{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:47:02Z","timestamp":1790084822710,"version":"4.0.1"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2020R1A6A1A0304 3539"],"award-info":[{"award-number":["2020R1A6A1A0304 3539"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2020M3A9D8037604"],"award-info":[{"award-number":["2020M3A9D8037604"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Science","award":["NRF-2022R1A2C2004487"],"award-info":[{"award-number":["NRF-2022R1A2C2004487"]}]},{"name":"Korea government","award":["RS-2025-16069322"],"award-info":[{"award-number":["RS-2025-16069322"]}]},{"name":"Korea Health Technology"},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Health & Welfare, Republic of Korea","award":["RS-2023-KH147044"],"award-info":[{"award-number":["RS-2023-KH147044"]}]},{"name":"Ministry of Health & Welfare, Republic of Korea","award":["RS-2024-00406461"],"award-info":[{"award-number":["RS-2024-00406461"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Melanocyte senescence predominantly occurs in the sun-exposed skin of older individuals and contributes to skin ageing and hypopigmentary disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To identify early molecular events preceding melanocyte senescence and to evaluate a therapeutic strategy for preventing melanocyte ageing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Single-cell RNA sequencing and time-course bulk transcriptome analyses were performed on ultraviolet (UV)B-induced senescent melanocytes to identify senescence-associated pathways. Autophagy impairment was validated using gene and protein assays, immunohistochemistry and ATG7 knockdown or overexpression. The protective effects of metformin on autophagy related 7 (ATG7)-dependent autophagy and redox balance were assessed in senescent melanocytes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Autophagy dysregulation was identified as an early event preceding glycolytic reprogramming during UV-induced melanocyte senescence. ATG7 downregulation emerged as the earliest molecular alteration and was consistently found in senescent melanocytes and idiopathic guttate hypomelanosis skin. Metformin treatment restored autophagic activity, including ATG7 upregulation, and mitigated oxidative stress, delaying melanocyte senescence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Early autophagy dysfunction represents a key initiating event in melanocyte senescence. Autophagy preservation, particularly through ATG7 maintenance, offers a promising early intervention strategy to prevent melanocyte ageing and related hypopigmentary disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjd\/ljaf529","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T12:54:45Z","timestamp":1766580885000},"page":"879-887","source":"Crossref","is-referenced-by-count":2,"title":["Autophagy related 7 dysfunction in senescent melanocytes and hypopigmented skin: reversal by metformin"],"prefix":"10.1093","volume":"194","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3820-8811","authenticated-orcid":false,"given":"Jin Cheol","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Dermatology, Ajou University School of Medicine , Suwon ,","place":["Korea"]},{"name":"Inflamm-Aging Translational Research Center, Ajou University School of Medicine , Suwon 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