{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:41:20Z","timestamp":1791844880325,"version":"4.3.4"},"reference-count":75,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Paediatric mycosis fungoides (MF) is characterized by early-stage disease, a strikingly indolent course and high rates of unusual variants. Despite these clinical peculiarities and the special treatment-related safety considerations in children and adolescents, detailed published data on treatments of paediatric MF are scarce, and management is currently based primarily on standard practice in adults. The aim of this work was to develop treatment recommendations specifically designed for MF in children and adolescents, on behalf of the three largest societies for cutaneous lymphomas, the International Society for Cutaneous Lymphomas (ISCL), the European Organisation for Research and Treatment of Cancer \u2013 Cutaneous Lymphoma Tumour Group (EORTC-CLTG), and the United States Cutaneous Lymphoma Consortium (USCLC). We developed this guideline through an international expert consensus process and in accordance with the EQUATOR Network\u2019s recommendations for guideline development. A modified Delphi process was conducted, using questionnaires covering treatment modalities that are recommended by international guidelines for adult MF. Two rounds of expert feedback were conducted, with an additional one hybrid consensus meeting. Therapeutic recommendations were formulated focusing mainly on early-stage disease. These recommendations take into account disease-specific parameters with therapeutic implications, including the specific stage of the disease, the type of lesion, and the presence of the folliculotropic variant, which is commonly observed in the paediatric age group. Patient-related factors, including safety concerns specific to this young age group, were also addressed. This ISCL\/EORTC-CLTG\/USCLC guideline provides up-to-date age-specific practical recommendations for the treatment of MF in children and adolescents.<\/jats:p>","DOI":"10.1093\/bjd\/ljaf198","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T02:37:56Z","timestamp":1748313476000},"page":"653-661","source":"Crossref","is-referenced-by-count":9,"title":["ISCL\/EORTC-CLTG\/USCLC recommendations for the diagnosis, staging and treatment of early-stage paediatric mycosis fungoides: a modified Delphi consensus. Part two: treatment"],"prefix":"10.1093","volume":"193","author":[{"given":"Emmilia","family":"Hodak","sequence":"first","affiliation":[{"name":"Division of Oncology, Davidoff Medical Center, Rabin Medical Center, Beilinson Hospital, Faculty of Medical and Health Sciences, Tel Aviv University , Tel Aviv ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Amitay-Laish","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Rabin Medical Center, Beilinson Hospital, Faculty of Medical and Health Sciences, Tel Aviv University , Tel Aviv ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Bagot","sequence":"additional","affiliation":[{"name":"Dermatology Department, Saint-Louis Hospital, AP-HP, Universit\u00e9 Paris Cit\u00e9 , Paris 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Dermatology, University of Texas, MD Anderson Cancer Center , Houston, TX ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katalin","family":"Ferenczi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Connecticut School of Medicine , Farmington, CT ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francine","family":"Foss","sequence":"additional","affiliation":[{"name":"Yale Cancer Center, Yale School of Medicine , New Haven, CT ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larisa","family":"Geskin","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Columbia University Irving Medical Center , New York, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5478-8735","authenticated-orcid":false,"given":"Emmanuella","family":"Guenova","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Lausanne University Hospital and University of Lausanne , Lausanne ,","place":["Switzerland"]},{"name":"University Institute and Clinic for Immunodermatology, Medical Faculty, Johannes Kepler University , Linz ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youn H","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Oncology, Department of Medicine, Stanford University , Stanford, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark Jean-Aan","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Dermatology, KK Women\u2019s and Children\u2019s Hospital 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Krefeld , Krefeld ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Ortiz-Romero","sequence":"additional","affiliation":[{"name":"Hospital Universitario 12 de Octubre, Institute i+12, University Complutense , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amra","family":"Osmancevic","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg , Gothenburg ,","place":["Sweden"]},{"name":"Region V\u00e4stra G\u00f6taland, Sahlgrenska University Hospital, Department of Dermatology and Venereology , Gothenburg ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelia","family":"Papadavid","sequence":"additional","affiliation":[{"name":"Attikon General University Hospital, National and Kapodistrian University of Athens , Athens ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Bin","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kosin University College of Medicine , Busan ,","place":["South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Quaglino","sequence":"additional","affiliation":[{"name":"Dermatologic Clinic, Department of Medical Sciences, University of Turin Medical School , Turin ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A","family":"Sanches","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of S\u00e3o Paulo Medical School , S\u00e3o Paulo ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Scarisbrick","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Hospital Birmingham , Birmingham 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