{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:21:25Z","timestamp":1790979685661,"version":"4.1.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Anti-p200 pemphigoid is an autoimmune bullous disorder, first described in 1996. Clinically, it presents with tense blisters, erosions, crusts and erythematous macules\/plaques, in addition to mucosal involvement in about 40% of cases, resembling bullous pemphigoid or the inflammatory variant of epidermolysis bullosa acquisita. As in other pemphigoid diseases, autoreactive IgG and\/or C3 bind along the cutaneous basement membrane zone. Serum autoantibodies recognize a 200\u2005kDa protein of the dermoepidermal junction that label the dermal side of human salt-split skin by indirect immunofluorescence microscopy. Subsequently, laminin \u03b31 has been described as a target antigen of anti-p200 pemphigoid. Laminin \u03b24 has also recently been identified as a target antigen. A standardized, highly specific and sensitive detection system for serum anti-laminin \u03b24 IgG is now widely available. This allows for the diagnosis of anti-p200 pemphigoid outside of specialized centres. Current in vitro and ex vivo data point to laminin \u03b24 as the pathophysiologically relevant autoantigen, while in vivo data to clarify the functional relevance of anti-laminin \u03b24 IgG are still lacking. Here, we summarize the current knowledge about the epidemiology, clinical presentation, diagnosis, target antigens, pathophysiology and treatment of this pemphigoid disease.<\/jats:p>","DOI":"10.1093\/bjd\/ljaf324","type":"journal-article","created":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T11:37:55Z","timestamp":1755949075000},"page":"10-17","source":"Crossref","is-referenced-by-count":7,"title":["Anti-p200 pemphigoid"],"prefix":"10.1093","volume":"194","author":[{"given":"Michael","family":"Kasperkiewicz","sequence":"first","affiliation":[{"name":"Division of Dermatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles , Los Angeles, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Pigors","sequence":"additional","affiliation":[{"name":"L\u00fcbeck Institute of Experimental Dermatology, University of L\u00fcbeck , L\u00fcbeck ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maike M","family":"Holtsche","sequence":"additional","affiliation":[{"name":"L\u00fcbeck Institute of Experimental Dermatology, University of L\u00fcbeck , L\u00fcbeck ,","place":["Germany"]},{"name":"University Clinic of Dermatology and Allergy, University of Oldenburg , Oldenburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Goletz","sequence":"additional","affiliation":[{"name":"L\u00fcbeck Institute of Experimental Dermatology, University of L\u00fcbeck , L\u00fcbeck ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1206-8913","authenticated-orcid":false,"given":"Enno","family":"Schmidt","sequence":"additional","affiliation":[{"name":"L\u00fcbeck Institute of Experimental Dermatology, University of L\u00fcbeck , L\u00fcbeck ,","place":["Germany"]},{"name":"Department of Dermatology, Universit\u00e4tsklinikum Schleswig-Holstein, Campus L\u00fcbeck , L\u00fcbeck ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,8,25]]},"reference":[{"key":"2026010607280219100_ljaf324-B1","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/S0140-6736(19)31778-7","article-title":"Pemphigus","volume":"394","author":"Schmidt","year":"2019","journal-title":"Lancet"},{"key":"2026010607280219100_ljaf324-B2","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/S0140-6736(12)61140-4","article-title":"Pemphigoid diseases","volume":"381","author":"Schmidt","year":"2013","journal-title":"Lancet"},{"key":"2026010607280219100_ljaf324-B3","first-page":"413","article-title":"Bullous autoimmune dermatoses: clinical features, diagnostic evaluation, and treatment options","volume":"118","author":"van Beek","year":"2021","journal-title":"Dtsch Arztebl 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