{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T16:40:15Z","timestamp":1776444015240,"version":"3.51.2"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Science and Technology Program of Guangzhou"},{"name":"Guangzhou Key Laboratory of Dermatology and Venereology Diagnosis"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,17]]},"abstract":"<jats:p>This letter contextualizes recent findings linking tumour necrosis factor-like weak inducer of apoptosis (TWEAK) to inflammation and disease severity in pemphigus, highlighting the potential relevance of the TWEAK\u2013Fn14 axis to keratinocyte injury and downstream cytokine\/chemokine signalling. We outline key considerations for clinical interpretability \u2013 including treatment status in \u2018new-onset\u2019 cohorts, incremental value beyond established serology and routine inflammatory indices, and appropriate handling of multiplicity \u2013 and propose priorities for prospective validation of TWEAK as a biomarker and therapeutic target.<\/jats:p>","DOI":"10.1093\/bjd\/ljag029","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T10:13:23Z","timestamp":1769422403000},"page":"987-988","source":"Crossref","is-referenced-by-count":0,"title":["Comment on \u2018Tumour necrosis factor-like weak inducer of apoptosis (TWEAK) is associated with inflammation and disease severity in pemphigus\u2019"],"prefix":"10.1093","volume":"194","author":[{"given":"Jiahui","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Dermatology, Guangzhou Dermatology Hospital (Guangzhou Institute of Dermatology, Guangzhou Medical University) , Guangzhou, Guangdong ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingdong","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Guangzhou Dermatology Hospital (Guangzhou Institute of Dermatology, Guangzhou Medical University) , Guangzhou, Guangdong ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"2026041711413245300_ljag029-B1","article-title":"Tumour necrosis factor-like weak inducer of apoptosis (TWEAK) is associated with inflammation and disease severity in pemphigus","volume":"194","author":"Peng","journal-title":"Br J Dermatol"},{"key":"2026041711413245300_ljag029-B2","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1093\/bjd\/ljae283","article-title":"Establishing minimal clinically important differences for the Pemphigus Disease Area Index (PDAI)","volume":"191","author":"Tseng","year":"2024","journal-title":"Br J Dermatol"},{"key":"2026041711413245300_ljag029-B3","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1093\/bjd\/ljaf152","article-title":"Outcome measurement in pemphigus clinical research: a scoping review on heterogeneity in outcome reporting and definitions","volume":"193","author":"Hiel","year":"2025","journal-title":"Br J Dermatol"},{"key":"2026041711413245300_ljag029-B4","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1093\/bjd\/ljae107","article-title":"Beyond the skin: B cells in pemphigus vulgaris, tolerance and treatment","volume":"191","author":"Strandmoe","year":"2024","journal-title":"Br J Dermatol"},{"key":"2026041711413245300_ljag029-B5","doi-asserted-by":"crossref","first-page":"6746870","DOI":"10.1155\/2017\/6746870","article-title":"TWEAK\/Fn14 activation participates in skin inflammation","volume":"2017","author":"Liu","year":"2017","journal-title":"Mediators Inflamm"}],"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bjd\/advance-article-pdf\/doi\/10.1093\/bjd\/ljag029\/66593813\/ljag029.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjd\/article-pdf\/194\/5\/987\/66593813\/ljag029.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjd\/article-pdf\/194\/5\/987\/66593813\/ljag029.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T15:41:41Z","timestamp":1776440501000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/article\/194\/5\/987\/8442810"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,28]]},"references-count":5,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,1,28]]},"published-print":{"date-parts":[[2026,4,17]]}},"URL":"https:\/\/doi.org\/10.1093\/bjd\/ljag029","relation":{},"ISSN":["0007-0963","1365-2133"],"issn-type":[{"value":"0007-0963","type":"print"},{"value":"1365-2133","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,5]]},"published":{"date-parts":[[2026,1,28]]}}}