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Our multicentre experience suggests that disease acceleration may occur in specific clinical contexts, particularly in patients initially diagnosed with dermatitis who were later recognized as having MF\/SS while receiving JAKis. It remains uncertain whether this acceleration represents a direct drug-related effect. Observations in post-transplant settings warrant further investigation, particularly given ruxolitinib\u2019s role in this context. However, symptom-focused benefit may be observed in carefully selected patients. Collectively, these findings highlight that the use of JAKis in treating patients with MF\/SS should be undertaken with caution.<\/jats:p>","DOI":"10.1093\/bjd\/ljag089","type":"journal-article","created":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T12:43:25Z","timestamp":1772801005000},"page":"1178-1180","source":"Crossref","is-referenced-by-count":3,"title":["Mycosis fungoides\/S\u00e9zary syndrome and systemic Janus kinase inhibitors: a real-world retrospective study on behalf of the EORTC CLTG"],"prefix":"10.1093","volume":"194","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4545-7472","authenticated-orcid":false,"given":"Iris","family":"Amitay-Laish","sequence":"first","affiliation":[{"name":"Division of Dermatology, Rabin Medical Center \u2013 Beilinson Hospital , Petah Tikva ,","place":["Israel"]},{"name":"Gray Faculty of Medical and Health Sciences, Tel Aviv University , Tel Aviv ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2893-3609","authenticated-orcid":false,"given":"Keila","family":"Mitsunaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2985-9639","authenticated-orcid":false,"given":"Pablo L","family":"Ortiz-Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7828-6211","authenticated-orcid":false,"given":"Ad\u00e8le","family":"de Masson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4453-6985","authenticated-orcid":false,"given":"Erika","family":"Morsia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5709-092X","authenticated-orcid":false,"given":"Jose A","family":"Sanches","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0890-1642","authenticated-orcid":false,"given":"Paula A","family":"Enz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9340-9152","authenticated-orcid":false,"given":"Vasiliki","family":"Nikolaou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2347-436X","authenticated-orcid":false,"given":"Constanze","family":"Jonak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5408-0312","authenticated-orcid":false,"given":"Stefanie","family":"Porkert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8740-9674","authenticated-orcid":false,"given":"Yael\u00a0A","family":"Leshem","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Rabin Medical Center \u2013 Beilinson Hospital , Petah Tikva ,","place":["Israel"]},{"name":"Gray Faculty of Medical and Health Sciences, Tel Aviv University , Tel Aviv ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2154-7609","authenticated-orcid":false,"given":"Emily","family":"Avitan-Hersh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1645-8038","authenticated-orcid":false,"given":"Emmilia","family":"Hodak","sequence":"additional","affiliation":[{"name":"Gray Faculty of Medical and Health Sciences, Tel Aviv University , Tel Aviv ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"key":"2026051910590162100_ljag089-B1","doi-asserted-by":"crossref","first-page":"1482866","DOI":"10.3389\/or.2025.1482866","article-title":"Janus kinase inhibitors \u2013 a role for the treatment of cutaneous T-cell lymphomas?","volume":"19","author":"Packer","year":"2025","journal-title":"Oncol Rev"},{"key":"2026051910590162100_ljag089-B2","doi-asserted-by":"crossref","first-page":"861","DOI":"10.3390\/cancers16050861","article-title":"JAK inhibitors in cutaneous T-cell lymphoma: friend or foe? 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