u00fcbeck , L\u00fcbeck ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf J","family":"Ludwig","sequence":"additional","affiliation":[{"name":"L\u00fcbeck Institute of Experimental Dermatology, University of L\u00fcbeck , L\u00fcbeck ,","place":["Germany"]},{"name":"Department of Dermatology, University-Hospital Schleswig-Holstein (UKSH) , L\u00fcbeck ,","place":["Germany"]},{"name":"Institute and Comprehensive Center for Inflammation Medicine, University of L\u00fcbeck , L\u00fcbeck ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,5,2]]},"reference":[{"key":"2025071703173197000_ljaf164-B1","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.jaad.2018.04.047","article-title":"Ethnic differences and comorbidities of 909 prurigo nodularis patients","volume":"79","author":"Boozalis","year":"2018","journal-title":"J Am Acad Dermatol"},{"key":"2025071703173197000_ljaf164-B2","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1111\/jdv.19700","article-title":"Comorbidities, healthcare resource utilization & treatment pattern among patients with prurigo nodularis, compared to a benchmark in Germany: a real-world evidence claims data study","volume":"38","author":"St\u00e4nder","year":"2024","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2025071703173197000_ljaf164-B3","doi-asserted-by":"crossref","first-page":"105123","DOI":"10.1016\/j.ebiom.2024.105123","article-title":"Increased cardiovascular risks and mortality in prurigo nodularis: a global cohort study","volume":"103","author":"Olbrich","year":"2024","journal-title":"EBioMedicine"},{"key":"2025071703173197000_ljaf164-B4","doi-asserted-by":"crossref","first-page":"105485","DOI":"10.1016\/j.ebiom.2024.105485","article-title":"Biological, as opposed to classic antipsoriatic drug or apremilast, treatment mitigates the risk of death and cardiovascular disease in psoriasis","volume":"111","author":"Kridin","year":"2025","journal-title":"EBioMedicine"},{"key":"2025071703173197000_ljaf164-B5","doi-asserted-by":"crossref","first-page":"1516126","DOI":"10.3389\/fphar.2025.1516126","article-title":"A comprehensive review of methodologies and application to use the real-world data and analytics platform TriNetX","volume":"16","author":"Ludwig","year":"2025","journal-title":"Front Pharmacol"},{"key":"2025071703173197000_ljaf164-B6","doi-asserted-by":"crossref","first-page":"e106","DOI":"10.1111\/jdv.13827","article-title":"Anxiety, depression and suicide in patients with prurigo nodularis","volume":"31","author":"J\u00f8rgensen","year":"2017","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2025071703173197000_ljaf164-B7","doi-asserted-by":"crossref","first-page":"adv40677","DOI":"10.2340\/actadv.v104.40677","article-title":"Depression, anxiety and suicidal ideation in prurigo nodularis: a systematic review and meta-analysis","volume":"104","author":"Jiang","year":"2024","journal-title":"Acta Derm Venereol"},{"key":"2025071703173197000_ljaf164-B8","doi-asserted-by":"crossref","first-page":"adv00754","DOI":"10.2340\/actadv.v102.2151","article-title":"Dupilumab significantly reduces symptoms of prurigo nodularis and depression: a case series","volume":"102","author":"L\u00f6nndahl","year":"2022","journal-title":"Acta Derm Venereol"},{"key":"2025071703173197000_ljaf164-B9","doi-asserted-by":"crossref","first-page":"2421429","DOI":"10.1080\/09546634.2024.2421429","article-title":"Comparison of safety profile in patients with atopic dermatitis treated with dupilumab or conventional systemic treatment: real world data from the US network","volume":"35","author":"Zirpel","year":"2024","journal-title":"J Dermatol Treat"}],"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bjd\/advance-article-pdf\/doi\/10.1093\/bjd\/ljaf164\/63045522\/ljaf164.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjd\/article-pdf\/193\/2\/343\/63045522\/ljaf164.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjd\/article-pdf\/193\/2\/343\/63045522\/ljaf164.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T07:17:39Z","timestamp":1752736659000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/article\/193\/2\/343\/8124091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,2]]},"references-count":9,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,5,2]]},"published-print":{"date-parts":[[2025,7,17]]}},"URL":"https:\/\/doi.org\/10.1093\/bjd\/ljaf164","relation":{},"ISSN":["0007-0963","1365-2133"],"issn-type":[{"value":"0007-0963","type":"print"},{"value":"1365-2133","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,8]]},"published":{"date-parts":[[2025,5,2]]}}}