{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T04:41:21Z","timestamp":1771476081303,"version":"3.50.1"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82504253"],"award-info":[{"award-number":["82504253"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471800"],"award-info":[{"award-number":["82471800"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82230107"],"award-info":[{"award-number":["82230107"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273545"],"award-info":[{"award-number":["82273545"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018546","name":"Postdoctoral Innovation Program of Shandong Province","doi-asserted-by":"publisher","award":["SDCX-ZG-202501041"],"award-info":[{"award-number":["SDCX-ZG-202501041"]}],"id":[{"id":"10.13039\/501100018546","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2023MH046"],"award-info":[{"award-number":["ZR2023MH046"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shandong Province Taishan Scholars Young Experts Program","award":["tsqn202408380"],"award-info":[{"award-number":["tsqn202408380"]}]},{"DOI":"10.13039\/100014103","name":"Key Research and Development Program of Shandong Province","doi-asserted-by":"publisher","award":["2021LCZX07"],"award-info":[{"award-number":["2021LCZX07"]}],"id":[{"id":"10.13039\/100014103","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shandong Province Taishan Scholar Project","award":["tspd20230608"],"award-info":[{"award-number":["tspd20230608"]}]},{"name":"Central Guidance for Local Scientific and Technological Development Projects of Shandong Province","award":["YDZX2023058"],"award-info":[{"award-number":["YDZX2023058"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Keratins are vital structural proteins in the formation of intermediate filaments (IFs). Dysfunctional keratins lead to various inherited skin fragilities. The keratin tail domain is essential for the proper functioning of IFs, with glycine loop variability prominent in certain keratin tails. However, the effects of glycine loop variations on the functioning of IFs, and the pathogenicity of excessive variations, remain elusive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To clarify the pathogenic effects of excessive glycine loop variations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed whole-exome sequencing on a patient with epidermolysis bullosa (EB) lacking mutations in known EB-causing genes. Sanger sequencing was used to verify the identified variations in the patient, the patient\u2019s family members and a cohort of 319 healthy control individuals. The pathogenicity of the identified variations was evaluated using in vitro and in vivo IF assembly experiments, mouse models, cellular experiments and human skin three-dimensional models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified a compound heterozygous mutation in KRT10, comprising insertions of two and four tandem c.1654_1683 repeats at the c.1683_1684 position, which increased the number of glycine loops by two and four in the keratin 10 tail domain. Although insertions of one and two c.1654_1683 repeats were prevalent in healthy individuals (16.5% and 14.3%, respectively), four insertions were not detected. In vivo and in vitro experiments revealed that excessive glycine loops prevented the proper assembly of IFs. Experiments in mouse and three-dimensional human skin models confirmed that an overabundance of glycine loops led to an EB-like phenotype.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In KRT10, the insertions of limited c.1654_1683 repeats were prevalent and harmless in the general population. However, excessive insertions, exemplified by compound heterozygous mutations with insertions of two and four c.1654_1683 repeats, could be pathogenic. This study was novel in highlighting the pathogenicity of excessive glycine loop extension in the keratin tail domain, establishing a paradigm for other human keratins with glycine-rich tail domains.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjd\/ljaf436","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T12:40:40Z","timestamp":1762173640000},"page":"520-530","source":"Crossref","is-referenced-by-count":0,"title":["Excessive glycine loop variations in the keratin 10 tail domain and implications for skin fragility"],"prefix":"10.1093","volume":"194","author":[{"given":"Zihao","family":"Mi","sequence":"first","affiliation":[{"name":"Dermatology Hospital of Shandong First Medical University , Jinan ,","place":["China"]},{"name":"Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences , Jinan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yueqian","family":"Yu","sequence":"additional","affiliation":[{"name":"Dermatology Hospital of Shandong First Medical University , Jinan ,","place":["China"]},{"name":"Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences , Jinan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenzhen","family":"Wang","sequence":"additional","affiliation":[{"name":"Dermatology Hospital of Shandong First Medical University , Jinan ,","place":["China"]},{"name":"Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences , Jinan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuxiang","family":"Bai","sequence":"additional","affiliation":[{"name":"Dermatology Hospital of Shandong First Medical University , Jinan ,","place":["China"]},{"name":"Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences , Jinan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gongqi","family":"Yu","sequence":"additional","affiliation":[{"name":"Dermatology Hospital of Shandong First Medical University , Jinan ,","place":["China"]},{"name":"Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences , Jinan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingqing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathogen Biology, School of Clinical and Basic Medical Sciences, Shandong First Medical University and Shandong Academy of Medical Sciences , Jinan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanji","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Pathogen Biology, School of Clinical and Basic Medical Sciences, Shandong First Medical University and Shandong Academy of Medical Sciences , Jinan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingjie","family":"Lin","sequence":"additional","affiliation":[{"name":"Dermatology Hospital of Shandong First Medical University , Jinan ,","place":["China"]},{"name":"Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences , Jinan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Sang","sequence":"additional","affiliation":[{"name":"Dermatology Hospital of Shandong First Medical University , Jinan ,","place":["China"]},{"name":"Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences , Jinan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinghong","family":"Han","sequence":"additional","affiliation":[{"name":"Dermatology Hospital of Shandong First Medical University , Jinan ,","place":["China"]},{"name":"Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences , Jinan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojiao","family":"Tu","sequence":"additional","affiliation":[{"name":"Dermatology Hospital of Shandong First Medical University , Jinan ,","place":["China"]},{"name":"Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences , Jinan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Dermatology Hospital of Shandong First Medical University , Jinan ,","place":["China"]},{"name":"Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences , Jinan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Cao","sequence":"additional","affiliation":[{"name":"Dermatology Hospital of Shandong First Medical University , Jinan ,","place":["China"]},{"name":"Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences , Jinan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4488-0372","authenticated-orcid":false,"given":"Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"Dermatology Hospital of Shandong First Medical University , Jinan ,","place":["China"]},{"name":"Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences , Jinan ,","place":["China"]},{"name":"School of Public Health, Shandong First Medical University and Shandong Academy of Medical Science , Jinan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3383-1973","authenticated-orcid":false,"given":"Furen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Dermatology Hospital of Shandong First Medical University , Jinan ,","place":["China"]},{"name":"Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences , Jinan ,","place":["China"]},{"name":"Shandong University of Traditional Chinese Medicine , Jinan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,11,4]]},"reference":[{"key":"2026021806340846900_ljaf436-B1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.12688\/f1000research.12658.1","article-title":"Advances in understanding the molecular basis of skin fragility","volume":"7","author":"Has","year":"2018","journal-title":"F1000Res"},{"key":"2026021806340846900_ljaf436-B2","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1146\/annurev-genom-090413-025540","article-title":"The genetics of skin fragility","volume":"15","author":"Has","year":"2014","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"2026021806340846900_ljaf436-B3","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.3390\/cells10081905","article-title":"Intermediate filaments from tissue integrity to single molecule mechanics","volume":"10","author":"van Bodegraven","year":"2021","journal-title":"Cells"},{"key":"2026021806340846900_ljaf436-B4","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ceb.2020.10.001","article-title":"Recent insight into intermediate filament structure","volume":"68","author":"Eldirany","year":"2021","journal-title":"Curr Opin Cell Biol"},{"key":"2026021806340846900_ljaf436-B5","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.3390\/cells10092457","article-title":"Molecular interactions driving intermediate filament assembly","volume":"10","author":"Vermeire","year":"2021","journal-title":"Cells"},{"key":"2026021806340846900_ljaf436-B6","first-page":"a018242","volume-title":"Cold Spring Harb Perspect Biol","author":"Herrmann","year":"2016"},{"key":"2026021806340846900_ljaf436-B7","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/0092-8674(90)90114-T","article-title":"Retrovirus-mediated transgenic keratin expression in cultured fibroblasts: specific domain functions in keratin stabilization and filament formation","volume":"62","author":"Lu","year":"1990","journal-title":"Cell"},{"key":"2026021806340846900_ljaf436-B8","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/0141-8130(91)90037-U","article-title":"Glycine loops in proteins: their occurrence in certain intermediate filament chains, loricrins and single-stranded RNA binding proteins","volume":"13","author":"Steinert","year":"1991","journal-title":"Int J Biol Macromol"},{"key":"2026021806340846900_ljaf436-B9","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1111\/1523-1747.ep12614149","article-title":"The two size alleles of human keratin 1 are due to a deletion in the glycine-rich carboxyl-terminal V2 subdomain","volume":"99","author":"Korge","year":"1992","journal-title":"J Invest Dermatol"},{"key":"2026021806340846900_ljaf436-B10","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1073\/pnas.89.3.910","article-title":"Extensive size polymorphism of the human keratin 10 chain resides in the C-terminal V2 subdomain due to variable numbers and sizes of glycine loops","volume":"89","author":"Korge","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026021806340846900_ljaf436-B11","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1093\/hmg\/2.5.618","article-title":"Frequencies of human keratin 10 alleles","volume":"2","author":"Mischke","year":"1993","journal-title":"Hum Mol Genet"},{"key":"2026021806340846900_ljaf436-B12","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/sj.jid.5700025","article-title":"A novel mutation and large size polymorphism affecting the V2 domain of keratin 1 in an African-American family with severe, diffuse palmoplantar keratoderma of the ichthyosis hystrix Curth-Macklin type","volume":"126","author":"Richardson","year":"2006","journal-title":"J Invest Dermatol"},{"key":"2026021806340846900_ljaf436-B13","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1111\/bjd.18921","article-title":"Consensus reclassification of inherited epidermolysis bullosa and other disorders with skin fragility","volume":"183","author":"Has","year":"2020","journal-title":"Br J Dermatol"},{"key":"2026021806340846900_ljaf436-B14","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/cge.13791","article-title":"Next-generation sequencing through multigene panel testing for the diagnosis of hereditary epidermolysis bullosa in Chinese population","volume":"98","author":"Chen","year":"2020","journal-title":"Clin Genet"},{"key":"2026021806340846900_ljaf436-B15","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/jdv.18692","article-title":"Genotype and phenotype correlations in 441 patients with epidermolysis bullosa from China","volume":"37","author":"Chen","year":"2023","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2026021806340846900_ljaf436-B16","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/cge.13555","article-title":"An overview of the genetic basis of epidermolysis bullosa in Brazil: discovery of novel and recurrent disease-causing variants","volume":"96","author":"Mariath","year":"2019","journal-title":"Clin Genet"},{"key":"2026021806340846900_ljaf436-B17","doi-asserted-by":"crossref","first-page":"adv00503","DOI":"10.2340\/00015555-3843","article-title":"Epidermolysis bullosa in Chinese patients: genetic analysis and mutation landscape in 57 pedigrees and sporadic cases","volume":"101","author":"Yu","year":"2021","journal-title":"Acta Derm Venereol"},{"key":"2026021806340846900_ljaf436-B18","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1046\/j.1523-1747.2001.01292.x","article-title":"Evidence for novel functions of the keratin tail emerging from a mutation causing ichthyosis hystrix","volume":"116","author":"Sprecher","year":"2001","journal-title":"J Invest Dermatol"},{"key":"2026021806340846900_ljaf436-B19","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1083\/jcb.119.2.401","article-title":"The roles of K5 and K14 head, tail, and R\/K L L E G E domains in keratin filament assembly in vitro","volume":"119","author":"Wilson","year":"1992","journal-title":"J Cell Biol"},{"key":"2026021806340846900_ljaf436-B20","doi-asserted-by":"crossref","first-page":"3539","DOI":"10.1091\/mbc.11.10.3539","article-title":"Coiled-coil trigger motifs in the 1B and 2B rod domain segments are required for the stability of keratin intermediate filaments","volume":"11","author":"Wu","year":"2000","journal-title":"Mol Biol Cell"},{"key":"2026021806340846900_ljaf436-B21","doi-asserted-by":"crossref","first-page":"148","DOI":"10.3390\/bioengineering8110148","article-title":"The importance of mimicking dermal\u2013epidermal junction for skin tissue engineering: a review","volume":"8","author":"Aleemardani","year":"2021","journal-title":"Bioengineering (Basel)"},{"key":"2026021806340846900_ljaf436-B22","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1093\/bjd\/ljaf154","article-title":"Nonsyndromic epidermal differentiation disorders: new classification toward pathogenesis-based therapy","volume":"193","author":"Akiyama","year":"2025","journal-title":"Br J Dermatol"},{"key":"2026021806340846900_ljaf436-B23","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1093\/hmg\/ddl028","article-title":"A human keratin 10 knockout causes recessive epidermolytic hyperkeratosis","volume":"15","author":"M\u00fcller","year":"2006","journal-title":"Hum Mol Genet"},{"key":"2026021806340846900_ljaf436-B24","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/S0923-1811(98)00055-3","article-title":"Arginine in the beginning of the 1A rod domain of the keratin 10 gene is the hot spot for the mutation in epidermolytic hyperkeratosis","volume":"19","author":"Yang","year":"1999","journal-title":"J Dermatol Sci"},{"key":"2026021806340846900_ljaf436-B25","doi-asserted-by":"crossref","first-page":"333","DOI":"10.2147\/CCID.S166849","article-title":"Epidermolytic hyperkeratosis: clinical update","volume":"12","author":"Peter Rout","year":"2019","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"2026021806340846900_ljaf436-B26","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/j.1365-2133.2011.10639.x","article-title":"Description of the natural course and clinical manifestations of ichthyosis with confetti caused by a novel KRT10 mutation","volume":"166","author":"Burger","year":"2012","journal-title":"Br J Dermatol"},{"key":"2026021806340846900_ljaf436-B27","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s13023-015-0336-4","article-title":"Ichthyosis with confetti: clinics, molecular genetics and management","volume":"10","author":"Guerra","year":"2015","journal-title":"Orphanet J Rare Dis"},{"key":"2026021806340846900_ljaf436-B28","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1001\/jamadermatol.2014.2526","article-title":"The phenotypic and genotypic spectra of ichthyosis with confetti plus novel genetic variation in the 3\u2019 end of KRT10: from disease to a syndrome","volume":"151","author":"Spoerri","year":"2015","journal-title":"JAMA Dermatol"},{"key":"2026021806340846900_ljaf436-B29","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/bies.20514","article-title":"Biomechanical properties of intermediate filaments: from tissues to single filaments and back","volume":"29","author":"Kreplak","year":"2007","journal-title":"Bioessays"},{"key":"2026021806340846900_ljaf436-B30","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/dvdy.24384","article-title":"Force transmission in epithelial tissues","volume":"245","author":"Vasquez","year":"2016","journal-title":"Dev Dyn"},{"key":"2026021806340846900_ljaf436-B31","doi-asserted-by":"crossref","first-page":"jcs260594","DOI":"10.1242\/jcs.260594","article-title":"Revisiting the significance of keratin expression in complex epithelia","volume":"135","author":"Cohen","year":"2022","journal-title":"J Cell Sci"},{"key":"2026021806340846900_ljaf436-B32","doi-asserted-by":"crossref","first-page":"4239","DOI":"10.1038\/s41467-020-18075-7","article-title":"Single cell transcriptomics of human epidermis identifies basal stem cell transition states","volume":"11","author":"Wang","year":"2020","journal-title":"Nat Commun"},{"key":"2026021806340846900_ljaf436-B33","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1046\/j.1523-1747.2002.01750.x","article-title":"Frameshift mutation in the V2 domain of human keratin 1 results in striate palmoplantar keratoderma","volume":"118","author":"Whittock","year":"2002","journal-title":"J Invest Dermatol"},{"key":"2026021806340846900_ljaf436-B34","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1126\/science.1192280","article-title":"Mitotic recombination in patients with ichthyosis causes reversion of dominant mutations in KRT10","volume":"330","author":"Choate","year":"2010","journal-title":"Science"},{"key":"2026021806340846900_ljaf436-B35","doi-asserted-by":"crossref","first-page":"579","DOI":"10.2340\/00015555-1796","article-title":"Early immunopathological diagnosis of ichthyosis with confetti in two sporadic cases with new mutations in keratin 10","volume":"94","author":"Diociaiuti","year":"2014","journal-title":"Acta Derm Venereol"},{"key":"2026021806340846900_ljaf436-B36","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jdermsci.2020.02.005","article-title":"Ichthyosis with confetti caused by new and recurrent mutations in KRT10 associated with varying degrees of keratin 10 mis-localization","volume":"98","author":"Pan","year":"2020","journal-title":"J Dermatol Sci"},{"key":"2026021806340846900_ljaf436-B37","doi-asserted-by":"crossref","first-page":"e68","DOI":"10.1111\/jdv.13729","article-title":"A case of epidermolytic ichthyosis showing a very mild phenotype due to a novel tail extension mutation in KRT10","volume":"31","author":"Kono","year":"2017","journal-title":"J Eur Acad Dermatol Venereol"}],"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bjd\/advance-article-pdf\/doi\/10.1093\/bjd\/ljaf436\/65137273\/ljaf436.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjd\/article-pdf\/194\/3\/520\/65137273\/ljaf436.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjd\/article-pdf\/194\/3\/520\/65137273\/ljaf436.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T11:34:19Z","timestamp":1771414459000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/article\/194\/3\/520\/8313676"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,4]]},"references-count":37,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,11,4]]},"published-print":{"date-parts":[[2026,2,18]]}},"URL":"https:\/\/doi.org\/10.1093\/bjd\/ljaf436","relation":{},"ISSN":["0007-0963","1365-2133"],"issn-type":[{"value":"0007-0963","type":"print"},{"value":"1365-2133","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,3]]},"published":{"date-parts":[[2025,11,4]]}}}