{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T02:13:03Z","timestamp":1769739183902,"version":"3.49.0"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Shenzhen Futian District Public Health Research Project","award":["FTWS2023012"],"award-info":[{"award-number":["FTWS2023012"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,27]]},"abstract":"<jats:p>Acquired reactive perforating collagenosis (ARPC) is driven by synergistic pathways involving metabolic stress and type 2 inflammation. Metabolic disorders (e.g. diabetes, renal failure) elevate advanced glycation end products (AGEs) and HMGB1, which activate the receptor for AGEs (RAGE) signalling. Concurrently, IL-4\/IL-13 promote STAT6 phosphorylation, enhancing S100A8\/A9 expression. These pathways converge via RAGE, leading to aberrant collagen synthesis and transepidermal elimination.<\/jats:p>","DOI":"10.1093\/bjd\/ljaf423","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T12:41:45Z","timestamp":1761568905000},"page":"388-390","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and histopathological correlates of elevated ligands of receptors for advanced glycation end products and type 2 cytokines in acquired reactive perforating collagenosis"],"prefix":"10.1093","volume":"194","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6436-0505","authenticated-orcid":false,"given":"Yu","family":"Lan","sequence":"first","affiliation":[{"name":"Department of Dermatology, The Eighth Affiliated Hospital, Sun Yat-Sen University , Shenzhen ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8618-2908","authenticated-orcid":false,"given":"Shaozhen","family":"Mai","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The Eighth Affiliated Hospital, Sun Yat-Sen University , Shenzhen ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daoming","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The Eighth Affiliated Hospital, Sun Yat-Sen University , Shenzhen ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengfei","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The Eighth Affiliated Hospital, Sun Yat-Sen University , Shenzhen ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The University of Hong Kong-Shenzhen Hospital , Shenzhen ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,10,28]]},"reference":[{"key":"2026012706481845900_ljaf423-B1","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/ced.14851","article-title":"Acquired perforating dermatoses show increased levels of cutaneous advanced glycation end-products","volume":"47","author":"Bellinato","year":"2022","journal-title":"Clin Exp Dermatol"},{"key":"2026012706481845900_ljaf423-B2","doi-asserted-by":"crossref","first-page":"432","DOI":"10.4103\/ijdvl.IJDVL_113_16","article-title":"Expression of the receptor for advanced glycation end products in acquired reactive perforating collagenosis","volume":"83","author":"Akoglu","year":"2017","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"2026012706481845900_ljaf423-B3","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1111\/all.14600","article-title":"The axis of the receptor for advanced glycation endproducts in asthma and allergic airway disease","volume":"76","author":"Perkins","year":"2021","journal-title":"Allergy"},{"key":"2026012706481845900_ljaf423-B4","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.jaci.2019.03.019","article-title":"The receptor for advanced glycation end products is a critical mediator of type 2 cytokine signaling in the lungs","volume":"144","author":"Perkins","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"2026012706481845900_ljaf423-B5","doi-asserted-by":"crossref","first-page":"1240262","DOI":"10.3389\/fimmu.2023.1240262","article-title":"Dupilumab improve acquired reactive perforating collagenosis characterized by type 2 inflammation","volume":"14","author":"Liu","year":"2023","journal-title":"Front Immunol"},{"key":"2026012706481845900_ljaf423-B6","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s10020-018-0060-3","article-title":"The role of advanced glycation end-products in the development of coronary artery disease in patients with and without diabetes mellitus: a review","volume":"24","author":"Fishman","year":"2018","journal-title":"Mol Med"},{"key":"2026012706481845900_ljaf423-B7","doi-asserted-by":"crossref","first-page":"8434","DOI":"10.1038\/s41598-018-26501-6","article-title":"Profibrogenic effect of high-mobility group box protein-1 in human dermal fibroblasts and its excess in keloid tissues","volume":"8","author":"Lee","year":"2018","journal-title":"Sci Rep"},{"key":"2026012706481845900_ljaf423-B8","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/jid.2009.269","article-title":"AGE-modified collagens I and III induce keratinocyte terminal differentiation through AGE receptor CD36: epidermal-dermal interaction in acquired perforating dermatosis","volume":"130","author":"Fujimoto","year":"2010","journal-title":"J Invest Dermatol"}],"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bjd\/advance-article-pdf\/doi\/10.1093\/bjd\/ljaf423\/64960120\/ljaf423.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjd\/article-pdf\/194\/2\/388\/64960120\/ljaf423.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjd\/article-pdf\/194\/2\/388\/64960120\/ljaf423.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T11:48:22Z","timestamp":1769514502000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/article\/194\/2\/388\/8304410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,28]]},"references-count":8,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,10,28]]},"published-print":{"date-parts":[[2026,1,27]]}},"URL":"https:\/\/doi.org\/10.1093\/bjd\/ljaf423","relation":{},"ISSN":["0007-0963","1365-2133"],"issn-type":[{"value":"0007-0963","type":"print"},{"value":"1365-2133","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,2]]},"published":{"date-parts":[[2025,10,28]]}}}