{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:21:54Z","timestamp":1760746914013,"version":"build-2065373602"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100008510","name":"University of Maryland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008510","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017062","name":"Johns Hopkins Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,17]]},"abstract":"<jats:p>This study integrates genome-wide DNA methylation and transcriptomic profiling to reveal key dysregulated pathways in prurigo nodularis (PN). Lesional PN skin exhibited distinct epigenetic reprogramming that activated neuroimmune, fibrotic and inflammatory gene networks, uncovering potential targets for precision therapies in chronic pruritic skin disease.<\/jats:p>","DOI":"10.1093\/bjd\/ljaf314","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T17:40:47Z","timestamp":1755020447000},"page":"1026-1028","source":"Crossref","is-referenced-by-count":0,"title":["Epigenetic profiling reveals neuroimmune and fibrotic pathway dysregulation in prurigo nodularis"],"prefix":"10.1093","volume":"193","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9774-4839","authenticated-orcid":false,"given":"Shahin","family":"Shahsavari","sequence":"first","affiliation":[{"name":"Department of Dermatology, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]},{"name":"Maryland Itch Center, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kavita","family":"Vats","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]},{"name":"Maryland Itch Center, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]},{"name":"Maryland Itch Center, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirin","family":"Shahsavari","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]},{"name":"Maryland Itch Center, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meena","family":"Alzamani","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]},{"name":"Maryland Itch Center, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaya","family":"Manjunath","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]},{"name":"Maryland Itch Center, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ze","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Dana-Farber Cancer Institute , Boston, MA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariam","family":"Sobh","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]},{"name":"Maryland Itch Center, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis","family":"Born","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]},{"name":"Maryland Itch Center, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]},{"name":"Maryland Itch Center, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selina","family":"Yossef","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]},{"name":"Maryland Itch Center, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9851-8523","authenticated-orcid":false,"given":"Yagiz Matthew","family":"Akiska","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]},{"name":"Maryland Itch Center, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davies","family":"Gage","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]},{"name":"Maryland Itch Center, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madan","family":"Kwatra","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Duke University, School of Medicine , Durham, NC ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3736-1515","authenticated-orcid":false,"given":"Shawn\u00a0G","family":"Kwatra","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]},{"name":"Maryland Itch Center, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,8,6]]},"reference":[{"key":"2025101708280109100_ljaf314-B1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jid.2024.06.1276","article-title":"Pathophysiology of prurigo nodularis: neuroimmune dysregulation and the role of type 2 inflammation","volume":"145","author":"Kwatra","year":"2025","journal-title":"J Invest Dermatol"},{"key":"2025101708280109100_ljaf314-B2","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.jaad.2018.04.047","article-title":"Ethnic differences and comorbidities of 909 prurigo nodularis patients","volume":"79","author":"Boozalis","year":"2018","journal-title":"J Am Acad Dermatol"},{"key":"2025101708280109100_ljaf314-B3","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.jaci.2019.10.015","article-title":"Epigenetic factors involved in the pathophysiology of inflammatory skin diseases","volume":"145","author":"M\u00f6bus","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"2025101708280109100_ljaf314-B4","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.semcdb.2023.04.005","article-title":"Epigenetic control of inflammation in Atopic Dermatitis","volume":"154","author":"Akhtar","year":"2024","journal-title":"Semin Cell Dev Biol"},{"key":"2025101708280109100_ljaf314-B5","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/imr.12903","article-title":"AIM2 in health and disease: inflammasome and beyond","volume":"297","author":"Kumari","year":"2020","journal-title":"Immunol Rev"},{"author":"Kwatra","key":"2025101708280109100_ljaf314-B6"},{"key":"2025101708280109100_ljaf314-B7","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.matbio.2022.04.004","article-title":"LTBP1 promotes fibrillin incorporation into the extracellular matrix","volume":"110","author":"Przyklenk","year":"2022","journal-title":"Matrix Biol"},{"key":"2025101708280109100_ljaf314-B8","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.immuni.2014.01.002","article-title":"The transcription factors T-bet and Runx are required for the ontogeny of pathogenic interferon-\u03b3-producing T helper 17 cells","volume":"40","author":"Wang","year":"2014","journal-title":"Immunity"}],"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bjd\/advance-article-pdf\/doi\/10.1093\/bjd\/ljaf314\/63966482\/ljaf314.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjd\/article-pdf\/193\/5\/1026\/63966482\/ljaf314.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjd\/article-pdf\/193\/5\/1026\/63966482\/ljaf314.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T12:28:11Z","timestamp":1760704091000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/article\/193\/5\/1026\/8223080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,6]]},"references-count":8,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,8,6]]},"published-print":{"date-parts":[[2025,10,17]]}},"URL":"https:\/\/doi.org\/10.1093\/bjd\/ljaf314","relation":{},"ISSN":["0007-0963","1365-2133"],"issn-type":[{"type":"print","value":"0007-0963"},{"type":"electronic","value":"1365-2133"}],"subject":[],"published-other":{"date-parts":[[2025,11]]},"published":{"date-parts":[[2025,8,6]]}}}