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However, patients in the metformin group demonstrated significant improvements in metabolic parameters. The observed improvements in metabolic parameters could be a reason to prescribe metformin for HS, especially in patients with known metabolic risk factors such as obesity, insulin resistance and metabolic syndrome.<\/jats:p>","DOI":"10.1093\/bjd\/ljaf361","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T11:55:03Z","timestamp":1757505303000},"page":"1262-1264","source":"Crossref","is-referenced-by-count":4,"title":["Metformin in conjunction with doxycycline is not superior to doxycycline monotherapy for hidradenitis suppurativa; results of a phase III double-blinded randomized placebo-\u00a0controlled trial"],"prefix":"10.1093","volume":"193","author":[{"given":"Pim","family":"Aarts","sequence":"first","affiliation":[{"name":"Department of Dermatology, Erasmus University Medical Center , Rotterdam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole D 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