{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:46:04Z","timestamp":1791233164769,"version":"4.1.0"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100020732","name":"Innovative Research Team of High-level Local Universities in Shanghai","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020732","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Understanding the roles of diverse fibroblast subsets is of great importance in elucidating the pathogenesis of systemic sclerosis (SSc). How the immunoregulatory function of fibroblasts contributes to the pathology of SSc remains poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To explore how fibroblasts promote fibrosis through immunoregulatory signalling and crosstalk with immune cells in SSc.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Skin and blood samples from seven patients with SSc and four healthy control participants were analysed with single-cell RNA sequencing (scRNAseq). Key findings were confirmed by multiplex immunohistochemistry and flow cytometry. CCL19 expression in fibroblasts was measured in response to exogenous stressors in vitro. The functional role of the CCL19\u2013CCR7 axis was further validated using a bleomycin-induced SSc mouse model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CCL19+ fibroblasts were upregulated in the dermis of patients with SSc and exhibited high expression of immunoregulatory genes. CCL19 expression correlated with the severity of dermal fibrosis in SSc, and these CCL19+ fibroblasts could be induced by vascular endothelial growth factor A (VEGFA). Spatial analysis revealed that CCL19+ fibroblasts were located in the T-cell-enriched niche in SSc skin. The most significant ligand\u2013receptor interaction between CCL19+ fibroblasts and T cells in SSc skin was CCL19\u2013CCR7. Furthermore, CCR7+ T cells, particularly CCR7+ CD8+ T cells, displayed profibrotic properties in SSc with enhanced cytotoxicity and actively interacting with extracellular matrix-producing fibroblasts. Blocking the CCL19\u2013CCR7 axis alleviated dermal fibrosis in the bleomycin-induced SSc mouse model. Trajectory pseudo-time analysis of paired scRNAseq from peripheral blood and skin T cells indicated that skin-infiltrating CCR7+ T cells might originate from peripheral blood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CCL19+ fibroblasts, potentially induced by VEGFA, may remodel profibrotic immune niches by promoting the infiltration of CCR7+ T cells, driving the progression of fibrosis in SSc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjd\/ljaf444","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:00:54Z","timestamp":1762520454000},"page":"326-339","source":"Crossref","is-referenced-by-count":5,"title":["CCL19+ fibroblast\u2013CCR7+ T-cell crosstalk coordinates immunofibrotic signalling networks in systemic sclerosis"],"prefix":"10.1093","volume":"194","author":[{"given":"Wei","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology, Peking University Third Hospital , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohua","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Peking University Third Hospital , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Peking University Third Hospital , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Peking University Third Hospital , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Peking University Third Hospital , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Peking University Third Hospital , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Peking University Third Hospital , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuebo","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Peking University People\u2019s Hospital , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6966-3134","authenticated-orcid":false,"given":"Dan","family":"Xing","sequence":"additional","affiliation":[{"name":"Arthritis Clinical and Research Center, Peking University People\u2019s Hospital , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Arthritis Clinical and Research Center, Peking University People\u2019s Hospital , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiandun","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Peking University Third Hospital , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Peking University Third Hospital , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Dong","sequence":"additional","affiliation":[{"name":"Westlake University School of Medicine , Hangzhou ,","place":["China"]},{"name":"Affiliated Hangzhou First People\u2019s Hospital, School of Medicine, Westlake University , Hangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8588-118X","authenticated-orcid":false,"given":"Huji","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Naval Medical University , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Varga","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, University of Michigan , Ann Arbor, MI ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Peking University Third Hospital , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Ge","sequence":"additional","affiliation":[{"name":"Westlake University School of Medicine , Hangzhou ,","place":["China"]},{"name":"Affiliated Hangzhou First People\u2019s Hospital, School of Medicine, Westlake University , Hangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Mu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Peking University Third Hospital , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,11,28]]},"reference":[{"key":"2026012706474430300_ljaf444-B1","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/S0140-6736(17)30933-9","article-title":"Systemic sclerosis","volume":"390","author":"Denton","year":"2017","journal-title":"Lancet"},{"key":"2026012706474430300_ljaf444-B2","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/S0140-6736(22)01692-0","article-title":"Systemic sclerosis","volume":"401","author":"Volkmann","year":"2023","journal-title":"Lancet"},{"key":"2026012706474430300_ljaf444-B3","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/s41580-024-00716-0","article-title":"Fibroblast and myofibroblast activation in normal tissue repair and fibrosis","volume":"25","author":"Younesi","year":"2024","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026012706474430300_ljaf444-B4","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/s41584-022-00864-7","article-title":"Immune cell dysregulation as a mediator of fibrosis in systemic sclerosis","volume":"18","author":"Fang","year":"2022","journal-title":"Nat Rev Rheumatol"},{"key":"2026012706474430300_ljaf444-B5","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1136\/annrheumdis-2021-221352","article-title":"Large-scale analysis of longitudinal skin gene expression in systemic sclerosis reveals relationships of immune cell and fibroblast activity with skin thickness and a trend towards normalisation over time","volume":"81","author":"Skaug","year":"2022","journal-title":"Ann Rheum Dis"},{"key":"2026012706474430300_ljaf444-B6","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1002\/art.24432","article-title":"Effector CD8+ T cells in systemic sclerosis patients produce abnormally high levels of interleukin-13 associated with increased skin fibrosis","volume":"60","author":"Fuschiotti","year":"2009","journal-title":"Arthritis Rheum"},{"key":"2026012706474430300_ljaf444-B7","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/art.37706","article-title":"Interleukin-13-producing CD8+ T cells mediate dermal fibrosis in patients with systemic sclerosis","volume":"65","author":"Fuschiotti","year":"2013","journal-title":"Arthritis Rheum"},{"key":"2026012706474430300_ljaf444-B8","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1002\/art.40915","article-title":"Induction of inflammation and fibrosis by semaphorin 4A in systemic sclerosis","volume":"71","author":"Carvalheiro","year":"2019","journal-title":"Arthritis Rheumatol"},{"key":"2026012706474430300_ljaf444-B9","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1136\/ard-2023-224827","article-title":"CD7 activation regulates cytotoxicity-driven pathology in systemic sclerosis, yielding a target for selective cell depletion","volume":"83","author":"Papadimitriou","year":"2024","journal-title":"Ann Rheum Dis"},{"key":"2026012706474430300_ljaf444-B10","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/s41586-020-2424-4","article-title":"Structural cells are key regulators of organ-specific immune responses","volume":"583","author":"Krausgruber","year":"2020","journal-title":"Nature"},{"key":"2026012706474430300_ljaf444-B11","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/s41577-021-00540-z","article-title":"Fibroblasts as immune regulators in infection, inflammation and cancer","volume":"21","author":"Davidson","year":"2021","journal-title":"Nat Rev Immunol"},{"key":"2026012706474430300_ljaf444-B12","doi-asserted-by":"crossref","first-page":"5670","DOI":"10.1038\/s41467-019-13636-x","article-title":"Trained immunity modulates inflammation-induced fibrosis","volume":"10","author":"Jeljeli","year":"2019","journal-title":"Nat Commun"},{"key":"2026012706474430300_ljaf444-B13","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.jid.2023.09.288","article-title":"Fibroblast subpopulations in systemic sclerosis: functional implications of individual subpopulations and correlations with clinical features","volume":"144","author":"Zhu","year":"2024","journal-title":"J Invest Dermatol"},{"key":"2026012706474430300_ljaf444-B14","first-page":"202","article-title":"Scleroderma (systemic sclerosis): classification, subsets and pathogenesis","volume":"15","author":"LeRoy","year":"1988","journal-title":"J Rheumatol"},{"key":"2026012706474430300_ljaf444-B15","doi-asserted-by":"crossref","first-page":"4384","DOI":"10.1038\/s41467-021-24607-6","article-title":"Myofibroblast transcriptome indicates SFRP2(hi) fibroblast progenitors in systemic sclerosis skin","volume":"12","author":"Tabib","year":"2021","journal-title":"Nat Commun"},{"key":"2026012706474430300_ljaf444-B16","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/j.cell.2022.03.011","article-title":"LGR5 expressing skin fibroblasts define a major cellular hub perturbed in scleroderma","volume":"185","author":"Gur","year":"2022","journal-title":"Cell"},{"key":"2026012706474430300_ljaf444-B17","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/s41467-023-44645-6","article-title":"Systems-based identification of the Hippo pathway for promoting fibrotic mesenchymal differentiation in systemic sclerosis","volume":"15","author":"Ma","year":"2024","journal-title":"Nat Commun"},{"key":"2026012706474430300_ljaf444-B18","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.1002\/art.39289","article-title":"Dissecting the heterogeneity of skin gene expression patterns in systemic sclerosis","volume":"67","author":"Assassi","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"2026012706474430300_ljaf444-B19","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/art.1780270607","article-title":"Lymphocytes in the skin of patients with progressive systemic sclerosis. Quantification, subtyping, and clinical correlations","volume":"27","author":"Roumm","year":"1984","journal-title":"Arthritis Rheum"},{"key":"2026012706474430300_ljaf444-B20","doi-asserted-by":"crossref","first-page":"3876","DOI":"10.3390\/ijms19123876","article-title":"Fluorescently tagged CCL19 and CCL21 to monitor CCR7 and ACKR4 functions","volume":"19","author":"Purvanov","year":"2018","journal-title":"Int J Mol Sci"},{"key":"2026012706474430300_ljaf444-B21","doi-asserted-by":"crossref","first-page":"eaba1972","DOI":"10.1126\/sciadv.aba1972","article-title":"Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis","volume":"6","author":"Habermann","year":"2020","journal-title":"Sci Adv"},{"key":"2026012706474430300_ljaf444-B22","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/44385","article-title":"Two subsets of memory T lymphocytes with distinct homing potentials and effector functions","volume":"401","author":"Sallusto","year":"1999","journal-title":"Nature"},{"key":"2026012706474430300_ljaf444-B23","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1161\/HYPERTENSIONAHA.121.17712","article-title":"Neutrophil gelatinase-associated lipocalin from macrophages plays a critical role in renal fibrosis via the CCL5 (chemokine ligand 5)-Th2 cells-IL4 (interleukin 4) pathway","volume":"79","author":"Bonnard","year":"2022","journal-title":"Hypertension"},{"key":"2026012706474430300_ljaf444-B24","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1172\/JCI200420997","article-title":"Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis","volume":"114","author":"Phillips","year":"2004","journal-title":"J Clin Invest"},{"key":"2026012706474430300_ljaf444-B25","doi-asserted-by":"crossref","first-page":"e2306965120","DOI":"10.1073\/pnas.2306965120","article-title":"IL-6 trans-signaling in a humanized mouse model of scleroderma","volume":"120","author":"Odell","year":"2023","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026012706474430300_ljaf444-B26","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1136\/annrheumdis-2017-211682","article-title":"Safety and efficacy of subcutaneous tocilizumab in systemic sclerosis: results from the open-label period of a phase II randomised controlled trial (faSScinate)","volume":"77","author":"Khanna","year":"2018","journal-title":"Ann Rheum Dis"},{"key":"2026012706474430300_ljaf444-B27","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/S2213-2600(20)30318-0","article-title":"Tocilizumab in systemic sclerosis: a randomised, double-blind, placebo-controlled, phase 3 trial","volume":"8","author":"Khanna","year":"2020","journal-title":"Lancet Respir Med"},{"key":"2026012706474430300_ljaf444-B28","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1002\/art.42061","article-title":"Interleukin-1\u03b2-activated microvascular endothelial cells promote DC-SIGN-positive alternatively activated macrophages as a mechanism of skin fibrosis in systemic sclerosis","volume":"74","author":"Laurent","year":"2022","journal-title":"Arthritis Rheumatol"},{"key":"2026012706474430300_ljaf444-B29","doi-asserted-by":"crossref","first-page":"1900154","DOI":"10.1183\/13993003.00154-2019","article-title":"IL-1 receptor blockade skews inflammation towards Th2 in a mouse model of systemic sclerosis","volume":"54","author":"Birnhuber","year":"2019","journal-title":"Eur Respir J"},{"key":"2026012706474430300_ljaf444-B30","doi-asserted-by":"crossref","first-page":"17444","DOI":"10.1073\/pnas.1107023108","article-title":"Macrophage migration inhibitory factor (MIF) exerts antifibrotic effects in experimental liver fibrosis via CD74","volume":"108","author":"Heinrichs","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026012706474430300_ljaf444-B31","doi-asserted-by":"crossref","first-page":"eadj7666","DOI":"10.1126\/sciadv.adj7666","article-title":"Disruption of epithelium integrity by inflammation-associated fibroblasts through prostaglandin signaling","volume":"10","author":"Dong","year":"2024","journal-title":"Sci Adv"},{"key":"2026012706474430300_ljaf444-B32","doi-asserted-by":"crossref","first-page":"L6","DOI":"10.1152\/ajplung.00288.2020","article-title":"Inhibition of macrophage migration inhibitory factor (MIF) as a therapeutic target in bleomycin-induced pulmonary fibrosis rats","volume":"321","author":"Luo","year":"2021","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026012706474430300_ljaf444-B33","doi-asserted-by":"crossref","first-page":"R6","DOI":"10.1186\/ar3226","article-title":"mPGES-1 null mice are resistant to bleomycin-induced skin fibrosis","volume":"13","author":"McCann","year":"2011","journal-title":"Arthritis Res Ther"},{"key":"2026012706474430300_ljaf444-B34","doi-asserted-by":"crossref","first-page":"107472","DOI":"10.1016\/j.burns.2025.107472","article-title":"CD147 inhibition reduced fibronectin expression in TGF-\u03b21-induced keloid fibroblasts by targeting Smad2 signaling pathway","volume":"51","author":"Diao","year":"2025","journal-title":"Burns"},{"key":"2026012706474430300_ljaf444-B35","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12931-016-0334-7","article-title":"Extracellular matrix metalloproteinase inducer (EMMPRIN) promotes lung fibroblast proliferation, survival and differentiation to myofibroblasts","volume":"17","author":"Hasaneen","year":"2016","journal-title":"Respir Res"},{"key":"2026012706474430300_ljaf444-B36","doi-asserted-by":"crossref","first-page":"8278","DOI":"10.1073\/pnas.1602899113","article-title":"CCR7 expression alters memory CD8\u2005T-cell homeostasis by regulating occupancy in IL-7- and IL-15-dependent niches","volume":"113","author":"Jung","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026012706474430300_ljaf444-B37","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nrrheum.2016.217","article-title":"Ectopic lymphoid neogenesis in rheumatic autoimmune diseases","volume":"13","author":"Bombardieri","year":"2017","journal-title":"Nat Rev Rheumatol"},{"key":"2026012706474430300_ljaf444-B38","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/art.1780210404","article-title":"Collagen in the cellular and fibrotic stages of scleroderma","volume":"21","author":"Fleischmajer","year":"1978","journal-title":"Arthritis Rheum"},{"key":"2026012706474430300_ljaf444-B39","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1016\/j.jaci.2020.01.042","article-title":"Single-cell transcriptome analysis of human skin identifies novel fibroblast subpopulation and enrichment of immune subsets in atopic dermatitis","volume":"145","author":"He","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"2026012706474430300_ljaf444-B40","doi-asserted-by":"crossref","first-page":"109742","DOI":"10.1016\/j.clim.2023.109742","article-title":"Cross-disease characterization of fibroblast heterogeneities and their pathogenic roles in skin inflammation","volume":"255","author":"Li","year":"2023","journal-title":"Clin Immunol"},{"key":"2026012706474430300_ljaf444-B41","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/art.42807","article-title":"CCL19-positive lymph \u00adnode stromal cells govern the onset of inflammatory arthritis via \u00adtropomyosin receptor kinase","volume":"76","author":"Sch\u00e4lter","year":"2024","journal-title":"Arthritis Rheumatol"},{"key":"2026012706474430300_ljaf444-B42","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.ccell.2024.07.006","article-title":"CCL19-producing fibroblasts promote tertiary lymphoid structure formation enhancing anti-tumor IgG response in colorectal cancer liver metastasis","volume":"42","author":"Zhang","year":"2024","journal-title":"Cancer Cell"},{"key":"2026012706474430300_ljaf444-B43","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1161\/01.RES.0000134644.89917.96","article-title":"Uncontrolled expression of vascular endothelial growth factor and its receptors leads to insufficient skin angiogenesis in patients with systemic sclerosis","volume":"95","author":"Distler","year":"2004","journal-title":"Circ Res"},{"key":"2026012706474430300_ljaf444-B44","doi-asserted-by":"crossref","first-page":"R11","DOI":"10.1186\/ar596","article-title":"Angiogenic and angiostatic factors in systemic sclerosis: increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers","volume":"4","author":"Distler","year":"2002","journal-title":"Arthritis Res"},{"key":"2026012706474430300_ljaf444-B45","doi-asserted-by":"crossref","first-page":"115282","DOI":"10.1016\/j.biopha.2023.115282","article-title":"Further insight into systemic sclerosis from the vasculopathy perspective","volume":"166","author":"Ren","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"2026012706474430300_ljaf444-B46","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s13075-015-0575-8","article-title":"Multiplex cytokine analysis of dermal interstitial blister fluid defines local disease mechanisms in systemic sclerosis","volume":"17","author":"Clark","year":"2015","journal-title":"Arthritis Res Ther"},{"key":"2026012706474430300_ljaf444-B47","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1172\/JCI89535","article-title":"Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands","volume":"127","author":"Chung","year":"2017","journal-title":"J Clin Invest"},{"key":"2026012706474430300_ljaf444-B48","doi-asserted-by":"crossref","first-page":"e154250","DOI":"10.1172\/jci.insight.154250","article-title":"Fibroblastic reticular cells mitigate acute GvHD via MHCII-dependent maintenance of regulatory T cells","volume":"7","author":"Shaikh","year":"2022","journal-title":"JCI Insight"},{"key":"2026012706474430300_ljaf444-B49","doi-asserted-by":"crossref","first-page":"588","DOI":"10.4049\/jimmunol.170.1.588","article-title":"Antagonist of secondary lymphoid-tissue chemokine (CCR ligand 21) prevents the development of chronic graft-versus-host disease in mice","volume":"170","author":"Sasaki","year":"2003","journal-title":"J Immunol"},{"key":"2026012706474430300_ljaf444-B50","doi-asserted-by":"crossref","first-page":"721","DOI":"10.55563\/clinexprheumatol\/sd1exj","article-title":"A multi-predictor model to predict risk of scleroderma renal crisis in systemic sclerosis: a multicentre, retrospective, cohort study","volume":"39","author":"Xu","year":"2021","journal-title":"Clin Exp Rheumatol"},{"key":"2026012706474430300_ljaf444-B51","doi-asserted-by":"crossref","first-page":"5013","DOI":"10.3390\/jcm11175013","article-title":"Anemia is an indicator for worse organ damage trajectories in patients with systemic sclerosis: a retrospective study","volume":"11","author":"Li","year":"2022","journal-title":"J Clin Med"},{"key":"2026012706474430300_ljaf444-B52","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1007\/s10067-019-04806-9","article-title":"Analysis of anti-RNA polymerase III antibodies in Chinese Han systemic sclerosis patients","volume":"39","author":"Liu","year":"2020","journal-title":"Clin Rheumatol"},{"key":"2026012706474430300_ljaf444-B53","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1097\/CM9.0000000000001935","article-title":"Clinical correlations with disease-associated auto-antibodies in a Chinese cohort with systemic sclerosis","volume":"135","author":"Yang","year":"2022","journal-title":"Chin Med J (Engl)"},{"key":"2026012706474430300_ljaf444-B54","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/s10067-012-2145-7","article-title":"Clinical and serological features of systemic sclerosis in a Chinese cohort","volume":"32","author":"Wang","year":"2013","journal-title":"Clin Rheumatol"},{"key":"2026012706474430300_ljaf444-B55","author":"Li"}],"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bjd\/advance-article-pdf\/doi\/10.1093\/bjd\/ljaf444\/65662792\/ljaf444.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjd\/article-pdf\/194\/2\/326\/65662792\/ljaf444.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjd\/article-pdf\/194\/2\/326\/65662792\/ljaf444.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T11:47:57Z","timestamp":1769514477000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/article\/194\/2\/326\/8361857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,28]]},"references-count":55,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,11,28]]},"published-print":{"date-parts":[[2026,1,27]]}},"URL":"https:\/\/doi.org\/10.1093\/bjd\/ljaf444","relation":{},"ISSN":["0007-0963","1365-2133"],"issn-type":[{"value":"0007-0963","type":"print"},{"value":"1365-2133","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,2]]},"published":{"date-parts":[[2025,11,28]]}}}