{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:23:17Z","timestamp":1791598997740,"version":"4.3.4"},"reference-count":95,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:00:00Z","timestamp":1757548800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100005706","name":"Beijing Technology and Business University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005706","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002888","name":"Beijing Municipal Education Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002888","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"publisher","award":["32100254"],"award-info":[{"award-number":["32100254"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The skin is the outermost barrier to organisms from the external environment. This natural role, endowed by evolution, results in a nutrient-poor skin surface that enables microbial nutrition-dependent lipids to shape microbial ecology by survival pressure and nutrient preference. In turn, the skin microbiota produce microorganism-metabolized bioactive molecules (MBMs) to increase molecular diversity. This crosstalk functions as a crucial component of niche-regulating skin properties via multiple mechanisms. Furthermore, the local and remote effects of different barrier sites provide a more comprehensive explanation for the crosstalk from a global perspective. The variable function and mechanism of crosstalk may represent an evolutionary means by which the skin uses fluctuating commensal signals \u2013 the highly dynamic MBMs \u2013 to calibrate skin status and provide heterologous protection against invasive pathogens. Elucidating the reasons for the differing selectivity and catalytic efficiency of lipid-metabolizing enzymes in microorganisms and revealing the biologic processes and regulatory mechanisms of the \u2018co-metabolic systems\u2019 on the skin will advance diagnostic and therapeutic strategies for local cutaneous disorders and comorbid diseases of distant organs.<\/jats:p>","DOI":"10.1093\/bjd\/ljaf353","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T11:44:40Z","timestamp":1756899880000},"page":"195-204","source":"Crossref","is-referenced-by-count":3,"title":["Lipidome\u2013microbiome crosstalk as an outer niche in the skin: regulatory networks in health and disease"],"prefix":"10.1093","volume":"194","author":[{"given":"Huaming","family":"He","sequence":"first","affiliation":[{"name":"Beijing Key Laboratory of Plant Resources Research and Development, School of Light Industry Science and Engineering, Beijing\u00a0Technology and Business University , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingren","family":"Xiao","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Plant Resources Research and Development, School of Light Industry Science and Engineering, Beijing\u00a0Technology and Business University , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liya","family":"Song","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Plant Resources Research and Development, School of Light Industry Science and Engineering, Beijing\u00a0Technology and Business University , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Tian","sequence":"additional","affiliation":[{"name":"Dermatology Department, Air Force Medical Center , PLA, Beijing 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